75 research outputs found
Numerische Behandlung von Kaskadengleichungen zur schnellen Simulation höchstenergetischer Luftschauer
- Author
- Publication venue
- KIT-Bibliothek, Karlsruhe
- Publication date
- 01/01/2007
- Field of study
Von Teilchen der kosmischen Strahlung ausgelöste Luftschauer können mit Kaskadengleichungen beschrieben werden. Dies sind Systeme gekoppelter partieller Differentialgleichungen. In der vorliegenden Arbeit wird ein numerisches Lösungsverfahren für die elektromagnetische Kaskadengleichung entwickelt. Ziel ist die Beschleunigung der Berechnung der elektromagnetischen Schauerkomponente in Hybrid-Luftschauersimulationen. Die Ergebnisse werden mit parallel dazu entwickelten Monte-Carlo-Simulationen und der historischen Approximation A und B verifiziert. Das Monte-Carlo- und das numerische Verfahren werden dann in einem Hybrid-Verfahren miteinander kombiniert. Die numerischen Lösungen werden abschließend mit CORSIKA-Simulationsrechnungen und Auger-Daten verglichen, und es wird eine Rechenzeitanalyse der verschiedenen Methoden durchgeführt
Numerische Behandlung von Kaskadengleichungen zur schnellen Simulation höchstenergetischer Luftschauer
- Author
- Publication venue
- KIT-Bibliothek, Karlsruhe
- Publication date
- 01/01/2007
- Field of study
Von Teilchen der kosmischen Strahlung ausgelöste Luftschauer können mit Kaskadengleichungen beschrieben werden. Dies sind Systeme gekoppelter partieller Differentialgleichungen. In der vorliegenden Arbeit wird ein numerisches Lösungsverfahren für die elektromagnetische Kaskadengleichung entwickelt. Ziel ist die Beschleunigung der Berechnung der elektromagnetischen Schauerkomponente in Hybrid-Luftschauersimulationen. Die Ergebnisse werden mit parallel dazu entwickelten Monte-Carlo-Simulationen und der historischen Approximation A und B verifiziert. Das Monte-Carlo- und das numerische Verfahren werden dann in einem Hybrid-Verfahren miteinander kombiniert. Die numerischen Lösungen werden abschließend mit CORSIKA-Simulationsrechnungen und Auger-Daten verglichen, und es wird eine Rechenzeitanalyse der verschiedenen Methoden durchgeführt
A Time-Saving Approach to Parameter Studies in Microwave-Assisted Freeze Drying
- Publication venue
- MDPI
- Publication date
- 13/11/2023
- Field of study
Microwave-assisted freeze drying (MFD) is particularly suited for drying heat-sensitive materials. However, optimizing process parameters is time-consuming due to lengthy individual experiments. This study investigates the feasibility of partial MFD for parameter studies, with the process being terminated after removing 20 wt% of the water contained. The proposed approach reduces the time required for parameter evaluation by 92.0% compared to complete MFD. It also enables the evaluation of the samples’ drying homogeneity. A subsequent parameter study based on partial MFD was then conducted to evaluate the effects of chamber pressure, microwave power, and microwave frequencies on the drying kinetics and drying homogeneity. Lowering the average chamber pressure from 0.87 mbar to 0.19 mbar reduced the process duration by 18.8%. An increase in the dissipated specific microwave power from 0.048 W/g to 0.143 W/g reduced the duration by 46.7%. The targeted application of frequencies increased the average energy efficiency to as high as 92.4%, contributing to a shortened process duration of up to 51.2%. Only the application of multiple frequencies caused a notable increase in drying homogeneity. In summary, this study demonstrates the feasibility and time-saving benefits of partial drying for parameter studies in MFD and potentially different types of drying processes
Electrical steel stacks for traction motors - fundamental investigations on the weldability
- Publication venue
- Publication date
- 04/12/2014
- Field of study
