Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc

The development of professional guidelines for the eye examination of people with dementia

Recently published guidelines��in the UK��relating to sight tests among people with dementia go some of the way to addressing the specific needs of this group. However, there is still a long way to go in terms of improving the provision of eye care services and optimising the visual health of this group.A��study, published by the Thomas Pocklington Trust,��which examines this subject - The development of professional guidelines for the eye examination of people with dementia - was presented at the first ever national “Dementia and Sight Loss conference” in London (1st December) - a forum where 100 dementia and sight loss professionals met to discuss ways to tackle the challenge of concurrent dementia and sight loss. The study, by researchers at the University of Bradford Schools of Optometry and Health Studies, reviewed procedures for sight tests and eye examinations among those with dementia. It found that policy and practice were hampered by a serious lack of basic research into concurrent dementia and sight loss and prompted recommendations which could lead to improved procedures, tools and techniques.Recommendations prompted by the study outline seven steps towards improving policy and practice:Conduct a systematic study of the availability and uptake of sight tests among people with dementia. Set up a website for people with dementia and their carers with information on how dementia affects eye health, and the importance of eye examinations. Develop education and training for optometrists and care home staff. Compile a list of optometrists experienced in providing eye care for people with dementia. Develop a template for recording the results of eye examinations in people with dementia – something which can be endorsed by professional bodies and made available to care homes. Measure the effectiveness of eye care, such as sight tests and cataract removals, on the quality of life of people with dementia. Research clinical testing methods so that guidelines can be strengthened. Measuring contrast sensitivity, for example, in someone with dementia could be vital as an inability to judge contrasts can make daily tasks impossible.To access the discussion paper please follow this link: The development of professional guidelines for the eye examination of people with dementia �

Meeting the Needs of Visually Impaired People Living in Lifetime Homes

This article explores perceptions on the suitability and effectiveness of Lifetime Homes standards (LTHS) for those with visual impairment in Northern Ireland. LTHS are a series of mandatory United Kingdom public-sector housing design interventions, providing a model for ensuring accessible and adaptable homes throughout an occupant’s life span. An aging demographic with increasing incidence of diabetes has led to rising numbers of elderly, visually impaired people wanting to remain in their homes for longer. Qualitative semi-structured interviews were conducted with 13 key stakeholders and thematically analyzed. Although findings show that employing LTHS offers benefits to visually impaired residents, shortcomings were also identified. Evidence indicates a need for policy makers, health-care professionals, and housing associations to modify practices to better meet the housing needs of visually impaired people. Findings may also be applicable to those with other impairments and disabilities in relation to housing for elderly residents

Long-term access to support for people with sight loss

The impact of sight loss on everyday life changes over time, through further deterioration of vision, as well as a result of other physical changes and key events in people’s lives. As such, even the support needs of people with relatively stable visual impairment are likely to change throughout their life course. This article explores the long-term support needs of people with sight loss and the barriers they face when accessing services over time and at the time of need. Data from biographical interviews with 36 participants with sight loss is presented, with particular focus upon three illustrative case studies. The study reveals that many participants experienced problems gaining information about, and access to, services in the short and longer term. There is a need for systematic referral from clinical services to social and voluntary services and for regular follow-up to identify and respond to people’s changing needs

The 'Choice and Autonomy Framework' : implications for occupational therapy practice

Introduction This paper presents findings from a PhD study exploring autonomy of adults with physical disability. The plethora of descriptions of autonomy in psychological, occupational therapy and rehabilitation literature (e.g. Ryan and Deci 2000, Rogers 1982, Cardol et al 2002) detracts from the centrality of autonomy and results in difficulty incorporating it into occupational therapy practice. This paper presents a framework providing an integrated, clinically useful approach to autonomy. Methods Sixteen people were recruited, based on age, gender, impairment and living circumstances (community/residential settings). All have significant physical disability, use a wheelchair and require personal assistance for some/all self-care activities. Qualitative methods were used for data collection, including life-history narrative, diary information and extensive interview. An integrated method of analysis was used, including content analysis and bracketing. Results The ‘Choice and Autonomy Framework’ consists of five strands, including: • the meaning of autonomy • whether or not autonomy is a goal or value • the experience of autonomy • personality factors that impact autonomy • environmental features that enhance or negate autonomy. This paper will describe each strand, as derived from the research. The results suggest that, contrary to common wisdom (Hmel and Pincus 2002), autonomy is not necessarily a universal goal for people with physical disability; an understanding of the person’s own perspective will enhance person-centred practice and enable therapists to further recognise individuality of clients. It will argue that the concept of autonomy needs to be further understood and incorporated into occupational therapy practice

