85 research outputs found
Perspectiva bioética intercultural e direitos humanos
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Epigenetic mechanisms in virus-induced tumorigenesis
- Author
- A Goel
- A Kuzmichev
- A SzalmĂĄs
- A Thain
- A Widschwendter
- AF Fernandez
- AF Fernandez
- AK Virmani
- AN Blackford
- AQ Araujo
- B Bhattacharjee
- B Gerle
- B TĂ€uber
- B Zhang
- BA Tine Van
- C Aresteâ
- C Biancotto
- C Endter
- C Lim
- C Seeger
- C Soria
- CB Woodman
- CC OâShea
- CN Tsai
- CT Garnett
- D Cougot
- D Cougot
- D Holland
- D Martin
- D Oliveira
- D Patel
- D Whitby
- DJ Wiley
- DL Bartolo Di
- DL Zheng
- E Gottwein
- E Kilger
- E Klein
- E Martinez-Garcia
- EJ Paulson
- EM Villiers de
- F Lu
- FA Proietti
- FL Graham
- G Ciuffo
- G Fejer
- G Mosialos
- G Narayan
- GA Horwitz
- GJ Nuovo
- GW Bornkamm
- H Feng
- H Hausen zur
- H Hausen zur
- H Hausen zur
- H Li
- H Williams
- H Zimmermann
- HH Niller
- IY Park
- J Beck
- J Doorbar
- J Doorbar
- J Heather
- J Kwong
- JA Simon
- JH Park
- JH Tong
- JK Countryman
- JK Jung
- JK Shon
- JL Brandsma
- JM Flanagan
- JS Butel
- JS Knight
- K Arisawa
- K Kamoi
- K Kim
- K Kosulin
- KD Brown
- KD Robertson
- KD Robertson
- KW Lo
- KW Lo
- L Arvanitakis
- L Wang
- LA Dourmishev
- LS Young
- M Esteller
- M Esteller
- M Fuchs
- M Fukayama
- M Jiang
- M Kalantari
- M Kulis
- M Li
- M Matsuoka
- M Nevels
- M Shamay
- M Takacs
- M Yoshida
- M Yoshida
- M Yoshioka
- MA Samols
- ME Martin
- ME McLaughlin-Drubin
- ME McLaughlin-Drubin
- ML Gatza
- MM Suzuki
- MS Longworth
- MT McCabe
- MT McCabe
- MY Yu
- N Avvakumov
- N Shivapurkar
- NG Iyer
- O Yokosuka
- P Chi
- P Hublarova
- P Zambrano
- PA Jones
- PM Bhende
- Q Tao
- Q Tao
- R Ferrari
- R Ferrari
- R Hino
- R Nakashima
- R Nakashima
- R Remus
- R Sun
- RT Javier
- S Badal
- S Hwang
- S Niemhom
- S Pai
- S Pfeffer
- S Ropero
- S Takeda
- SE Lang
- SJ Dickerson
- SN Pantry
- SS Liu
- T Ivanova
- T Koiwa
- T Turan
- T Turan
- U Moens
- V Badal
- V Nair
- VE Gurtsevitch
- W Doerfler
- W Doerfler
- W Doerfler
- W Doerfler
- WA Burgers
- WA Burgers
- WC Russell
- X Cai
- Y Chang
- Y Cohen
- Y Gwack
- Y Gwack
- Y Taniguchi
- ZM Zheng
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
About 15â20% of human cancers worldwide have viral etiology. Emerging data clearly indicate that several human DNA and RNA viruses, such as human papillomavirus, EpsteinâBarr virus, Kaposiâs sarcoma-associated herpesvirus, hepatitis B virus, hepatitis C virus, and human T-cell lymphotropic virus, contribute to cancer development. Human tumor-associated viruses have evolved multiple molecular mechanisms to disrupt specific cellular pathways to facilitate aberrant replication. Although oncogenic viruses belong to different families, their strategies in human cancer development show many similarities and involve viral-encoded oncoproteins targeting the key cellular proteins that regulate cell growth. Recent studies show that virus and host interactions also occur at the epigenetic level. In this review, we summarize the published information related to the interactions between viral proteins and epigenetic machinery which lead to alterations in the epigenetic landscape of the cell contributing to carcinogenesis
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- AbellĂĄn AN
- AbellĂĄn AN
- AbellĂĄn AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- AlcĂĄzar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- AlegrĂa L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- AntĂłn DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
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- Atchade E
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- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
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- Bachli EB
- Bader A
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- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- BalcĂĄzar LC
- BalcĂĄzar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
- Barberet G
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- Barbier J
- Barcenilla F
