Reaching Happiness beyond Emancipation: A Study on the Human-Centric Role of Linde in A Doll’s House by Henrik Ibsen

Henrik Ibsen’s drama A Doll’s House portrays the late 19th century Norway where protagonist Nora and her eventual manifestation of Feminism are almost all the time at the centre of critical attention. But Mrs. Kristina Linde is also a character of magnanimous stature with her enthusiastic sense of belonging and heart-felt services to family and society. In this manner, the human-centric role provides Linde with satisfaction that amounts to happiness, taking her ways ahead of emancipation in a world where women’s emancipation from sufferings is still an unresolved issue. Notably, Linde’s human-centric role gains authenticity as a true means of women’s emancipation by reflecting higher knowledge which is essential for any human affair to be true and real. Thus, this paper aims at exploring how Mrs. Kristina Linde in A Doll’s House by Henrik Ibsen, being in her family and society and playing vital roles accordingly, derives happiness proving the truth that all women can be human-centric in family and society, and can have happiness going far ahead of emancipation changing the global scenario of women’s misery. The methodology of thematic analysis was followed in this research. The research may contribute in propounding human-centric family and social life as the proper means of women’s emancipation

Philosophy of education is still fascinating educationists: A biblio-appraisal from 1929 - 2019

Purpose: This study design to explore the literature produced and published in journals indexed in the Scopus-Elsevier database in terms of educational philosophy. Methods: The data acquired from the journals indexed in the Scopus-Elsevier database for analysis. This study divided into eight spells and covered 92 years to examine; year-wise, type of documents, primary classification of subjects, authors\u27 contribution, an affiliation of the first author with country, and the statistical position of the journal from 1929 - 2019. Results: Total 1587 different types of documents written by 2168; 1.3% of authors with an average of 17.2 per annum. The data distributed in 10 categories published from 1929 – 2019. Research articles 1070; 67.4%, book chapters 164; 10.3%, and review articles 95; 6% standing on top slots. Spell 2011 – 2019, published maximum research in every category. The majority of 1189; 75% articles written by the single or solo author, followed by 242; 15% two authors, the authors of 28; 1.7% not traced. A total of 697 places published 1587 documents. Journal of Educational Theory 113; 7.1%, Journal of Educational Philosophy and Theory 103; 6.4%, Journal of Philosophy of Education 92; 5.8%, and Journal of Studies in Philosophy and Education 75; 4.7% provides maximum spaces in publications as on single entity. Social Sciences covered 1216, 77% of the research productivity, and followed by Science and Technology subjects. The United States of America 589; 37.1%, United Kingdom 318; 20%, and Canada 80; 5% got top three positions from the contribution of sixty[1]eight countries. Conclusion: Philosophy of education has the power to move society towards wisdom, to clarify the beliefs, strengthen values, relevant to intellectual thoughts of person and community, increase visualization of the spectrum of science and technological education

The clinical implications of adult-onset henoch-schonelin purpura

Henoch-Schonlein Purpura (HSP) is a small vessel vasculitis mediated by IgA-immune complex deposition. It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura, abdominal pain, arthritis and renal involvement. Pathologically, it can be considered a form of immune complex-mediated leukocytoclastic vasculitis (LCV) involving the skin and other organs. Though it primarily affects children (over 90% of cases), the occurrence in adults has been rarely reported. Management often involves the use of immunomodulatory or immune-suppressive regimens

The Clinical Implications of Adult-Onset Henoch-Schonelin purpura

bHenoch-Schonlein Purpura (HSP) is a small vessel vasculitis mediated by IgA-immune complex deposition. It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura, abdominal pain, arthritis and renal involvement. Pathologically, it can be considered a form of immune complex-mediated leukocytoclastic vasculitis (LCV) involving the skin and other organs. Though it primarily affects children (over 90% of cases), the occurrence in adults has been rarely reported. Management often involves the use of immunomodulatory or immune-suppressive regimens

Available Job Opportunity to Youth Graduate and its Relations to the Needs of the Saudi Labor Market "A Field Study"

