Relevance and justification of the regional development agency approach for the Brcko district of BiH

Still facing the consequences of a post-war and a post-communist transition, BiH is trying to consolidate the strategies for a sustainable peace, based on institutionalisation of a pluralistic democracy - less obsessed by the ethnic questions - and a socio-economic development - that does not necessarily have to rely on the international assistance. Bosnia and Herzegovina is far from being an unitarian institutional, political and social subject and the differences that have marked the years of the war have got consolidated in a constitutional structure that is for sure one of the most complicated that are currently existing in the world. The lack of the presence of a State in the policy making process, is often filled up in Bosnia by the emerging role of local authorities. The case of Brcko District of Bosnia and Herzegovina is rather unique and is a sort of paradox in the paradox of the BiH situation. After getting an autonomous status which was a result of a long and tiring political mediation, Brcko District is now facing the challenge of building a regional development strategy, which has not only to be "politically correct" (like almost all the decisions that have been recently regarding this little but strategic territorial area, so crucial for the BiH peace stability) but has as well to match the difficulties of achieving a future sustainability. The following paper aims to give an answer to the following crucial questions: Does it make sense to promote a regional development strategy and the institutionalisation of a Development Agency for a limited territorial area like Brcko, created as a consequence of a war scenario? What is the specificity of Brcko and what -on the contrary- can be used to build up a model replicable elsewhere in BiH?

Histochemistry through the years, browsing a long-established journal: novelties in traditional subjects

Histochemical journals represent a traditional forum where methodological and technological improvements can be presented and validated in view of their applications to investigate not only cytology and histology in normal and diseased conditions but to test as well hypotheses on more basic issues for life sciences, such as comparative and evolutionary biology. The earliest scientific journals on histochemistry began their publication in the first half of the ‘50s of the last century, and their readership did not probably change over the years; rather, the authors’ interests may have progressively been changing as well as the main topics of their articles. This hypothesis is discussed, based on the subjects of the article published in the first and last ten years in the European Journal of Histochemistry, as an example of old journal which started publication in 1954, being since then the official organ of the Italian Society of Histochemistry. This survey confirmed that histochemistry has provided and still offers unique opportunities for studying the structure, chemical composition and function of cells and tissues in a wide variety of living organisms, especially when the topological distribution of specific molecular components has diagnostic or predictive significance, as it occurs in human and veterinary biology and pathology. Some subjects (e.g. histochemistry applied to muscle cells or to mineralized tissues) have recently become rather popular, whereas a wider application of the histochemical approach may be envisaged for plant cells and tissues

Unaware Actors: Policies and Random Combinations of Aid Interventions in Bosnia and Herzegovina (1992-1995)

In the last ten years, international organizations have defined more clearly the role and the tasks of humanitarian aid in contemporary international relations. The case of Bosnia and Herzegovina is a good illustration of the advantages but also of the disadvantages of today’s humanitarian operations. The peacekeeping operation in Bosnia and Herzegovina is the largest operation of this kind that has been set in motion by the international community. In its humanitarian aspect it is complex and multi-layered. Humanitarian campaigns today are more philanthropically- than organizationally-driven, but it is the latter aspect that makes them fail or succeed. It is not enough to provide humanitarian aid, but its distribution to the recipients who need it must be organized. That process involves several essential factors: international and inter-state organizations, governmental organizations as well as non-governmental (international and local) organizations and associations. The example of Bosnia and Herzegovina shows to what extent the mentioned factors contribute to the success of a humanitarian operation, but also the problems which stem from their undefined role and tasks

From the Internet of Things to Cyber-Physical Systems: The Holonic Perspective

The paper presents a distributed model for implementing Cyber-Physical Systems aimed at controlling physical entities through the Internet of Things. The model tames the inherent complexity of the task by a recursive notion of modularity which makes each module both a controller and a controlled entity. Modules are arranged along part-whole tree-like hierarchies which collectively constitute the system. The behaviour of each module is strictly local since it has visibility only on its controlled modules, but not on the module which controls it. Each behaviour can be thus checked locally at design time against safety and liveness formulas, which still hold when component holons are composed into more complex ones, thus contributing, without the need of additional checks, to the overall safety and liveness of the final system

