182 research outputs found
The On-Orbit Performance of the Galaxy Evolution Explorer
- Author
- Alan Mazer
- Alex S. Szalay
- Amit Sen
- Arthur Vaughan
- Barry F. Madore
- Barry Y. Welsh
- Brian Blakkolb
- Brian Cooke
- Bruno Milliard
- D. Christopher Martin
- Dankai Liu
- David Randall
- David Schiminovich
- Frank Surber
- Hog E.
- James Fanson
- Jose Donas
- Karl Forster
- Kerry Erickson
- Luciana Bianchi
- Maurice Viton
- Oswald H. W. Siegmund
- Patrick Morrissey
- Patrick N. Jelinsky
- Peter G. Friedman
- R. Michael Rich
- Robert Grange
- Roger F. Malina
- Ryan McLean
- Siu-Chun Lee
- Susan G. Neff
- Ted K. Wyder
- Tim Conrow
- Timothy M. Heckman
- Todd Small
- Tom A. Barlow
- Wes Schmitigal
- Yong-Ik Byun
- Young-Wook Lee
- Publication venue
- 'University of Chicago Press'
- Publication date
- 11/11/2004
- Field of study
We report the first year on-orbit performance results for the Galaxy
Evolution Explorer (GALEX), a NASA Small Explorer that is performing a survey
of the sky in two ultraviolet bands. The instrument comprises a 50 cm diameter
modified Ritchey-Chretien telescope with a 1.25 degree field of view,
selectable imaging and objective grism spectroscopic modes, and an innovative
optical system with a thin-film multilayer dichroic beam splitter that enables
simultaneous imaging by a pair of photon counting, microchannel plate, delay
line readout detectors. Initial measurements demonstrate that GALEX is
performing well, meeting its requirements for resolution, efficiency,
astrometry, bandpass definition and survey sensitivity.Comment: This paper will be published as part of the Galaxy Evolution Explorer
(GALEX) Astrophysical Journal Letters Special Issu
Fluid flow in the osteocyte mechanical environment : a fluid-structure interaction approach
- Author
- A Rath Bonivtch
- A Sittichockechaiwut
- A Vatsa
- AD Bakker
- AFT Mak
- C Price
- D Deligianni
- DB Burr
- E Anderson
- E Anderson
- EH Burger
- EJ Anderson
- EM Darling
- FP Ross
- G Goulet
- G Ofek
- H Kamioka
- I Owan
- I Westbroek
- J Clover
- J Klein-Nulend
- J McGarry
- J Sodek
- J You
- JP McGarry
- JT Cheng
- K Piekarski
- K Tanaka-Kamioka
- L Wang
- L Wang
- Laoise M. McNamara
- LE Lanyon
- LM McNamara
- M Noda
- MA Biot
- MA Biot
- MD McKee
- ME Taylor
- ML Knothe Tate
- ML Knothe Tate
- ML Knothe Tate
- ML Knothe Tate
- N Chatterjee
- NE Ajubi
- P Manfredini
- R Smalt
- R Steck
- RE Devoll
- RG Bacabac
- RG Bacabac
- S Gururaja
- S Huang
- S Weinbaum
- SP Fritton
- Stefaan W. Verbruggen
- T Adachi
- Ted J. Vaughan
- TJ Vaughan
- TP Appelman
- VW Engleman
- W Ronan
- Y Han
- Y Sugawara
- Y Wang
- Y Zeng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Osteocytes are believed to be the primary sensor of mechanical stimuli in bone, which orchestrate osteoblasts and osteoclasts to adapt bone structure and composition to meet physiological loading demands. Experimental studies to quantify the mechanical environment surrounding bone cells are challenging, and as such, computational and theoretical approaches have modelled either the solid or fluid environment of osteocytes to predict how these cells are stimulated in vivo. Osteocytes are an elastic cellular structure that deforms in response to the external fluid flow imposed by mechanical loading. This represents a most challenging multi-physics problem in which fluid and solid domains interact, and as such, no previous study has accounted for this complex behaviour. The objective of this study is to employ fluid–structure interaction (FSI) modelling to investigate the complex mechanical environment of osteocytes in vivo. Fluorescent staining of osteocytes was performed in order to visualise their native environment and develop geometrically accurate models of the osteocyte in vivo. By simulating loading levels representative of vigorous physiological activity (3,000με compression and 300 Pa pressure gradient), we predict average interstitial fluid velocities (∼60.5μ m/s ) and average maximum shear stresses (∼11 Pa ) surrounding osteocytes in vivo. Interestingly, these values occur in the canaliculi around the osteocyte cell processes and are within the range of stimuli known to stimulate osteogenic responses by osteoblastic cells in vitro. Significantly our results suggest that the greatest mechanical stimulation of the osteocyte occurs in the cell processes, which, cell culture studies have indicated, is the most mechanosensitive area of the cell. These are the first computational FSI models to simulate the complex multi-physics mechanical environment of osteocyte in vivo and provide a deeper understanding of bone mechanobiology
The HLA–DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture
- Author
- Alarcón Graciela S.
- Bridges S. Louis
- Callahan Leigh F.
- Conn Doyt L.
- Dwivedi Harshit
- Gilkeson Gary S.
- Holers V. Michael
- Howard George
- Hughes Laura B.
- Jonas Beth L.
- Kelley James M.
- Mikuls Ted R.
- Moreland Larry W.
- Morrison Dahliann
- Padilla Miguel A.
- Parrish Lezlie A.
- Patterson Nick
- Reich David
- Smith Edwin A.
- Vaughan L. Kelly
- Westfall Andrew O.
- Publication venue
- Publication date
- 01/01/2008
- Field of study
To determine whether shared epitope (SE)–containing HLA–DRB1 alleles are associated with rheumatoid arthritis (RA) in African Americans and whether their presence is associated with higher degrees of global (genome-wide) genetic admixture from the European population
The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy
- Author
- Aawsaj Yousif
- Abayomi Michael
- Acharya Vikas
- Aggarwal Smeer Kumar
- Ahmad Anwar
- Ahmed Irfan
- Ahmed Jamil
- Ahmed Javed
- Ahmed Talat
- Ainley Paul
- Akhtar Mansoor
- Al Amari Khalid
- Al-Abed Yahya A.
- Al-Akash Musallam
- Al-Bahrani Ahmed Z.