- Barea-Mendoza JA
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- Bauer PR
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- Bañeras J
- Beane A
- Beduneau G
- Beduneau G
- Beduneau G
- Beeharry SD
- Beerepoot M
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- Bellissimo-Rodrigues F
- Belloli A
- Bellomo R
- Bellver BQ
- Belmonte R
- Ben-Hamouda N
- Bendel S
- Bendel S
- Benyamina M
- Beretta S
- Berg R
- Bergantino B
- Berghmans J
- Bernal FF
- Berric A
- Berrutti D
- Berthelsen RE
- Bertini P
- Bertini P
- Berto MB
- Besevli SG
- Bestle MH
- Bettex D
- Bettex DA
- Beunders R
- Bhasin D
- Bhattal MK
- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
- Bianzina S
- Bianzina S
- Bishop J
- Bissenova N
- Bisso MC
- Blans MJ
- Blobner M
- Bloomer MJ
- Blot K
- Blot S
- Blot S
- Boa F
- Bobi Q
- Bodingbauer M
- BodĂ M
- Boer C
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- Braschi A
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- Brasseur A
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- Braune S
- Brazzi L
- Breitkreutz R
- Brianti R
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- CAPCRI Study
- Capellier G
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- Cardellino S
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- Cariou A
- Cariou A
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- Casals XN
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- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
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- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
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- Catena E
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- Cauwenberghs H
- Cavalcanti D
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- Charitidou E
- Charpentier C
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- Chatelon J
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- Chaussard M
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- Chemam S
- Chen CM
- Chen CM
- Chen CW
- Chen CW
- Chen GQ
- Chen L
- Chen YS
- Chen YS
- Chen YS
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
- Chiang CH
- Chiang CH
- Chiang CH
- Chiappa C
- Chiou KR
- Chiou KR
- Chiou KR
- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
- Cho YJ
- Cho YJ
- Choi JY
- Choi JY
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- Choi YJ
- Choi YY
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- Cholkraisuwat J
- Cholley B
- Chondropoulos S
- Chou W
- Chouris I
- Chouvarda I
- Christopher KB
- Chrétien JM
- Chrétien JM
- Chrétien JM
- Chumaev A
- Chung CR
- Churchill K
- Chytas A
- Cinel I
- Cinnella G
- Citerio G
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- Clavel M
- Clemente EA
- Clermont G
- Cleyet M
- Cohen Y
- Colaprico A
- Colino L
- Collange O
- Colombo A
- Colombo A
- Colson P
- Combes A
- Concha P
- Connolly B
- Constan A
- Constan A
- Constan A
- Conte V
- Conti G
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- Contreras KM
- Contreras MR
- Cook DJ
- Coombs M
- Cordeiro CP
- Cordero M
- Cordolcini V
- Cordovilla-Guardia S
- CordĂłn J
- Corona A
- Corona A
- Corradi F
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- Correa-Chamorro E
- Corte FD
- Cortes ML
- Corzo L
- Coss-Bu JA
- Coss-Bu JA
- Costa MI
- Costa RC
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- Costanzo E
- Cotoia A
- Cottini SR
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- Crimella F
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- Cuellar AI
- Cui N
- Cunha MM
- Curiel-Balsera E
- Curiel-Balsera E
- Curinga M
- Curtis A
- Cuthbertson BH
- Cutuli SL
- CĂąmara M
- D'Arsigny C
- da Silva SL
- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- DamÄs JK
- Das Neves A
- David H
- Davis C
- Davis P
- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
- De La Rica AS
- De la Torre MA
- De Maglie M
- De Maglie M
- de Molina FJ
- De Morton N
- de Oca Sandoval MA
- De Pascale G
- De Rosa S
- De Sanctis F
- De Silva AP
- De Sousa I
- de Vera AP
- de Wilde W
- De Zani D
- Deblier I
