The Power of Sound An Exploration of Cooper’s Use of Language in The Last of the Mohicans

This essay examines the use of both language and paralanguage within Last of the Mohicans. Examples of paralanguage in the novel include: the Indian war-whoop, music, animal calls, and all other non-verbal aspects of speech. It is clear that throughout the novel language is a tool of power, if a character has the ability to properly understand and communicate across different language barriers, he or she is able to gain leverage within situations they may encounter, often dangerous. However, these kinds of language interactions can only go so far; they always require some kind of translation to take place in order to be understood. Translation itself is problematic because it is another example of potential power manipulation. This is where I argue paralanguage becomes a powerful tool. Ultimately, Cooper utilizes paralanguage as a tool within his novel to show how such a device can break across nationalistic boundaries of understanding. There is no need for secondary translation to take place when this kind of language is employed. To investigate this claim the paper examines scholarship centering on the use of bodies in Last of the Mohicans; specifically how bodies are manipulated, much like language, by nationalistic and cultural attempts for control. This paper also analyzes how verbal language functions in the novel. Lastly, there is an examination of paralanguage, paying close attention to the use of pure sound such as the war-whoop and music. Ultimately, Cooper utilizes paralanguage to show the sheer power of non-verbal elements of communication and the capabilities of being understood despite strong nationalistic communication barriers

Sensitivity of the Eocene climate to CO₂ and orbital variability

The early Eocene, from about 56 Ma, with high atmospheric CO2 levels, offers an analogue for the response of the Earth’s climate system to anthropogenic fossil fuel burning. In this study, we present an ensemble of 50 Earth system model runs with an early Eocene palaeogeography and variation in the forcing values of atmospheric CO2 and the Earth’s orbital parameters. Relationships between simple summary metrics of model outputs and the forcing parameters are identified by linear modelling, providing estimates of the relative magnitudes of the effects of atmospheric CO2 and each of the orbital parameters on important climatic features, including tropical–polar temperature difference, ocean–land temperature contrast, Asian, African and South (S.) American monsoon rains, and climate sensitivity. Our results indicate that although CO2 exerts a dominant control on most of the climatic features examined in this study, the orbital parameters also strongly influence important components of the ocean–atmosphere system in a greenhouse Earth. In our ensemble, atmospheric CO2 spans the range 280–3000 ppm, and this variation accounts for over 90 % of the effects on mean air temperature, southern winter high-latitude ocean– land temperature contrast and northern winter tropical–polar temperature difference. However, the variation of precession accounts for over 80 % of the influence of the forcing parameters on the Asian and African monsoon rainfall, and obliquity variation accounts for over 65 % of the effects on winter ocean–land temperature contrast in high northern latitudes and northern summer tropical–polar temperature difference. Our results indicate a bimodal climate sensitivity, with values of 4.36 and 2.54 ◦C, dependent on low or high states of atmospheric CO2 concentration, respectively, with a threshold at approximately 1000 ppm in this model, and due to a saturated vegetation–albedo feedback. Our method gives a quantitative ranking of the influence of each of the forcing parameters on key climatic model outputs, with additional spatial information from singular value decomposition providing insights into likely physical mechanisms. The results demonstrate the importance of orbital variation as an agent of change in climates of the past, and we demonstrate that emulators derived from our modelling output can be used as rapid and efficient surrogates of the full complexity model to provide estimates of climate conditions from any set of forcing parameters

Female high school students’ science, technology, engineering and mathematics intentions: the effects of stereotype threat

Bibliography: leaves 131-155The central objective of the present research was to provide a better understanding of stereotype threat and its underlying effects on female high school students’ intention to major in Science, Technology, Engineering and Mathematics (STEM) fields. Specifically, the study investigated the intervening effects of mathematics/science self-efficacy and the conditional effects of perceived social support with regards to the implications of stereotype threat. For this reason, three studies were conducted. Participants were female (Study 1 – 3) and male (Study 1) high school students from Harer and Dire Dawa Regions, located in the Eastern part of Ethiopia. Study 1 provided evidence that both female and male participants were well aware of the existence of the negative stereotype about females’ mathematics/science ability. Participants reported that the Ethiopian society attributes less mathematics/science ability to females than to males. Although female participants were well aware of the existence of the negative stereotype about females’ mathematics and science ability, they did not endorse it. Study 2 showed experimentally that stereotype threat reduces indeed females’ intention to major in STEM fields. Moreover, Study 2 revealed that mathematics/science self-efficacy mediated the relationship between stereotype threat and females’ intention to major in STEM fields. Study 3 addressed the role of social support. The results revealed that female participants who felt socially supported in their intention to major in a STEM field were found to be resistant to the negative effects of stereotype threat. In other words, it is the interaction between stereotype threat and the lack of social support that reduces females' intention to major in STEM fields. The findings of the present study are discussed in relation to stereotype threat theory and related literature as well as in relation to potential educational interventions relevant for the Ethiopian context.PsychologyD. Phil. (Psychology

