A Code of Ethics for Self-Driving Vehicles

As self-driving technology advances, relevant ethical frameworks must be developed to guide the engineering profession. This paper provides a deeper understanding of the ethical issues associated with self-driving vehicles. It reviews the relevant literature which makes it clear that there are several key ethical issues which must inform the development of a code of ethics specific to this field. These can be grouped into the four key principles: responsibility, safety, transparency and sustainability. The proposed code of ethics is then applied to a specific case study to evaluate it. The case study introduced is that of self-driving cars as rental cars with specific reference to the New Zealand context. This case study provides a complex real-world situation for the proposed code to be evaluated with. Applying the code of ethics to this case study indicates that the proposed code of ethics offers a relevant ethical framework to guide the engineering profession in self-driving vehicles

Innovations and best practice in undergraduate education.

University-based scientists hold the collective responsibility for educating the next generation of citizens, scientists and voters, but the degree to which they are individually trained and rewarded for this pursuit is variable. This F1000Research channel has its origin in a Society for Experimental Biology Conference held in Prague, 2015 and brings together researchers who excel at undergraduate education or the scholarship of teaching and learning to discuss challenges and best practices in contemporary higher science education

Perceptions and experiences of caregivers of severely malnourished children receiving inpatient care in Malawi: An exploratory study

BackgroundSevere acute malnutrition (SAM) affects approximately 18 million children under the age of five and is associated with more than 500 thousand deaths per year. Existing research has indicated that a high number of caregivers of children admitted for inpatient treatment of SAM experience psychological distress, depressive symptoms, and suicidality. However, no published studies in Malawi have been undertaken to qualitatively explore caregivers’ perceptions and experiences regarding their children’s malnutrition and inpatient treatment. AimTo explore caregivers’ perceptions and experiences surrounding childhood acute malnutrition and the experience of inpatient care in Malawi.MethodsInterviews were conducted utilising a semi-structured topic guide and were coded using thematic analysis.ResultsCaregivers (N=30) gave informed consent to participate in interviews. Caregiver understanding and perceptions of their children’s illness varied. Some caregivers identified a physical cause, with a minority identifying lack of dietary protein. Other narratives were around characteristics of the infant, other circumstantial events and religious and spiritual influences. One-third of caregivers described their own health difficulties and marital and relationship stressors. Challenges such as poverty, lack of access to food, poor food variability and competing demands for caregiver time were explained. Both positive and negative experiences of family and community support and hospital-based care were reported.ConclusionThe themes identified contribute to a greater contextual understanding of the multifactorial and integrated approaches required to address malnutrition. This study indicates that healthcare providers need to take a multi-faceted view of malnutrition and be aware of the many factors that may influence healthcare experience and response to treatment. Acknowledging pluralistic belief systems may improve engagement with care. This demands a broader appreciation of perceptions and experiences of malnutrition, hospital-based care, sources of support and stressors within the caregiver, family and community environment as well as consideration of social determinants such as poverty and how these influences present within a clinical context.

Intracontinental deformation in southern Africa during the late Cretaceous

Intracontinental deformation accommodated along major lithospheric scale shear zone systems and within associated extensional basins has been well documented within West, Central and East Africa during the Late Cretaceous. The nature of this deformation has been established by studies of the tectonic architecture of sedimentary basins preserved in this part of Africa. In southern Africa, where the post break-up history has been dominated by major erosion, little evidence for post-break-up tectonics has been preserved in the onshore geology. Here we present the results of 38 new apatite fission track analyses from the Damara region of northern Namibia and integrate these new data with our previous results that were focused on specific regions or sections only to comprehensively document the thermo-tectonic history of this region since continental break-up in the Early Cretaceous. The apatite fission track ages range from 449 ± 20 Ma to 59 ± 3 Ma, with mean confined track lengths between 14.61 ± 0.1 μm (SD 0.95 μm) to 10.83 ± 0.33 μm (SD 2.84 μm). The youngest ages (c. 80-60 Ma) yield the shortest mean track lengths, and combined with their spatial distribution, indicate major cooling during the latest Cretaceous. A simple numerical thermal model is used to demonstrate that this cooling is consistent with the combined effects of heating caused by magmatic underplating, related to the Etendeka continental flood volcanism associated with rifting and the opening of the South Atlantic, and enhanced erosion caused by major reactivation of major lithospheric structures within southern Africa during a key period of plate kinematic change that occurred in the South Atlantic and SW Indian ocean basins between 87-56 Ma. This phase of intraplate tectonism in northern Namibia, focused in discrete structurally defined zones, is coeval with similar phases elsewhere in Africa and suggests some form of trans-continental linkage between these lithospheric zones

Observations on three-dimensional measurement of confined fission track lengths in apatite using digital imagery