- DeBrunnar R
- Del Arco A
- Del Moral OL
- Del Olmo R
- Del Rosario CG
- Del Sorbo L
- Delgado CP
- Delgado MJ
- Delgado-Amaya M
- Demirkiran O
- Demoule A
- Denehy L
- Der Kinderen EP
- Descotte E
- Deshpande K
- Desmard M
- Desmard M
- Deveugele M
- Deye N
- Di Bello F
- Di Giancamillo M
- Di Gravio V
- Di Gregorio A
- Di Mussi R
- Di Rosso R
- Diaz DD
- Diaz P
- Dilek M
- Dilly MP
- Dima E
- Dimitroulakis K
- Dimitrov BD
- Dimitrov BD
- Dimopoulou IK
- Dinh A
- Divatia JV
- Dixon J
- Doganci M
- Doglia JA
- Doherty P
- Dolset RA
- Dominguez JP
- DomĂnguez JP
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- Doorduin J
- Dorent R
- Dos Reis Miranda D
- Dos Santos HP
- Dougall PC
- Doyle J
- Doyle J
- Drover J
- Duarte R
- Dubois EA
- Dubrawski A
- DubĂł S
- Dudas G
- Dudoignon E
- Dumas F
- Dunthorne E
- Duran N
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- Durovray JD
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- DĂaz PV
- DĂŒnser MW
- E Silva ZC
- E YY
- Ebeling G
- Echeverri JE
- EcheverrĂa JG
- Ediboglu O
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- Egea-Guerero JJ
- Egginton JS
- Egi M
- El Adawy AS
- El Hamid MA
- El Hossainy R
- El Sayed E
- El Sayed F
- El Sayed I
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- El-Keraie A
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- Elbers PW
- Elgendy M
- Eliet J
- Emmanuel J
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- Endacott R
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- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
- Eroles AA
- Escalada SH
- Escalada SH
- Escoval A
- EscribĂĄ A
- EscĂłrcio S
- Eslami S
- Espinasse F
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- Esteban A
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- Facchin F
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- Fanzaghi P
- Farias P
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- Feehan A
- Feijoo AM
- Feliot E
- Ferez MA
- Fernandes MJ
- Fernandes N
- Fernandez NG
- Fernandez R
- Fernandez-Zamora MD
- FernĂĄndez IF
- FernĂĄndez L
- FernĂĄndez MV
- FernĂĄndez PA
- FernĂĄndez-Barat L
- Fernåndez-Mondéjar E
- FernĂĄndez-Ortega JF
- Ferraz AB
- Ferrero-Calleja J
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- FerrĂłn FR
- Fiks T
- Fiks T
- FilekoviÄ S
- Filho CA
- Filho CA
- Filho CA
- Filipe E
- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
- Fless K
- Floccard B
- Flowers E
- Follin A
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- Fong KY
- Fontaiña LP
- Fontana V
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- Francioni JE
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- Frithiof R
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- FROG ICU Investigators
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- Frontera PR
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- Georgopoulos D
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- GonzĂĄlez JC
- Gonzålez-Jiménez AI
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- Grossestreuer A
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- Gubianas CM
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- Hatakeyama J
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- Healey AJ
- Hebert P
- Hegazy S
- Hellevuo H
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- Hernandis V
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- Herrera AN
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- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
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- Hewitt H
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- Hillier SD
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- Hua Y
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- Hualde JB
- Hualde JB
- Hualde JB
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- Huang CH
- Huang WC
- Huang WC
- Huang WC
- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
- Hung WT
- Hung WT
- Hung WT
- Hung WT
- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
- Iotti GA
- Iotti GA
- IPREA Study Group
