Oculo-visual changes and clinical considerations affecting older patients with dementia

Purpose: Dementia is associated with various alterations of the eye and visual function. Over 60% of cases are attributable to Alzheimer's disease, a significant proportion of the remainder to vascular dementia or dementia with Lewy bodies, while frontotemporal dementia, and Parkinson's disease dementia are less common. This review describes the oculo-visual problems of these five dementias and the pathological changes which may explain these symptoms. It further discusses clinical considerations to help the clinician care for older patients affected by dementia. Recent findings: Visual problems in dementia include loss of visual acuity, defects in colour vision and visual masking tests, changes in pupillary response to mydriatics, defects in fixation and smooth and saccadic eye movements, changes in contrast sensitivity function and visual evoked potentials, and disturbance of complex visual functions such as in reading ability, visuospatial function, and the naming and identification of objects. Pathological changes have also been reported affecting the crystalline lens, retina, optic nerve, and visual cortex. Clinically, issues such as cataract surgery, correcting the refractive error, quality of life, falls, visual impairment and eye care for dementia have been addressed. Summary: Many visual changes occur across dementias, are controversial, often based on limited patient numbers, and no single feature can be regarded as diagnostic of any specific dementia. Nevertheless, visual hallucinations may be more characteristic of dementia with Lewy bodies and Parkinson's disease dementia than Alzheimer's disease or frontotemporal dementia. Differences in saccadic eye movement dysfunction may also help to distinguish Alzheimer's disease from frontotemporal dementia and Parkinson's disease dementia from dementia with Lewy bodies. Eye care professionals need to keep informed of the growing literature in vision/dementia, be attentive to signs and symptoms suggestive of cognitive impairment, and be able to adapt their practice and clinical interventions to best serve patients with dementia

Perspectives on the use of transcriptomics to advance biofuels

As a field within the energy research sector, bioenergy is continuously expanding. Although much has been achieved and the yields of both ethanol and butanol have been improved, many avenues of research to further increase these yields still remain. This review covers current research related with transcriptomics and the application of this high-throughput analytical tool to engineer both microbes and plants with the penultimate goal being better biofuel production and yields. The initial focus is given to the responses of fermentative microbes during the fermentative production of acids, such as butyric acid, and solvents, including ethanol and butanol. As plants offer the greatest natural renewable source of fermentable sugars within the form of lignocellulose, the second focus area is the transcriptional responses of microbes when exposed to plant hydrolysates and lignin-related compounds. This is of particular importance as the acid/base hydrolysis methods commonly employed to make the plant-based cellulose available for enzymatic hydrolysis to sugars also generates significant amounts of lignin-derivatives that are inhibitory to fermentative bacteria and microbes. The article then transitions to transcriptional analyses of lignin-degrading organisms, such as Phanerochaete chrysosporium, as an alternative to acid/base hydrolysis. The final portion of this article will discuss recent transcriptome analyses of plants and, in particular, the genes involved in lignin production. The rationale behind these studies is to eventually reduce the lignin content present within these plants and, consequently, the amount of inhibitors generated during the acid/base hydrolysis of the lignocelluloses. All four of these topics represent key areas where transcriptomic research is currently being conducted to identify microbial genes and their responses to products and inhibitors as well as those related with lignin degradation/formation.clos

Asking “why” helps action control by goals but not plans

The present research investigated whether asking "why" concerning the pursuit of one goal can affect the subsequent pursuit of a previously chosen goal. Asking "why" should activate cognitive procedures involving deliberation over the pros and cons of a goal (why-mindset). This mode of thinking should spill over to subsequently pursued goals, with different consequences for goal striving guided by goal intentions and for goal striving guided by implementation intentions (if-then plans). As goal intentions guide behavior by effortful top-down action control processes motivated by the expected value of the desired outcomes, being in a why-mindset should induce defensive postdecisional deliberation and thereby promote goal pursuit. In contrast, implementation intentions guide behavior by automatic bottom-up action control processes triggered by the specified situational cues; in this case, being in a why-mindset should eliminate the effects implementation intentions have on goal pursuit. Performance on a handgrip self-control task (Study 1) as well as on a dual-task (simultaneous go/no-go task and tracking tasks; Study 2) supported these predictions: why-mindsets reinforced goal intention effects and impaired implementation intention effects on handgrip and dual-task performance. Implications for effective goal striving are discussed

Planning and the Control of Action

This chapter examines the role of spontaneous and strategic planning in turning an individual’s knowledge into action. The authors introduce specific if-then plans regarding when, where, and how to act and discuss how such implementation intentions (IIs) support goal attainment. They then differentiate two ways in which IIs can be formed on the basis of goal-related knowledge. For spontaneously formed IIs they highlight the importance of the accessibility of goal-relevant knowledge. For strategically formed IIs they point to the importance of systematically selecting relevant goal-relevant knowledge and translating it into IIs by using the Mental Contrasting with Implementation Intentions (MCII) self-regulation strategy. The interplay of automatic and reflective processes is a focus of discussion. The authors suggest that strategic planning of the automatic activation of goal-relevant knowledge can support reflective decision-making and goal-directed actions through use of context-sensitive reminders.publishe

On the Entity and Antiquity of the Aurignacian at Willendorf (Austria): Implications for Modern Human Emergence in Europe

International audienc