Identification of Y-Box Binding Protein 1 As a Core Regulator of MEK/ERK Pathway-Dependent Gene Signatures in Colorectal Cancer Cells
- Author
- A Astanehe
- A Farina
- A Testa
- A Walther
- AE Karnoub
- AH Bild
- AL Stratford
- AS Adler
- AS Ulkü
- B Weigelt
- BW Sutherland
- C Gessner
- C Lee
- C Sotiriou
- Christian Friese
- Christine Sers
- DR Marenstein
- DT Dudley
- ER Fearon
- H Chen
- H Davies
- H Linardou
- Hans-Dieter Royer
- Hanspeter Herzel
- I Manni
- IM Berquin
- J Downward
- J Fritzmann
- J Gayet
- J Zuber
- JL Duh
- Johannes Fritzmann
- JT Chang
- JW Tullai
- JW Tullai
- K Jurchott
- K Kohno
- K Shibahara
- K Shibao
- Karsten Jürchott
- KS Katula
- KW Kinzler
- LS Coles
- LT Therneau T
- M Chatterjee
- M Janz
- M Malumbres
- M Wasner
- Markus Morkel
- MF Favata
- MR Finkbeiner
- N Blüthgen
- N Blüthgen
- N Blüthgen
- N Blüthgen
- N Mitin
- N Osherov
- Nils Blüthgen
- NM Hamad
- OI Tchernitsa
- P Giménez-Bonafé
- Per Lund
- Peter M. Schlag
- PL Rice
- R Blum
- R Blum
- R Brem
- R Mantovani
- R Tibshirani
- Ralf-Jürgen Kuban
- RC Bargou
- Reinhold Schäfer
- S Bergmann
- S Rahmann
- S Shirasawa
- Silke Sperling
- SK Swamynathan
- Szymon M. Kiełbasa
- T Kamura
- T Knösel
- T Ohga
- Tammo Krueger
- Thomas Knösel
- Till Krech
- TJP Hubbard
- TP Pretlow
- U Stein
- Ulrike Stein
- Ute Ungethüm
- V Evdokimova
- V Evdokimova
- V Matys
- VG Tusher
- Vivian G. Cheung
- VR Iyer
- W Huber
- Walter Birchmeier
- Wolfgang Kemmner
- Wolfgang Walther
- X Huang
- Y Basaki
- Y Oda
- ZH Lu
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Transcriptional signatures are an indispensible source of correlative information on disease-related molecular alterations on a genome-wide level. Numerous candidate genes involved in disease and in factors of predictive, as well as of prognostic, value have been deduced from such molecular portraits, e.g. in cancer. However, mechanistic insights into the regulatory principles governing global transcriptional changes are lagging behind extensive compilations of deregulated genes. To identify regulators of transcriptome alterations, we used an integrated approach combining transcriptional profiling of colorectal cancer cell lines treated with inhibitors targeting the receptor tyrosine kinase (RTK)/RAS/mitogen-activated protein kinase pathway, computational prediction of regulatory elements in promoters of co-regulated genes, chromatin-based and functional cellular assays. We identified commonly co-regulated, proliferation-associated target genes that respond to the MAPK pathway. We recognized E2F and NFY transcription factor binding sites as prevalent motifs in those pathway-responsive genes and confirmed the predicted regulatory role of Y-box binding protein 1 (YBX1) by reporter gene, gel shift, and chromatin immunoprecipitation assays. We also validated the MAPK-dependent gene signature in colorectal cancers and provided evidence for the association of YBX1 with poor prognosis in colorectal cancer patients. This suggests that MEK/ERK-dependent, YBX1-regulated target genes are involved in executing malignant properties
Effects of conditioning hops on drop jump and sprint performance: a randomized crossover pilot study in elite athletes
- Author
- A Arampatzis
- A Kramer
- A Kramer
- A Smirniotou
- AT Zuur
- C Tsolakis
- C Tsolakis
- CT Farley
- CT Farley
- DN French
- DP Tobin
- DV Knudson
- ESS Villarreal De
- G Terzis
- G Terzis
- J Bergmann
- J Bergmann
- J McBride
- JB Cronin
- JD Macdougall
- JI Esformes
- KA Till
- KR Weber
- LZF Chiu
- M Hodgson
- M Kale
- M Lesinski
- M Pääsuke
- M Walsh
- MNA Tillin
- N Masamoto
- O Donti
- PE Shrout
- PJ Read
- PV Komi
- R Hilfiker
- R Rahimi
- RL Jensen
- S Fukashiro
- S Margaritopoulos
- T Hamada
- T Hamada
- WB Young
- Z-R Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
- Author
- Abecasis Goncalo R.