An ergonomics study on manual assembly process re-design in manufacturing firms

Nevertheless process automation is a global trend, some specific phases (i.e., assembly) in highly technological sectors (i.e., medical, pharmaceutical, diagnostics, dental) are still managed by human workers, due to high-precision tasks and low production volumes. In this context, operators are forced to work faster and adapt to not ergonomically workstations and workflows. As a consequence, human assembly is frequently the bottleneck of the entire process due a not ergonomic layout and process design. The study was conducted at a medical equipment manufacturer, leader of dental equipment production, and focused on the analysis of the assembly process of the dental units. Workers at the assembly line were observed by experts and involved also by interviews and focus groups to detect the assembly issues and process jam. The research provides a valuable example of how physical, cognitive and organizational ergonomic problems affect the final process performance and how human-oriented re-design actions can be easily defined according to the proposed analysis procedure

Identifying pathological biomarkers: histochemistry still ranks high in the omics era

In recent years, omic analyses have been proposed as possible approaches to diagnosis, in particular for tumours, as they should be able to provide quantitative tools to detect and measure abnormalities in gene and protein expression, through the evaluation of transcription and translation products in the abnormal vs normal tissues. Unfortunately, this approach proved to be much less powerful than expected, due to both intrinsic technical limits and the nature itself of the pathological tissues to be investigated, the heterogeneity deriving from polyclonality and tissue phenotype variability between patients being a major limiting factor in the search for unique omic biomarkers. Especially in the last few years, the application of refined techniques for investigating gene expression in situ has greatly increased the diagnostic/prognostic potential of histochemistry, while the progress in light microscopy technology and in the methods for imaging molecules in vivo have provided valuable tools for elucidating the molecular events and the basic mechanisms leading to a pathological condition. Histochemical techniques thus remain irreplaceable in pathologist's armamentarium, and it may be expected that even in the future histochemistry will keep a leading position among the methodological approaches for clinical pathology

Parametric virtual concept design of heavy machinery: a case study application

Virtual prototyping enables the validation and optimization of machinery equivalent to physical testing, saving time and costs in the product development, especially in case of heavy machines with complex motions. However, virtual prototyping is usually deployed only at the end of the design process, when product architecture is already developed. The present paper discusses the introduction of virtual prototypes since conceptual design stage as Virtual Concepts in which coarse models of machinery design variants are simulated obtaining useful information, sometimes fundamental to support best design choices. Virtual Concept modeling and preliminary validation and its later integration to a Virtual Prototype are expressly investigated using Multi Body Dynamics software. A verification case study on a large vibrating screen demonstrates that dynamic Virtual Concepts enable easier and effective evaluations on the design variants and increase the design process predictability

Benchmarking of Tools for User Experience Analysis in Industry 4.0

Abstract Industry 4.0 paradigm is based on systems communication and cooperation with each other and with humans in real time to improve process performances in terms of productivity, security, energy efficiency, and cost. Although industrial processes are more and more automated, human performance is still the main responsible for product quality and factory productivity. In this context, understanding how workers interact with production systems and how they experience the factory environment is fundamental to properly model the human interaction and optimize the processes. This research investigates the available technologies to monitor the user experience (UX) and defines a set of tools to be applied in the Industry 4.0 scenario to assure the workers' wellbeing, safety and satisfaction and improve the overall factory performance

Emergent factors in Eating Disorders in childhood and preadolescence

We have reviewed the literature related to the current advances in comprehension of Eating Disorders (ED) in childhood and preadolescence. The state of art regarding the psychodynamic models concerning the onset of ED are explained. DSM-IV and ICD-10 criteria are discussed, pointing out their little value in the characterization of early eating difficulties. Historic and new diagnostic classifications are displayed in detail. We provided a clearer description of subclinical patterns. Finally we focus on the key role of the paediatrician in detecting and managing parental concerns regarding feeding

A reference model to analyse User eXperience in integrated product-process design

The analysis of human factors is assuming an increasing importance in product and process design and the lack of common references for their assessment in industrial practices had driven to define a reference model to analyse the so-called User eXperience (UX) to support human-centred product-process design. Indeed, the recent advances in ubiquitous computing, wearable technologies and low-cost connected devices offer a huge amount of new tools for UX monitoring, but the main open issue is selecting the most proper devices for the specific application area and properly interpreting the collected information content in respect with the industrial design goals. The research investigates how to analyse the human behaviours of \u201cusers\u201d (i.e., workers) by a reference model to assess the perceived experience and a set of proper technologies for UX investigation for industrial scopes. In particular, the model has been defined for the automotive sector. The paper defines a set of evaluation metrics and a structured protocol analysis to objectify and measure the UX with the final aim to support the requirements definition in product-process design. The model has been defined to fit different cases: vehicle drivers at work, workers in the manufacturing line, and service operator