565 research outputs found
Search for sterile neutrino oscillation using RENO and NEOS data
We present a reactor model independent search for sterile neutrino
oscillation using 2\,509\,days of RENO near detector data and 180 days of NEOS
data. The reactor related systematic uncertainties are significantly suppressed
as both detectors are located at the same reactor complex of Hanbit Nuclear
Power Plant. The search is performed by electron
antineutrino\,() disappearance between six reactors and two
detectors with baselines of 294\,m\,(RENO) and 24\,m\,(NEOS). A spectral
comparison of the NEOS prompt-energy spectrum with a no-oscillation prediction
from the RENO measurement can explore reactor oscillations
to sterile neutrino. Based on the comparison, we obtain a 95\% C.L. excluded
region of \,eV. We also obtain a 68\% C.L. allowed
region with the best fit of \,eV and
=0.080.03 with a p-value of 8.2\%. Comparisons of
obtained reactor antineutrino spectra at reactor sources are made among RENO,
NEOS, and Daya Bay to find a possible spectral variation.Comment: 6 pages, 5 figures: This manuscript has been significantly revised by
the joint reanalysis by RENO and NEOS Collaborations. (In the previous
edition, the RENO collaboration used publicly available NEOS data to evaluate
the expected neutrino spectrum at NEOS.
Tracking Performance of the Scintillating Fiber Detector in the K2K Experiment
The K2K long-baseline neutrino oscillation experiment uses a Scintillating
Fiber Detector (SciFi) to reconstruct charged particles produced in neutrino
interactions in the near detector. We describe the track reconstruction
algorithm and the performance of the SciFi after three years of operation.Comment: 24pages,18 figures, and 1 table. Preprint submitted to NI
Classification of a supersolid: Trial wavefunctions, Symmetry breakings and Excitation spectra
A state of matter is characterized by its symmetry breaking and elementary
excitations.
A supersolid is a state which breaks both translational symmetry and internal
symmetry.
Here, we review some past and recent works in phenomenological
Ginsburg-Landau theories, ground state trial wavefunctions and microscopic
numerical calculations. We also write down a new effective supersolid
Hamiltonian on a lattice.
The eigenstates of the Hamiltonian contains both the ground state
wavefunction and all the excited states (supersolidon) wavefunctions. We
contrast various kinds of supersolids in both continuous systems and on
lattices, both condensed matter and cold atom systems. We provide additional
new insights in studying their order parameters, symmetry breaking patterns,
the excitation spectra and detection methods.Comment: REVTEX4, 19 pages, 3 figure
Measurement of single pi0 production in neutral current neutrino interactions with water by a 1.3 GeV wide band muon neutrino beam
Neutral current single pi0 production induced by neutrinos with a mean energy
of 1.3 GeV is measured at a 1000 ton water Cherenkov detector as a near
detector of the K2K long baseline neutrino experiment. The cross section for
this process relative to the total charged current cross section is measured to
be 0.064 +- 0.001 (stat.) +- 0.007 (sys.). The momentum distribution of
produced pi0s is measured and is found to be in good agreement with an
expectation from the present knowledge of the neutrino cross sections.Comment: 6 pages, 4 figures, Submitted to Phys. Lett.
Evidence for muon neutrino oscillation in an accelerator-based experiment
We present results for muon neutrino oscillation in the KEK to Kamioka (K2K)
long-baseline neutrino oscillation experiment. K2K uses an accelerator-produced
muon neutrino beam with a mean energy of 1.3 GeV directed at the
Super-Kamiokande detector. We observed the energy dependent disappearance of
muon neutrino, which we presume have oscillated to tau neutrino. The
probability that we would observe these results if there is no neutrino
oscillation is 0.0050% (4.0 sigma).Comment: 5 pages, 4 figure
PD-1 blockade in recurrent or metastatic cervical cancer: Data from cemiplimab phase I expansion cohorts and characterization of PD-L1 expression in cervical cancer
Objectives: To characterize the safety, tolerability, and anti-tumor activity of cemiplimab as monotherapy or in combination with hypofractionated radiation therapy (hfRT) in patients with recurrent or metastatic cervical cancer. To determine the association between histology and programmed death-ligand 1 (PD-L1) expression.
