31 research outputs found
Fatores associados à idade da primeira relação sexual em jovens: estudo de base populacional
- Author
- Ana Laura Sicca Cruzeiro
- Boislard PMA
- Borges ALV
- Borges ALV
- Carret ML
- Cristine Eliane Gomes Rodrigues
- Cruzeiro ALS
- Cruzeiro ALS
- Cunha JA
- Fatusi AO
- Gonçalves HB
- Henrique IFS
- Jamieson LK
- Karen Jansen
- Lam TH
- Langille DB
- Liliane da Costa Ores
- Luciano Dias de Mattos Souza
- Ma Q
- Madkour AS
- Mueller TE
- Ohene SA
- Paiva V
- Peltzer K
- Penfold SC
- Rebello LEFS
- Ricardo Silva
- Ricardo Tavares Pinheiro
- Sabia JJ
- Sandfort TGM
- Sinha JW
- Stulhofer A
- Tairana Dias de Oliveira Hugo
- Tavares CM
- Thomas L
- Vanessa Teixeira Maier
- Villela WVD
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Germline variation at 8q24 and prostate cancer risk in men of European ancestry
- Author
- Adolfsson Jan
- Aguado Miguel
- Aitken Joanne
- Albanes Demetrius
- Alcaraz Antonio
- Aly Markus
- Andriole Gerald
- Aukim-Hastie Claire
- Auvinen Anssi
- Bangma Christopher
- Barnett Gill
- Batra Jyotsna
- Beane Freeman Laura E.
- Benlloch Sara
- Bensen Jeanette T.
- Bentzen Søren
- Berndt Sonja I.
- Berry Clare
- Bisbjerg Rasmus
- Bohnert Philipp
- Borre Michael
- Brenner Hermann
- Broms Michael
- Brook Mark N.
- Brown Paul
- Burnet Neil
- Bustamante Mariona
- Butler Lisa
- Calvo Patricia
- Cancel-Tassin Géraldine
- Cannon-Albright Lisa A.
- Canzian Federico
- Cao Guangwen
- Carballo Ana
- Cardoso Marta
- Carracedo Angel
- Carter Brian D.
- Castaño-Vinyals Gemma
- Castelao Jose Esteban
- Cavalli-Bjoerkman Carin
- Cecchini Lluís
- Cenee Sylvie
- Chambers Suzanne
- Chanock Stephen J.
- Christova Svetlana
- Claessens Frank
- Clements Judith
- Conti David V.
- Cook Margaret
- Cox Angela
- Cuk Katarina
- Cussenot Olivier
- Cybulski Cezary
- Dadaev Tokhir
- Davis Michael
- De Langhe Sofie
- De Meerleer Gert
- De Ruyck Kim
- Dearnaley David
- Dierssen-Sotos Trinidad
- Dikov Tihomir
- Ding Yuan Chun
- Donovan Jenny L.
- Drake Bettina F.
- Dunning Alison M.
- Easton Douglas F.
- Eckert Allison
- Eeles Rosalind A.
- Eklund Martin
- Elliott Rebecca
- Evans Andrew
- Fachal Laura
- Feng Ninghan
- Finelli Antonio
- Fisher Cyril
- Fitzgerald Liesel M.
- Fleshner Neil E.
- Freedman Matthew
- Gago-Dominguez Manuela
- Gamulin Marija
- Gapstur Susan M.
- Gardiner Robert
- George Anne
- Geybels Milan S.
- Giles Graham G.
- Giovannucci Edward
- Goodman Phyllis J.
- Govindasami Koveela
- Gracia-Lavedan Esther
- Grindedal Eli M.
- Grönberg Henrik
- Guo Jianming
- Guo Xin
- Guy Michelle
- Gómez Acebo Inés
- Gómez-Caamaño Antonio
- Haiman Christopher A.
- Hakansson Niclas
- Hamdy Freddie C.
- Hamilton Robert J.
- Hayes Vanessa
- Haynes Anne-Maree
- Hazel Steve
- He Weiyang
- Henderson Brian E.
- Herkommer Kathleen
- Hicks Belynda
- Holleczek Bernd
- Hoover Robert N.
- Hopper John L.
- Horvath Lisa
- Hunter David J.
- Hutchinson Amy
- Imai Takashi
- Ingles Sue A.
- Iversen Peter
- Jenster Guido
- Johansson Jan-Erik
- John Esther M.
- Joniau Steven
- Kachakova Darina
- Kaneva Radka
- Karlsson Ami
- Kastelan Zeljko
- Kedda Mary-Anne
- Kerns Sarah
- Key Tim J.
- Khaw Kay-Tee
- Kibel Adam S.
- Kierzek Andrzej
- Kim Jeri
- Klarskov Peter
- Klim Aleksandra
- Kluzniak Wojciech
- Kogevinas Manolis
- Kolb Suzanne
- Kolonel Laurence N.
- Kote-Jarai Zsofia
- Koudou Yves Akoli
- Koutros Stella
- Kraft Peter
- Kujala Paula
- Kulis Tomislav
- Kulkarni Girish S.
- Lane Athene
- Larkin Samantha
- Le Marchand Loic
- Lessel Davor
- Lewis Sarah J.
- Li Jie
- Li Meiling
- Lim Jasmine
- Lin Daniel W.
- Lin Hui-Yi
- Lin Ji
- Lindström Sara
- Ling Jin
- Livni Naomi
- Llorca Javier
- Lobato-Busto Ramón
- Logothetis Christopher J. J.
- Lophatananon Artitaya
- Lu Yong-Jie
- Lubinski Jan
- Luedeke Manuel
- Ma Jing
- Machiela Mitchell J.
- MacInnis Robert J.
- Maehle Lovise
- Maia Sofia
- Maier Christiane
- Mao Xueying
- Marsden Gemma
- Martin Richard M.
- Martinez Maria Elena
- Marzec Jacek
- Matejcic Marco
- McDonnell Shannon K.
- Menegaux Florence
- Mengual Lourdes
- Michael Agnieszka
- Milne Roger
- Mitev Vanio
- Mitkova Atanaska
- Morgan Angela
- Moya Leire
- Mucci Lorelei
- Muir Kenneth
- Mulot Claire
- Murtola Teemu
- Neal David E.
- Neuhausen Susan L.
- Newcomb Lisa F.
- Nielsen Sune F.
- Nordestgaard Børge G.
- Nordström Tobias
- Olama Ali Amin Al
- Ong Aik T.
- Orntoft Torben Falck
- Ost Piet
- Ostrander Elaine A.
- Ostrer Harry
- Pandha Hardev
- Papargiris Melissa
- Park Hyun
- Park Jong Y.
- Parliament Matthew
- Pashayan Nora
- Paulo Paula
- Pedersen John
- Peleteiro Paula
- Penney Kathryn L.
- Pharoah Paul
- Popov Elenko
- Pow-Sang Julio
- Ranu Hardeep
- Razack Azad
- Rebillard Xavier
- Ren Guoping
- Riboli Elio
- Risbridger Gail
- Riska Shaun
- Roobol Monique J.
- Rosenstein Barry
- Ruiz-Dominguez José Manuel
- Røder Martin Andreas
- Saito Shiro
- Sanchez Marie
- Saunders Edward J.
- Saunders Pamela
- Schaid Daniel J.
- Schleutker Johanna
- Schnoeller Thomas
- Schroder F. H.
- Schumacher Fredrick R.
- Sellers Thomas A.
- Sheng Xin
- Siddiq Afshan
- Silva Maria P.
- Sipeky Csilla
- Slavov Chavdar
- Sorensen Karina D.
- Southey Melissa C.
- Spurdle Amanda
- Srinivasan Srilakshmi
- Stampfer Meir
- Stanford Janet L.
- Stattin Par
- Steele Linda
- Stegmaier Christa
- Stern Mariana C.
- Stevens Victoria L.
- Strom Sara S.
- Sun Zan
- Szulkin Robert
- Taari Kimmo
- Talala Kirsi
- Tammela Teuvo L. J.
- Tan Meng H.
- Tangen Catherine M.
- Taylor Renea
- Teixeira Manuel R.
- Teo Soo-Hwang
- Thibodeau Stephen N.
- Thierens Hubert
- Thompson Ian M.
- Thwaites Alison
- Tilley Wayne
- Tillmans Lori
- Toi Ants
- Townsend Paul A.
- Travis Ruth C.
- Tretarre Brigitte
- Truong Thérèse
- Turman Constance
- Usmani Nawaid
- Van den Broeck Thomas
- van der Kwast Theodorus H.
- van Schaik Ron H. N.