The labor market faces persistent challenges owing to the increasing number of job seekers as opposed to the low supply of jobs in addition to the sometimes exaggerated specifications required by employers in the job offered. The figures indicate an increase in the unemployment rate of female graduates with bachelor's degrees. This has created some concern. These indicators prompted the researchers to conduct this study to describe and analyze the needs of the Saudi labor market for graduates' specializations in humanities and what career opportunities are available? Also, what are the requirements of employers to employ a graduate and reduce unemployment and keep pace with the ambitions of Vision 2030? One of the most important findings is that the reasons for the lack of career opportunities are the employment requirements set by companies and institutions to get a job at 87.55%. The study recommended that a detailed database on the national labor market should be formed that would allocate the last level of education to job training and not only focused on acquiring knowledge, under the supervision of the university, so that the graduate would be familiar with the requirements of the labor market and be aware of the skills required for each job; This helps him to gain work experience before graduation so that he can take the right career decision after graduation

Human Relations among High School Principals in Irbid Directorate of Education and its Relation to Strategies of Conflict Management from the Teachers\u27 Point of View العلاقات الإنسانية لدى مديري المدارس الثانوية في مديرية تربية قصبة إربد وعلاقتها باستراتيجيات إدارة الصراع من وجهة نظر المعلمين

Abstract: The study aimed to reveal the human relations of the principals of secondary schools in Irbid directorate of education and their relationship with the strategies of conflict management from teachers\u27 point of view to answer the research questions of the study. A descriptive correlational methodology were used. The sample of the study was chosen by stratified random method. The study sample consisted of (209) teachers. To achieve the objectives of the study, the researchers used two questionnaires. The results of the study showed that the degree of practicing human relations among school principals was (very large) and the degree of practicing conflict management strategies in secondary schools was (medium to very large). The results also showed a statistically significant correlation at (a\u3c0.05) level between the degree of practicing human relations among secondary school principals in the directorate of education in Irbid and the strategies of methods of confronting the conflict from the teachers\u27 point of view. In light of the results of the study, the study recommended the need to strengthen the use of human relations in the management of conflict in schools, as well as to avoid non-professional conflict management methods such as domination and avoidance, and conducting further studies and using research tools and other variables. ملخص: هدفت الدراسة الكشف عن العلاقات الإنسانية لدى مديري المدارس الثانوية في مديرية تربية أربد وعلاقتها باستراتيجيات إدارة الصراع من وجهة نظر المعلمين، للإجابة عن أسئلة الدراسة وقد تم استخدام المَنْهَج الوصفيّ الارتباطي. وتم اختيار عيِّنة الدراسة بالطريقة الطبقية العشوائية، إذ اشتملت عيِّنة الدراسة من (209) معلمين ومعلمات. لتحقيق أهداف الدّراسة أُستخدم أداتين؛ الأولى تقيس درجة ممارسة العلاقات الإنسانية لدى مديري المدارس، أما الأداة الثانية فتقيس درجة ممارسة استراتيجيات إدارة الصراع. أظهرت نتائج الدراسة أن درجة ممارسة العلاقات الإنسانية لدى مديري المدارس جاءت بدرجة (كبيرة جداً)، كما أظهرت النتائج أن درجة ممارسة استراتيجيات إدارة الصراع في المدارس الثانوية جاءت بدرجة (متوسطة إلى كبيرة جداً)، كما أظهرت النتائج وجود علاقة ارتباطيه ذات دلالة إحصائية عند مستوى(a≤0.05) بين درجة ممارسة العلاقات الإنسانية لدى مديري المدارس الثانوية وبين استراتيجيات ادارة الصراع من وجهة نظر المعلمين. وفي ضوء نتائج الدراسة فقد أوصت الدراسة بضرورة تعزيز منحى استخدام العلاقات الإنسانية في إدارة الصراع في المدارس، كذلك تجنب استراتيجيات إدارة الصراع غير المهنية مثل الهيمنة والتجنب، فضلاً عن إجراء دراسات أخرى وباستخدام أدوات بحث ومتغيرات أخرى

RGD-Functionalized Hydrogel Supports the Chondrogenic Commitment of Adipose Mesenchymal Stromal Cells

Articular cartilage is known to have limited intrinsic self-healing capacity when a defect or a degeneration process occurs. Hydrogels represent promising biomaterials for cell encapsulation and injection in cartilage defects by creating an environment that mimics the cartilage extracellular matrix. The aim of this study is the analysis of two different concentrations (1:1 and 1:2) of VitroGel(®) (VG) hydrogels without (VG-3D) and with arginine-glycine-aspartic acid (RGD) motifs, (VG-RGD), verifying their ability to support chondrogenic differentiation of encapsulated human adipose mesenchymal stromal cells (hASCs). We analyzed the hydrogel properties in terms of rheometric measurements, cell viability, cytotoxicity, and the expression of chondrogenic markers using gene expression, histology, and immunohistochemical tests. We highlighted a shear-thinning behavior of both hydrogels, which showed good injectability. We demonstrated a good morphology and high viability of hASCs in both hydrogels. VG-RGD 1:2 hydrogels were the most effective, both at the gene and protein levels, to support the expression of the typical chondrogenic markers, including collagen type 2, SOX9, aggrecan, glycosaminoglycan, and cartilage oligomeric matrix protein and to decrease the proliferation marker MKI67 and the fibrotic marker collagen type 1. This study demonstrated that both hydrogels, at different concentrations, and the presence of RGD motifs, significantly contributed to the chondrogenic commitment of the laden hASCs

Polysaccharides on gelatin-based hydrogels differently affect chondrogenic differentiation of human mesenchymal stromal cells

Selection of feasible hybrid-hydrogels for best chondrogenic differentiation of human mesenchymal stromal cells (hMSCs) represents an important challenge in cartilage regeneration. In this study, three-dimensional hybrid hydrogels obtained by chemical crosslinking of poly (ethylene glycol) diglycidyl ether (PEGDGE), gelatin (G) without or with chitosan (Ch) or dextran (Dx) polysaccharides were developed. The hydrogels, namely G-PEG, G-PEG-Ch and G-PEG-Dx, were prepared with an innovative, versatile and cell-friendly technique that involves two preparation steps specifically chosen to increase the degree of crosslinking and the physical-mechanical stability of the product: a first homogeneous phase reaction followed by directional freezing, freeze-drying and post-curing. Chondrogenic differentiation of human bone marrow mesenchymal stromal cells (hBM-MSC) was tested on these hydrogels to ascertain whether the presence of different polysaccharides could favor the formation of the native cartilage structure. We demonstrated that the hydrogels exhibited an open pore porous morphology with high interconnectivity and the incorporation of Ch and Dx into the G-PEG common backbone determined a slightly reduced stiffness compared to that of G-PEG hydrogels. We demonstrated that G-PEG-Dx showed a significant increase of its anisotropic characteristic and G-PEG-Ch exhibited higher and faster stress relaxation behavior than the other hydrogels. These characteristics were associated to absence of chondrogenic differentiation on G-PEG-Dx scaffold and good chondrogenic differentiation on G-PEG and G-PEG-Ch. Furthermore, G-PEG-Ch induced the minor collagen proteins and the formation of collagen fibrils with a diameter like native cartilage. This study demonstrated that both anisotropic and stress relaxation characteristics of the hybrid hydrogels were important features directly influencing the chondrogenic differentiation potentiality of hBM-MSC

Preferential Solvation Study of Rosuvastatin in the {PEG400 (1) + Water (2)} Cosolvent Mixture and GastroPlus Software-Based In Vivo Predictions

Article claims that rosuvastatin (RST) is a poorly water-soluble drug responsible for limited in vivo dissolution and subsequently low oral systemic absorption (poor bioavailability). The results of inverse Kirkwood–Buff integrals showed the PS of RST by PEG400 as observed in all studied ratios of the binary mixture

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London