An Exploratory Study Using Participation Plans for Inclusive Social Studies Instruction

Limited research exists on teaching social studies content, including intervention research, in inclusive settings for students with intellectual and developmental disabilities. The purpose of this exploratory project was to evaluate the use of participation plans for supporting students with intellectual and developmental disabilities in inclusive high school social studies classrooms. The study addressed two questions: (1) To what extent can students with IDD learn prioritized social studies content and skills in inclusive secondary settings? and (2) How do participation plans support students in learning prioritized social studies content and skills in inclusive general education settings? A university research team supported a public high school staff to employ a single-case, multiple baseline design across prioritized skills (knowledge of content, vocabulary, and summarization) and participants. Results showed students’ correct responses increased across prioritized skills after the team began using the participation plans. This discreet intervention exhibits promise for school staff (i.e., teachers, paraprofessionals) needing mediating tools for effective inclusive education. We discuss implications for future research and practice

Scientific Knowledge Networks in Peripheral Regions and Local Innovation Systems: The Case of Chemistry in the State of Bahia

Scientific production and technological innovation growth in Brazil are not homogeneous in its different regions despite its public policies. The same phenomenon can be observed within the states of the Brazilian Federation. This article examines the diffusion of scientific expertise in six public institutions of science and technology in the state of Bahia between 2004 and 2008. The state is the largest in the north-east of Brazil, an area marked by a semi-arid climate and a low human development index; however, it has a large chemical and petrochemical complex. This article, focusing on the scientific field of chemistry, is based on foundations of innovation and knowledge management, as well as social network analysis, aiming to examine relations between scientific production and institutional, structural and relational characteristics of inter- and intra-institutional scientific knowledge networks. The results show that public policies on science, technology and innovation regarding the peripheral regions need to be rethought

The Application of 3D Landmark-Based Geometric Morphometrics towards Refinement of the Piglet Grimace Scale

Proper methods of assessment to objectively identify pain are essential for welfare improvements of piglets undergoing surgical castration on commercial farms. The Piglet Grimace Scale (PGS) is used to identify changes in facial expressions caused by acute pain in piglets undergoing tail docking and castration. However, subjective scoring methods are a concern for the validation of the PGS. The objectives of this study were to evaluate and refine the PGS through 3D landmark geometric morphometrics. Male piglets (n = 88) were randomly allocated to one of two treatments: castration and sham-castration. Piglet facial images were taken at four time points (before treatment, immediately post-treatment, 1 h post-treatment, and 4 h post-treatment) using a photogrammetry rig. Images were scored by four raters using five facial action units (FAUs): orbital tightening, ear position, temporal tension, lip contraction, and nose bulge/cheek tension. Three-dimensional facial models were generated and landmarked denoting 3 FAUs (orbital tightening, lip contraction, and nose bulge/cheek tension). Results suggest that orbital tightening and ear position may be reliable FAUs for the PGS. However, neither the PGS nor 3D landmark-based geometric morphometrics were able (both p > 0.10) to reliably identify facial indicators of pain in piglets undergoing castration

Desafios, políticas e estratégias determinantes para garantir a Disponibilidade e Acessibilidade da Enfermagem no Brasil: um protocolo de scoping review

The aim was to identify the existing challenges, determinants, policies, and strategies to ensure the availability and accessibility of nursing personnel by the population in Brazil. Scoping review of peer-reviewed papers and technical and political documents. Eight scientific databases will be searched (such as PubMed, BVS, and EMBASE). Sources of unpublished studies/ grey literature to be searched include websites from the Ministry of Health, councils, and institutions. No language or publication date restrictions will apply. The review will consider documents that contain information regarding nursing personnel in the Brazilian context and address: I. the challenge of availability and/or accessibility of nursing personnel; II. the causes of the challenge; or III: strategies to deal with the challenge: either (a) in a state of description of implemented interventions or (b) evaluation of the strategy in its implementation stage. The result will be described in a narrative way, descriptive statistics will be presented as necessary, and the information will be grouped, summarized, and compared. For the qualitative analysis of the documents, both inductive and deductive thematic content analysis will be used. The results can reveal information about gaps and imbalances in the workforce, enabling the implementation of strategies to address these challenges.Objetivou-se identificar os desafios, determinantes, políticas e estratégias existentes para garantir a disponibilidade e acessibilidade do pessoal de enfermagem pela população no Brasil. Revisão de escopo de artigos revisados por pares e documentos técnicos e políticos. Serão pesquisadas oito bases de dados científicas (como PubMed, BVS e EMBASE). As fontes de estudos não publicados/literatura cinzenta a serem pesquisadas incluem sites do Ministério da Saúde, conselhos e instituições. Nenhuma restrição de idioma ou data de publicação será aplicada. A revisão considerará documentos que contenham informações sobre o pessoal de enfermagem no contexto brasileiro e abordarão: I. o desafio da disponibilidade e/ou acessibilidade do pessoal de enfermagem; II. as causas do desafio; ou III: estratégias para lidar com o desafio: seja (a) em estado de descrição das intervenções implementadas ou (b) avaliação da estratégia em sua fase de implementação. O resultado será descrito de forma narrativa, estatísticas descritivas serão apresentadas conforme necessário e as informações serão agrupadas, resumidas e comparadas. Para a análise qualitativa dos documentos, será utilizada análise de conteúdo temática indutiva e dedutiva. Os resultados podem revelar informações sobre lacunas e desequilíbrios na força de trabalho, permitindo a implementação de estratégias para enfrentar estes desafios

Cuatro productos ancestrales y su importancia en la gastronomía Mexicana

La presente investigación, es un estudio bibliográfico, descriptivo de la historia de la dieta alimentaria del mexicano, así como significados e importancia del maíz, frijol, calabaza y chile, sus variedades y evolución

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Next-generation care pathways for allergic rhinitis and asthma multimorbidity:a model for multimorbid non-communicable diseases-Meeting Report (Part 1)

International audienceIn all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system for integrated care with organizational health literacy. MASK (Mobile Airways Sentinel NetworK) (1), a new development of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health) (2), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life integrated care pathways (ICPs) (3)-centred around the patient with rhinitis and using mHealth monitoring of environmental exposure (4).An expert meeting took place at the Pasteur Institute in Paris, December 3, 2018. The aim was to discuss next-generation care pathways: (I) Patient participation, health literacy and self-care through technology-assisted “patient activation”; (II) Implementation of care pathways by pharmacists and (III) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) assessed by mobile technology.The EU (5) and global political agendas are of great importance in supporting health care transformation. MASK has been recognized by DG Santé as a Good Practice (6) in the field of digitally-enabled, integrated, person-centred care.The one-day meeting objectives were clear (Figure 1). The meeting was followed by a workshop. The present paper reports the background of the two-day meeting

Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing

Pyrazolopyridine inhibitors with low micromolar potency for CHK1 and good selectivity against CHK2 were previously identified by fragment-based screening. The optimization of the pyrazolopyridines to a series of potent and CHK1-selective isoquinolines demonstrates how fragment-growing and scaffold morphing strategies arising from a structure-based understanding of CHK1 inhibitor binding can be combined to successfully progress fragment-derived hit matter to compounds with activity in vivo. The challenges of improving CHK1 potency and selectivity, addressing synthetic tractability, and achieving novelty in the crowded kinase inhibitor chemical space were tackled by multiple scaffold morphing steps, which progressed through tricyclic pyrimido[2,3-b]azaindoles to N-(pyrazin-2-yl)pyrimidin-4-amines and ultimately to imidazo[4,5-c]pyridines and isoquinolines. A potent and highly selective isoquinoline CHK1 inhibitor (SAR-020106) was identified, which potentiated the efficacies of irinotecan and gemcitabine in SW620 human colon carcinoma xenografts in nude mice

2019 ARIA Care pathways for allergen immunotherapy

Allergen immunotherapy (AIT) is a proven therapeutic option for the treatment of allergic rhinitis and/or asthma. Many guidelines or national practice guidelines have been produced but the evidence-based method varies, many are complex and none propose care pathways. This paper reviews care pathways for AIT using strict criteria and provides simple recommendations that can be used by all stakeholders including healthcare professionals. The decision to prescribe AIT for the patient should be individualized and based on the relevance of the allergens, the persistence of symptoms despite appropriate medications according to guidelines as well as the availability of good-quality and efficacious extracts. Allergen extracts cannot be regarded as generics. Immunotherapy is selected by specialists for stratified patients. There are no currently available validated biomarkers that can predict AIT success. In adolescents and adults, AIT should be reserved for patients with moderate/severe rhinitis or for those with moderate asthma who, despite appropriate pharmacotherapy and adherence, continue to exhibit exacerbations that appear to be related to allergen exposure, except in some specific cases. Immunotherapy may be even more advantageous in patients with multimorbidity. In children, AIT may prevent asthma onset in patients with rhinitis. mHealth tools are promising for the stratification and follow-up of patients.Peer reviewe