- Vega Ana
- Vlahova Aleksandrina
- Vogel Walther
- Vogt Aurelie
- Wang Guomin
- Wang Kan
- Weinstein Stephanie
- Weisher Maren
- West Catharine
- Whitmore Ian
- Wiklund Fredrik
- Wokolorczyk Dominika
- Wolk Alicja
- Wu Huihai
- Wu Ji
- Wu Yudong
- Xu Jianfeng
- Yeadon Trina
- Yu Yongwei
- Zachariah Babu
- Zhang Hong-Wei
- Zhang Yangling
- Zhao Shan-Chao
- Zhou Bo
- Zlotta Alexandre R.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10−15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
- Author
- Adolfsson J. (Jan)
- Aguado M. (Miguel)
- Ahmed M. (Mahbubl)
- Aitken J. (Joanne)
- Albanes D. (Demetrius)
- Alcaraz A. (Antonio)
- Aly M. (Markus)
- Andriole G.L. (Gerald)
- Anokian E. (Ezequiel)
- Aukim-Hastie C. (Claire)
- Auvinen A. (Anssi)
- Bangma C.H. (Chris)
- Barnett G. (Gill)
- Batra J. (Jyotsna)
- Benlloch S. (Sara)
- Bentzen Sø. (Søren)
- Berndt S.I. (Sonja)
- Berry C. (Clare)
- Bisbjerg R. (Rasmus)
- Bohnert P. (Philipp)
- Borre M. (M.)
- Brenner H. (Hermann)
- Broms M. (Michael)
- Brook R.H.
- Brown P. (Paul)
- Burnet N. (Neil)
- Bustamante M. (Mariona)
- Butler L. (Lisa)
- Calvo P. (Patricia)
- Cancel-Tassin G. (Géraldine)
- Cannon-Albright L.A. (Lisa)
- Canzian F. (Federico)
- Cao G. (Guangwen)
- Carballo A. (Ana)
- Cardoso M. (Marta)
- Carracedo A. (Angel)
- Carter B.D. (Brian D.)
- Castaño-Vinyals G. (Gemma)
- Castelao J.E. (Jose )
- Cavalli-Bjoerkman C. (Carin)
- Cecchini L. (Lluís)
- Cenee S. (Sylvie)
- Chambers S. (Suzanne)
- Chanock S.J. (Stephen)
- Christova S. (Svetlana)
- Cieza-Borrella C. (Clara)
- Claessens F.
- Clements J. (Judith)
- Conti G. (Giario)
- Cook M. (Margaret)
- Cox A. (Angela)
- Cuk K. (Katarina)
- Cussenot O. (Olivier)
- Cybulski C. (Cezary)
- Dadaev T. (Tokhir)
- Davis M. (Michael)
- De Langhe S. (Sofie)
- De Meerleer G. (Gert)
- De Ruyck K. (Kim)
- Dearnaley D. (David)
- Dierssen-Sotos T. (Trinidad)
- Dikov T. (Tihomir)
- Ding Y.C. (Yuan Chun)
- Donovan J. (Jenny)
- Drake B.F. (Bettina F.)
- Dunning A.M. (Alison)
- Easton D.F. (Douglas)
- Eckert A. (Allison)
- Eeles R.A. (Rosalind A.)
- Eklund M. (Martin)
- Elliott R. (Rebecca)
- Evans A. (Andrew)
- Fachal L. (Laura)
- Feng N. (Ninghan)
- Finelli A. (Antonio)
- Fisher C. (Cyril)
- Fitzgerald L.M. (Liesel M.)
- Fleshner N.E. (Neil)
- Freedman M. (Matthew)
- Freeman L.E.B. (Laura E. Beane)
- Gago-Dominguez M. (Manuela)
- Gamulin M. (Marija)
- Gapstur S.M. (Susan M.)
- Gardiner R. (Robert)
- George A. (Anne)
- Geybels M.S. (Milan S.)
- Giles G.G. (Graham G.)
- Giovannucci E. (Edward)
- Goh C. (Chee)
- Gomez-Acebo I. (Ines)
- Goodman P. (Phyllis)
- Govindasami K. (Koveela)
- Gracia-Lavedan E. (Esther)
- Grindedal E.M. (Eli Marie)
- Grönberg H. (Henrik)
- Guo J. (Jianming)
- Guo X. (Xin)
- Guy M. (Michelle)
- Gómez-Caamaño A. (Antonio)
- Haiman C.A. (Christopher)
- Hakansson N. (Niclas)
- Hamdy F. (Freddie)
- Hamilton R.J. (Robert J.)
- Hayes V. (Vanessa)
- Haynes A.-M. (Anne-Maree)
- Hazel S. (Steve)
- He W. (Weiyang)
- Henderson B.E. (Brian)
- Herkommer K. (Kathleen)
- Hicks B. (Belynda)
- Holleczek B. (B.)
- Hoover R.N. (Robert)
- Hopper J.L. (John L.)
- Horvath L. (Lisa)
- Hunter D. (David)
- Hutchinson A. (Amy)
- Imai T. (Takashi)
- Ingles S.A. (Sue)
- Iversen P. (Peter)
- Jenster G.W. (Guido)
- Johansson J.-E. (Jan-Erik)
- John E.M. (Esther)
- Joniau S. (Steven)
- Kachakova D. (Darina)
- Kaneva R. (Radka)
- Karlsson A. (Ami)
- Kastelan Z. (Zeljko)
- Kedda M.-A. (Mary-Anne)
- Kerns S.L. (Sarah L.)
- Key T.J. (Tim J.)
- Khaw K.-T. (Kay-Tee)
- Kibel A. (Adam)
- Kierzek A. (Andrzej)
- Kim J. (Jongoh)
- Klarskov P. (Peter)
- Klim A. (Aleksandra)
- Kluzniak W. (Wojciech)
- Kogevinas M. (Manolis)
- Kolb S. (Suzanne)
- Kolonel L.N. (Laurence)
- Kote-Jarai Z.
- Koudou Y.A. (Yves Akoli)
- Koutros S. (Stella)
- Kraft P. (Peter)
- Kujala P.M. (Paula)
- Kulis T. (Tomislav)
- Kulkarni G.S. (Girish S.)
- Kwast Th.H. (Theo) van der
- Lane A. (Athene)
- Larkin S. (Samantha)
- Le Marchand L. (Loic)
- Leongamornlert D.A. (Daniel A.)
- Lessel D. (Davor)
- Lewis S.J. (Sarah J.)
- Li J. (Jie)
- Li M. (Meiling)
- Lim J. (Jasmine)
- Lin D.W. (Daniel W.)
- Lin H.-Y. (Hui-Yi)
- Lin J. (Ji)
- Lindstrom S. (Sara)
- Ling J. (Jin)
- Livni N. (Naomi)
- Llorca J. (Javier)
- Lobato-Busto R. (Ramón)
- Logothetis N.K. (Nikos)
- Lophatananon A. (Artitaya)
- Lu Y.-J. (Yong-Jie)
- Lubinski J. (Jan)
- Luedeke M. (Manuel)
- Ma J. (Jing)
- Machiela M.J. (Mitchell J.)
- MacInnis R.J. (Robert J.)
- Maehle L.
- Maia S. (Sofia)
- Maier C. (Christiane)
- Mao X. (Xueying)
- Marsden G. (Gemma)
- Martin R.M. (Richard M.)
- Martinez M.E. (Maria Elena)
- Marzec J. (Jacek)
- McDonnell S.K. (Shannon K.)
- Menegaux F. (Florence)
- Mengual L. (Lourdes)
- Michael A. (Agnieszka)
- Mijuskovic M. (Martina)
- Milne R.L. (Roger)
- Mitev V. (Vanio)
- Mitkova A. (Atanaska)
- Morgan A. (Angela)
- Moya L. (Leire)
- Mucci L. (Lorelei)
- Muir K. (Kenneth)
- Mulot C. (Claire)
- Murtola T. (Teemu)
- Neal D. (David)
- Neuhausen S.L. (Susan)
- Newcomb L.F. (Lisa F.)
- Newcombe B.
- Nielsen S.F. (Sune F.)
- Nordestgaard B.G. (Børge)
- Nordström T. (Tobias)
- Olama A.A.A. (Ali Amin Al)
- Ong A.T. (Aik T.)
- Orntoft T.F. (Torben)
- Ost P. (Piet)
- Ostrander E.A. (Elaine)
- Ostrer H. (Harry)
- Pandha H. (Hardev)
- Papargiris M. (Melissa)
- Park H. (Hyun)
- Park J.Y. (Jong Y.)
- Parliament M. (Matthew)
- Pashayan N. (Nora)
- Paulo P. (Paula)
- Pedersen J. (John)
- Peleteiro P. (Paula)
- Penney K.L. (Kathryn L.)
- Pharoah P.D.P. (Paul)
- Popov E. (Elenko)
- Pow-Sang J. (Julio)
- Ranu H. (Hardeep)
- Razack A. (Azad)
- Ren G. (Guoping)
- Riboli E. (Elio)
- Risbridger G. (Gail)
- Riska S. (Shaun)
- Roobol-Bouts M.J. (Monique)
- Rosenstein B.S. (Barry S.)
- Ruiz-Dominguez J.M. (José Manuel)
- Rébillard X. (Xavier)
- Røder M.A. (Martin Andreas)
- Saito S. (Shiro)
- Sanchez M. (Marie)
- Saunders E.J. (Edward J.)
