Büyükanne ve büyükbabalarda torun bakmanın depresyon ve yaşam kalitesine etkisi

Başlangıç seviyesi projesiAmaç: Bu araştırma “Büyükanne ve büyükbabalarda torun bakmanın depresyon ve yasam kalitesine etkisini incelemek amacıyla planlanmış ve uygulanmıştır. Materiyal ve Metod: Araştırma tanımlayıcı ve kesitsel niteliktedir. Denizli il merkezinde 60 yas üzeri torun bakan ve bakmayan büyükanne ve büyük babalar araştırmanın evrenini oluşturmuştur. Toplum sağlığı merkezlerinden rastlantısal olarak birer aile sağlığı merkezi seçilmiş ve her birinden ikişer aile hekimliği bölgesi randomizasyon örnekleme yöntemi ile belirlenmiştir. Örnekleme çıkan her bir aile hekimliği bölgesinde kayıtlı olan 60 yas üzeri yaslı nüfus, toplam nüfusa orantılanmış ve bölgelerden kaçar yaslının örnekleme alınacağı belirlenmiştir. Evreni bilinen örneklem formülüne göre araştırmaya alınacak örneklem sayısı 920 olarak bulunmuştur. Veri toplama araçları olarak; Birinci bölümde “Büyükanne, büyükbaba ve toruna yönelik tanıtıcı bilgi formu” “, İkinci bölümde Büyükanne ve babaların depresyon düzeylerini ölçebilmek için “Geriatrik Depresyon Ölçeği, Üçüncü bölümde ise, Büyük anne ve babaların yasam kalitesini belirlemek amacıyla Dünya Sağlık Örgütü Yasam kalitesi Ölçeği (WHOQOL –OLD ) kullanılmıştır. Araştırmaya başlamadan önce benzer örneklemde ön uygulama yapılmıştır. Verilerin değerlendirilmesinde, SPSS 11.0 programı kullanılmış ve veriler sayı yüzde dağılımları, Independent t testi, varyans analizi, ki kare ve korelasyon analizi ile değerlendirilmiştir. Bulgular: Arastırmaya katılan büyük anne ve büyükbabaların yas ortalaması 62.20±7.71dir. Büyükanne ve büyükbabaların %59.6’sını bayanlar, %42.2’si ilkokul mezunu, %91.9’u gelir getiren herhangi bir iste çalısmıyor, %46.2’sinin aylık geliri 500-999TL arasındadır. Büyükanne ve büyükbabaların %49.6’sı torun baktığını, %50.4’ü torun bakmadığını belirtmiştir. %40.3’ü torun bakmanın ekonomik yük getirmediğini, %47.4’ü bundan kazanç elde etmediğini, %17.5’i torun bakmanın kendisini daha mutlu hissettirdiğini, %11.0’ı ise torun bakmanın aşırı yorgunluğa neden olduğunu belirtmiştir. Büyükanne ve büyükbabaların yasam kalitesi değerlendirildiğinde, yasam kalitesi ölçeğinin duygusal işlevler ile ölüm ve ölmek alt boyutlarında torun bakan ve bakmayanlar arasında istatistiksel olarak anlamlı bir fark olduğu saptanmıştır ( p<0.05). Torun bakanların %23.6’sında depresyon riski görülürken, %76.4’ünde depresyon riski yoktur. Torun bakmayanların %33.4’ünde depresyon riski görülürken, %66.6’sında depresyon riski yoktur. Algılanan sağlık durumu ile depresyon görülme riski ve yasam kalitesi arasında istatistiksel olarak anlamlı bir ilişki olduğu belirlenmiştir. Sonuç ve Öneriler: Sonuç olarak, torun bakan büyükanne ve babalarda bakmayanlara göre depresyon görülme riskinin daha az olduğu, yine torun bakmanın yasam kalitesi ölçeğinin duygusal işlevler ile ölüm ve ölmek alt boyutlarında etkili olduğu belirlenmiştir. Subjektif sağlık algısı hem depresyon görülme riskinde hem de yaşam kalitesinde etkili bulunmuştur. Projenin bulguları ülkemizde bir ilki oluşturmuştur. Bu yüzden bu arastırmanın farklı örneklemlerde yapılması önerilmektedir.Purpose: This study was planned and carried out in order to observe the effect of grandmother and grandfather’s looking after grandchildren on depression and life quality. Material and Method: The study is descriptive and cross-sectional. The universe of the study was composed of grandmothers and grandfather over the age of 60 years and who look and do not look after grandchildren in Denizli. One family health center was chosen randomly from public health centers and two family practice areas per each center were detected with randomization sampling method. Population over the age of 60 years registered in each family practice area for sampling was proportioned to total population and how many elder people was to be taken for sampling was determined. Sampling to be included in the study according sampling formula was determined to be 920. As data collection tool; In the first section “Identifying Information Form for the grandmothers, grandfathers and grandchild; in the second section “Geriatric Depression Scale” in order to measure grandmothers and grandfathers’ depression level, in the third section World Health Organization Quality of Life Scale (WHOQOL – OLD) in order to determine life quality of grandmothers and grandfathers were used. For the evaluation of data; SPSS 11.0 program was used and data were evaluated with percentage distribution, Independent t test, variance analysis, chi square and correlation analysis. Findings: Average of age of grandmothers and grandfathers who are involved in the study is 62.20±7.71. 59.6% of the grandparents are female, 42.2% of them are graduate of primary education, 91.9% of them do not work in a job that brings an income, monthly income of 46.2% of them is between 500-900 TL. It was detected that 49.6% of the grandparents look after grandchildren and 50.4% do not. 40.3% of grandparents expressed that looking after grandchildren do not bring any economic burden to them, 47.4% expressed that they do not gain profit from it, 17.5% expressed that they feel themselves happy for looking after their grandchildren, 11.0% expressed that looking after children brought overfatigue. When life quality of grandparents were considered, it was detected that there was a statistically meaningful difference in the lower dimensions of emotional functions and death and dying of life quality scale between grandparents who look and do not after grandchildren ( p<0.05). There is a risk of depression in 23.6% of grandparents who do not look after grandchildren while there was no risk of depression in 66.6% of them. It was detected that there was a statistically meaningful relation between health condition and risk of depression and life quality. Results and Suggestions: As a result, it was detected that the risk of depression is lower in grandparents who look after grandchildren compared with those who do not look after grandchildren and that looking after grandchildren is effective in the lower dimensions of emotional functions and death and dying of life quality scale. Subjective health perception was found to be effective in both the risk of depression and life quality. Findings of the project were a first in our country. Therefore the study was suggested to be carried out in different samplings as well

Synthesis, Characterization, and Antimicrobial Properties of a New Ligand and Its Pd(II), Ru(II), Fe(II), Co(II) Complexes

Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes and also exhibit a broad range of biological activities including antifungal, antibacterial, antimalarial, antiproliferative, antiviral, and antipyretic properties. In this study, the complexes of (E)-2-(3,5-di-tert-butyl-2-hydroxybenzylideneamino)-6-methyl4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (L) with Co(II), Fe(II), Pd(II) and Ru(II) were successfully prepared. Structures of Schiff base and its metal complexes obtained were confirmed by FT-IR, 1H-NMR, 13CNMR, UV–vis, magnetic susceptibility, mass spectroscopy and elemental analysis. Antimicrobial activity of the synthesized Schiff base and its metal complexes have been studied. When the antimicrobial activities of the compounds were examined, it was observed that the lowest activity was exhibited by the ligand, and the highest activity was exhibited by the Co(II) and Pd(II) complexes. None of our compounds were been found to exhibit antifungal activity

See and treat strategy by LEEP conization in patients with abnormal cervical cytology

Objectives: To determine the overtreatment and re-LEEP rates of see and treat strategy (S &amp; T) in women who underwent S &amp; T by LEEP and to identify the risk factors for overtreatment and surgical margin and/or endocervical curettage positivity. Material and methods: A total of 800 patients who underwent S &amp; T in Istanbul University Cerrahpasa Medical Faculty between June 2010 and June 2016 were retrospectively analyzed. Results: Overtreatment rate was found to be 46.6%, decreasing with higher grade of cervical smear abnormalities. Age more than 45, low grade of cervical cytologic abnormality and absence of glandular involvement were associated with higher overtreatment rates. The more advanced the histopathology, the more increased risk of surgical margin on LEEP and ECC positivity (p &lt; 0.0001, for both). Glandular involvement was associated with both surgical margin and ECC positivity. Conclusions: S &amp; T can be used in patients with high grade cytologic anomaly with an acceptable overtreatment rate. In addition, bigger pieces of specimens may need to be removed during LEEP in patients who have suspicious images of higher grade of abnormalities on colposcopy to reduce surgical margin or ECC positivity. When high rate of ECC positivity in patients with HSIL cytology is considered, we suggest performing ECC to every patients with HSIL

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual\u27s risk of non-communicable disease in later life: the developmental origins of health and disease (DOHaD) hypothesis. During the 1990s the validity of the DOHaD hypothesis was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in the in utero development between humans and guinea pigs, the strengths and limitations of the guinea pig as an experimental model of DOHaD and the guinea pig\u27s potential to enhance clinical therapeutic innovation to improve human health. (Figure presented.)

Synthesis, characterization and antioxidant activity of Schiff base and its metal complexes with Fe(II), Mn(II), Zn(II), and Ru(II) ions: Catalytic activity of ruthenium(II) complex

The synthesis, spectral, catalytic and antioxidant properties of ethyl-2-(2-hydroxy-3-methoxybenzylideneamino)-6-methyl-4,5,6-tetrahydrobenzo[b]thiophene-3-carboxylate (L) substituted iron(II), manganese(II), zinc(II), and ruthenium(II)-arene chlorides are described for the first time. The ligand and its metal complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, and spectral (1H NMR, 13C NMR, FT-IR, UV-Vis and Mass) techniques. The FT-IR spectra showed that the ligand can act as bidentate or tridentate. Magnetic moments and electronic spectral studies revealed an octahedral geometry for all the complexes obtained. The thermal behavior of the complexes showed that the water molecules were separated in the first step followed immediately by decomposition of the anions and ligand molecules in the subsequent steps. Ru(II) complex was used as catalysts for the transfer hydrogenation of ketones. At the same time, the effect of various bases such as NaOH, KOH, KOBut and NaOAc as organic base were investigated in the transfer hydrogenation of ketones by 2-propanol as the hydrogen source. The complexes and ligand were tested in vitro for their antioxidant activity. The experimental results showed that Ru(II) complex had more potent antioxidant activities than Zn(II), Fe(II), Mn(II) complexes and parent ligand

Synthesis, Spectroscopic and Thermal Characterization of a New Sustainable Polymer

Copolymerization is a very important method in the synthesis of products having the physical and chemical properties sought in industrial sense. In this paper, the copolymerization of N-(4-nitrophenyl) acrylamide monomer with D-limonene was carried out and LIM-co-NPA copolymer was synthesized by free radical chain polymerization reaction. The structure of sustainable copolymer of limonene was chemically characterized by FT-IR, 1H-NMR spectroscopic techniques. In addition, thermal stability of copolymer investigated by TGA/DTG/DTA simultaneous thermal analysis methods. The spectroscopic results are compatible with the amide or limonene polymers synthesized in the literature. From the important thermal results of the sustainable copolymer, it has been found that the initial decomposition temperature is 226°C, and the maximum decomposition temperatures is 329°C, glass transition temperature at 261°C and crystallization temperature at 340°C. It can be said that this promising sustainable copolymer is suitable for other mechanical, physical and biological study and research fields

Preparation of poly(MPAEMA)/halloysite nanocomposites and investigation of antiproliferative activity

In this present work, the synthesis, characterization, and thermal properties of poly(2-(4-methoxyphenylamino)-2-oxoethyl methacrylate) (MPAEMA) polymer/clay-based nanocomposites were investigated by in-situ polymerization. At the characterizations of nanomaterials FTIR, XRD, SEM, and TGA techniques were used. It was determined from XRD and SEM measurements that the morphology of nanocomposites was exfoliated when the clay content in the polymer matrix was kept at 3% and 5%. From thermal analysis, a positive correlation was observed between the clay ratio and thermal stability of nanomaterials. Also, the cytotoxic effect of halloysite and its nanocomposites was investigated using XTT assay on HeLa cells. According to the results, nanocomposites showed a non-cytotoxic response and thus they may use safety in many research areas such as medicine, agriculture, cosmetics. © 2021, Sociedad Química de México