Crystal electric field and possible coupling with phonons in Kondo lattice CeCuGa3

We investigate the magnetic and crystal electric field (CEF) states of the Kondo lattice system CeCuGa3 by muon spin relaxation (muSR), neutron diffraction, and inelastic neutron scattering (INS) measurements. A noncentrosymmetric BaNiSn3-type tetragonal crystal structure (space group I4mm) is inferred from x-ray as well as from neutron powder diffraction. The low-temperature magnetic susceptibility and heat capacity data show an anomaly near 2.3 - 2.5~K associated with long range magnetic ordering, which is further confirmed by muSR and neutron diffraction data. The neutron powder diffraction collected at 1.7 K shows the presence of magnetic Bragg peaks indexed by an incommensurate magnetic propagation vector k = (0.148, 0.148, 0) and the magnetic structure is best described by a longitudinal spin density wave with ordered moments lying in ab-plane. An analysis of the INS data based on a CEF model reveals the presence of two magnetic excitations near 4.5 meV and 6.9 meV. The magnetic heat capacity data suggest an overall CEF splitting of 20.7 meV, however the excitation between 20 and 30 meV is very broad and weak in our INS data, but could provide an evidence of CEF level in this energy range in agreement with the magnetic entropy. Our analysis of INS data based on the CEF-phonon model indicates that the two excitations at 4.5 meV and 6.9 meV have their origin in CEF-phonon coupling (i.e. splitting of one CEF peak into two peaks, called vibron), with an overall splitting of 28.16 meV, similar to the case of CeCuAl3 and CeAuAl3.Comment: 13 pages, 14 figure

A microscopic complex potential description of elastic, inelastic cross section in the Coulomb nuclear interference region in the 28Si on 28Si system

Elastic and inelastic angular distribution and excitation functions were measured for the 28Si + 28Si system in the vicinity of the Coulomb barrier. While the elastic data could be described very well by using fully microscopic complex potential, the inelastic cross sections were found to be more sensitive to small variations in the potential. In particular the Coulomb nuclear interference dip observed in the inelastic excitation functions could not be fitted satisfactorily with calculation. Inclusion of an energy dependent term of Gaussian shape to the associated matrix element with the reorientation coupling in the phenomenological calculations leads to a better fit the inelastic excitation functions. © 1998 Elsevier Science B.V

Effect of 3 p and 5 d electron doping on the Kondo Semiconductor CeFe2Al10

We examined the effect of 3p and 5d electron doping on the Kondo semiconductor CeFe2Al10 by means of the electrical resistivity amp; 961; , magnetic susceptibility amp; 967; , and specific heat C measurements. The results show that in the 3p electron doped system CeFe2Al10 amp; 8722;ySiy, the semiconducting behavior is suppressed for y 0.05, and the system adopts a metallic ground state with an increase in the density of states at the Fermi level. The Si substitution leads to a large decrease in the paramagnetic Weiss temperature amp; 952;P indicating a reduction in c f hybridization strength, however the Si does not induce magnetic order up to y 0.3 down to 2K. The systematic changes in amp; 961; T , amp; 967; T , and C T are similar to those for 5d electron doped system CeFe2 amp; 8722;xIrxAl10, although, Ir substitution induces a bulk antiferromagnetic transition below 3.1 K in CeFe1.7Ir0.3Al10. These changes can be explained by the collapse of the hybridization gap due to the suppression of the c f hybridization effect. Our results further confirm that the collapse of the spin charge gap by an excess electron doping is one of the universal features of the Kondo semiconductors CeT2Al10 T Fe, Ru, and O

Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation

Acute respiratory distress syndrome (ARDS) is a common and often fatal inflammatory lung condition without effective targeted therapies. Regulatory T cells (Tregs) resolve lung inflammation, but mechanisms that enhance Tregs to promote resolution of established damage remain unknown. DNA demethylation at the forkhead box protein 3 (Foxp3) locus and other key Treg loci typify the Treg lineage. To test how dynamic DNA demethylation affects lung injury resolution, we administered the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (DAC) to wild-type (WT) mice beginning 24 hours after intratracheal LPS-induced lung injury. Mice that received DAC exhibited accelerated resolution of their injury. Lung CD4+CD25hi Foxp3+ Tregs from D AC-treated WT mice increased in number and displayed enhanced Foxp3 expression, activation state, suppressive phenotype, and proliferative capacity. Lymphocyte-deficient recombinase activating gene-1-null mice and Treg-depleted (diphtheria toxin-treated Foxp3DTR) mice did not resolve their injury in response to DAC. Adoptive transfer of 2 ×105 DAC-treated, but not vehicle-treated, exogenous Tregs rescued Treg-deficient mice from ongoing lung inflammation. In addition, in WT mice with influenza-induced lung inflammation, DAC rescue treatment facilitated recovery of their injury and promoted an increase in lung Treg number. Thus, DNA methyltransferase inhibition, at least in part, augments Treg number and function to accelerate repair of experimental lung injury. Epigenetic pathways represent novel manipulable targets for the treatment of ARDS

Nonparametric Copula-Based Test for Conditional Independence with Applications to Granger Causality

This article proposes a new nonparametric test for conditional independence that can directly be applied to test for Granger causality. Based on the comparison of copula densities, the test is easy to implement because it does not involve a weighting function in the test statistic, and it can be applied in general settings since there is no restriction on the dimension of the time series data. In fact, to apply the test, only a bandwidth is needed for the nonparametric copula. We prove that the test statistic is asymptotically pivotal under the null hypothesis, establishes local power properties, and motivates the validity of the bootstrap technique that we use in finite sample settings. A simulation study illustrates the size and power properties of the test. We illustrate the practical relevance of our test by considering two empirical applications where we examine the Granger noncausality between financial variables. In a first application and contrary to the general findings in the literature, we provide evidence on two alternative mechanisms of nonlinear interaction between returns and volatilities: nonlinear leverage and volatility feedback effects. This can help better understand the well known asymmetric volatility phenomenon. In a second application, we investigate the Granger causality between stock index returns and trading volume. We find convincing evidence of linear and nonlinear feedback effects from stock returns to volume, but a weak evidence of nonlinear feedback effect from volume to stock returns

Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Additionally, we provide subnational disparity analyses to provide a comprehensive overview of anemia prevalence inequalities within these countries and predict progress toward the World Health Organization’s Global Nutrition Target (WHO GNT) to reduce anemia by half by 2030. Our results demonstrate widespread moderate improvements in overall anemia prevalence but identify only three LMICs with a high probability of achieving the WHO GNT by 2030 at a national scale, and no LMIC is expected to achieve the target in all their subnational administrative units. Our maps show where large within-country disparities occur, as well as areas likely to fall short of the WHO GNT, offering precision public health tools so that adequate resource allocation and subsequent interventions can be targeted to the most vulnerable populations.Peer reviewe

Measurement of the azimuthal anisotropy of Y(1S) and Y(2S) mesons in PbPb collisions at √S^{S}NN = 5.02 TeV

The second-order Fourier coefficients (υ$_{2}$) characterizing the azimuthal distributions of Υ(1S) and Υ(2S) mesons produced in PbPb collisions at $\sqrt{s_{NN}}$ = 5.02 TeV are studied. The Υmesons are reconstructed in their dimuon decay channel, as measured by the CMS detector. The collected data set corresponds to an integrated luminosity of 1.7 nb$^{-1}$. The scalar product method is used to extract the υ$_{2}$ coefficients of the azimuthal distributions. Results are reported for the rapidity range |y| < 2.4, in the transverse momentum interval 0 < p$_{T}$ < 50 GeV/c, and in three centrality ranges of 10–30%, 30–50% and 50–90%. In contrast to the J/ψ mesons, the measured υ$_{2}$ values for the Υ mesons are found to be consistent with zero