- Saunders P. (Pamela)
- Schaid D.J. (D.)
- Schaik R.H.N. (Ron) van
- Schleutker J. (Johanna)
- Schnoeller T. (Thomas)
- Schroder F.H. (F. H.)
- Schumacher F.R. (Fredrick R)
- Sellers T.F.
- Sheng X. (Xin)
- Siddiq A. (Afshan)
- Silva M.P. (Maria P.)
- Singhal S. (Sandeep)
- Sipeky C. (Csilla)
- Slavov C. (Chavdar)
- Sorensen K.D. (Karina Dalsgaard)
- Southey M.C. (Melissa C.)
- Spurdle A. (Amanda)
- Srinivasan S. (Srilakshmi)
- Stampfer M.J. (Meir J.)
- Stanford J.L. (Janet L.)
- Stattin P. (Pär)
- Steele L. (Linda)
- Stegmaier C. (Christa)
- Stern M.C. (Mariana C.)
- Stevens V.L. (Victoria L.)
- Sun Z. (Zan)
- Szulkin R. (Robert)
- Taari K. (Kimmo)
- Talala K. (Kirsi)
- Tammela T.L. (Teuvo)
- Tan M.H. (Meng H.)
- Tangen C.M. (Catherine M.)
- Taylor R. (Renea)
- Teixeira P.J.
- Teo S.-H. (Soo-Hwang)
- Thibodeau S.N. (Stephen N.)
- Thierens H. (Hubert)
- Thompson I.M. (Ian)
- Thwaites A. (Alison)
- Tilley W. (Wayne)
- Tillmans L. (Lori)
- Toi A. (Ants)
- Townsend P.A. (Paul A.)
- Travis S.P.L. (Simon)
- Tretarre B. (Brigitte)
- Truong T. (Thérèse)
- Turman C. (Constance)
- Usmani N. (Nawaid)
- van den Broeck T. (Thomas)
- Vega A. (Ana)
- Vlahova A. (Aleksandrina)
- Vogel W. (Walther)
- Vogt A. (Aurelie)
- Wakerell S. (Sarah)
- Wang G. (Guomin)
- Weinstein S. (Stephanie)
- Weisher M. (Maren)
- West C. (Catharine)
- Whitmore I. (Ian)
- Wiklund F. (Fredrik)
- Wokolorczyk D. (Dominika)
- Wolk K. (Kerstin)
- Wu H. (Huihai)
- Wu J. (Ji)
- Wu Y. (Yudong)
- Xu J. (Jianfeng)
- Yeadon T. (Trina)
- Yu Y. (Yongwei)
- Zachariah B. (Babu)
- Zhang H.-W. (Hong-Wei)
- Zhang Y. (Yangling)
- Zhang Z. (Zhuo)
- Zhao S.-C. (Shan-Chao)
- Zhou B. (Bo)
- Zlotta A.R. (Alexandre)
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Peer reviewe
Модель професійної культури юриста: критерії та підходи
- Author
- Adams Charleen
- Albanes Demetrius
- Amin Al Olama Ali
- Batra Jyotsna
- Benlloch Sara
- Berndt Sonja I
- Brenner Hermann
- Cancel-Tassin Geraldine
- Cannon-Albright Lisa A
- Chanock Stephen J
- Claessens Frank
- Clements Judith A
- Conti David V
- Cybulski Cezary
- Davey Smith George
- DeRuyck Kim
- Donovan Jenny L
- Eeles Rosalind A
- Gago Dominguez Manuela
- Gapstur Susan M
- Giles Graham G
- Grönberg Henrik
- Haiman Christopher A
- Hamdy Freddie C
- Hamilton Robert
- Henderson Brian E
- Ingles Sue Ann
- John Esther M
- Kaneva Radka P
- Khaw Kay-Tee
- Kibel Adam S
- Kim Jeri
- Kogevinas Manolis
- Kote-Jarai Zsofia
- Koutros Stella
- Lane J Athene
- Lessel Davor
- Lu Yong-Jie
- Maehle Lovise
- Maier Christiane
- Martin Richard M
- Menegaux Florence
- Mucci Lorelei A
- Muir Kenneth
- Neal David E
- Neuhausen Susan L
- Newcomb Lisa F
- Nordestgaard Borge G
- Pandha Hardev
- Park Jong Y
- Pashayan Nora
- Penney Kathryn L
- Razack Azad
- Relton Caroline L
- Richmond Rebecca C
- Roobol Monique J
- Rosenstein Barry S
- Santos Ferreira Diana L Dos
- Schleutker Johanna
- Schumacher Fredrick R
- Spiller Wes
- Stanford Janet L
- Stevens Victoria L
- Sørensen Karina D
- Tan Vanessa Y
- Tangen Catherine M
- Teixeira Manuel R
- Thibodeau Stephen N
- Townsend Paul
- Travis Ruth C
- Usmani Nawaid
- Vega Ana
- West Catharine M L
- Wiklund Fredrik
- Wolk Alicja
- Wurtz Peter
- Zheng Jie
- Publication venue
- Publication date
- 01/01/2009
- Field of study
В статті визначається модель професійної культури
Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan
- Author
- Agee Michelle
- Albanes Demetrius
- Alipanahi Babak
- Auton Adam
- Batra Jyotsna
- Bell Robert K.
- Benlloch Sara
- Berndt Sonja I.
- Brenner Hermann
- Bryc Katarzyna
- Busch Alexander S.
- Butler Lisa
- Cancel-Tassin Géraldine
- Cannon-Albright Lisa
- Chanock Stephen
- Claessens Frank
- Clements Judith
- Conti David V.
- Cybulski Cezary
- Day Felix R.
- De Ruyck Kim
- Donovan Jenny L.
- Easton Doug F.
- Eckert Allison
- Eeles Rosalind A.
- Elson Sarah L.
- Fontanillas Pierre
- Furlotte Nicholas A.
- Gago-Dominguez Manuela
- Gapstur Susan
- Giles Graham G.
- Grindedal Eli Marie
- Gronberg Henrik
- Haiman Christopher A.
- Hamdy Freddie C.
- Hamilton Robert J.
- Hayes Vanessa
- Haynes Anne Maree
- Henderson Brian E.
- Hinds David A.
- Hollis Ben
- Horvath Lisa
- Huber Karen E.
- Ingles Sue Ann
- John Esther M.
- Joshi Peter K.
- Kaneva Radka
- Kedda Mary Anne
- Khaw Kay Tee
- Kibel Adam S.
- Kim Jeri
- Kleinman Aaron
- Kogevinas Manolis
- Kote-Jarai Zsofia
- Koutros Stella
- Kwong Alex
- Lessel Davor
- Litterman Nadia K.
- Lu Yong Jie
- Maier Christiane
- McIntyre Matthew H.
- Menegaux Florence
- Mountain Joanna L.
- Moya Leire
- Mucci Lorelei
- Muir Kenneth
- Neal David E.
- Neuhausen Susan L.
- Newcomb Lisa F.
- Noblin Elizabeth S.
- Nordestgaard Børge G.
- Northover Carrie A.M.
- Olama Ali Amin Al
- Ong Ken K.
- other and
- Pandha Hardev
- Papargiris Melissa
- Park Jong Y.
- Pashayan Nora
- Penney Kathryn L.
- Perry John R.B.
- Pitts Steven J.
- Razack Azad
- Risbridger Gail P.
- Roobol Monique J.
- Rosenstein Barry S.
- Sathirapongsasuti J. Fah
- Saunders Pamela
- Sazonova Olga V.
- Schleutker Johanna
- Schumacher Fredrick R.
- Shelton Janie F.
- Shringarpure Suyash
- Soares Ana Luiza G.
- Sorensen Karina Dalsgaard
- Srinivasan Srilakshmi
- Stanford Janet L.
- Stevens Victoria L.
- Tangen Catherine M.
- Taylor Renea
- Teixeira Manuel R.
- Thibodeau Stephen N.
- Thompson Deborah J.
- Tian Chao
- Tilley Wayne
- Timmers Paul R.H.J.
- Timpson Nicholas J.
- Townsend Paul A.
- Travis Ruth C.
- Tung Joyce Y.
- Usmani Nawaid
- Vacic Vladimir
- Vega Ana
- West Catharine
- Wiklund Fredrik
- Wilson Catherine H.
