16 research outputs found
Phylogenetic congruence of lichenised fungi and algae is affected by spatial scale and taxonomic diversity
Spatial and temporal variations of nitrogen pollution in Wen-Rui Tang River watershed, Zhejiang, China
Do people living with HIV experience greater age advancement than their HIV-negative counterparts?
Objectives: Despite successful antiretroviral therapy, people living with HIV (PLWH)
may show signs of premature/accentuated aging. We compared established biomarkers
of aging in PLWH, appropriately chosen HIV-negative individuals, and blood donors,
and explored factors associated with biological age advancement.
Design: Cross-sectional analysis of 134 PLWH on suppressive antiretroviral therapy, 79
lifestyle-comparable HIV-negative controls aged 45 years or older from the Co-mor-
Bidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors.
Methods: Biological age was estimated using a validated algorithm based on 10
biomarkers. Associations between âage advancementâ (biological minus chronological
age) and HIV status/parameters, lifestyle, cytomegalovirus (CMV), hepatitis
B (HBV) and hepatitis C virus (HCV) infections were investigated using linear regression.
Results: The average (95% CI) age advancement was greater in both HIV-positive [13.2
(11.6â14.9) years] and HIV-negative [5.5 (3.8â7.2) years] COBRA participants compared
with blood donors [7.0 (4.1 to 9.9) years, both Pâs<0.001)], but also in HIV-positive
compared with HIV-negative participants (P<0.001). Chronic HBV, higher anti-CMV
IgG titer and CD8ĂŸ T-cell count were each associated with increased age advancement,
independently of HIV-status/group. Among HIV-positive participants, age
advancement was increased by 3.5 (0.1â6.8) years among those with nadir CD4ĂŸ
T-cell count less than 200 cells/ml and by 0.1 (0.06â0.2) years for each additional
month of exposure to saquinavir
Letter to the Editor Regarding Fleischer et al. Neurological Study Does Not Provide Any Evidence that Long COVID is Psychosomatic
Die Ăbersicht zur aktuellen Evidenz ignoriert die aktuelle Evidenz : Leserbrief
Leserbrief zu Ludwig B et al (2022) Myalgische Enzephalo-
myelitis/chronisches Fatigue-Syndrom: eine Ăbersicht zur aktuellen Evidenz. Nervenarzt.
https://doi.org/10.1007/s00115-022-01431-