364 research outputs found
On a class of linearizable Monge-Amp\`ere equations
Monge-Amp\`ere equations of the form,
arise in many areas of fluid and solid mechanics. Here it is shown that in the
special case , where denotes an arbitrary function,
the Monge-Amp\`ere equation can be linearized by using a sequence of Amp\`ere,
point, Legendre and rotation transformations. This linearization is a
generalization of three examples from finite elasticity, involving plane strain
and plane stress deformations of the incompressible perfectly elastic Varga
material and also relates to a previous linearization of this equation due to
Khabirov [7]
Structure formation in binary colloids
A theoretical study of the structure formation observed very recently [Phys.
Rev. Lett. 90, 128303 (2003)] in binary colloids is presented. In our model
solely the dipole-dipole interaction of the particles is considered,
electrohidrodynamic effects are excluded. Based on molecular dynamics
simulations and analytic calculations we show that the total concentration of
the particles, the relative concentration and the relative dipole moment of the
components determine the structure of the colloid. At low concentrations the
kinetic aggregation of particles results in fractal structures which show a
crossover behavior when increasing the concentration. At high concentration
various lattice structures are obtained in a good agreement with experiments.Comment: revtex, 4 pages, figures available from authors due to size problem
Effect of Stress Annealing on Domain Wall Dynamics in Nanocrystalline Hitperm-Type Microwires
We have studied the effect of stress induced anisotropy on domain wall dynamics in as-cast and annealed nanocrystalline Hitperm-type microwires. Annealing without stress leads to stress relaxation of the strong stresses frozen-in post the production process. Stress annealing at 300oC under 222.7 and 270.9 MPa, respectively, has triggered most complex domain wall dynamics.
Observed results are discussed considering that annealing under higher stresses leads to an enhancement of longitudinal (axial) anisotropy due to positive magnetostriction of both bcc-(Fe, Co) grain as well as the residual amorphous matrix, and subsequently due to the decreasing of axial anisotropy due to back stresses arising from the glass-coating after removing the mechanical load.
Magnetic anisotropies (axial and radial ones) after stress annealing can be responsible for the considerable influence of the annealing conditions on domain wall dynamics observed in Hitperm-type microwires. As a result of decreasing both anisotropies by different ways, the domain wall velocity decreased
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The role of plasma membrane STIM1 and Ca(2+)entry in platelet aggregation. STIM1 binds to novel proteins in human platelets.
Ca(2+) elevation is essential to platelet activation. STIM1 senses Ca(2+) in the endoplasmic reticulum and activates Orai channels allowing store-operated Ca(2+) entry (SOCE). STIM1 has also been reported to be present in the plasma membrane (PM) with its N-terminal region exposed to the outside medium but its role is not fully understood. We have examined the effects of the antibody GOK/STIM1, which recognises the N-terminal region of STIM1, on SOCE, agonist-stimulated Ca(2+) entry, surface exposure, in vitro thrombus formation and aggregation in human platelets. We also determined novel binding partners of STIM1 using proteomics. The dialysed GOK/STIM1 antibody failed to reduced thapsigargin- and agonist-mediated Ca(2+) entry in Fura2-labelled cells. Using flow cytometry we detect a portion of STIM1 to be surface-exposed. The dialysed GOK/STIM1 antibody reduced thrombus formation by whole blood on collagen-coated capillaries under flow and platelet aggregation induced by collagen. In immunoprecipitation experiments followed by proteomic analysis, STIM1 was found to extract a number of proteins including myosin, DOCK10, thrombospondin-1 and actin. These studies suggest that PM STIM1 may facilitate platelet activation by collagen through novel interactions at the plasma membrane while the essential Ca(2+)-sensing role of STIM1 is served by the protein in the ER
Weakly-Bound Three-Body Systems with No Bound Subsystems
We investigate the domain of coupling constants which achieve binding for a
3-body system, while none of the 2-body subsystems is bound. We derive some
general properties of the shape of the domain, and rigorous upper bounds on its
size, using a Hall--Post decomposition of the Hamiltonian. Numerical
illustrations are provided in the case of a Yukawa potential, using a simple
variational method.Comment: gzipped ps with 11 figures included. To appear in Phys. Rev.
Response of Wheat Fungal Diseases to Elevated Atmospheric CO2 Level
Infection with fungal pathogens on wheat varieties with different levels of resistance was
tested at ambient (NC, 390 ppm) and elevated (EC, 750 ppm) atmospheric CO2 levels in the
phytotron. EC was found to affect many aspects of the plant-pathogen interaction. Infection
with most fungal diseases was usually found to be promoted by elevated CO2 level in susceptible
varieties. Powdery mildew, leaf rust and stem rust produced more severe symptoms on
plants of susceptible varieties, while resistant varieties were not infected even at EC. The penetration
of Fusarium head blight (FHB) into the spike was delayed by EC in Mv Mambo, while
it was unaffected in Mv Regiment and stimulated in Mv Emma. EC increased the propagation
of FHB in Mv Mambo and Mv Emma. Enhanced resistance to the spread of Fusarium within
the plant was only found in Mv Regiment, which has good resistance to penetration but poor
resistance to the spread of FHB at NC. FHB infection was more severe at EC in two varieties,
while the plants of Mv Regiment, which has the best field resistance at NC, did not exhibit a
higher infection level at EC.
The above results suggest that breeding for new resistant varieties will remain a useful
means of preventing more severe infection in a future with higher atmospheric CO2 levels
Evidence of pseudoprogression in patients treated with PD1/ PDL1 antibodies across tumor types
Background: PD(L)1 antibodies (anti-PD(L)-1) have been a major breakthrough
in several types of cancer. Novel patterns of response and progression have been
described with anti-PD(L)-1. We aimed at characterizing pseudoprogression (PSPD)
among patients with various solid tumor types treated by anti-PD(L)-1.
Methods: All consecutive patients (pts) enrolled in phase 1 trials with advanced
solid tumors and lymphomas treated in phase I clinical trials evaluating monotherapy
by anti-PD(L)-1 at Gustave Roussy were analyzed. We aimed to assess prevalence
and outcome of PSPD across tumor types. We also intended to describe potential
clinical and pathological factors associated with PSPD.
Results: A total of 169 patients treated with anti-PD(L)-1 were included in the study.
Most frequent tumor types included melanoma (n = 57) and non-small cell lung cancer (n = 19). At first tumor evaluation 77 patients (46%) presented with immune unconfirmed progressive disease. Six patients (8%) experienced PSPD: 2 patients with
partial response; 4 patients with stable disease. Increase in target lesions in the first
CT-scan was more frequently associated to PSPD (67% vs 33%; P = .04). Patients
with a PSPD had a superior survival when compared to patients progressing (median
OS: 10.7 months vs 8.7 months; P = .07).
Conclusions: A small subset of PSPD patients may experience response after an
initial progression. Assessment of the current strategy for immune-related response
evaluations may require further attention
Measurements of the Sigma_c^0 and Sigma_c^{++} Mass Splittings
Using a high statistics sample of photoproduced charmed particles from the
FOCUS experiment at Fermilab (FNAL-E831), we measure the mass splittings of the
charmed baryons Sigma_c^0 and Sigma_c^{++}. We find M(Sigma_c^0 - Lambda_c^+) =
167.38 +/- 0.21 +/- 0.13 MeV/c^2 and M(Sigma_c^++ - Lambda_c^+) = 167.35 +/-
0.19 +/- 0.12 MeV/c^2 with samples of 362 +/- 36 and 461 +/- 39 events,
respectively. We measure the isospin mass splitting M(Sigma_c^++ - Sigma_c^0)
to be -0.03 +/- 0.28 +/- 0.11 Mev/c^2. The first errors are statistical and the
second are systematic.Comment: 10 pages, 2 figure
Results on correlations and fluctuations from NA49
The large acceptance and high momentum resolution as well as the significant
particle identification capabilities of the NA49 experiment at the CERN SPS
allow for a broad study of fluctuations and correlations in hadronic
interactions. In the first part recent results on event-by-event charge and p_t
fluctuations are presented. Charge fluctuations in central Pb+Pb reactions are
investigated at three different beam energies (40, 80, and 158 AGeV), while for
the p_t fluctuations the focus is put on the system size dependence at 158
AGeV. In the second part recent results on Bose Einstein correlations of h-h-
pairs in minimum bias Pb+Pb reactions at 40 and 158 AGeV, as well as of K+K+
and K-K- pairs in central Pb+Pb collisions at 158 AGeV are shown. Additionally,
other types of two particle correlations, namely pi p, Lambda p, and Lambda
Lambda correlations, have been measured by the NA49 experiment. Finally,
results on the energy and system size dependence of deuteron coalescence are
discussed.Comment: 10 pages, 12 figures, Presented at Quark Matter 2002, Nantes, France,
Corrected error in Eq.
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