- Ahluwalia Tarunveer S.
- Albrecht Eva
- Bakker Stephan J. L.
- Barlassina Cristina
- Bartz Traci M.
- Beilby John
- Bellis Claire
- Bergman Richard N.
- Bergmann Sven
- Blangero John
- Blüher Matthias
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Bouchard Claude
- Bragg-Gresham Jennifer L.
- Bruinenberg Marcel
- Cadby Gemma
- Campbell Harry
- Carola Zillikens
- Chambers John C.
- Chasman Daniel I.
- Chen Yii-Der Ida
- Chiang Charleston W. K.
- Chines Peter S.
- Chu Audrey Y.
- Collins Francis S
- Couto Alves Alexessander
- Cucca Fracensco
- Cupples L Adrienne
- Cusi Daniele
- D'avila Francesca
- De Geus Eco J.C.
- Dedoussis George
- Deloukas Panos
- Dimitriou Maria
- Döring Angela
- Eklund Niina
- Eriksson Joel
- Eriksson Johan G.
- Esko Toñu
- Farmaki Aliki-Eleni
- Farrall Martin
- Feitosa Mary F.
- Ferreira Teresa
- Fischer Krista
- Forouhi Nita G.
- Fox Caroline
- Frayling Timothy
- Friedrich Nele
- Gansevoort Ron T.
- Gieger Christian
- Gjesing Anette Prior
- Glorioso Nicola
- Goel Anuj
- Gorski Mathias
- Graff Mariaelisa
- Grallert Harald
- Grarup Niels
- Grewal Jagvir
- Groop Leif C.
- Gräßler Jürgen
- Hamsten Anders
- Hansen Torben
- Harder Marie Neergaard
- Hartman Catharina A.
- Hassinen Maija
- Hastie Nicholas
- Hattersley Andrew Tym
- Havulinna Aki S.
- Hayward Caroline
- Heard-Costa Nancy L.
- Heid Iris M.
- Heliövaara Markku
- Hicks Andrew A.
- Hillege Hans
- Hirschhorn Joel N.
- Hofman Albert
- Holmen Oddgeir
- Homuth Georg
- Hottenga Jouke-Jan
- Hu Frank
- Huffman Jennifer E.
- Hui Jennie
- Hunter David J.
- Husemoen Lise Lotte
- Hveem Kristian
- Hysi Pirro G.
- Isaacs Aaron
- Ittermann Till
- Jackson Anne U.
- Jalilzadeh Shapour
- James Alan L.
- Jarvelin Marjo-Riitta
- Jeff Janina M.
- Jokinen Eero
- Jousilahti Pekka
- Ju Sung Yun
- Jula Antti
- Justice Anne E.
- Jørgensen Torben
- Kajantie Eero
- Kanoni Stavroula
- Kaplan Robert C.
- Karaleftheri Maria
- Keinanen-Kiukaanniemi Sirkka M.
- Kinnunen Leena
- Knekt Paul B.
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Ishminder K.
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kristiansson Kati
- Kuh Diana
- Kutalik Zoltán
- Kuusisto Johanna
- Kyriakou Theodosios
- Kähönen Mika
- Laakso Markku
- Lahti Jari
- Laitinen Tomi
- Lakka Timo A.
