La nueva pintura del emperador

El texto repasa la conocida "Ley de Ripolin" que Le Corbusier expone en su famoso texto L'art décoratif d'aujourd'hui, en el que el arquitecto suizo aspira a encontrar respuesta a la pregunta fundamental: ¿dónde está la arquitectura? A partir de una brillante reflexión sobre el papel de las paredes blancas en la arquitectura moderna, Wigley rescata el carácter textil y en consecuencia "superficial" de la condición moderna de la arquitectura. De este modo se muestra cómo la arquitectura de Le Corbusier enlaza con los argumentos de Loos y Semper, y más aun se ve con claridad la auténtica condición de la arquitectura como fenómeno visual que a su vez se localiza en el espacio de la comunicación. Como Wigley apunta, es necesario explorar con mucho detalle la fina capa blanca y para eso es preciso ahondar con mucha más profundidad en la superficie

La policía de la moda

Se presenta en castellano el texto del profesor Wigley que originalmente constituye el segundo capítulo de su conocido White Walls, Designer Dresses. The Fashioning of Modern Architecture. El texto profundiza con brillantez en la compleja relación entre moda y arquitectura moderna. Parte de la convicción de que "el discurso contemporáneo sobre la arquitectura continúa organizado alrededor de los continuos ataques a la moda". Para mostrar esta realidad repasa la actitud defensiva y en ocasiones de "perro guardian" de algunos de sus principales representantes teóricos: desde Le Corbusier y sus escritos sobre las paredes blancas, hasta Giedion, cuya posición es rastreada con minuciosidad a lo largo de sus principales escritos, hasta Tafuri, que en su influyente Teoría e Historia de la Arquitectura presenta una similar actitud hacia la moda. Wigley concluye mostrando cómo estos rechazos de la moda son en definitiva una prueba de su vigencia como disciplina y explica que, en consecuencia, "ningún discurso puede aislarse de la moda sin más"

Using the past to constrain the future: how the palaeorecord can improve estimates of global warming

Climate sensitivity is defined as the change in global mean equilibrium temperature after a doubling of atmospheric CO2 concentration and provides a simple measure of global warming. An early estimate of climate sensitivity, 1.5-4.5{\deg}C, has changed little subsequently, including the latest assessment by the Intergovernmental Panel on Climate Change. The persistence of such large uncertainties in this simple measure casts doubt on our understanding of the mechanisms of climate change and our ability to predict the response of the climate system to future perturbations. This has motivated continued attempts to constrain the range with climate data, alone or in conjunction with models. The majority of studies use data from the instrumental period (post-1850) but recent work has made use of information about the large climate changes experienced in the geological past. In this review, we first outline approaches that estimate climate sensitivity using instrumental climate observations and then summarise attempts to use the record of climate change on geological timescales. We examine the limitations of these studies and suggest ways in which the power of the palaeoclimate record could be better used to reduce uncertainties in our predictions of climate sensitivity.Comment: The final, definitive version of this paper has been published in Progress in Physical Geography, 31(5), 2007 by SAGE Publications Ltd, All rights reserved. \c{opyright} 2007 Edwards, Crucifix and Harriso

Women and Haunted Houses in the Films of Jaume Balagueró: The Nightmares of Presence

Jaume Balagueró has developed a successful resumé of horror films that show a decided preference for the classic Gothic motif of the haunted house and the Gothic heroine who investigates its interior. This paper touches first on the Derridean concept of ‘dreams of presence’ (as theorized by cultural geographer Mitch Rose), in order to propose the ‘nightmares of presence’ in which the relationship, the call to care or commitment, between the subject and the space in which the subject dwells or moves is Gothicised but nonetheless remains to tie the subject to the space concerned. It then focuses on Balagueró’s Los sin nombre, Fragile and [REC] to consider three very different Gothic heroines: the mother of a dead daughter, a nurse in a children’s hospital, and a television reporter. The antagonistic call to care of the ‘nightmare of presence’ will be used to interrogate spatial aspects of the Gothic heroine. Keywords: Jaume Balagueró; haunted house; Spanish Gothic; Spanish horror; Spanish film Jaume Balagueró ha desarrollado un grupo de películas exitosas que demuestra una preferencia hacia el escenario clásico de lo gótico, la casa encantada tanto como la heroína gótica que la investiga. Este ensayo estudia en primer lugar el concepto derrideano de ‘los sueños de presencia’ (según la teoría de geógrafo cultural Mitch Rose), para proponer las ‘pesadillas de presencia’ en que el vínculo, la llamada a compromiso, entre el sujeto y el espacio en que se mueve o que habita, llega a ser gotizado; pero que fija al sujeto en el espacio relevante. El argumento se enfoca en Los sin nombre, Fragile y [REC] para considerar tres heroínas distintas: la madre de una hija muerta, una enfermera en un hospital para niños, y una locutora para un programa televisivo. La llamada antagonista de la pesadilla de presencia se usa para interrogar los aspectos espaciales de la heroína gótica

Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: Results from the scleroderma lung study

Objective To assess the impact of cyclophosphamide (CYC) on the health-related quality of life (HRQOL) of patients with scleroderma after 12 months of treatment. Methods One hundred fifty-eight subjects participated in the Scleroderma Lung Study, with 79 each randomized to CYC and placebo arms. The study evaluated the results of 3 measures of health status: the Short Form 36 (SF-36), the Health Assessment Questionnaire (HAQ) disability index (DI), and Mahler's dyspnea index, and the results of 1 preference-based measure, the SF-6D. The differences in the HRQOL between the 2 groups at 12 months were calculated using a linear mixed model. Responsiveness was evaluated using the effect size. The proportion of subjects in each treatment group whose scores improved at least as much as or more than the minimum clinically important difference (MCID) in HRQOL measures was assessed. Results After adjustment for baseline scores, differences in the HAQ DI, SF-36 role physical, general health, vitality, role emotional, mental health scales, and SF-36 mental component summary (MCS) score were statistically significant for CYC versus placebo ( P < 0.05). Effect sizes were negligible (<0.20) for all of the scales of the SF-36, HAQ DI, and SF-6D at 12 months. In contrast, a higher proportion of patients who received CYC achieved the MCID compared with placebo in the HAQ DI score (30.9% versus 14.8%), transitional dyspnea index score (46.4% versus 12.7%), SF-36 MCS score (33.3% versus 18.5%), and SF-6D score (21.3% versus 3.8%). Conclusion One year of treatment with CYC leads to an improvement in HRQOL in patients with scleroderma lung disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/56039/1/22580_ftp.pd

Volcanic Contribution to Decadal Changes in Tropospheric Temperature

Despite continued growth in atmospheric levels of greenhouse gases, global mean surface and tropospheric temperatures have shown slower warming since 1998 than previously. Possible explanations for the slow-down include internal climate variability, external cooling influences and observational errors. Several recent modelling studies have examined the contribution of early twenty-first-century volcanic eruptions to the muted surface warming. Here we present a detailed analysis of the impact of recent volcanic forcing on tropospheric temperature, based on observations as well as climate model simulations. We identify statistically significant correlations between observations of stratospheric aerosol optical depth and satellite-based estimates of both tropospheric temperature and short-wave fluxes at the top of the atmosphere. We show that climate model simulations without the effects of early twenty-first-century volcanic eruptions overestimate the tropospheric warming observed since 1998. In two simulations with more realistic volcanic influences following the 1991 Pinatubo eruption, differences between simulated and observed tropospheric temperature trends over the period 1998 to 2012 are up to 15% smaller, with large uncertainties in the magnitude of the effect. To reduce these uncertainties, better observations of eruption-specific properties of volcanic aerosols are needed, as well as improved representation of these eruption-specific properties in climate model simulations

TDP-43 Identified from a Genome Wide RNAi Screen for SOD1 Regulators

Amyotrophic Lateral Sclerosis (ALS) is a late-onset, progressive neurodegenerative disease affecting motor neurons in the brain stem and spinal cord leading to loss of voluntary muscular function and ultimately, death due to respiratory failure. A subset of ALS cases are familial and associated with mutations in superoxide dismutase 1 (SOD1) that destabilize the protein and predispose it to aggregation. In spite of the fact that sporadic and familial forms of ALS share many common patho-physiological features, the mechanistic relationship between SOD1-associated and sporadic forms of the disease if any, is not well understood. To better understand any molecular connections, a cell-based protein folding assay was employed to screen a whole genome RNAi library for genes that regulate levels of soluble SOD1. Statistically significant hits that modulate SOD1 levels, when analyzed by pathway analysis revealed a highly ranked network containing TAR DNA binging protein (TDP-43), a major component of aggregates characteristic of sporadic ALS. Biochemical experiments confirmed the action of TDP-43 on SOD1. These results highlight an unexpected relationship between TDP-43 and SOD1 which may have implications in disease pathogenesis

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

dentification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 x 10(-8)) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.Peer reviewe