新しいカルパイン阻害剤はラット生体位心における緩和な虚血再灌流による左心室機能障害を保護する

We have previously indicated that a new soluble calpain inhibitor, SNJ-1945 (SNJ), attenuates cardiac dysfunction after cardioplegia arrest-reperfusion by inhibiting the proteolysis of α-fodrin in in vitro study. Nevertheless, the in vivo study design is indispensable to explore realistic therapeutic approaches for clinical use. The aim of the present in situ study was to investigate whether SNJ attenuated left ventricular (LV) dysfunction (stunning) after mild ischemic-reperfusion (mI-R) in rat hearts. SNJ (60 μmol/l, 5 ml i.p.) was injected 30 min before gradual and partial coronary occlusion at proximal left anterior descending artery. To investigate LV function, we obtained curvilinear end-systolic pressure–volume relationship by increasing afterload 60 min after reperfusion. In the mI-R group, specific LV functional indices at midrange LV volume (mLVV), end-systolic pressure (ESPmLVV), and pressure–volume area (PVAmLVV: a total mechanical energy per beat, linearly related to oxygen consumption) significantly decreased, but SNJ reversed these decreases to time control level. Furthermore, SNJ prevented the α-fodrin degradation and attenuated degradation of Ca2+ handling proteins after mI-R. Our results indicate that improvements in LV function following mI-R injury are associated with inhibition of the proteolysis of α-fodrin in in situ rat hearts. In conclusion, SNJ should be a promising tool to protect the heart from the stunning.博士（医学）・甲617号・平成26年3月17

Complete set of polarization transfer observables for the 16O(p⃗,n⃗)16F{}^{16}{\rm O}(\vec{p},\vec{n}){}^{16}{\rm F} reaction at 296 MeV and 0 degrees

We report measurements of the cross section and a complete set of polarization transfer observables for the ${}^{16}{\rm O}(\vec{p},\vec{n}){}^{16}{\rm F}$ reaction at a bombarding energy of $T_p$ = 296 MeV and a reaction angle of $\theta_{\rm lab}$ = $0^{\circ}$. The data are compared with distorted-wave impulse approximation calculations employing the large configuration-space shell-model (SM) wave functions. The well-known Gamow-Teller and spin-dipole (SD) states at excitation energies of $E_x$ $\lesssim$ 8 MeV have been reasonably reproduced by the calculations except for the spin--parity $J^{\pi}$ = $2^-$ state at $E_x$ = 5.86 MeV. The SD resonance at $E_x$ $\simeq$ 9.5 MeV appears to have more $J^{\pi}$ = $2^-$ strength than $J^{\pi}$ = $1^-$ strength, consistent with the calculations. The data show significant strength in the spin-longitudinal polarized cross section $ID_L(0^{\circ})$ at $E_x$ $\simeq$ 15 MeV, which indicates existence of the $J^{\pi}$ = $0^-$ SD resonance as predicted in the SM calculations.Comment: 6 figures, submitted to Physical Review

Distribution of Air Temperature in Tajimi City in Summer

To research the distribution of air temperature in the city of Tajimi, Gifu prefecture, a total of 15 thermometers were placed at the schools and parks in the city of Tajimi, and the city of Kasugai, Aichi prefecture in August 2010. From the distribution of monthly average air temperature, air temperature at the center of Tajimi city was higher than the suburbs. Also, the days of daily minimum air temperature more than or equal to 25°C and daily maximum air temperature more than or equal to 35°C at the elementary school near the center of Tajimi city was more than those at other schools. This tendency appeared more clearly on the days of daily minimum air temperature more than or equal to 25°C. Also, the air temperature near the center of the city was higher than that ofthe suburbs in the early morning. Thus, it was indicated that the air temperature was hard to decrease as the bottom of the basin. From these results, the influence of urbanization to the formation of the daily minimum temperature in Tajimi city was indicated

Observational Study and Numerical Prediction Experiments on Wet-Bulb Globe Temperature in Tajimi, Gifu Prefecture: Consideration of Uncertainty with a Physics Parameterization Scheme and Horizontal Resolution of the Weather Research and Forecasting Model

As part of research on the actual conditions of the thermal environment surrounding the city of Tajimi, Gifu prefecture, and the city of Kasugai, Aichi prefecture, the surface air temperature and wet-bulb globe temperature (WBGT) were investigated by observation at these locations on clear-sky days in August 2010. Numerical prediction experiments on the WBGT were performed to confirm the utility of the Weather Research and Forecasting (WRF) model. Sensitivity experiments utilizing physics parameterization schemes and horizontal resolution of the WRF model were conducted to confirm the predicted WBGT. The resultsshowed that the maximum sensitivity with the parameterization scheme was 8.4°C for the daytime average, and especially, the simple thermal diffusion surface (SLAB) scheme caused an over/estimation of 6.8°C. On the other hand, the maximum sensitivity with horizontal resolution was 0.5°C, which is much less than that with the parameterization scheme

Factors causing climatologically high temperatures in a hottest city in Japan: a multi-scale analysis of Tajimi

In this study, multi-scale climatological features of extreme high temperature (EHT) events in Tajimi, the hottest cities in Japan, were investigated using observational data collected by the Japan Meteorological Agency over the past 23 years, and original data observed by the authors over the last 3 years. Results revealed the background factors that lead to climatologically high temperatures in Tajimi: the occurrence of a characteristic pressure pattern called ‘whale’: the synoptic-scale factors, and the urbanization of Tajimi: the meso-γ-scale factors. In addition, the high temperatures measured in Tajimi are affected by the foehn-like westerly airflow coming from the mountains located in the northwest/west towards the Nobi Plain where Tajimi is located at the east end: the meso-β-scale factors, and the location of the Tajimi observation site, which is within an urbanized area where the highest temperatures tend to be observed: the micro-scale factors. In contrast, statistical analysis demonstrated that the small-scale basin effects and soil dryness around Tajimi were of lesser importance than aforementioned factors, in the occurrence of EHT events in Tajimi

Suppression of charged particle production at large transverse momentum in central Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}} = 2.76 TeV

Inclusive transverse momentum spectra of primary charged particles in Pb-Pb collisions at $\sqrt{s_{_{\rm NN}}}$ = 2.76 TeV have been measured by the ALICE Collaboration at the LHC. The data are presented for central and peripheral collisions, corresponding to 0-5% and 70-80% of the hadronic Pb-Pb cross section. The measured charged particle spectra in $|\eta|<0.8$ and $0.3 < p_T < 20$ GeV/$c$ are compared to the expectation in pp collisions at the same $\sqrt{s_{\rm NN}}$, scaled by the number of underlying nucleon-nucleon collisions. The comparison is expressed in terms of the nuclear modification factor $R_{\rm AA}$. The result indicates only weak medium effects ($R_{\rm AA} \approx$ 0.7) in peripheral collisions. In central collisions, $R_{\rm AA}$ reaches a minimum of about 0.14 at $p_{\rm T}=6$-7GeV/$c$ and increases significantly at larger $p_{\rm T}$. The measured suppression of high-$p_{\rm T}$ particles is stronger than that observed at lower collision energies, indicating that a very dense medium is formed in central Pb-Pb collisions at the LHC.Comment: 15 pages, 5 captioned figures, 3 tables, authors from page 10, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/98

Two-pion Bose-Einstein correlations in central Pb-Pb collisions at sNN\sqrt{s_{\rm NN}} = 2.76 TeV

The first measurement of two-pion Bose-Einstein correlations in central Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV at the Large Hadron Collider is presented. We observe a growing trend with energy now not only for the longitudinal and the outward but also for the sideward pion source radius. The pion homogeneity volume and the decoupling time are significantly larger than those measured at RHIC.Comment: 17 pages, 5 captioned figures, 1 table, authors from page 12, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/388

Neutral pion and η\eta meson production in proton-proton collisions at s=0.9\sqrt{s}=0.9 TeV and s=7\sqrt{s}=7 TeV

The first measurements of the invariant differential cross sections of inclusive $\pi^0$ and $\eta$ meson production at mid-rapidity in proton-proton collisions at $\sqrt{s}=0.9$ TeV and $\sqrt{s}=7$ TeV are reported. The $\pi^0$ measurement covers the ranges $0.4<p_T<7$ GeV/$c$ and $0.3<p_T<25$ GeV/$c$ for these two energies, respectively. The production of $\eta$ mesons was measured at $\sqrt{s}=7$ TeV in the range $0.4<p_T<15$ GeV/$c$. Next-to-Leading Order perturbative QCD calculations, which are consistent with the $\pi^0$ spectrum at $\sqrt{s}=0.9$ TeV, overestimate those of $\pi^0$ and $\eta$ mesons at $\sqrt{s}=7$ TeV, but agree with the measured $\eta/\pi^0$ ratio at $\sqrt{s}=7$ TeV.Comment: 17 pages, 5 captioned figures, 2 tables, authors from page 12, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/310

Higher harmonic anisotropic flow measurements of charged particles in Pb-Pb collisions at 2.76 TeV

We report on the first measurement of the triangular $v_3$, quadrangular $v_4$, and pentagonal $v_5$ charged particle flow in Pb-Pb collisions at 2.76 TeV measured with the ALICE detector at the CERN Large Hadron Collider. We show that the triangular flow can be described in terms of the initial spatial anisotropy and its fluctuations, which provides strong constraints on its origin. In the most central events, where the elliptic flow $v_2$ and $v_3$ have similar magnitude, a double peaked structure in the two-particle azimuthal correlations is observed, which is often interpreted as a Mach cone response to fast partons. We show that this structure can be naturally explained from the measured anisotropic flow Fourier coefficients.Comment: 10 pages, 4 figures, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/387