T Cell Effector Responses in HIV-1 Cure Strategies

HIV-1 is a virus that affects over 35 million individuals around the world, and yet despite present treatments, there remains a need for a cure. A current cure tactic widely researched is the “shock and kill” strategy, where cART-treated HIV-positive individuals would be given latency reactivating agents (LRAs) to induce HIV-1 production from latently-infected CD4+ T cells, allowing for the CD8+ T cell response to eliminate the latent reservoir. Here, I examined the capabilities of the CD8+ T cell response from HIV-positive individuals to eliminate macrophages, another cell type infected by HIV-1, and reactivated latently-infected primary CD4+ T cells, both reactivated with PMA and ionomycin and with LRAs. Both CD4+ and CD8+ T cells from elite suppressors, HIV-positive individuals with viral loads of less than 50 copies per milliliter of blood, were capable of suppressing virus production from HIV-infected monocyte-derived macrophages, with the CD8+ T cells actually killing the infected cells. As to the latently-infected CD4+ T cells, CD8+ T cells from chronic progressors were not consistently capable of eliminating the infected cells upon reactivation, although those from two of four viremic controllers were when PMA and ionomycin were used for stimulation. Treatment with LRAs such as bryostatin and romidepsin both alone and in combination significantly inhibited the CD8+ T cell response to HIV-1, with the mechanism for bryostatin inhibition being an increase in cell death, downregulation of CD3, and upregulation of exhaustion markers. Despite that the elite suppressor CD8+ T cell response was capable of inhibiting HIV-1 infection of macrophages and that the response of some viremic controllers and chronic progressors can do so for latently-infected CD4+ T cells, there remains a need for some sort of immunologic boost for the average individual with HIV-1 infection. Worse, some LRAs and combinations of LRAs decrease the ability of the CD8+ T cell response to eliminate infected CD4+ T cells. Therefore, any given LRA or combination of LRAs should be examined for their effects upon the adaptive immune response prior to use in clinical investigations of HIV-1 cure strategies

Attributes of children and adolescents with avoidant/restrictive food intake disorder.

BackgroundAvoidant/Restrictive Food Intake Disorder (ARFID) is a comparatively new DSM-5 diagnosis. In an effort to better understand this heterogeneous patient group, this study aimed to describe the physical and psychological attributes of children and adolescents with ARFID, and to compare them to patients with full-threshold or atypical anorexia nervosa (AN).MethodsChildren and adolescents aged 7-to-19 years (N = 193) were examined upon presenting at a pediatric eating disorder center between July 2015 and December 2017. Data included diagnosis assessed via the semi-structured Eating Disorder Examination interview along with measures of anthropometrics, depression, anxiety, self-esteem, perfectionism and clinical impairment.ResultsCompared to AN and atypical AN (n = 87), patients with ARFID (n = 106) were significantly younger (12.4 vs. 15.1 years, p < .0001), male (41% vs. 15%, p < .0002), and were more likely to be diagnosed with at least one co-morbid DSM-5 diagnosis (75% vs. 61%, p = .04). Patients with ARFID were less likely to be bradycardic (4.7% vs. 24.1%, p < .0001), amenorrheic (11.1 and 34.7%, p = .001), admitted to the hospital (14.2% vs. 27.6%, p = .02), and have a diagnosis of depression (18.9% vs. 48.3%, p < .0001). Patients with ARFID were significantly less likely to experience acute weight loss vs. chronic weight loss as compared with those with AN or atypical AN (p = .0001). On self-report measures, patients with ARFID reported significantly fewer symptoms of depression, anxiety, perfectionism, clinical impairment, concerns about weight and shape, and higher self-esteem than patients with AN or atypical AN (all ps < .0001). No differences were observed by race, anxiety disorder, orthostatic instability, suicidal ideation, and history of eating disorder treatment.ConclusionsStudy results highlight the clinical significance of ARFID as a distinct DSM-5 diagnosis and the physical and psychological differences between ARFID and AN/atypical AN. The novel finding that ARFID patients are more likely than those diagnosed with AN to experience chronic, rather than acute, weight loss suggests important related treatment considerations

Fear of negative appearance evaluation: Development and evaluation of a new construct for risk factor work in the field of eating disorders

Abstract The psychometric properties and correlates of a measure designed to assess fear of negative appearance evaluation are presented. In Study 1, 165 college females completed the Fear of Negative Appearance Evaluation Scale [FNAES; Thomas, C.M., Keery, H., Williams, R., & Thompson, J. K. (1998, November). The Fear of Negative Appearance Evaluation Scale: Development and preliminary validation. Paper presented at the annual meeting of the Association for the Advancement of Behavior Therapy, Washington, DC] along with measures of body image, eating disturbance, and depression. Results replicated previous analyses indicating the presence of a single factor, good internal consistency, and significant association with measures of body image and eating disturbance. Additionally, the FNAES accounted for unique variance beyond that explained by general fear of negative evaluation, and other measures of body image and eating disturbance, in the prediction of body shape dysphoria, dietary restraint, and trait anxiety. Study 2 further examined the validity of the FNAES, finding it to correlate significantly with measures of social physique anxiety, body image, eating attitude, and mood. The FNAES did not significantly correlate with body mass index (BMI). Regression analyses found the FNAES to predict levels of body image, eating attitude, and mood beyond variance explained by social physique anxiety. The FNAES appears to measure a conceptually unique aspect of body image that has not been indexed by previous measures and may serve a useful role in risk factor and preventive work.

LPMLE3 : a novel 1-D approach to study water flow in streambeds using heat as a tracer

We introduce LPMLE3, a new 1-D approach to quantify vertical water flow components at streambeds using temperature data collected in different depths. LPMLE3 solves the partial differential equation for coupled water flow and heat transport in the frequency domain. Unlike other 1-D approaches it does not assume a semi-infinite halfspace with the location of the lower boundary condition approaching infinity. Instead, it uses local upper and lower boundary conditions. As such, the streambed can be divided into finite subdomains bound at the top and bottom by a temperature-time series. Information from a third temperature sensor within each subdomain is then used for parameter estimation. LPMLE3 applies a low order local polynomial to separate periodic and transient parts (including the noise contributions) of a temperature-time series and calculates the frequency response of each subdomain to a known temperature input at the streambed top. A maximum-likelihood estimator is used to estimate the vertical component of water flow, thermal diffusivity, and their uncertainties for each streambed subdomain and provides information regarding model quality. We tested the method on synthetic temperature data generated with the numerical model STRIVE and demonstrate how the vertical flow component can be quantified for field data collected in a Belgian stream. We show that by using the results in additional analyses, nonvertical flow components could be identified and by making certain assumptions they could be quantified for each subdomain. LPMLE3 performed well on both simulated and field data and can be considered a valuable addition to the existing 1-D methods

Happy being me in the UK: A controlled evaluation of a school-based body image intervention with pre-adolescent children

This study evaluated an adapted version of 'Happy Being Me', a school-based body image intervention, with girls and boys aged 10-11 years. Forty-three children participated in a three-week intervention, and 45 children formed a control group. Both groups completed measures of body satisfaction, risk factors for negative body image, eating behaviors, self-esteem, and intervention topic knowledge, at baseline, post-intervention, and 3-month follow-up. For girls, participation in the intervention resulted in significant improvements in body satisfaction, appearance-related conversations, appearance comparisons, eating behaviors and intervention topic knowledge at post-intervention, although only the change in body satisfaction was maintained. There was also a significant decrease in internalization of cultural appearance ideals from baseline to follow-up. For boys, participation in the intervention resulted in significant improvements in internalization and appearance comparisons at post-intervention; however, neither of these changes were sustained at follow-up. There were no improvements in the control group over time. © 2013 Elsevier Ltd

Riparian shading controls instream spring phytoplankton and benthic diatom growth

Dissolved oxygen (DO) concentrations showed a striking pattern in a multi-year study of the River Enborne, a small river in SE England. In each of three years (2010-2012), maximum DO concentrations were attained in mid-April, preceded by a period of steadily increasing diurnal amplitudes, followed by a steady reduction in both amplitude and concentration. Flow events during the reduction period reduce DO to low concentrations until the following spring. Evidence is presented that this pattern is mainly due to benthic algal growth which is eventually supressed by the growth of the riparian tree canopy. Nitrate and silicate concentrations are too high to inhibit the growth of either benthic algae or phytoplankton, but phosphate concentrations might have started to reduce growth if the tree canopy development had been delayed. This interpretation is supported by evidence from weekly flow cytometry measurements and analysis of the diurnal, seasonal and annual patterns of nutrient concentrations. As the tree canopy develops, the river switches from an autotrophic to a heterotrophic state. The results support the use of riparian shading to help control algal growth, and highlight the risks of reducing riparian shade