- Irazabal JM
- Irazabal JM
- Ishimatsu S
- Itenov TS
- Iwamoto M
- Izawa M
- Izdes S
- Jaber S
- Jacky A
- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
- Jeong IY
- Jeong WY
- Jeong WY
- Jian Z
- Jiao LR
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- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
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- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
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- Kang PL
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- Kang PL
- Kang Y
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- Kappler F
- Kara A
- Karachi F
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- Karbing DS
- Karsten E
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- Kashiya S
- Kashyap R
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- Katabami K
- Katabami K
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- Kavanagh BP
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- Kim DJ
- Kim HJ
- Kim JM
- Kim JM
- Kim JW
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- Kim KS
- Kim KS
- Kim KS
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- Kim MH
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- Kirakli C
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- Kleinpell R
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- Knafelj R
- Knight LD
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- Ko SB
- Kobayashi A
- Koco E
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- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
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- Kou PS
- Kouatchet A
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- Kox M
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- Krenn CG
- Krishna B
- Kristof J
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- Kruger A
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- Ku NS
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- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
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- Kwon HM
- Kwon WY
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- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
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- Lagos R
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- Lapteva K
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- Latini R
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- Liao X
- Lichtenstein D
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- Limuti R
- Lin KC
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- Lischinsky A
- Lissonde F
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- Liu CP
- Liu CP
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- Merino-Vega D
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- Midwinter MJ
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- Muhammad JB
- Mukherjee DN
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- Okayama Research Investigation Organizing Network (ORION)investigators
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- Orden VA
- Ori C
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- PICS- HCPA: Programa Intrahospitalar de Combate Ă Sepse do Hospital de ClĂnicas de Porto Alegre
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
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- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
State of the Climate in 2016
- Author
- Aaron-Morrison AP
- Abdallah A
- Ackerman SA
- Adler R
- Alfaro EJ
- Allan R
- Allan RP
- Alvarez LA
- Alves LM
- Amador JA
- Andreassen LM
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- Arndt DS
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- Awatif EM
- Azorin-Molina C
- Baez J
- Bardin MU
- Barichivich J
- Baringer MO
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- Beck HE
- Becker A
- Bedka KM
- Behrenfeld MJ
- Bell GD
- Belmont M
- Benedetti A
- Bernhard GH
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- Berry DI
- Bettolli ML
- Bhatt US
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- Blunden J
