Impact of Laparoscopic Surgical Management of Deep Endometriosis on Pregnancy Rate

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Oleogranulomatous Mastitis: A Topical Subject:

Paraffin and petrolatum have been known for more than 100 years as volumizing products. Certain countries still use them despite important complications. The authors report the case of a 39-year-old patient presenting a bilateral oleogranulomatous mastitis. An injection of petrolatum had been realized 2 years ago in Chechnya for cosmetic reasons. Clinically, she presented dense, erythemic, and painful breasts. The radiological examination found diffuse oily cysts. After first abdominal expansion, a bilateral mastectomy with immediate reconstruction was performed. The authors present a literature review about the clinical and radiological data and the possible treatments, and underline the numerous risks of this procedure, which should be strictly forbidden

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders

Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders. In this review, the focus will be on a biochemical pathway that remains under-recognised in its implications for brain function, even though it can be responsible for moderating the activity of two neurotransmitters fundamentally involved in cognition – glutamate and acetylcholine. Since this pathway – the kynurenine pathway of tryptophan metabolism - is induced by immunological activation and stress it also stands in an unique position to mediate the effects of environmental factors on cognition and behaviour. Targetting the pathway for new drug development could, therefore, be of value not only for the treatment of existing psychiatric conditions, but also for preventing the development of cognitive disorders in response to environmental pressures

Heteroglossia: Interpretation and the Experiences of Coptic Immigrants from Egypt in North America, 1955–1975

Scholarship on Coptic Orthodox Christians, built on textual sources left behind by elites and institutions, has focused largely on the unwavering persistence of an insular faith community. Instead, oral history can focus on the material engagements of immigrants to central Canada and the northeastern United States in its analysis. In doing so, the histories of Egyptian migrants reveal how some people carved out a space for autobiographies within collective communal narratives. Adopting a methodology that privileges the heteroglossia—varied and opposing voices—of migrating actors, the author insists that a transnational and reflexive analysis is necessary to appreciate the everyday lives and motivations of Copts from Egypt in North America.Les recherches sur les chrétiens orthodoxes coptes, basées sur les sources écrites laissées par les élites et les institutions, se sont surtout concentrées sur la persévérance inébranlable d’une communauté de fidèles fermée sur elle-même. Au lieu de cela, les analyses d’histoire orale des immigrants du centre du Canada et du nord-est des États-Unis peuvent porter davantage sur la façon dont ils s’inscrivent dans le monde concret. Ce faisant, les histoires des migrants égyptiens révèlent la façon dont certaines personnes se sont créé un espace autobiographique au sein des grands récits du collectif communautaire. Grâce à une méthodologie qui fait la part belle à l’hétéroglossie — les voix diverses et contradictoires — des acteursmigrants, l’auteur insiste sur le fait qu’il est nécessaire de procéder à une analyse réflexive et transnationale afin d’apprécier à leur juste valeur la vie quotidienne et les motivations des coptes d’Égypte en Amérique du Nord

Safety by design: An expert systems approach.

Industries may require the application of new technologies. In recent years, these technologies have undergone rapid development. Intensely scrutinized in terms of design, new technologies surprisingly receive little attention when assessing the hazards they might pose to worker health and safety. These technologies are usually designed by experts who know very little about safety and health issues. A user-friendly, easily accessible system that is devised to assist designers during the design phase by pointing out the different downfalls of their design with respect to safety and health issues and impacts, can dramatically improve safety, reduce costs, and most importantly, reduce the chances of injuries and fatalities associated with such technologies. This concept involves obtaining data for defining a technology, identifying and defining the elements and the hazards associated with these technology elements in terms of sources and types, evaluating the process to identify potential for human errors, building queries to suggest for removing or controlling the hazards, evaluating the interaction of technology elements, and finally, providing a summary of the hazards identified and suggested corrective measures. Hence, this study was carried out using a knowledge-based expert system (ES). The system was initially prototyped to a small existing technology of very limited scope. All hazardous events related to using this machine were documented into the rules of the ES. This system showed that design-for-safety can indeed be possible using computer systems. The system was researched for its robustness, design integrity, and the advantage of using expert systems for “What-If†scenarios. Ultimately, this system will allow designers to enter and analyze their designs in terms of safety and health. Recommendations will be provided to reduce the potential for hazard exposure and corresponding hazardous events. This tool should dramatically enhance the safety of new technologies at a fraction of the currently incurred costs