- Wolk Alicja
- Yeadon Trina
- Publication venue
- Nature Communications
- Publication date
- 01/12/2020
- Field of study
Abstract: The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
- Author
- Abdukahil Sheryl Ann
- Abdukahil Sheryl,
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abreu Julia,
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- Adrião Diana
- Ainscough Kate
- Akimoto Takako
- Al Qasim Eman
- Al-Dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Alidjnou Kazali Enagnon
- Alidjnou Kazali,
- Aliudin Jeffrey
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves Rita
- Amaral Maria
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andrejak Claire
- Angheben Andrea
- ANGOULVANT François
- Ansart Séverine
- Antonelli Massimo
- Arabi Yaseen
- Aragao Irene
- Arcadipane Antonio
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Artaud-Macari Elise
- Asensio Angel
- Assie Jean Baptiste
- Assie Jean,
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Azemar Laurène
- Azoulay Cécile
- Bach Benjamin
- Bachelet Delphine
- Baillie J. Kenneth,
- Bak Erica
- Bakakos Agamemnon
- Banisadr Firouzé
- Barbalho Renata
- Barclay Wendy,
- Barnikel Michaela
- Barrelet Audrey
- Barrigoto Cleide
- Basmaci Romain
- Bassi Gianluigi Li
- Bassi Gianluigi,
- Bedossa Alexandra
- Behilill Sylvie
- Bekken Gry Kloumann
- Bekken Gry,
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bhavsar Krishna
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Blanco-Schweizer Pablo
- Blot Mathieu
- Boccia Filomena
- Bogaert Debby
- Bompart François
- Booth Gareth
- Borges Diogo
- Borie Raphaël
- Bos Jeannet
- Bosse Hans Martin
- Bosse Hans,
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camille
- Boureau Anne-Sophie
- Bouscambert Maude
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brozzi Nicolas
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Bustos Ingrid,
- Butnaru Denis
- Cabie André
- Cabral Susana
- Caceres Eder
- Callahan Mia
- Calligy Kate
- Calvache Jose Andres
- Calvache Jose,
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carney Gayle
- Carpenter Chloe
- Carret Marie-Christine
- Carrier François Martin
- Carrier François,
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavalli Giulio,
- Cavayas Alexandros
- Ceccato Adrian
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chas Julie
- Chassin Camille
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheng Matthew,
- Cheret Antoine
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Hwa Jin
- Cho Hwa,
- Cho Sung Min
- Cho Sung,
- Choez Xavier Sánchez
- Choez Xavier,
- Choileain Orna Ni
- Choileain Orna,
- Cholley Bernard
- Cidade Jose Pedro
- Cidade Jose,
- Citarella Barbara Wanjiru
- Citarella Barbara,
- Ciullo Anna
- Clarke Jennifer
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Colombo Sebastiano,
- Combs Pamela
- Connelly J.,
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Cooke Graham,
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cormican Sarah
- Cornelis Sabine
- Corpuz Arianne Joy
- Corpuz Arianne,
- Corvaisier Grégory
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cucino Alberto
- Cullen Caroline
- Cummings Matthew
- Curley Gerard
- Curlier Elodie
- Curto Elena Gallego
- Curto Elena,
- Custodio Paula
- Cárcel Sheila
- Da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew,
- Dalton Heidi
- Dalton Jo
- Daneman Nick
- Dankwa Emmanuelle,
- Dantas Jorge
- De Araújo Mariz Carolline
- De Brito Carlos Alexandre Antunes
- De Brito Carlos,
- De Castro Nathalie
- De Mendoza Diego
- De Oliveira França Rafael Freitas
- De Oliveira França Rafael,
- De Rosa Rosanna
- De Silva Thushan
- De Vries Peter
- Dean David
- Debray Marie-Pierre
- Dechert William
- Deconninck Lauren
- Decours Romain
- Delacroix Isabelle
- Delavigne Karen
- Deligiannis Ionna
- Dell’amore Andrea
- Delobel Pierre
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Devouge Eglantine,
- Dewayanti Santi Rahayu
- Dewayanti Santi,
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose Diaz
- Diaz Juan,
- DIAZ Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie,
- Dominguez Carmen Infante
- Dominguez Carmen,
- Dong Andy
- Donnelly Christl,
- Donnelly Maria
- Donohue Chloe
- Dorival Céline
- Douglas James Joshua
- Douglas James,
- Douma Renee
- Dournon Nathalie
- Downer Triona
- Downing Mark
- Drake Tom
- Dubee Vincent
- DUBOS François
- Ducancelle Alexandra
- Dudman Susanne
- Dunning Jake
- Duranti Silvia
- Durham Lucian
- Dussol Bertrand
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Dyrhol-Riise Anne,
- D’aragon Frédérick
- D’Orleans Charles Crepy
- D’orleans Charles,
- D’Ortenzio Eric
- Eid Charbel Maroun
- Eid Charbel,
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Elkheir Natalie
- Ellerbroek Jacobien
- Ellis Rachael
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Everding Anna,
- Evers Mirjam
- Fabre Isabelle
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron,
- Faria Pedro
- Farshait Nataly
- Fatoni Arie Zainul
- Fatoni Arie,
- Faure Karine
- Fayed Mohamed
- Feely Niamh
- Fernandes Jorge
- Fernandes Marília
- Fernandes Susana
- Ferraz Mário
- Ferreira Benigno
- Ferrer-Roca Ricard
- Ferrão Joana
- Figueiredo-Mello Claudia
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Florio Letizia,
- Foley Claire
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Claudio,
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foti Giuseppe
- Fourn Erwan
- Fowler Rob
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John
- Freire Marcela Vieira
- Freire Marcela,
- Friedrich Caren
- Fry Stéphane
- Fuentes Nora
- Fukuda Masahiro
- Gaborieau Valérie
- Gachet Benoît
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
- Gallagher Phil
- Gamble Carrol
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- GarcÍa Ruth Noemí Jorge
- García Ruth,
- Garot Denis
- Garrait Valérie
- Gault Nathalie
- Gavin Aisling
- Gaymard Alexandre
- Gebauer Johannes
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Giaquinto Carlo
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Giwangkancana Gezy
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gorenne Isabelle
- Goujard Cécile
- Goulenok Tiphaine
- Grable Margarite
- Grandin Edward Wilson
- Grandin Edward,
- Granier Pascal
- Grasselli Giacomo
- Green Christopher,
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Grieco Domenico,
- Griffee Matthew
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haber Daniel
- Hakak Sheeba
- Hall Matthew
- Halpin Sophie
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Hardwick Hayley
- Harley Kristen
- Harrison Ewen,
- Harrison Janet
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Henriquez-Trujillo Aquiles
- Hentzien Maxime
- Hernandez-Montfort Jaime
- Herreros Jose Miguel Cisneros
- Herreros Jose,
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Hinton Samuel
- Hipólito-Reis Ana
- Hiraiwa Hiroaki
- Hiscox Julian,
- Ho Antonia Ying Wai
- Ho Antonia,
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holten Aleksander,
- Holter Jan Cato
- Holter Jan,
- Horby Peter
- Horcajada Juan Pablo
- Horcajada Juan,
- Hoshino Koji
- Hoshino Kota
- Hough Catherine,
- Hssain Ali Ait
- Hssain Ali,
- Hsu Jimmy Ming-Yang
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Humaid Felwa,
- Ijaz Samreen
- Illes Hajnal-Gabriela
- Inácio Hugo
- Iosifidis Elias
- Irvine Lacey
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Itai Junji
- Ivulich Daniel
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Jaureguiberry Stéphane
- Javidfar Jeffrey
- Jean-Benoît Zabbe
- Jego Florence
- Jenum Synne
- Jimenez Juan Fernado Masa
- Jimenez Juan,
- Johal Simreen Kaur
- Johal Simreen,
- Joseph Cédric
- Joseph Mark
- Jouvet Philippe
- Jung Hanna
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandamby Darshana,
- Kandel Chris
- Kant Ravi
- Kartsonaki Christiana
- Kasugai Daisuke
- Katz Kevin
- Keating Sean
- Kelly Andrea
- Kelly Sadie
- Kennedy Lisa
- Kennon Kalynn
- Kerroumi Younes
- Kestelyn Evelyne
- Khalid Imrana
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Kho Michelle,
- Khoo Saye
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kildal Anders,
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Knight Stephen
