The catalytically inactive tyrosine phosphatase HD-PTP/PTPN23 is a novel regulator of SMN complex localization

The survival motor neuron (SMN) complex fulfils essential functions in the assembly of snRNPs, which are key components in the splicing of pre-mRNAs. Little is known about the regulation of SMN complex activity by posttranslational modification despite its complicated phosphorylation pattern. Several phosphatases had been implicated in the regulation of SMN, including the nuclear phosphatases PPM1G and PP1γ. Here we systematically screened all human phosphatase gene products for a regulatory role in the SMN complex. We used the accumulation of SMN in Cajal bodies of intact proliferating cells, which actively assemble snRNPs, as a readout for unperturbed SMN complex function. Knockdown of 29 protein phosphatases interfered with SMN accumulation in Cajal bodies, suggesting impaired SMN complex function, among those the catalytically inactive, non–receptor-type tyrosine phosphatase PTPN23/HD-PTP. Knockdown of PTPN23 also led to changes in the phosphorylation pattern of SMN without affecting the assembly of the SMN complex. We further show interaction between SMN and PTPN23 and document that PTPN23, like SMN, shuttles between nucleus and cytoplasm. Our data provide the first comprehensive screen for SMN complex regulators and establish a novel regulatory function of PTPN23 in maintaining a highly phosphorylated state of SMN, which is important for its proper function in snRNP assembly

Dust properties in M31.I.Basic properties and a discussion on age-dependent dust heating

Context. Spitzer Space Telescope observations and dust emission models are used to discuss the distribution of dust and its characteristics in M31. Together with GALEX FUV, NUV, and SDSS images we studied the age dependence of the dust heating process. Methods.Spitzer IRAC/MIPS maps of M31 were matched together and compared to dust emission models allowing to constrain the dust mass, the intensity of the mean radiation field, the abundance of Polycyclic Aromatic Hydrocarbons (PAH) particles. The total infrared emission (TIR) was analyzed in function of UV and Optical colors and compared to predictions of models which consider the age-dependent dust heating. Results. We demonstrate that cold-dust component emission dominates the infrared spectral energy distribution of M31. The mean intensity of the radiation field heating the dust is low (typically U<2, where U=1 is the value in the solar surrounding). Due to the lack of submillimetric measurements the dust mass (M_{dust}) is only weakly constrained by the infrared spectrum. We show that across the spiral-ring structure of M31 a fraction >3% of the total dust mass is in PAHs. UV and optical colors are correlated to (TIR/FUV) ratios in \sim 670 pc-sized regions overall the disk of M31, although deviating from the IRX-beta relationship for starburst galaxies. We derived that in 83% of the regions analyzed across the 10kpc ring more than 50% of the energy absorbed by the dust is rediated at \lambda > 4000 \AA and that dust in M31 appears mainly heated by populations a few Gyr old even across the star-forming ring. The attenuation is varying radially peaking near 10kpc and decreasing faster in the inner regions of M31 than in the outer regions. We finally derived the attenuation map of M31 at 6"/px resolution (\sim 100 pc/px along the plane of M31).[abridged]Comment: 21 pages, 18 figures, accepted for publication in A&A. Only low resolution images included, full resolution images will be avaiable in the journal electronic version. Fig.14 and Fig.17 will be avaiable via CD

Coulombically Interacting Electrons in a One-dimensional Quantum Dot

The spectral properties of up to four interacting electrons confined within a quasi one--dimensional system of finite length are determined by numerical diagonalization including the spin degree of freedom. The ground state energy is investigated as a function of the electron number and of the system length. The limitations of a description in terms of a capacitance are demonstrated. The energetically lowest lying excitations are physically explained as vibrational and tunneling modes. The limits of a dilute, Wigner-type arrangement of the electrons, and a dense, more homogeneous charge distribution are discussed.Comment: 10 pages (excl. Figures), Figures added in POSTSCRIPT, LaTe

The young star cluster system of the Antennae galaxies

“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s10509-009-0103-xThe study of young star cluster (YSC) systems, preferentially in starburst and merging galaxies, has seen great interest in the recent past, as it provides important input to models of star formation. However, even some basic properties (such as the luminosity function; LF) of YSC systems are still being debated. Here, we study the photometric properties of the YSC system in the nearest major merger system, the Antennae galaxies. We find evidence for the existence of a statistically significant turnover in the LF.Peer reviewe

Multiwavelength star formation indicators: Observations

We present a compilation of multiwavelength data on different star formation indicators for a sample of nearby star forming galaxies. Here we discuss the observations, reductions and measurements of ultraviolet images obtained with STIS, on board the Hubble Space Telescope, ground-based Halpha, and VLA 8.46 GHz radio images. These observations are complemented with infrared fluxes, as well as large aperture optical radio and ultraviolet data from the literature. This database will be used in a forthcoming paper to compare star formation rates at different wavebands. We also present spectral energy distributions (SEDs) for those galaxies with at least one far-infrared measurements from ISO, longward of 100 um. These SEDs are divided in two groups, those which are dominated by the far-infrared emission, and those where the contribution from the far-infrared and optical emission is comparable. These SEDs are useful tools to study the properties of high redshift galaxies.Comment: 39 pages, 17 jpeg figures, 1 eps figure, To appear in ApJS May 200

