69 research outputs found
Water in Emission in the ISO Spectrum of the Early M Supergiant Star mu Cephei
We report a detection of water in emission in the spectrum of the M2
supergiant atar mu Cep (M2Ia) observed by the Short Wavelength Spectrometer
(SWS) aboard Infrared Space Observatory (ISO) and now released as the ISO
Archives. The emission first appears in the 6 micron region (nu2 fundamental)
and then in the 40 micron region (pure rotation lines) despite the rather
strong dust emission. The intensity ratios of the emission features are far
from those of the optically thin gaseous emission. Instead, we could reproduce
the major observed emission features by an optically thick water sphere of the
inner radius about two stellar radii (1300Rsun), Tex = 1500K, and Ncol (H2O) =
3.0E+20/cm2. This model also accounts for the H2O absorption bands in the near
infrared (1.4, 1.9, and 2.7 micron) as well. The detection of water in emission
provides strong constraints on the nature of water in the early M supergiant
stars, and especially its origin in the outer atmosphere is confirmed against
other models such as the large convective cell model. We finally confirm that
the early M supergiant star is surrounded by a huge optically thick sphere of
the warm water vapor, which may be referred to as MOLsphere for simplicity.
Thus, the outer atmosphere of M supergiant stars should have a complicated
hierarchical and/or hybrid structure with at least three major constituents
including the warm MOLsphere (T about 1.0E+3K) together with the previously
known hot chromosphere (T about 1.0E+4K) and cool expanding gas-dust envelope
(T about 1.0E+2K).Comment: 14 pages, 5 postscript figures, to appear in ApJ
Herschel/HIFI deepens the circumstellar NH3 enigma
Circumstellar envelopes (CSEs) of a variety of evolved stars have been found
to contain ammonia (NH3) in amounts that exceed predictions from conventional
chemical models by many orders of magnitude. The observations reported here
were performed in order to better constrain the NH3 abundance in the CSEs of
four, quite diverse, oxygen-rich stars using the NH3 ortho J_K = 1_0 - 0_0
ground-state line. We used the Heterodyne Instrument for the Far Infrared
aboard Herschel to observe the NH3 J_K = 1_0 - 0_0 transition near 572.5 GHz,
simultaneously with the ortho-H2O J_Ka,Kc = 1_1,0 -1_0,1 transition, toward VY
CMa, OH 26.5+0.6, IRC+10420, and IK Tau. We conducted non-LTE radiative
transfer modeling with the goal to derive the NH3 abundance in these objects'
CSEs. For the latter two stars, Very Large Array imaging of NH3
radio-wavelength inversion lines were used to provide further constraints,
particularly on the spatial extent of the NH3-emitting regions. Results. We
find remarkably strong NH3 emission in all of our objects with the NH3 line
intensities rivaling those obtained for the ground state H2O line. The NH3
abundances relative to H2 are very high and range from 2 x 10-7 to 3 x 10-6 for
the objects we have studied. Our observations confirm and even deepen the
circumstellar NH3 enigma. While our radiative transfer modeling does not yield
satisfactory fits to the observed line profiles, it leads to abundance
estimates that confirm the very high values found in earlier studies. New ways
to tackle this mystery will include further Herschel observations of more NH3
lines and imaging with the Expanded Very Large Array.Comment: 4+2 page
Water and Dust Emission from W Hydrae
We construct a self-consistent model for the wind around W Hya by solving the
coupled equations describing the hydrodynamics and dust radiative transfer
problems. The model matches simultaneously the observed continuum radiation and
wind velocity profile. The water line emission is calculated next using the
water abundance as the only free parameter, fitted from the ISO observations of
Neufeld et al. (1996) and Barlow et al. (1996). The gas temperature is
determined from a thermal balance calculation that includes water as one of its
main components. Our model successfully fits all the observed water lines,
resolving a major discrepancy between the modeling results of the two observing
teams. The mass loss rate is 2.3 x 10^{-6} M_solar yr^{-1}, the water abundance
is 1.0 x 10^{-4} and the ortho:para ratio is 1:1.3.Comment: 5 pages, 3 figures, uses aastex.cls and emulateapj5.sty, accepted by
ApJ Letter
CN and HCN in Dense Interstellar Clouds
We present a theoretical investigation of CN and HCN molecule formation in
dense interstellar clouds. We study the gas-phase CN and HCN production
efficiencies from the outer photon-dominated regions (PDRs) into the opaque
cosmic-ray dominated cores. We calculate the equilibrium densities of CN and
HCN, and of the associated species C+, C, and CO, as functions of the
far-ultraviolet (FUV) optical depth. We consider isothermal gas at 50 K, with