- Kobbe Robin
- Korten Volkan
- Kosgei Caroline
- Krawczyk Karolina
- KUMAR Deepali
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kyriakoulis Konstantinos
- LACHATRE Marie
- Lacoste Marie
- Laffey John,
- Lagrange Marie
- Laine Fabrice
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Lantang Eka Yudha
- Lantang Eka,
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
- Lariviere Delphine
- Launay Odile
- Lavie-Badie Yoan
- Law Andrew
- Le Bihan Clément
- Le Bris Cyril
- Le Coustumier Eve
- Le Falher Georges
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Maréchal Marion
- Le Mestre Soizic
- Le Moing Vincent
- Le Nagard Hervé
- Le Turnier Paul
- Le Van Tan
- Le Minh
- Leal Ema
- Lee James
- Lee Su Hwan
- Lee Su,
- Lee Todd
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefevre Benjamin
- Lellouche François
- Lemaignen Adrien
- Lemee Véronique
- Lemmink Gretchen
- Leone Michela
- Lepiller Quentin
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- León Rafael
- Liang Janet
- Lim Wei Shen
- Lim Wei,
- Lina Bruno
- Lind Andreas
- Lingas Guillaume
- Lion-Daolio Sylvie
- Liu Keibun
- Loforte Antonio
- Lolong Navy
- Lopes Diogo
- Lopez-Colon Dalia
- Lordemann Anja Grosse
- Lordemann Anja,
- Loubet Paul
- Lucet Jean Christophe
- Lucet Jean,
- Luna Carlos,
- Lungu Olguta
- Luong Liem
- Luton Dominique
- Lyons Ruth
- L’Her Erwan
- Maasikas Olavi
- Macdonald Sarah
- Machado Moïse
- Macheda Gabrielle
- Madhok Jai
- Mahieu Rafael
- Mahy Sophie
- Maier Lars Siegfrid
- Maier Lars,
- Maillet Mylène
- Maitre Thomas
- Malaque Ana
- Maldonado Hugo Miranda
- Maldonado Hugo,
- Malfertheiner Maximilian
- Malik Nadia
- Maltez Fernando
- Malvy Denis
- MAMBERT Marina
- Manda Victoria
- Mandei Jose,
- Mangoni Emanuele Durante
- Mangoni Emanuele,
- Manning Edmund
- Manuel Aldric
- Marino Flávio
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshall John
- Martelli Celina Turchi
- Martelli Celina,
- Martin Dori-Ann
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martin-Quiros Alejandro
- Martinot Martin
- Martins Ana
- Martins João
- Martucci Gennaro
- Marwali Eva Miranda
- Marwali Eva,
- Maslove David
- Mason Sabina
- Matan Moshe
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
- Maulin Laurence
- Mc Evoy Natalie
- Mccarthy Aine
- Mccloskey Colin
- Mcconnochie Rachael
- Mcdermott Sherry
- McDonald Sarah
- Mcelwee Samuel
- Mcevoy Natalie
- McGeer Allison
- Mcguinness Niki
- Mclean Kenneth,
- Mcnicholas Bairbre
- Meaney Edel
- Mear-Passard Cécile
- Mechlin Maggie
- Mele Ferruccio
- Menon Kusum
- Mentré France
- Mentzer Alexander,
- Mercier Noémie
- Merckx Antoine
- Mergler Blake
- Merson Laura
- Mesquita António
- Meybeck Agnès
- Meynert Alison,
- Meyssonnier Vanina
- Meziane Amina
- Mezidi Medhi
- Michelanglei Céline
- Mihnovitš Vladislav
- Mohammed Nassima Si
- Mohammed Nassima,
- Moin Asma
- Molina David
- Molinos Elena
- Mone Mary
- Monteiro Agostinho
- Montes Claudia
- Montrucchio Giorgia
- Moore Sarah
- Moore Shona,
- Morales-Cely Lina
- Morlaes Louis Gerbaud
- Morlaes Louis,
- Moro Lucia
- Motos Ana
- Mouquet Hugo
- Moyet Julien
- Mullaert Jimmy
- Munblit Daniel
- Murphy Derek
- Murris Marlène
- Myrodia Dimitra Melia
- Myrodia Dimitra,
- Müller Fredrik
- Müller Karl Erik
- Müller Karl,
- Neant Nadège
- Neb Holger
- Nekliudov Nikita,
- Neto Raul
- Neumann Emily
- Neves Bernardo
- Ng Pauline Yeung
- Ng Pauline,
- Ng Wing Yiu
- Ng Wing,
- Nichol Alistair
- Nonas Stephanie
- Noret Marion
- Norman Lisa
- Notari Alessandra
- Noursadeghi Mahdad
- Nowicka Karolina
- Nseir Saad
- Nunez Jose,
- Nuñez Maria Angelica Rivera
- Nuñez Maria,
- Nyamankolly Elsa
- N’Guyen Yohan
- Occhipinti Giovanna
- Ogston Tawnya
- Ogura Takayuki
- Oh Tak-Hyuk
- Ohshimo Shinichiro
- Oinam Budha Charan Singh
- Oinam Budha,
- Oliveira Ana Pinho
- Oliveira Ana,
- Oliveira João
- Olliaro Piero
- Ong David,
- Oosthuyzen Wilna
- Openshaw Peter,
- Orozco-Chamorro Claudia Milena
- Orozco-Chamorro Claudia,
- Orquera Andrés
- Osatnik Javier
- Ouamara Nadia
- Ouissa Rachida
- Owyang Clark
- Oziol Eric
- O’donnell Max
- O’hearn Katie
- O’neil Conar
- Pagadoy Maïder
- Pages Justine
- Palacios Mario
- Palmarini Massimo
- Panarello Giovanna
- Panda Prasan Kumar
- Panda Prasan,
- Panigada Mauro
- Pansu Nathalie
- Papadopoulos Aurélie
- Parra Briseida
- Pasquier Jérémie
- Patauner Fabian
- Patrão Luís
- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William,
- Payen Jean-François
- Pearse India
- Peek Giles,
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Peltan Ithan,
- Pereira Rui
- Perez Daniel
- Perpoint Thomas
- Perrot Clara Mouton
- Perrot Clara,
- Pesenti Antonio
- Petroušová Lenka
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pharand Scott
- Piagnerelli Michael
- Picard Walter
- Picone Olivier
- Piel-Julian Marie
- Pierobon Carola
- Pimentel Carlos
- Piroth Lionel
- Pius Riinu
- Piva Simone
- Plantier Laurent
- Plotkin Daniel
- Poissy Julien
- Pokorska-Spiewak Maria
- Poli Sergio
- Pollakis Georgios
- Popielska Jolanta
- Postma Douwe,
- Povoa Pedro
- Powis Jeff
- Prapa Sofia
- Prebensen Christian
- Preiser Jean-Charles
- Prestre Vincent
- Price Nicholas
- Prinssen Anton
- Pritchard Mark,
- Proença Lúcia
- Purcell Gregory
- Puéchal Oriane
- Póvoas Diana
- Quesada Luisa
- Quist-Paulsen Else
- Quraishi Mohammed
- Rabaud Christian
- Rafiq Marie
- Ragazzo Gabrielle
- Rainieri Fernando
- Ramakrishnan Nagarajan
- Ramanathan Kollengode
- Rammaert Blandine
- Rapp Christophe
- Rasmin Menaldi
- Rau Cornelius
- Rebaudet Stanislas
- Redl Sarah
- Reeve Brenda
- Rego Caroline Martins
- Rego Caroline,
- Reid Liadain
- Reis Renato
- Remppis Jonathan
- Remy Martine
- Renk Hanna
- Resende Liliana
- Resseguier Anne-Sophie
- Revest Matthieu
- Rewa Oleksa
- Reyes Luis Felipe
- Reyes Luis,
- Ribeiro Ana Freitas
- Ribeiro Ana,
- Richardson David
- Richardson Denise
- Richier Laurent
- Riera Jordi
- Rincon Diego Fernando Bautista
- Rincon Diego,
- Rios Ana Lúcia
- Rios Ana,
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Roberto André
- Roberts Stephanie
- Robertson David,
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia Simão
- Roilides Emmanuel
- Rojek Amanda
- Romaru Juliette
- Roncon-Albuquerque Roberto
- Roriz Mélanie
- Rosa-Calatrava Manuel
- Rose Michael
- Rosenberger Dorothea
- Rossanese Andrea
- Rossignol Bénédicte
- Rossignol Patrick
- Roy Carine
- Roze Benoît
- Russell Clark,
- Ryckaert Steffi
- Rätsep Indrek
- Rössler Bernhard
- Saba Isabela
- Sadat Musharaf
- Saidani Nadia
- Salazar Leonardo
- Sales Gabriele
- Sallaberry Stéphane
- Salvator Hélène
- Sanchez Juan Macias
- Sanchez Juan,
- Sanchez Olivier
- Sanchez-Miralles Angel
- Sancho-Shimizu Vanessa
- Sandhu Gyan
- Sandulescu Oana
- Sanharawi Mohammed El
- Sanharawi Mohammed,
- Sant Ceila Maria
- Sant Ceila,
- Santos Marlene
- Santos Marta Leal
- Santos Marta,
- Santos-Olmo Rosario Maria Torres
- Santos-Olmo Rosario,
- Sarfo-Mensah Shirley
- Sarton Benjamine
- Saviciute Egle
- Savvidou Parthena
- Scarsbrook Joshua
- Schermer Tjard
- Scherpereel Arnaud
- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scott Janet,
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Semaille Caroline
- Semple Malcolm,
- Senneville Eric
- Sequeira Filipa
- Sequeira Tânia
- Shadowitz Ellen
- Shamsah Mohammad
- Sharma Pratima
- Shaw Catherine,
- Shaw Victoria
- Shiban Nisreen
- Shime Nobuaki
- Shimizu Hiroaki
- Shimizu Keiki
- Shrapnel Sally
- Shum Hoi Ping
- Shum Hoi,
- Sigfrid Louise
- Silva Catarina
- Silva Maria Joao
- Silva Maria,
- Sin Wai Ching
- Sin Wai,
- Skogen Vegard
- Smith Sue
- Smood Benjamin
- Smyth Michelle
- Snacken Morgane
- So Dominic
- Solis Monserrat
- Solomon Joshua
- Solomon Tom
- Somers Emily
- Sommet Agnès
- Song Myung Jin
- Song Myung,
- Song Rima
- Song Tae
- Sonntagbauer Michael
- Sotomayor Ruth Jimbo
- Sotomayor Ruth,
- Soum Edouard
- Sousa Marta
- Souza-Dantas Vicente
- Sperry Alexandra
- Sriskandan Shiranee
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Stienstra Ymkje
- Stiksrud Birgitte
- Streinu-Cercel Adrian
- Streinu-Cercel Anca
- Strudwick Samantha
- Stuart Ami
- Stuart David
- Suen Jacky,
- Sultana Asfia
- Summers Charlotte
- Svistunov Magdalena Surovcová Andrey A.