- Langenberg Claudia
- Leach Irene Mateo
- Lehtimäki Terho
- Lewin Alexandra M.
- Lichtner Peter
- Lindgren Cecilia M.
- Lindström Jaana
- Linneberg Allan
- Loos Ruth J. F.
- Lorbeer Roberto
- Lorentzon Mattias
- Luan Jian'an
- Luben Robert
- Lyssenko Valeriya
- Mahajan Anubha
- Mangino Massimo
- Manunta Paolo
- Marie Justesen Johanne
- Mcardle Wendy L.
- Mccarthy Mark I.
- Mcknight Barbara
- Medina-Gomez Carolina
- Metspalu Andres
- Mihailov Evelin
- Milani Lili
- Mills Rebecca
- Mohlke Karen L.
- Monda Keri L.
- Montasser May E.
- Morris Andrew P.
- Musk Arthur W.
- Mägi Reedik
- Männistö Satu
- Müller Gabriele
- Müller-Nurasyid Martina
- Narisu Narisu
- Njølstad Inger
- Nolte Ilja M.
- North Kari E.
- O'connell Jeffrey R.
- Ohlsson Claes
- Oldehinkel Albertine J.
- Ong Ken K.
- Oostra Ben A.
- Osmond Clive
- Palmer Lyle J.
- Palotie Aarno
- Pankow James S.
- Paternoster Lavinia
- Pedersen Oluf
- Penninx Brenda W.
- Perola Markus
- Peters Annette
- Pichler Irene
- Pilia Maria G.
- Polašek Ozren
- Pramstaller Peter P.
- Prokopenko Inga
- Psaty Bruce M.
- Puolijoki Hannu
- Pérusse Louis
- Qi Lu
- Raitakari Olli T
- Rankinen Tuomo
- Rao
- Rauramaa Rainer
- Rayner Nigel W.
- Ribel-Madsen Rasmus
- Rice Treva K.
- Richards Marcus
- Ridker Paul M.
- Ried Janina S.
- Rivadeneira Fernando
- Rose Lynda M.
- Rudan Igor
- Ryan Kathy A.
- Salomaa Veikko
- Salvi Erika
- Sanna Serena
- Sarzynski Mark A.
- Schlessinger David
- Scholtens Salome
- Schwarz Peter E. H.
- Scott Robert A.
- Sebert Sylvain
- Shudiner Alan R.
- Smit Jan H.
- Smith Megan T.
- Snieder Harold
- Southam Lorraine
- Sparsø Thomas Hempel
- Spector Timothy D.
- Standáková Alena
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stirrups Kathleen
- Stolk Ronald P.
- Strachan David P.
- Strauch Konstantin
- Stringham Heather M.
- Stumvoll Michael
- Swertz Morris A.
- Swift Amy J.
- Sørensen Thorkild I. A.
- Tachmazidou Ioanna
- Tee Khaw Kay
- Teumer Alexander
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tremblay Angelo
- Tsafantakis Emmanouil
- Tuomilehto Jaakko
- Tönjes Anke
- Uitterlinden André G.
- Uusitupa Matti
- Van Der Harst Pim
- Van Der Most Peter J.
- Van Dongen Jenny
- Van Duijn Cornelia M.
- Van Vliet-Ostaptchouk Jana V.
- Vandenput Liesbeth
- Vartiainen Erkki
- Venturini Cristina
- Verweij Niek
- Viikari Jorma S.
- Vitart Veronique
- Vohl Marie-Claude
- Vollenweider Peter
- Vonk Judith M.
- Völker Uwe
- Waeber Gérard
- Walker Ryan W.
- Wang Sophie R.
- Wareham Nicholas J.
- Watkins Hugh
- Widén Elisabeth
- Wild Sarah H.
- Willems Sara M.