hydrogen particle densities from 10^2 to 10^6 cm^-3. We study clouds that are
exposed to FUV fields with intensities 20 to 2*10^5 times the mean interstellar
FUV intensity. We assume cosmic-ray H2 ionization rates ranging from 5*10^-17
s^-1, to an enhanced value of 5*10^-16 s^-1. We also examine the sensitivity of
the density profiles to the gas-phase sulfur abundance.Comment: Accepted for publication in ApJ, 33 pages, 8 figure
Spatially Resolved Chemistry in Nearby Galaxies I. The Center of IC 342
We have imaged emission from the millimeter lines of eight molecules--C2H,
C34S, N2H+, CH3OH, HNCO, HNC, HC3N, and SO--in the central half kpc of the
nearby spiral galaxy IC 342. The 5" (~50 pc) resolution images were made with
OVRO. Using these maps we obtain a picture of the chemistry within the nuclear
region on the sizescales of individual GMCs. Bright emission is detected from
all but SO. There are marked differences in morphology for the different
molecules. A principal component analysis is performed to quantify similarities
and differences among the images. This analysis reveals that while all
molecules are to zeroth order correlated, that is, they are all found in dense
molecular clouds, there are three distinct groups of molecules distinguished by
the location of their emission within the nuclear region. N2H+, C18O, HNC and
HCN are widespread and bright, good overall tracers of dense molecular gas. C2H
and C34S, tracers of PDR chemistry, originate exclusively from the central
50-100 pc region, where radiation fields are high. The third group of
molecules, CH3OH and HNCO, correlates well with the expected locations of
bar-induced orbital shocks. The good correlation of HNCO with the established
shock tracer molecule CH3OH is evidence that this molecule, whose chemistry has
been uncertain, is indeed produced by processing of grains. HC3N is observed to
correlate tightly with 3mm continuum emission, demonstrating that the young
starbursts are the sites of the warmest and densest molecular gas. We compare
our HNC images with the HCN images of Downes et al. (1992) to produce the first
high resolution, extragalactic HCN/HNC map: the HNC/HCN ratio is near unity
across the nucleus and the correlation of both of these gas tracers with the
star formation is excellent. (Abridged).Comment: 54 pages including 10 figures and 8 tables. Accepted for publication
in Ap
Molecular excitation in the Interstellar Medium: recent advances in collisional, radiative and chemical processes
We review the different excitation processes in the interstellar mediumComment: Accepted in Chem. Re
A Spitzer Space Telescope far-infrared spectral atlas of compact sources in the Magellanic Clouds. I. The Large Magellanic Cloud
[abridged] We present 52-93 micron spectra obtained with Spitzer in the
MIPS-SED mode, of a representative sample of luminous compact far-IR sources in
the LMC. These include carbon stars, OH/IR AGB stars, post-AGB objects and PNe,
RCrB-type star HV2671, OH/IR red supergiants WOHG064 and IRAS05280-6910, B[e]
stars IRAS04530-6916, R66 and R126, Wolf-Rayet star Brey3a, Luminous Blue
Variable R71, supernova remnant N49, a large number of young stellar objects,
compact HII regions and molecular cores, and a background galaxy (z~0.175). We
use the spectra to constrain the presence and temperature of cold dust and the
excitation conditions and shocks within the neutral and ionized gas, in the
circumstellar environments and interfaces with the surrounding ISM. Evolved
stars, including LBV R71, lack cold dust except in some cases where we argue
that this is swept-up ISM. This leads to an estimate of the duration of the
prolific dust-producing phase ("superwind") of several thousand years for both
RSGs and massive AGB stars, with a similar fractional mass loss experienced
despite the different masses. We tentatively detect line emission from neutral
oxygen in the extreme RSG WOHG064, with implications for the wind driving. In
N49, the shock between the supernova ejecta and ISM is revealed by its strong
[OI] 63-micron emission and possibly water vapour; we estimate that 0.2 Msun of
ISM dust was swept up. Some of the compact HII regions display pronounced
[OIII] 88-micron emission. The efficiency of photo-electric heating in the
interfaces of ionized gas and molecular clouds is estimated at 0.1-0.3%. We
confirm earlier indications of a low nitrogen content in the LMC. Evidence for
solid state emission features is found in both young and evolved object; some
of the YSOs are found to contain crystalline water ice.Comment: Accepted for publication in The Astronomical Journal. This paper
accompanies the Summer 2009 SAGE-Spec release of 48 MIPS-SED spectra, but
uses improved spectrum extraction. (Fig. 2 reduced resolution because of
arXiv limit.
Viral Etiology of Encephalitis in Children in Southern Vietnam: Results of a One-Year Prospective Descriptive Study
Viral encephalitis is associated with high morbidity and mortality in Vietnam. However little is known about the causes of the disease due to a lack of diagnostic facilities in this relatively resource-poor setting. Knowledge about the etiologies and clinical outcome of viral encephalitis is necessary for future design of intervention studies targeted at improvement of clinical management, treatment and prevention of the disease. We report the viral agents, clinical outcome and prognostic factors of mortality of encephalitis in children admitted to a referral hospital for children in southern Vietnam. We show that about one third of the enrolled patients die acutely, and that mortality is independently associated with patient age and Glasgow Coma Scale on admission. Japanese encephalitis, dengue virus and enterovirus (including enterovirus 71) are the major viruses detected in our patients. However, more than half of the patients remain undiagnosed, while mortality in this group is as high as in the diagnosed group. This study will benefit clinicians and public health in terms of clinical management and prevention of childhood encephalitis in Vietnam
Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
Background:
Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels.
Methods:
We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level.
Findings:
In 2019, there were 12Β·2 million (95% UI 11Β·0β13Β·6) incident cases of stroke, 101 million (93Β·2β111) prevalent cases of stroke, 143 million (133β153) DALYs due to stroke, and 6Β·55 million (6Β·00β7Β·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11Β·6% [10Β·8β12Β·2] of total deaths) and the third-leading cause of death and disability combined (5Β·7% [5Β·1β6Β·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70Β·0% (67Β·0β73Β·0), prevalent strokes increased by 85Β·0% (83Β·0β88Β·0), deaths from stroke increased by 43Β·0% (31Β·0β55Β·0), and DALYs due to stroke increased by 32Β·0% (22Β·0β42Β·0). During the same period, age-standardised rates of stroke incidence decreased by 17Β·0% (15Β·0β18Β·0), mortality decreased by 36Β·0% (31Β·0β42Β·0), prevalence decreased by 6Β·0% (5Β·0β7Β·0), and DALYs decreased by 36Β·0% (31Β·0β42Β·0). However, among people younger than 70 years, prevalence rates increased by 22Β·0% (21Β·0β24Β·0) and incidence rates increased by 15Β·0% (12Β·0β18Β·0). In 2019, the age-standardised stroke-related mortality rate was 3Β·6 (3Β·5β3Β·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3Β·7 (3Β·5β3Β·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62Β·4% of all incident strokes in 2019 (7Β·63 million [6Β·57β8Β·96]), while intracerebral haemorrhage constituted 27Β·9% (3Β·41 million [2Β·97β3Β·91]) and subarachnoid haemorrhage constituted 9Β·7% (1Β·18 million [1Β·01β1Β·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79Β·6 million [67Β·7β90Β·8] DALYs or 55Β·5% [48Β·2β62Β·0] of total stroke DALYs), high body-mass index (34Β·9 million [22Β·3β48Β·6] DALYs or 24Β·3% [15Β·7β33Β·2]), high fasting plasma glucose (28Β·9 million [19Β·8β41Β·5] DALYs or 20Β·2% [13Β·8β29Β·1]), ambient particulate matter pollution (28Β·7 million [23Β·4β33Β·4] DALYs or 20Β·1% [16Β·6β23Β·0]), and smoking (25Β·3 million [22Β·6β28Β·2] DALYs or 17Β·6% [16Β·4β19Β·0]).
Interpretation:
The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
Funding:
Bill & Melinda Gates Foundation
Mechanism of cellular rejection in transplantation
The explosion of new discoveries in the field of immunology has provided new insights into mechanisms that promote an immune response directed against a transplanted organ. Central to the allograft response are T lymphocytes. This review summarizes the current literature on allorecognition, costimulation, memory T cells, T cell migration, and their role in both acute and chronic graft destruction. An in depth understanding of the cellular mechanisms that result in both acute and chronic allograft rejection will provide new strategies and targeted therapeutics capable of inducing long-lasting, allograft-specific tolerance
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