- Svistunov Magdalena,
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Tagherset Lysa
- Talarek Ewa
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tamlihat Younes,
- Tanaka Hiroyuki
- Tanaka Taku
- Taniguchi Hayato
- Tardivon Coralie
- Tattevin Pierre
- Taufik M. Azhari,
- Tedder Richard,
- Teixeira João
- Tellier Marie-Capucine
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Thibault V.
- Thiberville Simon-Djamel
- Thill Benoît
- Thompson A.,
- Thompson Shaun
- Thomson David
- Thomson Emma,
- Thuy Duong Bich
- Thuy Duong,
- Thwaites Ryan,
- Timashev Peter,
- Timsit Jean-François
- Toki Maria
- Tonby Kristian
- Torres Antoni
- Torres Margarida
- Trieu Huynh Trung
- Trieu Huynh,
- Trioux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Troost Jonathan
- Trouillon Tiffany
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turtle Lance,
- Tutillo Diego Rolando Morocho
- Tutillo Diego,
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uva Maria,
- Val-Flores Luís
- Van De Velde Stijn
- Van Den Berge Marcel
- Van Der Feltz Machteld
- Van Der Vekens Nicky
- Van Der Voort Peter
- Van Der Werf Sylvie
- Van Dyk Marlice
- Van Gulik Laura
- Van Hattem Jarne
- Van Lelyveld Steven
- Van Netten Carolien
- Van Vinh Chau Nguyen
- Vanel Noémie
- Vanoverschelde Henk
- Vasconcelos Malte Kohns
- Vasconcelos Malte,
- Vauchy Charline
- Vecham Pavan Kumar
- Vecham Pavan,
- Veislinger Aurélie
- Velazco Jorge
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vidal José,
- Vieira César
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath,
- Villanueva Joy Ann
- Villanueva Joy,
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vuorinen Aapeli
- Vuotto Fanny
- Wang Chih-Hsien
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wiedemann Aurélie
- Wille Keith
- Wils Evert-Jan
- Xynogalas Ioannis
- Yacoub Sophie
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Young Paul
- Yuliarto Saptadi
- Zabbe Marion
- Zacharowski Kai
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zawadka Konrad
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
ATLAS Run 1 searches for direct pair production of third-generation squarks at the Large Hadron Collider
- Author
- Abbott Brad
- Abdallah Jalal
- Abdinov Ovsat
- Aben Rosemarie
- Abolins Maris
- AbouZeid Ossama
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby Sami
- Adamczyk Leszek
- Adams David
- Adelman Jahred
- Adomeit Stefanie
- Adye Tim
- Affolder Tony
- Agatonovic-Jovin Tatjana
- Agricola Johannes
- Aguilar-Saavedra Juan Anton
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akerstedt Henrik
- Akimov Andrei
- Alberghi Gian Luigi
- Albert Justin
- Albrand Solveig
- Alconada Verzini Maria Jose
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Alimonti Gianluca
- Alio Lion
- Alison John
- Alkire Steven Pat
- Allbrooke Benedict
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Altheimer Andrew Dav
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazi
- Amadio Brian Thom
- Amako Katsuya
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana Pat
- Amorim Antonio
- Amoroso Simone
- Amram Nir
- Amundsen Glenn
- Anastopoulos Christos
- Ancu Lucian Ste
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders Gabriel
- Anders John Kenne
- Anderson Kelby
- Andreazza Attilio
- Andrei George Vic
- Angelidakis Stylianos
- Angelozzi Ivan
- Anger Philipp
- Angerami Aaron
- Anghinolfi Francis
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antonelli Mario
- Antonov Alexey
- Antos Jaroslav
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan Pedro
- Arce Ayana
- Arduh Francisco
- Arguin Jean-Franc
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron Jame
- Arnaez Olivier
- Arnal Vanessa
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim Bora
- Auerbach Benjamin
- Augsten Kamil
- Aurousseau Mathieu
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad Ka
- Azuelos Georges
- Baak Max
- Baas Alessandra
- Baca Matthew Jo
- Bacci Cesare
- Bachacou Henri
- Bachas Konstantin
- Backes Moritz
- Backhaus Malte
- Bagiacchi Paolo
- Bagnaia Paolo
- Bai Yu
- Bain Travis
- Baines John
- Baker Oliver Kei
- Baldin Evgenii
- Balek Petr
- Balestri Thomas
- Balli Fabrice
- Banas Elzbieta
- Banerjee Swagato
- Bannoura Arwa A E
- Bansil Hardeep Si
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisonzi Marcello
- Barklow Timothy
- Barlow Nick
- Barnes Sarah Loui
- Barnett Bruce
- Barnett Michael
- Barnovska Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros do Vale Maria Alin
- Bartoldus Rainer
- Barton Adam Edwar
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Basye Austin
- Bates Richard
- Batista Santiago J
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder S
- Beacham James Bake
- Beattie Michael Da
- Beau Tristan
- Beauchemin Pierre-Hug
- Beccherle Roberto
- Bechtle Philip
- Beck Hans Peter
- Becker Kathrin
- Becker Maurice
- Becker Sebastian
- Beckingham Matthew
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bee Christophe
- Beemster Lars
- Beermann Thomas
- Begel Michael
- Behr Janna Kath
- Belanger-Champagne Camille
- Bell William
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimilia
- Belotskiy Konstantin
- Beltramello Olga
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Bendtz Katarina
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Garcia Jorge-Arma
- Benjamin Douglas
- Bensinger James
- Bentvelsen Stan
- Beresford Lydia
- Beretta Matteo
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
- Berghaus Frank
- Beringer Jürg
- Bernard Clare
- Bernard Nathan Rog
- Bernius Catrin
- Bernlochner Florian Ur
- Berry Tracey
- Berta Peter
- Bertella Claudia
- Bertoli Gabriele
- Bertolucci Federico
- Bertsche Carolyn
- Bertsche David
- Besana Maria Ilar
- Besjes Geert-Jan
- Bessidskaia Bylund Olga
- Bessner Martin Flo
- Besson Nathalie
- Betancourt Christophe
- Bethke Siegfried
- Bevan Adrian Joh
- Bhimji Wahid
- Bianchi Riccardo-M
- Bianchini Louis
- Bianco Michele
- Biebel Otmar
- Biedermann Dustin
- Bieniek Stephen Pa
- Biglietti Michela
- Bilbao De Mendizabal Javier
- Bilokon Halina
- Bindi Marcello
- Binet Sebastien
- Bingul Ahmet
- Bini Cesare
- Biondi Silvia
- Black Curtis
- Black James
- Black Kevin
- Blackburn Daniel
- Blair Robert
- Blanchard Jean-Bapti
- Blanco Jacobo Eze
- Blazek Tomas
- Bloch Ingo
- Blocker Craig
- Blum Walter
- Blumenschein Ulrike
- Bobbink Gerjan
- Bobrovnikov Victor
- Bocchetta Simona Ser
- Bocci Andrea
- Bock Christophe
- Boehler Michael
- Bogaerts Joannes An
- Bogavac Danijela
- Bogdanchikov Alexander
- Bohm Christian
- Boisvert Veronique
- Bold Tomasz
- Boldea Venera
- Boldyrev Alexey
- Bomben Marco
- Bona Marcella
- Boonekamp Maarten
- Borisov Anatoly
- Borissov Guennadi
- Borroni Sara
- Bortfeldt Jonathan
- Bortolotto Valerio
- Bos Kors
- Boscherini Davide
- Bosman Martine
- Boudreau Joseph
- Bouffard Julian
- Bouhova-Thacker Evelina Va
- Boumediene Djamel Edd
- Bourdarios Claire
- Bousson Nicolas