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- Box JE
- Boyer T
- Braathen GO
- Brimelow J
- Bromwich DH
- Brown R
- Buehler S
- Bulygina ON
- Burgess D
- Calderon B
- Camargo SJ
- Campbell JD
- Cappelen J
- Caroff P
- Carrea L
- Carter BR
- Chambers DP
- Chandler E
- Cheng M-D
- Christiansen HH
- Christy JR
- Chung D
- Chung E-S
- Clem KR
- Coelho CAS
- Coldewey-Egbers M
- Colwell S
- Cooper OR
- Copland L
- Cross JN
- Crouch J
- Cutie V
- Davis SM
- de Eyto E
- de Jeu RAM
- de Laat J
- DeGasperi CL
- Degenstein D
- Demircan M
- Derksen C
- Di Girolamo L
- Diamond HJ
- Dindyal S
- Dlugokencky EJ
- Dohan K
- Dokulil MT
- Dolman AJ
- Domingues CM
- Donat MG
- Dong S
- Dorigo WA
- Drozdov DS
- Dunn RJH
- Dunn RJH
- Duran-Quesada AM
- Dutton GS
- ElKharrim M
- Elkins JW
- Epstein HE
- Espinoza JC
- Etienne-LeBlanc S
- Famiglietti JS
- Farrell S
- Fateh S
- Fausto RS
- Feely RA
- Feng Z
- Fenimore C
- Fettweis X
- Fioletov VE
- Flannigan M
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- Foster MJ
- Francis SD
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- Frith SM
- Froidevaux L
- Ganter C
- Gerland S
- Gilson J
- Gobron N
- Goldenberg SB
- Goni G
- Gonzalez IT
- Goto A
- Greenhough MD
- Grooss J-U
- Gruber A
- Guard C
- Gupta SK
- Gutierrez JM
- Haas C
- Hagos S
- Hahn S
- Haimberger L
- Hall BD
- Halpert MS
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- Hanssen-Bauer I
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- Ialongo I
- III SCJ
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- Inness A
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- Ishii M
- Jevrejeva S
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- John V
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- Johnsen B
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- Jr HRR
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- Perkins-Kirkpatrick SE
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- Rodell M
- Rollenbeck R
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- Ronchail J
- Roquet F
- Rosenlof KH
- Roth C
- Rusak JA
- Sallee J-B
- Sanchez-Lugo A
- Santee ML
- Sarmiento JL
- Sawaengphokhai P
- Sayouri A
- Scambos TA
- Schemm J
- Schladow SG
- Schmid C
- Schmid M
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- Selkirk HB
- Send U
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- Sharp M
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- Shimaraeva SV
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- Silov E
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- Spence JM
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- Steinbrecht W
- Stella JL
- Stennett-Brown R
- Stephenson TS
- Strahan S
- Streletskiy DA
- Sun-Mack S
- Swart S
- Sweet W
- Tamar G
- Taylor MA
- Tedesco M
- Thoman RL
- Thompson L
- Thompson PR
- Timmermans M-L
- Timofeev MA
- Tirnanes JA
- Tobin S
- Trachte K
- Trewin BC
- Trotman AR
- Tschudi M
- Tweedy O
- van As D
- van de Wal RSW
- van der Schalie R
- van der Schrier G
- van der Werf GR
- van Meerbeeck CJ
- Velicogna I
- Verburg P
- Vieira G
- Vincent LA
- Voemel H
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- Wagner W
- Wahlin A
- Walker DA
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- Wang B
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- Wang L
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- Wanninkhof R
- Watanabe S
- Weber M
- Weller RA
- Weyhenmeyer GA
- Whitewood R
- Wiese DN
- Wijffels SE
- Wilber AC
- Wild JD
- Willett KM
- Willie S
- Willis JK
- Wolken G
- Wong T
- Wood EF
- Woolway RI
- Wouters B
- Xiangze J
- Xue Y
- Yim S-Y
- Yin X
- Yu L
- Zambrano E
- Zhang H-M
- Zhang P
- Zhao G
- Zhao L
- Ziemke JR
- Zilberman N
- Publication venue
- 'American Meteorological Society'
- Publication date
- 01/08/2017
- Field of study
Potential biomechanical roles of risk factors in the evolution of thrombusâladen abdominal aortic aneurysms
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Identification of a binding site for the human immunodeficiency virus type 1 nucleocapsid protein.