- Willemsen Gonneke
- Wilsgaard Tom
- Wilson James F.
- Winkler Thomas W.
- Wong Andrew
- Wright Alan F.
- Yerges-Armstrong Laura M.
- Zeggini Eleftheria
- Zhang Weihua
- Zhao Jing Hua
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
- Dehghan Abbas
- Delgado Graciela
- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
- Duncan Emma L
- Dupuis Josee
- Dupuis Josée
- Durbin Richard
- Durda Peter
- Döring Angela
- Dörr Marcus
- Eastell Richard
- Easton Douglas F
- Ebrahim Shah
- Econs Michael J
- Edkins Sarah
- Egan Josephine
- Ehret Georg
- Eiriksdottir Gudny
- Eisman John A
- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
- Epstein Stephen E
- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
- Eriksson Joel
- Eriksson Johan
- Eriksson Niclas
- Eriksson Per
- Ernst Florian
- Esko Tonu
- Esko Tõnu
- Esko Tönu
- Estrada Karol
- Eury Elodie
- Evangelou Evangelos
- Evans Alun
- Evans David M
- Eyheramendy Susana
- Eyjolfsson Gudmundur Ingi
- Fagerholm Emma
- Falhammar Henrik
- Fall Tove
- Farrall Martin
- Fauser Bart C J M
- Fava Cristiano
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary
- Feranil Alan B
- Ferrannini Ele
- Ferrario Marco M
- Ferreira Teresa
- Ferreli Liana
- Ferrières Jean
- Ferrucci Luigi
- Fischer Krista
- Florez Jose C
- Folkersen Lasse
- Folsom Aaron R
- Fontanillas Pierre
- Ford Ian
- Fornage Myriam
- Foroud Tatiana
- Forouhi Nita G
- Forrester Terrence
- Forsblom Carol
- Foster Meredith C
- Fowke Jay
- Fowkes F Gerald R
- Fowkes Gerard R
- Fox Caroline S
- Fox Ervin R
- Franceschini Nora
- Franco Oscar H
- Franco-Cereceda Anders
- Franke Andre
- Franke Lude
- Franks Paul W
- Frants Rune
- Fraser Ross M
- Frayling Timothy M
- Freedman Barry I
- Freimer Nelson B
- Freitag Daniel F
- Friedrich Nele
- Froguel Philippe
- Frost Morten
- Fuchsberger Christian
- Galan Pilar
- Ganesh Santhi K
- Ganna Andrea
- Gansevoort Ron T
- Gao Xiaoyi
- Garcia Melissa
- Garcia-Giralt Natàlia
- Garnaas Maija
- Gasparini Paolo
- Gauguier Dominique
- Gaunt Tom R
- Gautvik Kaare M
- Geller Frank
- Gharavi Ali G
- Giedraitis Vilmantas
- Gieger Christian
- Gierman Hinco J
- Gigante Bruna
- Gill Geoffrey V
- Giroux Sylvie
- Giulianini Franco
- Glass Daniel
- Glazer Nicole
- Glazer Nicole L
- Glenn Kim
- Glorioso Nicola
- Go Alan S
- Go Min Jin
- Godson Catherine
- Goel Anuj
- Goessling Wolfram
- Golay Alain
- Goldstein Benjamin A
- Goltzman David
- Gong Jian
- González-Macías Jesús
- Goodall Alison H
- Goodarzi Mark O
- Goodloe Robert
- Gordin Daniel
- Gordon Scott D
- Gorski Mathias
- Grabe Hans-Jörgen
- Graff Misa
- Grallert Harald
- Grammer Tanja B
- Gravito Martha L
- Greenwood Celia M T
- Grewal Jagvir
- Grimsby Jonna
- Grobbee Diederick E
- Groop Leif
- Groop Per-Henrik
- Gross Myron
- Groves Christopher J
- Grundberg Elin
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- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
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- Adamopoulos IE
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
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- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
- …