The Social Stratification of Social Risks: Class and Responsibility in the 'New' Welfare State

Welfare states are said to have evolved over the course of the past twenty years towards a ‘social investment’ model of welfare, characterised by a focus on equality of opportunity and upward social mobility combined with greater emphasis on individual responsibility. More or less concurrently, under the mantra of ‘individualisation’, scepticism has grown with regard to the relevance of traditional stratification schemes. This paper sets out to ascertain whether social class, i.e. intergenerational background, (still) affects the occurrence of ‘social risks’. Using SILC 2005 data, it considers the impact of social class (of origin) on a relevant selection of social risks: unemployment, ill-health, living in a jobless household, single parenthood, temporary employment, and low-paid employment. The results provide clear evidence of a continuing influence of social class. On this basis, we argue that a one-sided focus on individual responsibility could open the door to new forms of marginalisation.Ireland, Austerity, Fiscal Policy, Monetary Policy

Definitions, characteristics and measures of IT Project Complexity - a systematic literature review

As the world of Information Technology (IT) engineering becomes more complex every day, the formal study of project complexity becomes more and more important for managing projects effectively, to avoid poor performance and failure. Complexity is not yet clearly understood nor sufficiently defined and the terminology itself is being overloaded and over-used. This paper is a systematic literature review that attempts to identify and classify proposed definitions and measures of IT project complexity. The results include a map of the identified approaches and definitions, a list of classifications of project complexity, a set of proposed measurement tools and complexity measures available to practitioners. The paper contributes to establishing a common language when discussing complexity, as well as to a better understanding of project complexity and its implications to practical IT engineering projects

Maximum Likelihood Estimation of the Parameters of Linear Systems

A method is presented which estimates the parameters of Linear Systems (LS), modelled by their transfer function, using a very efficient iteration algorithm. The estimator is an error in variables method and takes into account the noise on the input and output measurements. During the estimation process, an approximation of the Cramer-Rao lower bound on the covariance matrix of the estimates is derived and the 'mean' model error is discussed

Basal ryanodine receptor activity suppresses autophagic flux

The inositol 1,4,5-trisphosphate receptors (IP3Rs) and intracellular Ca2+ signaling are critically involved in regulating different steps of autophagy, a lysosomal degradation pathway. The ryanodine receptors (RyR), intracellular Ca2+-release channels mainly expressed in excitable cell types including muscle and neurons, have however not yet been extensively studied in relation to autophagy. Yet, aberrant expression and excessive activity of RyRs in these tissues has been implicated in the onset of several diseases including Alzheimer’s disease, where impaired autophagy regulation contributes to the pathology. In this study, we determined whether pharmacological RyR inhibition could modulate autophagic flux in ectopic RyR-expressing models, like HEK293 cells and in cell types that endogenously express RyRs, like C2C12 myoblasts and primary hippocampal neurons. Importantly, RyR3 overexpression in HEK293 cells impaired the autophagic flux. Conversely, in all cell models tested, pharmacological inhibition of endogenous or ectopically expressed RyRs, using dantrolene or ryanodine, augmented autophagic flux by increasing lysosomal turn-over (number of autophagosomes and autolysosomes measured as mCherry-LC3 punctae/cell increased from 70.37 ± 7.81 in control HEK RyR3 cells to 111.18 ± 7.72 and 98.14 ± 7.31 after dantrolene and ryanodine treatments, respectively). Moreover, in differentiated C2C12 cells, transmission electron microscopy demonstrated that dantrolene treatment decreased the number of early autophagic vacuoles from 5.9 ± 2.97 to 1.8 ± 1.03 per cellular cross section. The modulation of the autophagic flux could be linked to the functional inhibition of RyR channels as both RyR inhibitors efficiently diminished the number of cells showing spontaneous RyR3 activity in the HEK293 cell model (from 41.14% ± 2.12 in control cells to 18.70% ± 2.25 and 9.74% ± 2.67 after dantrolene and ryanodine treatments, respectively). In conclusion, basal RyR-mediated Ca2+-release events suppress autophagic flux at the level of the lysosomes

Modeling the non-stationary behaviour of time-varying electrical bioimpedance

The electrical bioimpedance (EBI) measurement of varying biological systems Z(¿,t) (e.g. the heart, the lungs,.) by means of electrical impedance spectroscopy (EIS) remains an open challenge today. Briefly stated, the bioimpedance is widely assumed to be time-invariant when it is measured with the frequency sweep EIS approach. Hence, time-varying changes are thus ignored or treated as a noise source. In this work, we attempt to model the time-variant effects and obtain a simple (periodically) time-varying [(P)TV)] electrical circuit model with (P)TV parameters from experimental in vivo EBI data using the model proposed by Fricke- Morse. The aim is then to illustrate that a limited number of harmonic components of the electrical circuit parameters, which corresponds to an integer number of the bio-system periodicity, can be used to have a realistic evolution of the bioimpedance over time as well as in frequency.Peer ReviewedPostprint (published version