On the dependence between UV luminosity and Lyman-alpha equivalent width in high redshift galaxies

We show that with the simple assumption of no correlation between the Ly-alpha equivalent width and the UV luminosity of a galaxy, the observed distribution of high redshift galaxies in an equivalent width - absolute UV magnitude plane can be reproduced. We further show that there is no dependence between Ly-alpha equivalent width and Ly-alpha luminosity in a sample of Ly-alpha emitters. The test was expanded to Lyman-break galaxies and again no dependence was found. Simultaneously, we show that a recently proposed lack of large equivalent width, UV bright galaxies (Ando et al. 2006) can be explained by a simple observational effect, based on too small survey volumes.Comment: 7 pages, 3 figures, 2 tables, accepted in MNRA

Star cluster formation and star formation: the role of environment and star-formation efficiencies

“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s10509-009-0088-5By analyzing global starburst properties in various kinds of starburst and post-starburst galaxies and relating them to the properties of the star cluster populations they form, I explore the conditions for the formation of massive, compact, long-lived star clusters. The aim is to determine whether the relative amount of star formation that goes into star cluster formation as opposed to field star formation, and into the formation of massive long-lived clusters in particular, is universal or scales with star-formation rate, burst strength, star-formation efficiency, galaxy or gas mass, and whether or not there are special conditions or some threshold for the formation of star clusters that merit to be called globular clusters a few billion years later.Peer reviewe

Effective charge-spin models for quantum dots

It is shown that at low densities, quantum dots with few electrons may be mapped onto effective charge-spin models for the low-energy eigenstates. This is justified by defining a lattice model based on a many-electron pocket-state basis in which electrons are localised near their classical ground-state positions. The equivalence to a single-band Hubbard model is then established leading to a charge-spin ($t-J-V$) model which for most geometries reduces to a spin (Heisenberg) model. The method is refined to include processes which involve cyclic rotations of a ``ring'' of neighboring electrons. This is achieved by introducing intermediate lattice points and the importance of ring processes relative to pair-exchange processes is investigated using high-order degenerate perturbation theory and the WKB approximation. The energy spectra are computed from the effective models for specific cases and compared with exact results and other approximation methods.Comment: RevTex, 24 pages, 7 figures submitted as compressed and PostScript file

Vertically coupled double quantum dots in magnetic fields

Ground-state and excited-state properties of vertically coupled double quantum dots are studied by exact diagonalization. Magic-number total angular momenta that minimize the total energy are found to reflect a crossover between electron configurations dominated by intra-layer correlation and ones dominated by inter-layer correlation. The position of the crossover is governed by the strength of the inter-layer electron tunneling and magnetic field. The magic numbers should have an observable effect on the far infra-red optical absorption spectrum, since Kohn's theorem does not hold when the confinement potential is different for two dots. This is indeed confirmed here from a numerical calculation that includes Landau level mixing. Our results take full account of the effect of spin degrees of freedom. A key feature is that the total spin, $S$, of the system and the magic-number angular momentum are intimately linked because of strong electron correlation. Thus $S$ jumps hand in hand with the total angular momentum as the magnetic field is varied. One important consequence of this is that the spin blockade (an inhibition of single-electron tunneling) should occur in some magnetic field regions because of a spin selection rule. Owing to the flexibility arising from the presence of both intra-layer and inter-layer correlations, the spin blockade is easier to realize in double dots than in single dots.Comment: to be published in Phys. Rev. B1

Comparison of large-angle production of charged pions with incident protons on cylindrical long and short targets

The HARP collaboration has presented measurements of the double-differential pi+/pi- production cross-section in the range of momentum 100 MeV/c <= p 800 MeV/c and angle 0.35 rad <= theta <= 2.15 rad with proton beams hitting thin nuclear targets. In many applications the extrapolation to long targets is necessary. In this paper the analysis of data taken with long (one interaction length) solid cylindrical targets made of carbon, tantalum and lead is presented. The data were taken with the large acceptance HARP detector in the T9 beam line of the CERN PS. The secondary pions were produced by beams of protons with momenta 5 GeV/c, 8 GeV/c and 12 GeV/c. The tracking and identification of the produced particles were performed using a small-radius cylindrical time projection chamber (TPC) placed inside a solenoidal magnet. Incident protons were identified by an elaborate system of beam detectors. Results are obtained for the double-differential yields per target nucleon d2 sigma / dp dtheta. The measurements are compared with predictions of the MARS and GEANT4 Monte Carlo simulations.Comment: 43 pages, 20 figure