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bozic Ivan
- Bracinik Juraj
- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Bratzler Uwe
- Brau Benjamin
- Brau James
- Braun Helmut
- Brazzale Simone Fed
- Breaden Madden William Dm
- Brendlinger Kurt
- Brennan Amelia Jea
- Brenner Lydia
- Brenner Richard
- Bressler Shikma
- Bristow Kieran
- Bristow Timothy Mi
- Britton Dave
- Britzger Daniel
- Brochu Frederic
- Brock Ian
- Brock Raymond
- Bronner Johanna
- Brooijmans Gustaaf
- Brooks Timothy
- Brooks William
- Brosamer Jacquelyn
- Brost Elizabeth
- Brown Jonathan
- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruneliere Renaud
- Bruni Alessia
- Bruni Graziano
- Bruschi Marco
- Bruscino Nello
- Bryngemark Lene
- Buanes Trygve
- Buat Quentin
- Buchholz Peter
- Buckley Andrew
- Buda Stelian Io
- Budagov Ioulian
- Buehrer Felix
- Bugge Lars
- Bugge Magnar Kop
- Bulekov Oleg
- Bullock Daniel
- Burckhart Helfried
- Burdin Sergey
- Burghgrave Blake
- Burke Stephen
- Burmeister Ingo
- Busato Emmanuel
- Bussey Peter
- Butler John
- Butt Aatif Imti
- Buttar Craig
- Butterworth Jonathan
- Butti Pierfrance
- Buttinger William
- Buzatu Adrian
- Buzykaev Aleksey
- Büscher Daniel
- Büscher Volker
- Cabrera Urbán Susana
- Caforio Davide
- Cairo Valentina
- Cakir Orhan
- Calace Noemi
- Calafiura Paolo
- Calandri Alessandro
- Calderini Giovanni
- Calfayan Philippe
- Caloba Luiz
- Calvet David
- Calvet Samuel
- Camacho Toro Reina
- Camarda Stefano
- Camarri Paolo
- Cameron David
- Caminal Armadans Roger
- Campana Simone
- Campanelli Mario
- Campoverde Angel
- Canale Vincenzo
- Canepa Anadi
- Cano Bret Marc
- Cantero Josu
- Cantrill Robert
- Cao Tingting
- Capeans Garrido Maria Del
- Caprini Irinel
- Caprini Mihai
- Capua Marcella
- Caputo Regina
- Cardarelli Roberto
- Cardillo Fabio
- Carli Tancredi
- Carlino Gianpaolo
- Carminati Leonardo
- Caron Sascha
- Carquin Edson
- Carrillo-Montoya German D
- Carter Janet
- Carvalho João
- Casadei Diego
- Casado Maria Pila
- Casolino Mirkoanton
- Castaneda-Miranda Elizabeth
- Castelli Angelanton
- Castillo Gimenez Victoria
- Castro Nuno Filip
- Catastini Pierluigi
- Catinaccio Andrea
- Catmore James
- Cattai Ariella
- Caudron Julien
- Cavaliere Viviana
- Cavalli Donatella
- Cavalli-Sforza Matteo
- Cavasinni Vincenzo
- Ceradini Filippo
- Cerio Benjamin
- Cerny Karel
- Cerri Alessandro
- Cerrito Lucio
- Cerutti Fabio
- Cerv Matevz
- Cervelli Alberto
- Cetin Serkant Al
- Chafaq Aziz
- Chakraborty Dhiman
- Chalupkova Ina
- Chang Philip
- Chapman John Derek
- Charlton Dave
- Chau Chav Chhiv
- Chavez Barajas Carlos Alb
- Cheatham Susan
- Chegwidden Andrew
- Chekanov Sergei
- Chekulaev Sergey
- Chelkov Gueorgui
- Chelstowska Magda Anna
- Chen Chunhui
- Chen Hucheng
- Chen Karen
- Chen Liming
- Chen Shenjian
- Chen Xin
- Chen Ye
- Cheng Hok Chuen
- Cheng Yangyang
- Cheplakov Alexander
- Cheremushkina Evgenia
- Cherkaoui El Moursli Rajaa
- Chernyatin Valeriy
- Cheu Elliott
- Chevalier Laurent
- Chiarella Vitaliano
- Chiarelli Giorgio
- Childers John Taylo
- Chiodini Gabriele
- Chisholm Andrew
- Chislett Rebecca Th
- Chitan Adrian
- Chizhov Mihail
- Choi Kyungeon
- Chouridou Sofia
- Chow Bonnie Kar
- Christodoulou Valentinos
- Chromek-Burckhart Doris
- Chudoba Jiri
- Chuinard Annabelle
- Chwastowski Janusz
- Chytka Ladislav
- Ciapetti Guido
- Ciftci Abbas Kena
- Cinca Diane
- Cindro Vladimir
- Cioara Irina Anto
- Ciocio Alessandra
- Citron Zvi Hirsh
- Ciubancan Mihai
- Clark Allan G
- Clark Brian Lee
- Clark Philip Jam
- Clarke Robert
- Cleland Bill
- Clement Christophe
- Coadou Yann
- Cobal Marina
- Coccaro Andrea
- Cochran James H
- Coffey Laurel
- Cogan Joshua God
- Colasurdo Luca
- Cole Brian
- Cole Stephen
- Colijn Auke-Piete
- Collot Johann
- Colombo Tommaso
- Compostella Gabriele
- Conde Muiño Patricia
- Coniavitis Elias
- Connell Simon Henr
- Connelly Ian
- Consonni Sofia Mari
- Consorti Valerio
- Constantinescu Serban
- Conta Claudio
- Conti Geraldine
- Conventi Francesco
- Cooke Mark
- Cooper Ben
- Cooper-Sarkar Amanda
- Cornelissen Thijs
- Corradi Massimo
- Corriveau Francois
- Corso-Radu Alina
- Cortes-Gonzalez Arely
- Cortiana Giorgio
- Costa Giuseppe
- Costa María Jos
- Costanzo Davide
- Cottin Giovanna
- Cowan Glen
- Cox Brian
- Cranmer Kyle
- Cree Graham
- Crescioli Francesco
- Cribbs Wayne Alle
- Crispin Ortuzar Mireia
- Cristinziani Markus
- Croft Vince
- Crosetti Giovanni
- Crépé-Renaudin Sabine
- Cuhadar Donszelmann Tulay
- Cummings Jane
- Curatolo Maria
- Cuthbert Cameron
- Czirr Hendrik
- Czodrowski Patrick
- Côté David
- D'Auria Saverio
- D'Onofrio Monica
- Da Cunha Sargedas De Sousa Mario Jose
- Da Via Cinzia
- Dabrowski Wladyslaw
- Dafinca Alexandru
- Dai Tiesheng
- Dale Orjan
- Dallaire Frederick
- Dallapiccola Carlo
- Dam Mogens
- Dandoy Jeffrey Ro
- Dang Nguyen Phu
- Daniells Andrew Chr
- Danninger Matthias
- Dano Hoffmann Maria
- Dao Valerio
- Darbo Giovanni
- Darmora Smita
- Dassoulas James
- Dattagupta Aparajita
- Davey Will
- David Claire
- Davidek Tomas
- Davies Eleanor
- Davies Merlin
- Davison Peter
- Davygora Yuriy
- Dawe Edmund
- Dawson Ian
- Daya-Ishmukhametova Rozmin
- de Asmundis Riccardo
- De Benedetti Abraham
- De Castro Stefano
- De Cecco Sandro
- De Groot Nicolo
- de Jong Paul
- De la Torre Hector
- De Lorenzi Francesco
- De Nooij Lucie
- De Pedis Daniele
- De Salvo Alessandro
- De Sanctis Umberto
- De Santo Antonella
- De Vivie De Regie Jean-Bapti
- De Kaushik
- Dearnaley William Ja
- Debbe Ramiro
- Debenedetti Chiara
- Dedovich Dmitri
- Deigaard Ingrid
- Del Peso Jose
- Del Prete Tarcisio
- Delgove David
- Deliot Frederic
- Delitzsch Chris Male
- Deliyergiyev Maksym
- Dell'Acqua Andrea
- Dell'Asta Lidia
- Dell'Orso Mauro
- Della Pietra Massimo
- della Volpe Domenico
- Delmastro Marco
- Delsart Pierre-Ant
- Deluca Carolina
- DeMarco David
- Demers Sarah
- Demichev Mikhail
- Demilly Aurelien
- Denisov Sergey
- Derendarz Dominik
- Derkaoui Jamal Eddi
- Derue Frederic
- Dervan Paul
- Desch Klaus Kurt
- Deterre Cecile
- Deviveiros Pier-Olivi
- Dewhurst Alastair
- Dhaliwal Saminder
- Di Ciaccio Anna
- Di Ciaccio Lucia
- Di Domenico Antonio
- Di Donato Camilla
- Di Girolamo Alessandro
- Di Girolamo Beniamino
- Di Mattia Alessandro
- Di Micco Biagio
- Di Nardo Roberto
- Di Simone Andrea
- Di Sipio Riccardo
- Di Valentino David
- Diaconu Cristinel
- Diamond Miriam
- Dias Flavia
- Diaz Marco Aure
- Diehl Edward
- Dietrich Janet
- Diglio Sara
- Dimitrievska Aleksandra
- Dingfelder Jochen
- Dita Petre
- Dita Sanda
- Dittus Fridolin
- Djama Fares
- Djobava Tamar
- Djuvsland Julia Isab
- Dobos Daniel
- Dobre Monica
- Doglioni Caterina
- Dohmae Takeshi
- Dolejsi Jiri
- Dolezal Zdenek
- Dolgoshein Boris
- Donadelli Marisilvia
- Donati Simone
- Dondero Paolo
- Donini Julien
- Dopke Jens
- Doria Alessandra
- Dova Maria-Tere
- Doyle Tony
- Drechsler Eric
- Dris Manolis
- Dubreuil Emmanuelle
- Duchovni Ehud
- Duckeck Guenter
- Ducu Otilia Ana
- Duda Dominik
- Dudarev Alexey
- Duflot Laurent
- Duguid Liam
- Dunford Monica
- Duran Yildiz Hatice
- Durglishvili Archil
- Duschinger Dirk
- Dyndal Mateusz
- Dührssen Michael
- Düren Michael
- Eckardt Christoph
- Ecker Katharina
- Edgar Ryan Chris
- Edson William
- Edwards Nicholas C
- Ehrenfeld Wolfgang
- Eifert Till
- Eigen Gerald
- Einsweiler Kevin
- Ekelof Tord
- El Kacimi Mohamed
- Ellert Mattias
- Elles Sabine
- Ellinghaus Frank
- Elliot Alison
- Ellis Nicolas
- Elmsheuser Johannes
- Elsing Markus
- Emeliyanov Dmitry
- Enari Yuji
- Endner Oliver Chr
- Endo Masaki
- Erdmann Johannes
- Ereditato Antonio
- Ernis Gunar
- Ernst Jesse
- Ernst Michael
- Errede Steven
- Ertel Eugen
- Escalier Marc
- Esch Hendrik
- Escobar Carlos
- Esposito Bellisario
- Etienvre Anne-Isabe
- Etzion Erez
- Evans Hal
- Ezhilov Alexey
- Fabbri Laura
- Facini Gabriel
- Fakhrutdinov Rinat
- Falciano Speranza
- Falla Rebecca Ja
- Faltova Jana
- Fang Yaquan
- Fanti Marcello
- Farbin Amir
- Farilla Addolorata
- Farooque Trisha
- Farrell Steven
- Farrington Sinead
- Farthouat Philippe
- Fassi Farida
- Fassnacht Patrick
- Fassouliotis Dimitrios
- Faucci Giannelli Michele
- Favareto Andrea
- Fayard Louis
- Federic Pavol
- Fedin Oleg
- Fedorko Wojciech
- Feigl Simon
- Feligioni Lorenzo
- Feng Cunfeng
- Feng Eric
- Feng Haolu
- Fenyuk Alexander
- Feremenga Last
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- O'Brien Brendan Jo
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- Oakham Gerald
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- Spousta Martin
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- Talby Mossadek
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- Tam Jason
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- Tanaka Junichi
- Tanaka Reisaburo
- Tanaka Shuji
- Tannenwald Benjamin B
- Tannoury Nancy
- Tapprogge Stefan
- Tarem Shlomit
- Tarrade Fabien
- Tartarelli Giuseppe F
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- Tashiro Takuya
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- Tayalati Yahya
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- Terada Susumu
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- von der Schmitt Hans
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- Wanotayaroj Chaowaroj
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- Watson Alan
- Watson Ian
- Watson Miriam
- Watts Gordon
- Watts Stephen
- Waugh Ben
- Webb Samuel
- Weber Michele
- Weber Stefan Wol
- Webster Jordan S
- Weidberg Anthony
- Weinert Benjamin
- Weingarten Jens
- Weiser Christian
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- Wells Phillippa
- Wenaus Torre
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- Wickens Fred
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- Wiglesworth Craig
- Wiik-Fuchs Liv Antje
- Wildauer Andreas
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- Williams Hugh
- Williams Sarah
- Willis Christophe
- Willocq Stephane
- Wilson Alan
- Wilson John
- Wingerter-Seez Isabelle
- Winklmeier Frank
- Winter Benedict T
- Wittgen Matthias
- Wittkowski Josephine
- Wollstadt Simon Jako
- Wolter Marcin Wla
- Wolters Helmut
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- Wotschack Jorg
- Woudstra Martin
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- Wu Mengqing
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- Wu Yusheng
- Wyatt Terry Rich
- Wynne Benjamin
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- Xu Da
- Xu Lailin
- Yabsley Bruce
- Yacoob Sahal
- Yakabe Ryota
- Yamada Miho
- Yamaguchi Yohei
- Yamamoto Akira
- Yamamoto Shimpei
- Yamanaka Takashi
- Yamauchi Katsuya
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
- Yang Hongtao
- Yang Yi
- Yao Weiming
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven Henr
- Ye Jingbo
- Ye Shuwei
- Yeletskikh Ivan
- Yen Andy L
- Yildirim Eda
- Yorita Kohei
- Yoshida Rikutaro
- Yoshihara Keisuke
- Young Charles
- Young Christophe
- Youssef Saul
- Yu David Ren-
- Yu Jaehoon
- Yu Jiaming
- Yu Jie
- Yuan Li
- Yuen Stephanie
- Yurkewicz Adam
- Yusuff Imran
- Zabinski Bartlomiej
- Zaidan Remi
- Zaitsev Alexander
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanello Lucia
- Zanzi Daniele
- Zeitnitz Christian
- Zeman Martin
- Zemla Andrzej
- Zengel Keith
- Zenin Oleg
- Zerwas Dirk
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhong Jiahang
- Zhou Bing
- Zhou Chen
- Zhou Lei
- Zhou Li
- Zhou Ning
- Zhu Cheng Guan
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- zur Nedden Martin
- Zurzolo Giovanni
- Zwalinski Lukasz
- Åkesson Torsten Pa
- Åsman Barbro
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/10/2015
- Field of study
Pharmacological Evaluation and Preliminary Pharmacokinetics Studies of a New Diclofenac Prodrug without Gastric Ulceration Effect
- Author
- Adamson
- Agrawal
- Bandarage
- Bandgar
- Becker
- Bonaterra
- Bosquesi
- Cardoso
- Catarina Teixeira
- Cena
- Cha
- Charakida
- Chung
- Chung Chin
- Cioli
- Cuzzocrea
- Cuzzocrea
- Dos Santos
- Elder
- Go
- Grösch
- Halen
- Halen
- Hartmann
- Jean Santos
- Karina Barbieri
- Kaur
- Kaur
- Khan
- Kim
- Laemmli
- Laine
- Maier
- Malech
- Michel Campos
- Mukherjee
- Márcio Matsubara
- Nakamura
- Niederberger
- Pathan
- Pollyana Souto
- Poole
- Portanova
- Posadas
- Pradelles
- Priscila Bosquesi
- Rafael Chelucci
- Rosângela Peccinini
- Rouzer
- Saleh
- Sardi
- Scheja
- Silverstein
- Tammara
- Tegeder
- Utsunomiya
- Vanessa Moreira
- Wermuth
- Winter
- Publication venue
- MDPI AG
- Publication date
- 01/11/2012
- Field of study
Long-term nonsteroidal anti-inflammatory drugs (NSAIDs) therapy has been associated with several adverse effects such as gastric ulceration and cardiovascular events. Among the molecular modifications strategies, the prodrug approach is a useful tool to discover new safe NSAIDs. The 1-(2,6-dichlorophenyl)indolin-2-one is a diclofenac prodrug which demonstrated relevant anti-inflammatory properties without gastro ulceration effect. In addition, the prodrug decreases PGE2 levels, COX-2 expression and cellular influx into peritoneal cavity induced by carrageenan treatment. Preliminary pharmacokinetic studies have shown in vivo bioconversion of prodrug to diclofenac. This prodrug is a new nonulcerogenic NSAID useful to treat inflammatory events by long-term therapy
Japanese barberry seed predation by Rhagoletis meigenii fruit flies harboring Wolbachia endosymbionts
- Author
- A Renvoise
- A Saridaki
- AA Augustinos
- AJ Rokas
- AV Markov
- BD Heath
- CT Maier
- ER Haine
- F Dedeine
- F Vavre
- H Mercot
- H Ostergard
- H Schuler
- HR Dambroski
- IS Winkler
- J Jaenike
- JA Gagliardi
- JA Silander Jr
- JA White
- JD Lubell
- JG Ehrenfeld
- JH Werren
- JH Werren
- JH Werren
- JJ Smith
- K Jolley
- L Baldo
- L Baldo
- L Teixeira
- LL Soldaat
- LM Hedges
- LR Serbus
- M Aluja
- Mary E. Rumpho
- Philip A. Stack
- R Zug
- RH Foote
- RJ Prokopy
- S Charlat
- S Sintupachee
- S Siozios
- SB Sim
- T Hosokawa
- Vanessa C. Coats
- VC Coats
- VE Coscrato
- W Arthofer
- Y Kikuchi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study