Methods: In non-randomized phase I expansion cohorts, patients (squamous or non-squamous histology) received cemiplimab 3 mg/kg intravenously every 2 weeks for 48 weeks, either alone (monotherapy cohort) or with hfRT during week 2 (combination cohort). Due to insufficient tissue material, PD-L1 protein expression was evaluated in commercially purchased samples and mRNA expression levels were analyzed from The Cancer Genome Atlas (TCGA).
Results: Twenty patients enrolled in both cohorts in total; 10 had squamous histology. The most common adverse events of any grade were diarrhea, fatigue, and hypokalemia, occurring in 35%, 25%, and 25%, respectively. Objective response rate was 10% in each cohort; responders had squamous histology. Duration of response was 11.2 months and 6.4 months for the responder in the monotherapy and combination cohort, respectively. Irradiated lesions were not included in the response assessments. In separate archived specimens (N = 155), PD-L1 protein expression in tumor and immune cells was negative (<1%) more commonly in adenocarcinoma than in squamous tumors. PD-L1 mRNA levels were lower in adenocarcinoma than squamous cell tumors (1.2 vs 5.0 mean transcripts per million, respectively) in TCGA.
Conclusions: Cemiplimab has activity in cervical squamous cell carcinoma. The phase I results, combined with results from other anti-PD-1 trials in cervical cancer and our biomarker analyses have informed the design of the ongoing phase III trial, with the primary overall survival hierarchical analyses being done first in patients with squamous histology
Prevalence and predictors for sustained remission in rheumatoid arthritis
Objective
Remission is a key goal in managing rheumatoid arthritis (RA), with sustained remission as
the preferred sequelae of short-term remission. However little is known about the predictors
of sustained remission for patients reaching remission. Using two independent cohorts, we
aimed to evaluate the prevalence and predictors for sustained remission.
Methods
The study cohort consisted of subjects with RA from the Brigham and Women’s Hospital
Rheumatoid Arthritis Sequential Study (BRASS) and the Korean Observational Study Network for Arthritis (KORONA). We analyzed subjects who reached remission in 2009 with follow up data for two consecutive years. Remission was defined by the Disease Activity Score
28- (DAS28-CRP) of less than 2.6. Sustained remission was defined as three consecutive
annual visits in remission. Predictors for sustained remission were identified by multivariate
logistic regression analysis.
Results
A total of 465 subjects were in remission in 2009. Sustained remission was achieved by 53
of 92 (57.5%) in BRASS and by 198 of 373 (53.1%) in KORONA. In multivariate analyses,
baseline predictors of sustained remission were: disease duration less than 5 years [odds
ratio (OR) 1.96, 95% confidence interval (95% CI) 1.08–3.58], Modified Health Assessment
Questionnaire (MHAQ) score of 0 (OR 1.80, 95% CI 1.18–2.74), and non-use of oral glucocorticoid (OR 1.58, 95% CI 1.01–2.47). Conclusion
More than half of RA subjects in remission in 2009 remained in remission through 2011.
Short disease duration, no disability, and non-use of oral glucocorticoid at baseline were
associated with sustained remission
Single Spin Asymmetry in Polarized Proton-Proton Elastic Scattering at GeV
We report a high precision measurement of the transverse single spin
asymmetry at the center of mass energy GeV in elastic
proton-proton scattering by the STAR experiment at RHIC. The was measured
in the four-momentum transfer squared range \GeVcSq, the region of a significant interference between the
electromagnetic and hadronic scattering amplitudes. The measured values of
and its -dependence are consistent with a vanishing hadronic spin-flip
amplitude, thus providing strong constraints on the ratio of the single
spin-flip to the non-flip amplitudes. Since the hadronic amplitude is dominated
by the Pomeron amplitude at this , we conclude that this measurement
addresses the question about the presence of a hadronic spin flip due to the
Pomeron exchange in polarized proton-proton elastic scattering.Comment: 12 pages, 6 figure
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