- Al-Khyatt Waleed
- Al-Muhktar Ahmed
- Al-Sarireh Bilal
- Al-Taan Omer
- Alagaratnam Swethan
- Alam Imran
- Alberts Justin
- Alderson Derek
- Aldridge Roland C.
- Aleksandrov Danail
- Ali Haythem
- Ali Shahda
- Amin Khalid
- Andrew David R.
- Appleton Shaun
- Arhi Chanpreet
- Aroori Somaiah
- Aryal Kamal
- Asad Mehek
- Aseem Rabiya
- Asprou Fotini M.
- Awan Altaf
- Ayaani Soofiyah
- Aymon null
- Babu Benoy I.
- Bajwa Dalvir S.
- Bajwa Farrukh M.
- Baker Andrew L.
- Balfe Paul
- Ball William R.
- Ballance Laura
- Banwell Victoria
- Barnes James
- Barrie Jenifer
- Bartlett Francis
- Basheer Mohammed
- Bashir Gareth
- Basra Melvinder
- Basu Sanjoy
- Basynat Pradeep
- Batt Jeremy
- Bausbacher Harald
- Bawa Sadiq
- Beasley William D.
- Belding Rowena
- Bellini Maria Irene
- Bennett Stephen P.
- Bhandari Santosh
- Bharamgoudar Reshma
- Bhattacharya Vish
- Blane Christine
- Blazeby Jane M.
- Boal Matthew
- Boddy Alexander
- Boland Michael
- Bond-Smith Giles
- Booth Michael I.
- Borowski David W.
- Bowen Laura
- Boyce Kathryn M.
- Boyd Alan T.
- Bradley Donal
- Bradley Neil
- Brennan Stephen
- Brett Daniel
- Broadhurst Jack
- Brooke Eleanor
- Brown Timothy H.
- Bryant Alice
- Buchan Joanna
- Bullen Naomi
- Bunnell Catherine
- Bunting David M.
- Burke Paul
- Byrne James P.
- Byrnes Colman K.
- Campbell William
- Carney Kate
- Carney Kate
- Carroll Paul
- Carter C. Ross
- Carter Nicholas C.
- Carty Nick
- Cassidy John T.
- Chambers Adam
- Chambers Alice
- Chambers Alice
- Chan Wei Ming
- Chang Jessica
- Charalabopoulos Alexandros
- Chauhan Neal
- Cheung Melanie
- Chhabra Alok
- Chishti Imran A.
- Chitre Vivek
- Choy Alfred
- Cieplucha Krzysztos
- Clements Joshua M.
- Coats Maria
- Cockbain Andrew J.
- Coe Peter O.
- Connelly Martin
- Cooke Fiachra
- Courtney Michael J.
- Cowley Jonathan B.
- Cross Keith S.
- Cuming Tamzin
- Cunha Pedro
- Dalgaty Faith
- Dar Farooq
- Date Ravindra
- Dave Rajiv V.
- Davey Phil
- Davies James
- Dawson Suzanne
- De Marchi Joshua A.
- de Siqueira Jonathan
- Deguara Jean
- Delisle Theo G.
- Dennison A. R.
- Derbyshire Laura
- Devoto Laurence
- Dhillon Ajit
- Diamond Tom
- Dickson-Lowe Richard
- Digney Ruairi
- Dindyal Shiva
- Dobbins Brian
- Doe Matthew
- Dorrian Emmet
- Doulias Triantafyllos
- Downing Justine
- Drake Benjamin
- Driscoll Peter J.
- Duke Diana
- Durkin Damien
- Dwerryhouse Simon J.
- D’Costa Conrad
- Ebdewi Hamdi
- Ebied Husam
- Eisawi Abdalla
- El-Dhuwaib Yesar
- El-Hasani Shamsi S.
- Elkheir Natalie
- Elmasry Mohamed
- Elsayed Mohammed
- Elshaer Mohamed
- Emesih Sophie
- Farag Sameh F.
- Farooq Ansar
- Farouk Marwan
- Fasih Tani
- Fawole Adeshina S.
- Fenwick Stephen
- Ferguson Graeme
- Ferris Paul
- Finch David
- Finch J. G.
- Finlay Ian
- Fleming Katie
- Fletcher Ted
- Fordham Imogen J.
- Forouzanfar Amir
- Forrest Craig R.
- Forster Luke
- Fothergill Laura
- Frame Richard J.
- Francombe James
- Frank Lucinda
- Fusai Guiseppe
- Galanopoulos Giorgios
- Gallagher Paul V.
- Garcea Giuseppe
- Gardner-Thorpe James
- Geoghegan Justin G.
- Geogloma Ileana
- Gerakopoulos Stratos
- Ghareeb Essam
- Ghazanfar Mudassar A.
- Gibson Simon
- Giles Mathew
- Giovinazzo Francesco
- Giwa Lola
- Goh Yan Li
- Gopalswamy Sivakumar
- Goscimski Andrzej
- Gossage James A.
- Gough Martin
- Gould Laura
- Gould Laura
- Grant Alan J.
- Gravante Gianpiero
- Griffiths Ewen
- Griffiths Ewen A.
- Gull Sadaf
- Gunasekera Rohan T.
- Gurung Kabita
- Guthrie Graeme J. K.
- Guy Finch J.
- Hafiz Shazia
- Halkias Constantine
- Hall Claire
- Hamady Zayed
- Hamdan Alhafidz
- Hamdan Mohammed F.
- Hamilton Emma
- Hancorn Kate
- Haque Manzarul
- Haque Samer Ul
- Hardy Thomas J.
- Hargreaves Anita
- Harilingam Mohan
- Harris Andrew
- Harrison Ewen
- Hawkins Helen
- Heath Jonathan
- Hebbar Madhusoodhana
- Henderson Lucy T.
- Henley Natasha
- Heshaishi Mohamed
- Hewes James
- Hewes James C.
- Heywood Nick
- Higgs Simon M.
- Hill Arnold D. K.
- Hindley Caroline
- Hirst Natalie A.
- Hisham Elzanati
- Ho Wei-Min
- Hoban Jennifer R.
- Hodgkins Kathryn A.
- Hodson James
- Holroyd David J.
- Hooks Gareth
- Hopwood Benjamin
- Hornby Steve T.
- Hornsby Jane
- Hosie Kenneth B.
- Hosie Kenneth B.
- Hossack Martin R.
- Hossain Tanvir
- Hoti Emir
- Hou David
- Hrycaiczuk Alex
- Hughes Michael
- Hunter David I.
- Hussain Abdulzahra A.
- Hussain Adnan
- Hussain Anwar
- Hussain Najam
- Iftikhar Syed Yusuf
- Iqbal Nusrat
- Iskandar Edrin
- Issa Eyad
- Ivanovski Ivan
- Jackson Andrew
- Jackson Claire
- Jafferbhoy Sadaf F.
- Jambulingam Periyathambi
- Jamdar Saurabh
- Jamel Sara
- Janeczko Adam
- Jaunoo Shameen
- Jayanthi Naga V. G.
- Jelley Clare
- Jennings Neil A.
- Joel Abraham
- Johnpulle Michelle A.
- Johnston Dorothy
- Johnstone Marianne
- Johnstone Marianne
- Joji Nikita
- Jones Claire
- Jones Elinor
- Jones Gareth H.
- Jones M. Angharad
- Jones Michael J.
- Jones Robert P.
- Jones Steven M.
- Kadhim Abbas
- Kadirkamanathan Sritharan
- Kallaway Charlotte
- Kanakala Venkatesh
- Kanavati Osama
- Kansal Nisheeth
- Kaptanis Sarantos
- Karavadra Babu
- Karim Lawen
- Karunakaran Priyadarssini
- Kaur Parminder
- Kausar Ambareen
- Kelly Michael E.
- Kendal Chris
- Kennedy David
- Kenny Ross
- Keogh Ken
- Khalil Ahmed M.
- Khan Amarah
- Khan Mohammad A.
- Khan Muhammad A. S.
- Khan Raja Basit
- Khan Shabuddin
- Khan Shahab
- Khawaja Amir
- Khawaja Zechan
- Khogali Elmoataz
- Kimble Adam
- Kinghorn Alison
- Kirkham Amanda J.
- Knight Benjamin
- Knight Katrina
- Kourkulos Michail
- Krysztopik Richard
- Kumar Pradeep
- Kynaston James
- Kyriakidis Dimitrios
- Lalla Kushik
- Lambert Joel
- Lammy Simon
- Lane Risha
- Larkin David
- Law Jennifer
- Lawther Roger
- Lazim Taha
- Lee Kathryn
- Lee Matthew
- Leeder Paul
- Lennon Hannah
- Lewis Michael
- Lim Henry C. C.
- Lim Pei J.
- Lindsay David
- Lloyd David
- Lo Christina
- Lodhia Joshil
- Longbotham David A.
- Loughlin Paula
- Lovett Bryony
- Luhmann Andreas
- Luther Ali Alison
- Lyons Emma M.
- Macano Christina A. W.
- MacArtney Matthew
- Macdonald Andrew
- Madanipour Suroosh
- Madbak Khaliel
- Madurska Marta
- Magee Conor J.
- Maguire Donal
- Maharaj Geta
- Majeed Ali
- Malcolm Cathy
- Malde Deep
- Malik Nabeela S.
- Mallik Mekhlola
- Mansour Sami
- Manu Mangta
- Manzelli Antonio
- Marriott Paul
- Martin Jack
- Martin Sean T.
- Martin Serena
- Marudanayagam Ravi
- Mason Denise
- Mathur Pawan
- Mawhinney Abi
- Mbuvi James
- McAree Barry
- McCain Stephen
- McCallum Iain J. D.
- McClarey Andrew
- McCune Ken
- McDermott Frank
- McEntee Gerry P.
- McGlone Emma R.
- McGuigan Andrew
- McIlmunn Colin
- McKay Damian
- McKenzie Stephen
- McNair Angus G. K.
- Mealy Ken
- Menzies Donald
- Mercer Stuart J.
- Milburn James
- Mirza Ahmed K.
- Mirza Darius
- Miu Victor
- Mockford Justine Downing Katherine A.
- Mohamed Sarah
- Mohan Helen M.
- Mok Kam Wa Jessica
- Monk David
- Morcous Paul
- Morrison Tamsin E. M.
- Mothe Bhavani Sidhartha
- Mowbray Nicholas
- Mozolowski Kirsty L.
- Mukherjee Dipankar
- Murphy James O.
- Murtaza Ghulam
- Nally Deirdre M.
- Napetti Sara
- Nassar Ahmad H.
- Naumann David
- Nedujchelyn Yuwaraja
- Needham Paul J.
- Newton Katy
- Newton Richard C.
- Ngu Wee Sing
- Nicholson Gary A.
- Nicholson James
- Nicholson James A.
- Nicol Laura
- Nicolay Christopher R.
- Nieto Tom
- Nijjar Rajwinder S.
- Nilsen-Nunn April
- Nilsson Frida
- Noble Fergus
- Nofal Emma
- Noor Nigel
- Nunes Quentin M.
- Obeidallah Mohd Rami
- Ogedegbe Arikoge
- Old Oliver J.
- Orchard Philippa
- Orizu Mavis N.
- O’Dwyer Patrick
- O’Neill Maeve A.
- O’Neill Stephen
- O’Reilly Derek A.
- O’shea Kathryn M.
- O’Sullivan Adrian W.
- Packer Jessica R.
- Padwick Robert
- Pannu Arslan
- Panteleimonitis Sofoklis
- Parappally Ciny P.
- Parmar J.
- Pasquali Sandro
- Patel Abhilasha
- Patel Krashna
- Patel Shakira
- Pati Pradeep
- Pearce Belinda
- Pearson Katherine L.
- Peirce Colin
- Pellen Mike
- Peter Mark B.
- Peterson Mark
- Pezzuto Roberto
- Photi Evangelos
- Phull Manraj
- Pinho-Gomes Ana C.
- Pollock Sarah
- Popplewell Matthew
- Pore Naresh
- Porter Jonathan
- Prasad Abheesh R.
- Prasad Raj
- Preston Shaun R.
- Preziosi Giuseppe
- Prince Sarah
- Psica Alicja
- Puig Sonia
- Puntis Daniel J.
- Puri Yogesh
- Qandeel Haitham
- Rabie Mohamed
- Radwan Rami
- Rae David M.
- Rahman Saquib
- Rajaganeshan Rajasundaram
- Rajendran Ilayaraja
- Ramage Michael I.
- Rao Sudhindra T. V.
- Rate Anthony J.
- Raza Soulat
- Read Edward
- Reddy Marcus
- Reece-Bolton Obuobi
- Reed Joanna
- Reid Alistair
- Rengifo Carla
- Rhys Thomas
- Richards Colin H.
- Riera Manel
- Ritchie Judith
- Robb William
- Roberts Geoffrey P.
- Robinson Sarah
- Robinson Steven J.
- Robinson Stuart
- Rodriguez Dan
- Rodriguez Daniel Urriza
- Roebuck Amanda
- Rogers Paul N.
- Rolph Rachel C.
- Roy Sudipta
- Rutherford Claire L.
- Sadat Mohammed M.
- Sakai Naomi
- Sampat Keerthika
- Samuel Nehemiah
- Sarmah Piyush B.
- Sarvananthan Kas
- Sarveswaran Janahan
- Satheesan Steve
- Saunders Michael
- Sayegh Mazin
- Segaran Ashvina
- Sekhar Hema
- Sen Gourab
- Seymour Keith
- Shabo Wael
- Shah Nayab
- Shah Reena
- Shahin Yousef
- Sheel Andrea R. G.
- Shenoy Hrishikesh
- Shetty Vinutha
- Shier David
- Shingler Guy M.
- Shiwani Muhammad Hanif
- Shrestha Ashish Kiran
- Siddiqi Najaf
- Siddiqui Midhat N.
- Siddiqui Zohaib
- Sillo Toritseju O.
- Silva Michael
- Simpson Duncan J.
- Singh Shailendra
- Singh-Ranger Deepak
- Sinha Sidhartha
- Skelly Brendan L.
- Slavin John P.
- Slawinski Corinna
- Sloane Jake
- Smith Stella R.
- Smith Stella R.
- Sonsale Aniket
- Spearman John
- Spence Gary
- Spreadborough Philip
- Spreadborough Philip
- Starmer Benjamin Z.
- Stevenson Thomas E. J.
- Stewart Duncan J.
- Stirland E.
- Subramanium Dhivya
- Sufi Pratik A.
- Sukha Anisha
- Sutcliffe Robert
- Suttie Stuart
- Sutton Cherith M. L. R.
- Szentpali Karoly
- Tang Cheuk-Bong
- Tanner Nicola
- Tate Sophie
- Tayeh Salim
- Taylor Christopher
- Taylor Greg W.
- Teasdale Rebecca L.
- Templeton Alexa
- Terrace John
- Thakkar Rohan
- Thomas George
- Thompson Ronald L. E.
- Tilston Michael P.
- Toh Simon K. C.
- Tolofari Sotonye
- Tomlinson Mark A.
- Trevatt Alexander E. J.
- Trotter Martin
- Tsang Andrew
- Tsavellas George
- Tuck Liz
- Turner Paul
- Tutton Matthew G.
- Ullah Muhammad Fahad
- Upchurch Emma A.
- Urbonas Tomas
- Varghase Joseph
- Vass David G.
- Vaughan Elizabeth M.
- Vijay Vardhini
- Vijayan Deepak
- Vijayanand Dhakshinamoorthy
- Villatoro Eduardo
- Virupaksha Suvi
- Vitone Louis J.
- Vohra Ravinder S.
- Wadley Martin
- Wainwright Denise
- Wajed Saj
- Wallace Tom
- Wardle Stacy
- Warren Conor
- Watkin Helen
- Watson Angus J. M.
- Watson Nicholas F.
- Wayman John
- Weaver Simon
- Weber Beatrix
- Weber Beatrix
- Weerasinghe Chamindri
- Welbourn Hannah
- Wheatley Kevin
- White Timothy J.
- Wijetunga Imeshi
- Wild Jonathan R. L.
- Wilkinson Marc D.
- Williams Sophie V.
- Williamson Tracey K.
- Willson Peter D.
- Wilson Michael S. J.
- Wilson Timothy R.
- Winter Des C.
- Winter Hannah
- Wood Christopher P. J.
- Wood Peter
- Wood Simon
- Woodman Thomas
- Yahya Salama
- Yao Caroline
- Yeldham Geoffrey
- Yoganathan Thusidaran
- Youssef Haney
- Zafar Sara
- Zafrani Zakhi
- Zarsadias Prizzi
- Zeeshan Saquib
- Zhang Catherine
- Ziprin Paul
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations.
Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves.
Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p 90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score.
Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
- Author
- Adams Mark J
- Adan Roger A H
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Akil Huda
- Albani Diego
- Alda Martin
- Alexander Madeline
- Alfredsson Lars
- Als Thomas D
- Andlauer Till F M
- Ando Tetsuya
- Andreassen Ole A
- Androutsos Christos
- Anjorin Adebayo
- Anney Richard J L
- Anttila Verneri
- Arking Dan E
- Arnold Paul D
- Arranz M. J.
- Artigas Maria Soler
- Aschauer Harald
- Asherson Philip
- Backlund Lena
- Baker Jessica H
- Baldursson Gísli
- Banaschewski Tobias
- Barr Cathy L
- Barta Csaba
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Begemann Martin
- Belangero Sintia
- Bellgrove Mark
- Belliveau Richard A
- Bellivier Frank
- Bencko Vladimir
- Bergen Andrew W
- Bergen Sarah E
- Berger Klaus
- Berrettini Wade H
- Bettella Francesco
- Bey Katharina
- Bienvenu O Joseph
- Biernacka Joanna M
- Binder Elisabeth B
- Birgegård Andreas
- Black Donald W
- Blackwood Douglas H R
- Boomsma Dorret I
- Bramon Elvira
- Brandt Harry
- Breen Gerome
- Brown Lawrence W
- Buccola Nancy G
- Budde Monika
- Budman Cathy
- Buitelaar Jan
- Bulik Cynthia M
- Bunney William
- Burghardt Roland
- Burmeister Margit
- Burton Christie L
- Buxbaum Joseph D
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D
- Cairns Murray J
- Campion Dominique
- Carlberg Laura
- Carr Vaughan J
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Cath Danielle
- Cerrato Felecia
- Chambert Kimberly
- Cheon Keun-Ah
- Christensen Jane H
- Churchhouse Claire
- Cichon Sven
- Ciullo Valentina
- Clarke Toni-Kim
- Clementi Maurizio
- Cloninger C Robert
- Coffey Barbara J
- Cohen David
- Coleman Jonathan R I
- Collier David A
- Collins Ryan L
- Colodro-Conde Lucía
- Cook Edwin H
- Coon Hilary
- Coppola Giovanni
- Cormand Bru
- Corvin Aiden
- Courtet Philippe
- Craddock Nicholas
- Crawford Steven
- Crosbie Jennifer
- Crow Scott
- Crowley James J
- Curtis David
- Cusi Daniele
- Czerski Piotr M
- Dale Anders M
- Dalkner Nina
- Dalsgaard Søren
- Daly Mark J
- Danner Unna N
- Dannlowski Udo
- Davis Lea K
- Davis Oliver S P
- de Geus E. J. C.
- De Rubeis Silvia
- Degenhardt Franziska
- Degortes Daniela
- DeLisi Lynn E
- Delorme Richard
- Demontis Ditte
- Denys Damiaan
- Depienne Christel
- Derks Eske M
- DeSocio Janiece E
- Di Florio Arianna
- Dick Danielle M
- Dietrich Andrea
- Dina Christian
- Direk Nese
- Docampo Elisa
- Docherty Anna R
- Domenici Enrico
- Domschke Katharina
- Donohoe Gary
- Doyle Alysa E
- Duan Jubao
- Dudbridge Frank
- Dumont Ashley
- Duncan Laramie E
- Dunn Erin C
- Eapen Valsamma
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- Zinner Samuel H
- Zipfel Stephan
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
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- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
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- Gupta Samir
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- Xu Wei
- Yang Jian
- Yao Shuyang
- Yeh Shing Shing
- Yilmaz Zeynep
- Yilmaz Zeynep
- Young Allan H.
- Young Hannah
- Zablocki Clement J.
- Zai Clement C.
- Zandi Peter P.
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Global Retinoblastoma Presentation and Analysis by National Income Level.
- Author
- Abdallah Elhassan
- Abdullahi Shehu U
- Abdulqader Rula A
- Adamou Boubacar Sahadatou
- Ademola-Popoola Dupe S
- Adio Adedayo
- Afshar Armin R
- Aggarwal Priyanka
- Aghaji Ada E
- Ahmad Alia
- Akib Marliyanti NR
- Al Ani Mouroge H
- Al Harby Lamis
- Al-Badri Safaa AF
- Al-Dahmash Saad A
- Al-Haddad Christiane
- Al-Hussaini Hamoud HY
- Al-Jadiry Mazin F
- Al-Jumaily Usama
- Al-Mafrachi Ali ARM
- Al-Shaheen Athar ASM
- Al-Shammary Entissar H
- Alakbarova Aygun
- Alcasabas Ana Patricia A
- Alejos Amanda
- Alemany-Rubio Ernesto
- Alfa Bio Amadou I
- Alfonso Carreras Yvania
- Ali Amany M
- Alia Donjeta B
- Alkatan Hind M
- All-Eriksson Charlotta
- Almeida Argentino A
- Alsawidi Khalifa M
- Amiruddin Primawita O
- Antonino Romanzo
- Astbury Nicholas J
- Atalay Hatice T
- Atchaneeyasakul La-Ongsri
- Atsiaya Rose
- Attaseth Taweevat
- Aung Than H
- Ayala Silvia
- Baizakova Baglan
- Balaguer Julia
- Balayeva Ruhengiz
- Balwierz Walentyna
- Barranco Honorio
- Bascaran Covadonga
- Beck Popovic Maja
- Benavides Raquel
- Benmiloud Sarra
- Bennani Guebessi Nissrine
- Berete Rokia C
- Berry Jesse L
- Bhaduri Anirban
- Bhat Sunil
- Biddulph Shelley J
- Biewald Eva M
- Bobrova Nadia
- Boehme Marianna
- Boldt HC
- Bonanomi Maria Teresa BC
- Bornfeld Norbert
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- Bowman Richard
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- Buaboonnam Jassada
- Calderón-Sotelo Patricia
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- Delgado Karina Q
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- Desjardins Laurence
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- Dimaras Helen
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- Donaldson Craig
- Donato Macedo Carla R
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- Du Bruyn Magritha
- Du Yi
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- Essuman Vera A
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- Fabian Ido Didi
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- Scanlan Trish A
- Schefler Amy C
- Schoeman Judy
- Sedaghat Ahad
- Seregard Stefan
- Seth Rachna
- Shah Ankoor S
- Shakoor Shawkat A
- Sharma Manoj K
- Sherief Sadik T
- Shetye Nandan G
- Shields Carol L
- Siddiqui Sorath Noorani
- Sidi Cheikh Sidi
- Silva Sónia
- Singh Arun D
- Singh Niharika
- Singh Usha
- Singha Penny
- Sitorus Rita S
- Skalet Alison H
- Soebagjo Hendrian D
- Sorochynska Tetyana
- Ssali Grace
- Stacey Andrew W
- Staffieri Sandra E
- Stahl Erin D
- Stathopoulos Christina
- Stirn Kranjc Branka
- Stones David K
- Strahlendorf Caron
- Suarez Maria Estela Coleoni
- Sultana Sadia
- Sun Xiantao
- Sundy Meryl
- Superstein Rosanne
- Supriyadi Eddy
- Surukrattanaskul Supawan
- Suzuki Shigenobu
- Svojgr Karel
- Sylla Fatoumata
- Sánchez Gissela L
- Tamamyan Gevorg
- Tan Deborah
- Tandili Alketa
- Tarrillo Leiva Fanny F
- Tashvighi Maryam
- Tateshi Bekim
- Teh Kok Hoi
- Tehuteru Edi S
- Teixeira Luiz F
- Theophile Tuyisabe
- Toledano Helen
- Trang Doan L
- Traoré Fousseyni
- Trichaiyaporn Sumalin
- Tuncer Samuray
- Tyau-Tyau Harba
- Umar Ali B
- Unal Emel
- Uner Ogul E
- Urbak Steen F
- Ushakova Tatiana L
- Usmanov Rustam H
- Valeina Sandra
- van Hoefen Wijsard Milo
- Varadisai Adisai
- Vasquez Liliana
- Vaughan Leon O
- Veleva-Krasteva Nevyana V
- Verma Nishant
- Victor Andi A
- Viksnins Maris
- Villacís Chafla Edwin G
- Vishnevskia-Dai Vicktoria
- Vora Tushar
- Wachtel Antonio E
- Wackernagel Werner
- Waddell Keith
- Wade Patricia D
- Wali Amina H
- Wang Yi-Zhuo
- Weiss Avery
- Wilson Matthew W
- Wime Amelia DC
- Wiwatwongwana Atchareeya
- Wiwatwongwana Damrong
- Wolley Dod Charlotte
- Wongwai Phanthipha
- Xiang Daoman
- Xiao Yishuang
- Yam Jason C
- Yang Huasheng
- Yanga Jenny M
- Yaqub Muhammad A
- Yarovaya Vera A
- Yarovoy Andrey A
- Ye Huijing
- Yousef Yacoub A
- Yuliawati Putu
- Zapata López Arturo M
- Zein Ekhtelbenina
- Zhang Chengyue
- Zhang Yi
- Zhao Junyang
- Zheng Xiaoyu
- Zhilyaeva Katsiaryna
- Zia Nida
- Ziko Othman AO
- Zondervan Marcia
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/01/2020
- Field of study
Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs
The global retinoblastoma outcome study : a prospective, cluster-based analysis of 4064 patients from 149 countries
- Author
- Abdallah Elhassan
- Abdullahi Shehu U.
- Abdulqader Rula A.
- Abdulrahaman Aminatu A.
- Abouelnaga Sherif
- Ademola-Popoola Dupe S.
- Adio Adedayo
- Afifi Mahmoud A.
- Afshar Armin R.
- Aggarwal Priyanka
- Aghaji Ada E.
- Ahmad Alia
- Akib Indonesia Marliyanti N.R.
- Akinsete Adeseye
- Al Ani Mouroge H.
- Al Harby Lamis
- Al Mesfer Saleh
- Al-Badri Safaa A.F.
- Al-Dahmash Saad A.
- Al-Haddad Christiane E.
- Al-Hussaini Hamoud H.Y.
- Al-Jadiry Mazin F.
- Al-Janabi Allawi N. Hussein
- Al-Jumaily Usama
- Al-Mafrachi Ali A.R.M.
- Al-Shaheen Athar A.S.M.
- Al-Shammary Entissar H.
- Alcasabas Ana Patricia A.
- Aldana David Garcia
- Alejos Amanda
- Alemany-Rubio Ernesto
- Alfa Bio Amadou I.
- Ali Amany M.
- Alia Donjeta B.
- Alkatan Hind M.
- All-Eriksson Charlotta
- Almeida Argentino A.
- Alsawidi Khalifa M.
- Amankwaa-Frempong Doreen
- Amiruddin Primawita O.
- Anchaya Jacqueline Karina Vasquez
- Armytasari Inggar
- Astbury Nicholas J.
- Atalay Hatice T.
- Atchaneeyasakul La-ongsri
- Atsiaya Rose
- Autrata Rudolf
- Balaguer Julia
- Balayeva Ruhengiz
- Barranco Honorio
- Bartoszek Paulina
- Bartuma Katarina
- Bascaran Covadonga
- Bechrakis Nikolaos E.
- Begimkulova Ainura S.
- Benmiloud Sarra
- Berete Rokia C.
- Berry Jesse L.
- Bhaduri Anirban
- Bhat Sunil
- Bhattacharyya Arpita
- Biewald Eva M.
- Binkley Elaine
- Blum Sharon
- Bobrova Nadia
- Boldt H.C.
- Bonanomi Maria Teresa B.C.
- Bouda Gabrielle C.
- Bouguila Hedi
- Bowman Richard
- Bowman Richard
- Brennan Rachel C.
- Brichard Benedicte G.
- Buaboonnam Jassada
- Budiongo Aleine
- Burton Matthew J.
- Calderon-Sotelo Patricia
- Calvo Jesus Peralta
- Camuglia Jayne E.
- Cano Miriam R.
- Capra Michael
- Carreras Yvania Alfonso
- Caspi Shani
- Cassoux Nathalie
- Castela Guilherme
- Castillo Luis
- Catala-Mora Jaume
- Cavieres Isabel
- Chafla Edwin G. Villacis
- Chandramohan Arthika
- Chantada Guillermo L.
- Chantada Guillermo L.
- Chantada Guillermo L.
- Chaudhry Shabana
- Chawla Bhavna
- Chen Wensi
- Chiwanga Faraja S.
- Chuluunbat Tsengelmaa
- Cieslik Krzysztof
- Clark Antony
- Cockcroft Ruellyn L.
- Comsa Codruta
- Coronado Rosdali Y. Díaz
- Corson Timothy W.
- Couitchere Line
- Cowan-Lyn Kristin E.
- Csoka Monika
- Dangboon Wantanee
- Das Anirban
- Das Pranab
- Das Sima
- Davanzo Jacquelyn M.
- Davidson Alan
- De Francesco Sonia
- De Potter Patrick
- Demirci Hakan
- Desjardins Laurence
- Dimaras Helen
- Dod Charlotte Wolley
- Dodgshun Andrew J.
- Dragomir Monica D.
- Du Bruyn Magritha
- Du Plessis Johannes
- Du Yi
- Dudeja Gagan
- Eerme Katrin
- El Kettani Asmaa
- Elbahi Amal M.
- Elder James E.
- Elhaddad Alaa M.
- Elhassan Moawia M.A.
- Elzembely M.
- Ericksen Connor
- Essuman Vera A.
- Evina Ted Grimbert A.
- Ezegwui Ifeoma R.
- Fabian Ido Didi
- Fabian Ido Didi
- Fadoo Zehra
- Fandiño Adriana C.
- Faranoush Mohammad
- Fasina Oluyemi
- Fernandez Delia D.P.G.
- Fernandez-Teijeiro Ana
- Foster Allen
- Frenkel Shahar
- Fu Ligia D.
- Fuentes-Alabi Soad L.
- Garcia Juan L.
- Geel Jennifer A.
- Ghassemi Fariba
- Giron Ana V.
- Goenz Marco A.
- Gold Aaron S.
- Goldberg Hila
- Gomel Nir
- Gonzalez Efren
- Gonzalez-Rodriguez Liudmira
- Gopinathan Nair Akshay
- Gorfine Malka
- Graells Jaime
- Gregersen Pernille A.
- Grigorovski Nathalia D.A.K.
- Groznik Alenka Lavric
- Guedenon Koffi M.
- Gunasekera D. Sanjeeva
- Gupta Himika
- Gupta Sanjiv
- Gupta Vineeta
- Gündüz Ahmet K.
- Hadjistilianou Theodora
- Hamel Patrick
- Hamid Syed A.
- Hamzah Norhafizah
- Hansen Eric D.
- Harbour William
- Hartnett M. Elizabeth
- Hasanreisoglu Murat
- Hassan Muhammad
- Hassan Sadiq
- Hassan Shadab
- Hautz Wojciech
- Haydar Huda
- Hederova Stanislava
- Hessissen Laila
- Hongeng Suradej
- Hordofa Diriba F.
- Hubbard G. Baker
- Hummelen Marlies
- Husakova Kristina
- Ibanga Affiong
- Ida Russo
- Ilic Vesna R.
- Islamia Ispahani
- Islamov Ziyavuddin
- Jairaj Vivekaraj
- Jara Doris A. Calle
- Jeeva Irfan
- Ji Xunda
- Jo Dong Hyun
- Jones Michael M.
- Kabesha Amani Theophile B.
- Kabore Rolande L.
- Kaliki Swathi
- Kalinaki Abubakar
- Kamsang Pius
- Kapelushnik Noa
- Kardava Tamar
- Kebudi Rejin
- Keomisy Jonny
- Kepak Tomas
- Ketteler Petra
- Khan Zohora
- Khaqan Hussain A.
- Khetan Vikas
- Khodabande Alireza
- Khotenashvili Zaza
- Kim Jeong Hun
- Kim Jonathan W.
- Kiratli Hayyam
- Kivela Tero T.
- Klett Artur
- Kosh Komba Palet Jess Elio
- Ko~ Irem
- Krivaitiene Dalia
- Kruger Mariana
- Kulvichit Kittisak
- Kuntorini Mayasari W.
- Kyara Alice
- Lam Geoffrey C.
- Larson Scott A.
- Latinovic Slobodanka
- Laurenti Kelly D.
- Lavy Yotam
- Leiva Fanny F. Tarrillo
- Leverant Amy A.
- Li Cairui
- Li Kaijun
- Limbu Ben
- Liu Chun-Hsiu
- Llano Maria G. Correa
- Lopez Arturo M. Zapata
- Lopez Juan P.
- Lukamba Robert M.
- Luna-Fineman Sandra
- Lutfi Delfitri
- Lysytsia Lesia
- Macedo Carla R. Donato
- Madgar Shiran
- Magrath George N.
- Mahajan Amita
- Maitra Puja
- Maka Erika
- Makimbetov Emil K.
- Maktabi Azza
- Maldonado Carlos
- Mallipatna Ashwin
- Manudhane Rebecca
- Manzhuova Lyazat
- Martin-Begue Nieves
- Masud Sidra
- Matende Ibrahim O.
- Mattosinho Clarissa C.D.S.
- Matua Marchelo
- Mayet Ismail
- Mbumba Freddy B.
- McKenzie John D.
- Mehrvar Azim
- Mengesha Aemero A.
- Menon Vikas
- Mercado Gary John V.
- Mets Marilyn B.
- Midena Edoardo
- Midena Edoardo
- Miller Audra
- Mishra Divyansh K.C.
- Mndeme Furahini G.
- Mohamedani Ahmed A.
- Mohammad Mona T.
- Moll Annette C.
- Montero Margarita M.
- Morales Claudia R. Pascual
- Moreira Claude
- Mruthyunjaya Prithvi
- Msina Mchikirwa S.
- Msukwa Gerald
- Mudaliar Sangeeta S.
- Muma Kangwa I.M.
- Munier Francis L.
- Murray Timothy G.
- Musa Kareem O.
- Mushtaq Asma
- Musika Anne A.
- Mustak Hamzah
- Mustapha Tajudeen
- Muyen Okwen M.
- Myezo Khumo H.
- Naidu Gita
- Naidu Natasha
- Nair Akshay Gopinathan
- Natarajan Sundaram
- Naumenko Larisa
- Nency Yetty M.
- Neroev Vladimir
- Ng Yvonne
- Nikitovic Marina
- Nkanga Elizabeth D.
- Nkumbe Henry E.
- Numbi Marcel N.
- Nummi Kalle
- Nuruddin Murtuza
- Nyaywa Mutale
- Nyirenda Chinsisi
- Obono-Obiang Ghislaine
- Oliver Scott C .
- Oporto Joaquin
- Orozco Alma Janeth Sanchez
- Ortega-Hernández Miriam
- Oscar Alexander H.
- Ossandon Diego
- Pacheco Henry N. Garcia
- Pacheco Sonsoles San Roman
- Paintsil Vivian
- Paiva Luisa
- Palanivelu Mahesh Shanmugam
- Papyan Ruzanna
- Parrozzani Raffaele
- Paton Katherine E.
- Perez Graciela Gonzalez
- Peric Sanja
- Pe’er Jacob
- Pham Chau T.M.
- Philbert Remezo
- Plager David A.
- Pochop Pavel
- Polania Rodrigo A.
- Polyakov Vladimir
- Pompe Manca Tekavcic
- Ponce Jimena
- Popovic Maja Beck
- Portabella Silvia Alarcon
- Qadir Ali O.
- Qayyum Seema
- Qian Jiang
- Quah BoonLong
- Quintero D Karina
- Rahman Ardizal
- Rajkarnikar Purnima
- Ramanjulu Rajesh
- Ramasubramanian Aparna
- Ramirez-Ortiz Marco A.
- Randhawa Jasmeen K.
- Randrianarisoa Hoby Lalaina
- Raobela Lea
- Rashid Riffat
- Reddy M. Ashwin
- Refaeli David
- Renner Lorna A.
- Reynders David
- Ribadu Dahiru
- Ritter-Sovinz Petra
- Rogowska Anna
- Rojanaporn Duangnate
- Romero Livia
- Roth Paule Aida Ndoye
- Roy Soma R.
- Saab Raya H.
- Saakyan Svetlana
- Sabhan Ahmed H.
- Sagoo Mandeep S.
- Said Azza M.A.
- Saiju Rohit
- Salas Beatriz
- Sanchez Gissela L.
- Sayalith Phayvanh
- Scanlan Trish A.
- Schluter Sabrina
- Schwab Christoph
- Sedaghat Ahad
- Seth Rachna
- Sgroi Mariana
- Shah Ankoor S.
- Shakoor Shawkat A.
- Sharma Manoj K.
- Sherief Sadik T.
- Shields Carol L.
- Sia David
- Siddiqui Sorath Noorani
- Sidi cheikh Sidi
- Silva Sonia
- Singh Arun D.
- Singh Usha
- Singha Penny
- Sitorus Rita S.
- Skalet Alison H.
- Soebagjo Hendrian D.
- Sorochynska Tetyana
- Ssali Grace
- Stacey Andrew W.
- Staffieri Sandra E.
- Stahl Erin D.
- Steinberg David M.
- Stones David K.
- Strahlendorf Caron
- Suarez Maria Estela Coleoni
- Sultana Sadia
- Sun Xiantao
- Superstein Rosanne
- Supriyadi Eddy
- Surukrattanaskul Supawan
- Sutyawan I. Wayan Eka
- Suzuki Shigenobu
- Svojgr Karel
- Sylla Fatoumata
- Tamamyan Gevorg
- Tan Deborah
- Tandili Alketa
- Tang Jing
- Tashvighi Maryam
- Tateshi Bekim
- Teh Kok Hoi
- Tehuteru Edi S.
- Teixeira Luiz F.
- Thawaba Abdullah Dahan M.
- Theophile Tuyisabe
- Toledano Helen
- Trang Doan L.
- Traore Fousseyni
- Tripathy Devjyoti
- Tuncer Samuray
- Tyau-Tyau Harba
- Umar Ali B.
- Unal Emel
- Uner Ogul E.
- Urbak Steen F.
- Ushakova Tatiana L.
- Usmanov Rustam H.
- Valeina Sandra
- Valente Paola
- Van Hoefen Wijsard Milo
- Vaughan Leon O.
- Veleva-Krasteva Nevyana V.
- Verma Nishant
- Victor Andi A.
- Viksnins Maris
- Villegas Victor M.
- Vishnevskia-Dai Victoria
- Waddell Keith
- Wali Amina H.
- Wang Yi-Zhuo
- Wangtiraumnuay Nutsuchar
- Wetter Julie
- Widiarti Widiarti
- Wilson Matthew W.
- Wime Amelia D.C.
- Wiwatwongwana Atchareeya
- Wiwatwongwana Damrong
- Wong Emily S.
- Wongwai Phanthipha
- Wu Si-qi
- Xiang Daoman
- Xiao Yishuang
- Xu Bing
- Xue Kang
- Yaghy Antonio
- Yam Jason C.
- Yang Huasheng
- Yanga Jenny M.
- Yarovaya Vera A.
- Yarovoy Andrey A.
- Ye Huijing
- Yee Roberto I.
- Yousef Yacoub A.
- Yuliawati Putu
- Zein Ekhtelbenina
- Zhang Yi
- Zhilyaeva Katsiaryna
- Zia Nida
- Ziko Othman A.O.
- Zondervan Marcia
- Publication venue
- Elsevier
- Publication date
- 23/08/2022
- Field of study
DATA SHARING : The study data will become available online once all analyses are complete.BACKGROUND : Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS : We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS : The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). INTERPRETATION : This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes.The Queen Elizabeth Diamond Jubilee Trust and the Wellcome Trust.https://www.thelancet.com/journals/langlo/homeam2023Paediatrics and Child Healt
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- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adair Antony
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Arora Sanjay
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baur Ulrich
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Bedjidian Marc
- Beernaert Kelly
- Behrenhoff Wolf
- Behrens Ulf
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W.
- Bellan Paolo
- Bellan Riccardo
- Bellinger James Nugent
- Belotelov Ivan
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Bergholz Matthias
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Berzano Umberto
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Beuselinck Raymond
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialas Wojciech
- Bialkowska Helena
- Bian Jian-Guo
- Bianchi Giovanni
- Bianchini Lorenzo
- Bianco Stefano
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- Luiggi Lopez Eduardo
- Lujan Paul
- Luk Michael
- Lungu Gheorghe
- Luo Wuming
- Lusito Letizia
- Lustermann Werner
- Luthra Arun
- Lutz Benjamin
- Luukka Panja-Riina
- Luyckx Sten
- Lychkovskaya Natalia
- Lykken Joseph
- Lynch Sean
- Lyons Louis
- Léonard Alexandre
- Ma Teng
- Ma Yousi
- Macneill Ian
- Maes Michael
- Maes Thomas
- Maeshima Kaori
- Magass Carsten
- Magaña Villalba Ricardo
- Maggi Giorgio
- Maggi Marcello
- Magnan Anne-Marie
- Maguire Charles
- Mahmoud Mohammed
- Maity Manas
- Majumder Devdatta
- Majumder Gobinda
- Maki Tuula
- Makouski Mikhail
- Maksimovic Petar
- Malberti Martina
- Malbouisson Helena
- Malcles Julie
- Malek Magdalena
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- Mangano Boris
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- Manolakos Ioannis
- Mans Jeremy
- Manthos Nikolaos
- Mantovani Giancarlo
- Manzoni Riccardo Andrea
- Mao Yajun
- Marage Pierre Edouard
- Marangelli Bartolomeo
- Maravin Yurii
- Marcellini Stefano
- Marco Jesus
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- Shepherd-Themistocleous Claire H.
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- Smith John
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- Smith Vincent J.
- Smith Wesley H.
- Snigirev Alexander
- Snoek Hella
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- Steinbrück Georg
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- Vodopiyanov Igor
- Vogel Helmut
- Volkov Alexey
- Volobouev Igor
- Volodko Anton
- Volpe Roberta
- Vorobiev Igor
- Vorobyev Alexey
- Vorobyev Andrey
- Voutilainen Mikko
- Vuosalo Carl
- Vutova Mariana
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- Wagner-Kuhr Jeannine
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- Walzel Gerhard
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- Wang Jian
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- Wang Zheng
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- Wardrope David
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- Wayne Mitchell
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- Weber Hendrik
- Weber Martin
- Weber Matthias
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- Weinberg Marc
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- Weng Joanna
- Weng Yao
- Wenger Edward Allen
- Werner Jeremy Scott
- West Christopher
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- Whitbeck Andrew
- Whitmore Juliana
- Whyntie Tom
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- Wickramage Nadeesha
- Widl Edmund
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- Wood Jeffrey Scott
- Wood John
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- Wright Douglas
- Wrochna Grzegorz
- Wu Weimin
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xu Ming
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yildirim Eda
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zotto Pierluigi
- Zou Wei
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
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- Wyslouch Bolek
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xu Ming
- Yagil Avraham
- Yan Ming
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yildirim Eda
- Yilmaz Yetkin
- Yiu Chun Hin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou Wei
- Zumerle Gianni
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2011
- Field of study
A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació
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