- Author
- Publication venue
- Publication date
- 01/01/1993
- Field of study
The nucleocapsid (NC) protein NCp7 of human immunodeficiency virus type 1 (HIV-1) is important for encapsidation of the virus genome, RNA dimerization, and primer tRNA annealing in vitro. Here we present evidence from gel mobility-shift experiments indicating that NCp7 binds specifically to an RNA sequence. Two complexes were identified in native gels. The more slowly migrating complex contained two RNA molecules and one peptide, while the more rapidly migrating one is composed of one RNA and one peptide. Further, mutational analysis of the RNA shows that the predicted stem and loop structure of stem-loop 1 plays a critical role. Our results show that NCp7 binds to a unique RNA structure within the psi region; in addition, this structure is necessary for RNA dimerization. We propose that NCp7 binds to the RNA via a direct interaction of one zinc-binding motif to stem-loop 1 followed by binding of the other zinc-binding motif to stem-loop 1, stem-loop 2, or the linker region of the second RNA molecule, forming a bridge between the two RNAs
Genetic epidemiology of dengue virus in phase III trials of the CYD tetravalent vaccine and implications for efficacy
- Author
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- 01/01/2017
- Field of study
This study defined the genetic epidemiology of dengue viruses (DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYDTDV, and thereby enabled virus genotype-specific estimates of vaccine efficacy (VE). Envelope gene sequences (n=661) from 11 DENV genotypes in 10 endemic countries provided a contemporaneous global snapshot of DENV population genetics and revealed high amino acid identity between the E genes of vaccine strains and wild-type viruses from trial participants, including at epitope sites targeted by virus neutralising human monoclonal antibodies. Post-hoc analysis of all CYD14/15 trial participants revealed a statistically significant genotype-level VE association within DENV-4, where efficacy was lowest against genotype I. In subgroup analysis of trial participants age 9-16 years, VE estimates appeared more balanced within each serotype, suggesting that genotype-level heterogeneity may be limited in older children. Post-licensure surveillance is needed to monitor vaccine performance against the backdrop of DENV sequence diversity and evolution
Total parenteral nutrition-associated cholestasis and risk factors in preterm infants
- Author
- Publication venue
- 'Medknow'
- Publication date
- 01/01/2014
- Field of study
The embryo as moral work object: PGD/IVF staff views and experiences
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TPA
- Akimoto G
- Akimov AV
- Aktas A
- Alam MA
- Alam MS
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexaa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amelung C
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Andeen T
- Anders CF
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonelli S
- Antos J
- Antunovic B
- Anulli F
- Aoun S
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin JF
- Argyropoulos T
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Arutinov D
- Asai M
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asner D
- Asquith L
- Assamagan K
- Astvatsatourov A
- Atoian G
- Auerbach B
- Augsten K
- Aurousseau M
- Austin N
- Avolio G
- Avramidou R
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Badescua E
- Bagnaia P
- Bai Y
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncellia A
- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
- Bartsch D
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Bauer F
- Bawa HS
- Beare B
- Beau T
- Beauchemin PH
- Beccherle R
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- Beck GA
- Beck HP
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bee C
- Begel M
- Behera PK
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- Zhou Y
- Zhu CG
- Zhu H
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zutshi V D
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2008
- Field of study
Copyright @ 2008 the authors. This article is available in accordance with the Creative Commons Deed, Attribution 2.5, see http://creativecommons.org/licenses/by-nc-nd/2.5/deed.en_CA.We report on one aspect of a study that explored the views and experiences of practitioners and scientists on social, ethical and clinical dilemmas encountered when working in the field of preimplantation genetic diagnosis (PGD) for serious genetic disorders. The study produced an ethnography based on observation, interviews and ethics discussion groups with staff from two PGD/IVF Units in the UK. We focus here on staff perceptions of work with embryos that entails disposing of âaffectedâ or âspareâ embryos or using them for research. A variety of views were expressed on the âembryo questionâ in contrast to polarised media debates. We argue that the prevailing policy acceptance of destroying affected embryos, and allowing research on embryos up to 14 days leaves some staff with rarely reported, ambivalent feelings. Staff views are under-researched in this area and we focus on how they may reconcile their personal moral views with the ethical framework in their field. Staff construct embryos in a variety of ways as âmoral work objectsâ. This allows them to shift attention between micro-level and overarching institutional work goals, building on Casper's concept of âwork objectsâ and focusing on negotiation of the social order in a morally contested field.The Wellcome Trust Biomedical Ethics Programme, who funded the projectsâFacilitating choice, framing choice: the experience of staff working in pre-implantation genetic diagnosisâ (no: 074935), and âEthical Frameworks for Embryo Donation:the views and practices of IVF/PGD staffâ (no: 081414)
IL-5 blocks apoptosis and tau hyperphosphorylation induced by AÎČ25â35 peptide in PC12 cells
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- âŠ