Литература о Свердловской области: [указатель]. 1954. Вып. 3-4

0|5|Предисловие [c. 5]0|6|Схема классификации летописи литературы о Свердловской области [c. 6]0|9|Коммунистическая партия Советского Союза [c. 9]1|9|Партийное строительство. Руководство партии хозяйственным и культурным строительством [c. 9]1|15|Пропаганда и агитация. Партийное просвещение [c. 15]1|17|История Коммунистической партии Советского Союза [c. 17]0|18|ВЛКСМ. [c. 18]0|21|Пионерские организации и внешкольная работа [c. 21]0|22|История гор. Свердловска и Свердловской области [c. 22]0|23|Социалистическое строительство в Свердловской области [c. 23]0|23|Финансы [c. 23]0|24|Труд [c. 24]1|26|Профессиональные союзы [c. 26]1|27|Социалистическое соревнование. Общие материалы [c. 27]1|28|Соревнование городов [c. 28]0|28|Советское строительство [c. 28]1|28|Выборы в Верховный Совет РСФСР [c. 28]1|28|Местные органы государственной власти [c. 28]1|29|Органы юстиции. Суд и прокуратура [c. 29]0|31|Природа Свердловской области [c. 31]1|31|Геология. Палеонтология. Археология [c. 31]1|32|География [c. 32]1|32|Животный и растительный мир [c. 32]0|32|Техника. Промышленность [c. 32]1|32|История техники и промышленности [c. 32]1|33|Общие вопросы [c. 33]1|34|Производство предметов народного потребления [c. 34]1|35|Строительство. Строительные материалы. Строительная промышленность [c. 35]1|35|Строительство заводов железобетонных изделий [c. 35]1|40|Энергетическая промышленность [c. 40]1|41|Горная промышленность [c. 41]1|44|Металлургическая промышленность [c. 44]1|51|Машиностроительная промышленность [c. 51]1|57|Химическая промышленность [c. 57]1|58|Лесная промышленность [c. 58]1|60|Легкая промышленность [c. 60]1|60|Камнерезное дело [c. 60]1|61|Местная и кооперативная промышленность [c. 61]0|62|Транспорт. Связь [c. 62]1|62|Транспорт [c. 62]1|65|Связь [c. 65]0|65|Сельское хозяйство [c. 65]1|65|Свердловская область на сельскохозяйственной выставке [c. 65]1|69|Трудящиеся города — сельскому хозяйству [c. 69]1|70|Общие вопросы. Колхозы. Совхозы [c. 70]1|72|Освоение целинных и залежных земель [c. 72]1|73|Механизация. Электрификация. МТС [c. 73]1|77|Агротехника. Общее растениеводство. Почвоведение [c. 77]1|79|Частное растениеводство [c. 79]2|79|Зерновые и бобовые культуры [c. 79]2|79|Кормовые культуры . Луга. Пастбища [c. 79]2|79|Садоводство. Плодоводство [c. 79]2|80|Овощеводство [c. 80]1|82|Животноводство [c. 82]0|86|Охота. Рыбоводство [c. 86]0|86|Торговля. Общественное питание [c. 86]0|89|Гражданское строительство. Коммунальное хозяйство. Бытовое обслуживание населения [c. 89]0|91|Здравоохранение. Медицина [c. 91]0|92|Физическая культура. Спорт. Игры [c. 92]0|94|Культура. Просвещение. Наука [c. 94]1|94|Общие вопросы культуры и просвещения. Наука [c. 94]1|95|Семья и быт [c. 95]1|96|Дошкольное воспитание [c. 96]1|96|Начальное и среднее образование [c. 96]1|98|Политехническое обучение в школах [c. 98]1|98|Высшее и среднее специальное образование [c. 98]1|101|Ремесленные училища. Фабрично-заводское обучение. Технические училища [c. 101]1|102|Культурно-просветительная работа [c. 102]0|105|Литературоведение. Художественная литература. Фольклор [c. 105]1|105|Литературная критика и библиография [c. 105]1|107|Художественная литература [c. 107]2|107|Проза [c. 107]2|108|Поэзия [c. 108]2|109|Драматургия [c. 109]2|109|Фельетоны [c. 109]0|111|Искусство [c. 111]1|111|Архитектура [c. 111]1|111|Изобразительное искусство [c. 111]1|112|Театр. Зрелищные предприятия [c. 112]1|114|Музыка [c. 114]1|114|Художественная самодеятельность [c. 114]1|115|Кино [c. 115]1|115|Религия. Наука и религия. Атеизм [c. 115]1|116|Печать [c. 116

Biological insights from 108 schizophrenia-associated genetic loci

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia