Mining at the Fringes. High-Altitude Prehistoric Copper Mining in the Oberhalbstein Valley (Grisons, Switzerland)

The mining region of Oberhalbstein, to date sparsely studied, has been the subject of archaeological research since 2013. Two mining areas which lie well above the forest line were studied in the summer of 2017. The Avagna-Ochsenalp site includes multi-phased heap features, of which the earliest phase has been dendrochronologically dated to the 11th century BC. In Cotschens, mining traces in an area of approximately 0.1 km2 from an unknown time period have been observed. Here, the flooded mine 1 was studied in more detail. After the cavity had been drained, 66 wood objects were revealed, including mining tools from the 1st century BC. 14C dating further confirms Late Bronze Age and Early to Late Iron Age activity. Stone tools from the adjacent heap also confirm prehistoric on-site ore processing, a unique find so far in the Oberhalbstein region

Chemical analysis of pottery demonstrates prehistoric origin for high-altitude alpine dairying

The European high Alps are internationally renowned for their dairy produce, which are of huge cultural and economic significance to the region. Although the recent history of alpine dairying has been well studied, virtually nothing is known regarding the origins of this practice. This is due to poor preservation of high altitude archaeological sites and the ephemeral nature of transhumance economic practices. Archaeologists have suggested that stone structures that appear around 3,000 years ago are associated with more intense seasonal occupation of the high Alps and perhaps the establishment of new economic strategies. Here, we report on organic residue analysis of small fragments of pottery sherds that are occasionally preserved both at these sites and earlier prehistoric rock-shelters. Based mainly on isotopic criteria, dairy lipids could only be identified on ceramics from the stone structures, which date to the Iron Age (ca. 3,000 - 2,500 BP), providing the earliest evidence of this practice in the high Alps. Dairy production in such a marginal environment implies a high degree of risk even by today’s standards. We postulate that this practice was driven by population increase and climate deterioration that put pressure on lowland agropastoral systems and the establishment of more extensive trade networks, leading to greater demand for highly nutritious and transportable dairy products

Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay

Candida albicans, the most common human pathogenic fungus, can establish a persistent lethal infection in the intestine of the microscopic nematode Caenorhabditis elegans. The C. elegans–C. albicans infection model was previously adapted to screen for antifungal compounds. Modifications to this screen have been made to facilitate a high-throughput assay including co-inoculation of nematodes with C. albicans and instrumentation allowing precise dispensing of worms into assay wells, eliminating two labor-intensive steps. This high-throughput method was utilized to screen a library of 3,228 compounds represented by 1,948 bioactive compounds and 1,280 small molecules derived via diversity-oriented synthesis. Nineteen compounds were identified that conferred an increase in C. elegans survival, including most known antifungal compounds within the chemical library. In addition to seven clinically used antifungal compounds, twelve compounds were identified which are not primarily used as antifungal agents, including three immunosuppressive drugs. This assay also allowed the assessment of the relative minimal inhibitory concentration, the effective concentration in vivo, and the toxicity of the compound in a single assay

Design of analog front-ends for the RD53 demonstrator chip

The RD53 collaboration is developing a large scale pixel front-end chip, which will be a tool to evaluate the performance of 65 nm CMOS technology in view of its application to the readout of the innermost detector layers of ATLAS and CMS at the HL-LHC. Experimental results of the characterization of small prototypes will be discussed in the frame of the design work that is currently leading to the development of the large scale demonstrator chip RD53A to be submitted in early 2017. The paper is focused on the analog processors developed in the framework of the RD53 collaboration, including three time over threshold front-ends, designed by INFN Torino and Pavia, University of Bergamo and LBNL and a zero dead time front-end based on flash ADC designed by a joint collaboration between the Fermilab and INFN. The paper will also discuss the radiation tolerance features of the front-end channels, which were exposed to up to 800 Mrad of total ionizing dose to reproduce the system operation in the actual experiment

Linguistic Naturalism and Natural Style. From Varro and Cicero to Dionysius of Halicarnassus

NWO276-30-009Classics and Classical Civilizatio

A Prehistoric Rock Crystal Procurement Site at Fiescheralp (Valais, Switzerland)

Rock crystal is among the most fascinating materials in the archaeological record. It is formed in alpine-type fissures by hydrothermal processes. Due to its physical properties, rock crystal has been a valuable resource throughout human history. In alpine regions, it was frequently used for the production of stone tools between the Mesolithic and the Bronze Age. However, there are only a handful of known prehistoric crystal quartz quarries in Europe. The following article presents evidence for rock crystal mining during the Early Mesolithic and the final stage of the Neolithic at a high-altitude site in the Canton of Valais, Switzerland. In combination with radiocarbon dates from previous studies, the results of our fieldwork indicate that in the Swiss Alps rock crystal was mined almost 10,000 years ago. Furthermore, typo-technological analyses provide new insights into the way in which the raw material was processed during the represented time periods