Experimental Approach for Development of a Powder Spreading Metric in Additive Manufacturing

The Powder Spreading is a Vital Step of Powder-Based Additive Manufacturing (AM) Processes. the Quality of Spread Powder Can Considerably Influence the Properties of Fabricated Parts. Poorly Packed Powder Beds with High Surface Roughness Result in Printed Part Layers with Large Porosity and Low Dimensional Accuracy, Leading to Poor Mechanical Properties. Therefore, the Powder Spread ability and its Dependence on Process Parameters and Powder Characteristics Should Be Quantified to Improve the Efficiency of Powder-Based AM Methods. This Study Proposes a Novel Dimensionless Powder Spread Ability Metric that Can Be Commonly Used in Different Powder-Based AM Processes. the Quality of Spread Powder in Terms of Powder Bed Density and Surface Roughness Was Evaluated by Adjusting the Process Parameters Including Recoating Velocity and Layer Thickness, and Powder Characteristics Including Particle Size Distribution. in Addition, the Dynamic Repose Angle Was Proposed and Examined as Another Powder Spread Ability Metric. the Results Showed that These Two Proposed Metrics Were Strongly Correlated and Lower Recoating Velocity and Larger Layer Thickness Led to Higher Spread ability and Lower Dynamic Repose Angle

A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children

ObjectivesLimited data exist on the effects of extracorporeal membrane oxygenation on pharmacokinetics of cefepime in critically ill pediatric patients. The objective was to describe cefepime disposition in children treated with extracorporeal membrane oxygenation using population pharmacokinetic modeling.DesignMulticenter, prospective observational study.SettingThe pediatric and cardiac ICUs of six sites of the Collaborative Pediatric Critical Care Research Network.PatientsSeventeen critically ill children (30 d to < 2 yr old) on extracorporeal membrane oxygenation who received cefepime as standard of care between January 4, 2014, and August 24, 2015, were enrolled.InterventionsNone.Measurements and main resultsA pharmacokinetic model was developed to evaluate cefepime disposition differences due to extracorporeal membrane oxygenation. A two-compartment model with linear elimination, weight effects on clearance, intercompartmental clearance (Q), central volume of distribution (V1), and peripheral volume of distribution (V2) adequately described the data. The typical value of clearance in this study was 7.1 mL/min (1.9 mL/min/kg) for a patient weighing 5.8 kg. This value decreased by approximately 40% with the addition of renal replacement therapy. The typical value for V1 was 1,170 mL. In the setting of blood transfusions, V1 increased by over two-fold but was reduced with increasing age of the extracorporeal membrane oxygenation circuit oxygenator.ConclusionsCefepime clearance was reduced in pediatric patients treated with extracorporeal membrane oxygenation compared with previously reported values in children not receiving extracorporeal membrane oxygenation. The model demonstrated that the age of the extracorporeal membrane oxygenation circuit oxygenator is inversely correlated to V1. For free cefepime, only 14 of the 19 doses (74%) demonstrated a fT_minimum inhibitory concentration of 16 mg/L, an appropriate target for the treatment of pseudomonal infections, for greater than 70% of the dosing interval. Pediatric patients on extracorporeal membrane oxygenation might benefit from the addition of therapeutic drug monitoring of cefepime to assure appropriate dosing

Evidence for the magnetar nature of 1E 161348-5055 in RCW 103

We report on the detection of a bright, short, structured X-ray burst coming from the supernova remnant RCW 103 on 2016 June 22 caught by the Swift/Burst Alert Telescope (BAT) monitor, and on the follow-up campaign made with Swift/X-ray Telescope, Swift/UV/Optical Telescope, and the optical/near-infrared (NIR) Gamma-Ray burst Optical and Near-infrared Detector. The characteristics of this flash, such as duration and spectral shape, are consistent with typical short bursts observed from soft gamma repeaters. The BAT error circle at 68 per cent confidence range encloses the point-like X-ray source at the centre of the nebula, 1E 161348−5055. Its nature has been long debated due to a periodicity of 6.67 h in X-rays, which could indicate either an extremely slow pulsating neutron star, or the orbital period of a very compact X-ray binary system. We found that 20 min before the BAT trigger, the soft X-ray emission of 1E 161348−5055 was a factor of ∼100 higher than measured 2 yr earlier, indicating that an outburst had already started. By comparing the spectral and timing characteristics of the source in the 2 yr before the outburst and after the BAT event, we find that, besides a change in luminosity and spectral shape, also the 6.67 h pulsed profile has significantly changed with a clear phase shift with respect to its low-flux profile. The UV/optical/NIR observations did not reveal any counterpart at the position of 1E 161348−5055. Based on these findings, we associate the BAT burst with 1E 161348−5055, we classify it as a magnetar, and pinpoint the 6.67 h periodicity as the magnetar spin period