Forward and midrapidity like-particle ratios from p+p collisions at sqrt(s)=200 GeV

We present a measurement of pi-\pi+, K-/K+ and pbar/p from p+p collisions at sqrt(s) = 20 0GeV over the rapidity range 0<y<3.4. For pT < 2.0 GeV/c we see no significant transverse momentum dependence of the ratios. All three ratios are independent of rapidity for y ~< 1.5 and then steadily decline from y ~ 1.5 to y ~ 3. The pi-\pi+ ratio is below unity for y > 2.0. The pbar/p ratio is very similar for p+p and 20% central Au+Au collisions at all rapidities. In the fragmentation region the three ratios seem to be independent of beam energy when viewed from the rest frame of one of the protons. Theoretical models based on quark-diquark breaking mechanisms overestimate the pbar/p ratio up to y ~< 3. Including additional mechanisms for baryon number transport such as baryon junctions leads to a better description of the data.Comment: 15 pages, 4 figures, uses elsart.sty. Changes to references and discussion based on referee comments, resubmitted to Phys. Lett.

Thioredoxin 1 in prostate tissue is associated with gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidants

Background. Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US. Growing evidence suggests that oxidative stress is involved in prostate cancer. Methods. In this study, thioredoxin 1 (Trx 1), an enzyme and subcellular indicator of redox status, was measured in prostate biopsy tissue from 55 men from the North Carolina-Louisiana Prostate Cancer Project. A pathologist blindly scored levels of Trx 1. The association between Trx 1 and the Gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidant intake was determined using Fisher's exact test. Results. Trx 1 levels in benign prostate tissue in men with incident prostate cancer were positively associated with the Gleason score (P=0.01) and inversely associated with dietary antioxidant intake (P=0.03). In prostate cancer tissue, Trx 1 levels were associated with erythrocyte glutathione peroxidase activity (P=0.01). No association was found for other erythrocyte enzymes. Greater Gleason score of malignant tissue corresponds to a greater difference in Trx 1 levels between malignant and benign tissue (P=0.04). Conclusion. These results suggest that the redox status of prostate tissue is associated with prostate cancer grade and both endogenous and exogenous antioxidants

Nuclear stopping and rapidity loss in Au+Au collisions at sqrt{s_{NN}}=62.4 GeV

Transverse momentum spectra of protons and anti-protons measured in the rapidity range 0<y<3.1 from 0-10% central Au+Au collisions at sqrt{s_{NN}}=62.4 GeV are presented. The rapidity densities, dN/dy, of protons, anti-protons and net-protons N()p-N(pbar) have been deduced from the spectra over a rapidity range wide enough to observe the expected maximum net-baryon density. From mid-rapidity to y=1 the net-proton yield is roughly constant (dN/dy ~ 10),but rises to dN/dy ~25 at 2.3<y<3.1. The mean rapidity loss is 2.01 +-0.16 units from beam rapidity. The measured rapidity distributions are compared to model predictions. Systematics of net-baryon distributions and rapidity loss vs. collision energy are discussed.Comment: 5 pages, 5 figures. Submitted Phys.Lett.

The provenance of Borneo's enigmatic alluvial diamonds:A case study from Cempaka, SE Kalimantan