We report the results of a comparative study to explore the usefulness of 3D measurements of confined fission track lengths (TINTs) relative to horizontal confined track length measurements (dips ≤10°), and evaluate their suitability for thermal history modeling. Confined fission track lengths were measured in 10 annealed Fish Canyon Tuff apatites containing synthetic mixtures of different length components, and two Durango apatites containing spontaneous fission tracks. Measurements were primarily carried out using a digital image-based microscope system, and they were compared to those from a regular optical drawing tube-digitizing tablet setup, and a confocal laser scanning microscope. The results indicate that 3D measurements of confined track lengths are closely comparable to conventional horizontal track measurements, and the mean track lengths of inclined (dips >10°) and horizontal (dips ≤10°) confined tracks from the one sample are equivalent within the measurement uncertainty. A strong dip-bias was observed, so that almost all the confined tracks measured were dipping at <30°, and the great majority (~70%) were dipping at ≤10°, thereby qualifying as “horizontal” confined tracks. Our results suggest that a useful increase of more than 40% in sample size can be achieved from including dip- and refraction-corrected 3D track length measurements. Some evidence was seen for a small bias in favor of shorter tracks at higher dip angles but this has very little influence on the mean lengths or length distributions up to the practical limit of dips (~30°) observed in these measurements. Results obtained using the same measurement system by a single analyst over time and between six different observers in the one laboratory show good reproducibility. These results also agree well with conventional horizontal confined track length measurements in the same samples in the second laboratory involved. We conclude that 3D measurements of confined track lengths, including both horizontal and inclined tracks, are suitable for use in current fission track annealing models derived from experiments using horizontal confined tracks

HIV and mental illness in Malawi and the neuropsychiatric sequelae of efavirenz

IntroductionLittle is published about mental disorders in Malawi, specifically in relation to Human Immunodeficiency Virus (HIV) and it’s treatment. Efavirenz is a medication commonly used as part of triple therapy for HIV treatment. Indeed, in 2013, Malawi introduced 5A with Efavirenz as part of it’s 1st line treatment for HIV. There exists some literature documenting known psychiatric side effects of Efavirenz, which include anxiety, mood changes, nightmares, psychosis and suicidal ideation. Little is known about what features are most common in the presentation and what factors in the patient and drug which may make this reaction more likely.AimThe aim of this commentary is to review the association between HIV and psychiatric disorder, and consider the neuropsychiatric side-effects of Efavirenz.MethodAn evaluative literature review was completed by means of multiple electronic database search as well as an additional manual search to obtain published works identified through the electronic search. Search terms used were: Efavirenz, Acquired Immunodeficiency Syndrome, Africa, Antiretroviral Therapy, Developing Countries, Malawi, Mental Disorders, Public Health, and Psychiatry.ConclusionThis is an important area of study, as potentially large numbers of individuals with HIV are being placed on Efavirenz as first line treatment, yet 60% may experience some form of neuropsychiatric side effects.

Age versus stage: does ontogeny modify the effect of phosphorus and arbuscular mycorrhizas on above- and below-ground defence in forage sorghum?

Article first published online: 11 NOV 2013Arbuscular mycorrhizas (AM) can increase plant acquisition of P and N. No published studies have investigated the impact of P and AM on the allocation of N to the plant defence, cyanogenic glucosides. We investigated the effects of soil P and AM on cyanogenic glucoside (dhurrin) concentration in roots and shoots of two forage sorghum lines differing in cyanogenic potential (HCNp). Two harvest times allowed plants grown at high and low P to be compared at the same age and the same size, to take account of known ontogenetic changes in shoot HCNp. P responses were dependent on ontogeny and tissue type. At the same age, P-limited plants were smaller and had higher shoot HCNp but lower root HCNp. Ontogenetically controlled comparisons showed a P effect of lesser magnitude, and that there was also an increase in the allocation of N to dhurrin in shoots of P-limited plants. Colonization by AM had little effect on shoot HCNp, but increased root HCNp and the allocation of N to dhurrin in roots. Divergent responses of roots and shoots to P, AM and with ontogeny demonstrate the importance of broadening the predominantly foliar focus of plant defence studies/theory, and of ontogenetically controlled comparisons.Rebecca E. Miller, Roslyn M. Gleadow and Timothy R. Cavagnar

Insights in the exhumation history of the NWZagros frombedrock and detrital apatite fission-track analysis: evidence for a long-lived orogeny

We present the ¢rst ¢ssion-track (FT) thermochronology results for theNWZagrosBelt (SWIran) in order to identify denudation episodes that occurred during the protracted Zagros orogeny. Samples were collected from the two main detrital successions of the NWZagros foreland basin: the Palaeocene^early Eocene Amiran^Kashkan succession and theMiocene Agha Jari and Bakhtyari Formations. In situ bedrock samples were furthermore collected in the Sanandaj-Sirjan Zone. Only apatite ¢ssion-track (AFT) data have been successfully obtained, including 26 ages and11track-length distributions. Five families of AFTages have been documented from analyses of in situ bedrock and detrital samples: pre-middle Jurassic at 171 and 225Ma, early^late Cretaceous at 91Ma, Maastrichtian at 66Ma,middle^late Eocene at 38Ma and Oligocene^early Miocene at 22Ma.The most widespread middle^late Eocene cooling phase, around 38Ma, is documented by a predominant grain-age population in Agha Jari sediments and by cooling ages of a granitic boulder sample. AFTages document at least three cooling/denudation periods linked to major geodynamic events related to the Zagros orogeny, during the lateCretaceous oceanic obduction event, during the middle and late Eocene and during the earlyMiocene. Both late Cretaceous and early Miocene orogenic processes produced bending of the Arabian plate and concomitant foreland deposition. Between the two major £exural foreland episodes, the middle^late Eocene phase mostly produced a long-lasting slow- or nondepositional episode in the inner part of the foreland basin, whereas deposition and tectonics migrated to theNE along the Sanandaj-Sirjan domain and its Gaveh Rud fore-arc basin. As evidenced in this study, the Zagros orogeny was long-lived and multiepisodic, implying that the timing of accretion of the di¡erent tectonic domains that form the Zagros Mountains requires cautious interpretation