COMPARATIVE STUDY OF LITHOTRIPSY AND MINIPERC IN 11 TO 18 MM IMPACTED PUJ CALCULI

Background: Impacted PUJ calculi are well known entity.  Nephrolithiasis is a common disorder that accounts for significant cost, morbidity, and loss of work. Over last 3 decades considerable advances have been made in the management of kidney stone disease, still there is no single universally accepted and uniformly effective modality of treatment in medium size of impacted PUJ calculi. Aim: To study the efficacy of lithotripsy and MINIPERC in 11mm to 18mm impacted PUJ calculi. Methodology: The patients with impacted PUJ calculi of size 11 to 18mm of both sexes of all age group varying form 18-60 years, on consecutive sampling method total 84 patients were included. All patients underwent basic lab investigations, USG, IVU and investigations for fitness purpose. Group 1: All procedures were tubeless.  We used 15 Fr Richard Wolf nephroscope for the procedure. 16 to 20 Fr Amplatz sheath was used depending upon situation. Fragmentation was performed using pneumatic lithoclast or holmium Laser depending upon stone size and characteristics. Group 2: Underwent DJ stenting under subarachnoid block or short GA depending upon situation. On the next day they were subjected for lithotripsy on Dorniel alpha machine under USG guidance, 3000 shocks were given in each sitting. One to three such sittings were given. Post operatively ultrasonography and X-ray KUB was done in all the patients and stents were removed after assuring complete clearance. Patients with absence of stone or presence of stone less than 4 mm on USG or x-ray KUB were declared as completely cleared. Results: Average hospital stay was 48 hours in miniperc group and it was 30 hours in DJ with ESWL group. Clearance rate was 100 % in Miniperc group and it was 85.71 % in DJ with ESWL group. Five patients (11.9%) in DJ lithotripsy group required another procedure. (Two needed miniperc and three needed URS). Two(4.76 %) patients in miniperc group had fever in post op period but nobody suffered major sepsis. Conclusion: Miniperc fulfils many criteria if we see results and complications. Although bigger sized multicentric study and long term follow up is needed

COMPARATIVE STUDY OF LITHOTRIPSY AND MINIPERC IN 11 TO 18 MM IMPACTED PUJ CALCULI

Background: Impacted PUJ calculi are well known entity.  Nephrolithiasis is a common disorder that accounts for significant cost, morbidity, and loss of work. Over last 3 decades considerable advances have been made in the management of kidney stone disease, still there is no single universally accepted and uniformly effective modality of treatment in medium size of impacted PUJ calculi. Aim: To study the efficacy of lithotripsy and MINIPERC in 11mm to 18mm impacted PUJ calculi. Methodology: The patients with impacted PUJ calculi of size 11 to 18mm of both sexes of all age group varying form 18-60 years, on consecutive sampling method total 84 patients were included. All patients underwent basic lab investigations, USG, IVU and investigations for fitness purpose. Group 1: All procedures were tubeless.  We used 15 Fr Richard Wolf nephroscope for the procedure. 16 to 20 Fr Amplatz sheath was used depending upon situation. Fragmentation was performed using pneumatic lithoclast or holmium Laser depending upon stone size and characteristics. Group 2: Underwent DJ stenting under subarachnoid block or short GA depending upon situation. On the next day they were subjected for lithotripsy on Dorniel alpha machine under USG guidance, 3000 shocks were given in each sitting. One to three such sittings were given. Post operatively ultrasonography and X-ray KUB was done in all the patients and stents were removed after assuring complete clearance. Patients with absence of stone or presence of stone less than 4 mm on USG or x-ray KUB were declared as completely cleared. Results: Average hospital stay was 48 hours in miniperc group and it was 30 hours in DJ with ESWL group. Clearance rate was 100 % in Miniperc group and it was 85.71 % in DJ with ESWL group. Five patients (11.9%) in DJ lithotripsy group required another procedure. (Two needed miniperc and three needed URS). Two(4.76 %) patients in miniperc group had fever in post op period but nobody suffered major sepsis. Conclusion: Miniperc fulfils many criteria if we see results and complications. Although bigger sized multicentric study and long term follow up is needed

Synthesis of quercetin–iron (Fe) complex and its in silico and in vitro confirmation towards antibacterial activity

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Low temperature synthesis of pure anatase carbon doped titanium dioxide: An efficient visible light active photocatalyst

Low temperature pure anatase Carbon Doped Titanium Dioxide (C-TiO2) is successfully synthesized by using starch as an effective, economical, and nonhazardous carbon source. The synthesized C-TiO2 has been further characterized by X-Ray Diffraction, SEM, TEM, BET, XPS and UV- DRS techniques, which reveal that the particles are crystalline with spherical morphology, high surface area and an optical band gap of 2.79 eV for CTiO2 calcined at 400 °C. Furthermore photocatalytic degradation of Rhodamine B dye was carried out using asprepared C-TiO2 under visible light irradiation. Prepared C-TiO2 calcined at 200 °C and 400 °C show higher degradation efficiency (85% and 100% in 120 min respectively) as compared to that of undoped TiO2 and commercial Degussa P-25. Result shows that the C-TiO2 containing lower carbon percentage has higher photocatalytic activity. Thus enhanced photocatalytic activity of C-TiO2, may be due to synergic effect of carbon doping and [101] facet enhanced synthesis of anatase C-TiO2

Investigation of Volumetric and Acoustic Properties of Procainamide Hydrochloride in Aqueous Binary and (Water + Amino Acid) Ternary Mixtures at Different Temperatures

For effective drug design and development, an integrated process utilizing all available information from structural, thermodynamic, and biological studies plays a very important role. To understand the energy basis of molecular interactions utilizing various thermodynamic methods, volumetric and acoustic studies are vital early in the development process of any drug toward an optimal energy interaction profile while retaining a good pharmacological assay. In this article, we are reporting the data of densities (ρ) and speeds of sound (<i>u</i>) of an antiarrhythmic agent, namely, procainamide hydrochloride in an aqueous binary and aqueous solution of amino acids, i.e., l-alanine and l-valine at <i>T</i> = (298.15, 308.15 and 318.15) K. Different thermodynamic parameters such as the apparent molar volume (<i>V</i>_ϕ) of the solute, the isentropic compressibility (κ_s) of the solution, and the apparent molar isentropic compressibility (κ_ϕ) of procainamide hydrochloride in water and aqueous solutions of l-alanine and l-valine have been computed using the density and speed of sound data at different temperatures. The limiting apparent molar volume (<i>V</i>_ϕ⁰) of solute and the limiting apparent molar compressibility (κ_ϕ⁰) of solute in binary and ternary aqueous solutions have been obtained by extrapolating the plots. The results have been interpreted in light of the competing solute–solute and solute–solvent interactions