Gem-quality diamonds have been found in several alluvial deposits across central and southern Borneo. Borneo has been a known source of diamonds for centuries, but the location of their primary igneous source remains enigmatic. Many geological models have been proposed to explain their distribution, including: the diamonds were derived from a local diatreme; they were brought to the surface through ophiolite obduction or exhumation of UHP metamorphic rocks; they were transported long distances southward via major Asian river systems; or, they were transported from the Australian continent before Borneo was rifted from its northwestern margin in the Late Jurassic. To assess these models, we conducted a study of the provenance of heavy minerals from Kalimantan's Cempaka alluvial diamond deposit. This involved collecting U–Pb isotopic data, fission track and trace element geochemistry of zircon as well as major element geochemical data of spinels and morphological descriptions of zircon and diamond. The results indicate that the Cempaka diamonds were likely derived from at least two sources, one which was relatively local and/or involved little reworking, and the other more distal which records several periods of reworking. The distal diamond source is interpreted to be diamond-bearing pipes that intruded the basement of a block that: (1) rifted from northwest Australia (East Java or SW Borneo) and the diamonds were recycled into its sedimentary cover, or: (2) were emplaced elsewhere (e.g. NW Australia) and transported to a block (e.g. East Java or SW Borneo). Both of these scenarios require the diamonds to be transported with the block when it rifted from NW Australia in the Late Jurassic. The local source could be diamondiferous diatremes associated with eroded Miocene high-K alkaline intrusions north of the Barito Basin, which would indicate that the lithosphere beneath SW Borneo is thick (~ 150 km or greater). The ‘local’ diamonds could also be associated with ophiolitic rocks that are exposed in the nearby Meratus Mountains

Communication and mutual resource exchange in north Florida hermit crabs

The patterns of shell exchange in three species of hermit crabs which overlap in distribution and shell use were observed in the laboratory. Crabs showed no tendency to initiate more exchanges with conspecifics as compared with nonconspecific individuals and there were no specific size dominance effects. Lack of common communicatory patterns between Clibararius vittatus and Pagurus pollicaris was correlated with minimal actual exchange, while Pagurus impressus exchanged with both species and executed patterns in common with both. The pattern of shell exchanges and preferences indicated that, in some cases, both individuals may gain in interspecific exchanges.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46904/1/265_2004_Article_BF00569198.pd

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Reproducibility in the absence of selective reporting : An illustration from large-scale brain asymmetry research

Altres ajuts: Max Planck Society (Germany).The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p-hacking. Low statistical power in individual studies is also understood to be an important factor. In a recent multisite collaborative study, we mapped brain anatomical left-right asymmetries for regional measures of surface area and cortical thickness, in 99 MRI datasets from around the world, for a total of over 17,000 participants. In the present study, we revisited these hemispheric effects from the perspective of reproducibility. Within each dataset, we considered that an effect had been reproduced when it matched the meta-analytic effect from the 98 other datasets, in terms of effect direction and significance threshold. In this sense, the results within each dataset were viewed as coming from separate studies in an "ideal publishing environment," that is, free from selective reporting and p hacking. We found an average reproducibility rate of 63.2% (SD = 22.9%, min = 22.2%, max = 97.0%). As expected, reproducibility was higher for larger effects and in larger datasets. Reproducibility was not obviously related to the age of participants, scanner field strength, FreeSurfer software version, cortical regional measurement reliability, or regional size. These findings constitute an empirical illustration of reproducibility in the absence of publication bias or p hacking, when assessing realistic biological effects in heterogeneous neuroscience data, and given typically-used sample sizes

Efeito Do Sistema De Plantio E Doses Do Nicosulfuron Sobre A Atividade Microbiana Do Solo

This study aimed to evaluate the effect of atrazine + nicosulfuron on soil microbial activity, under the conventional and no-tillage systems. The experiment was carried out in an area of maize-brachiaria intercropping, where atrazine + nicosulfuron were applied at (1,500 + 10 and 1,500 + 30 g h -1) with a weed-handed area being maintained without prior cultivation and another area without weed control. At flowering, soil samples were collected to determine the rate of CO 2 unfastening, microbial biomass carbon (MBC) and metabolic quotient (qCO 2) using the relation between accumulated CO 2 and MBC. The rate of CO 2 unfastening was lower only in plots without weed control. MBC was higher in the no-tillage system, being negatively affected due to the absence of vegetation. Lower MBC was observed in the weed-handed areas, probably due to the absence of straw. Under no-tillage system conditions, no difference was observed between the soil treatments with herbicide application and those without weed control. It can be concluded that the evaluated microbiological indicators were sensitive to the treatments, showing lower soil disturbance under no-tillage system conditions. However, in crop-livestock integration under the conventional system, the negative herbicide effect increase of nicosulfuron rate

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele