Inkjet-printed stretchable and low voltage synaptic transistor array.

Wearable and skin electronics benefit from mechanically soft and stretchable materials to conform to curved and dynamic surfaces, thereby enabling seamless integration with the human body. However, such materials are challenging to process using traditional microelectronics techniques. Here, stretchable transistor arrays are patterned exclusively from solution by inkjet printing of polymers and carbon nanotubes. The additive, non-contact and maskless nature of inkjet printing provides a simple, inexpensive and scalable route for stacking and patterning these chemically-sensitive materials over large areas. The transistors, which are stable at ambient conditions, display mobilities as high as 30 cm2 V-1 s-1 and currents per channel width of 0.2 mA cm-1 at operation voltages as low as 1 V, owing to the ionic character of their printed gate dielectric. Furthermore, these transistors with double-layer capacitive dielectric can mimic the synaptic behavior of neurons, making them interesting for conformal brain-machine interfaces and other wearable bioelectronics

A 3D Model of the Membrane Protein Complex Formed by the White Spot Syndrome Virus Structural Proteins

Outbreaks of white spot disease have had a large negative economic impact on cultured shrimp worldwide. However, the pathogenesis of the causative virus, WSSV (whit spot syndrome virus), is not yet well understood. WSSV is a large enveloped virus. The WSSV virion has three structural layers surrounding its core DNA: an outer envelope, a tegument and a nucleocapsid. In this study, we investigated the protein-protein interactions of the major WSSV structural proteins, including several envelope and tegument proteins that are known to be involved in the infection process.In the present report, we used coimmunoprecipitation and yeast two-hybrid assays to elucidate and/or confirm all the interactions that occur among the WSSV structural (envelope and tegument) proteins VP51A, VP19, VP24, VP26 and VP28. We found that VP51A interacted directly not only with VP26 but also with VP19 and VP24. VP51A, VP19 and VP24 were also shown to have an affinity for self-interaction. Chemical cross-linking assays showed that these three self-interacting proteins could occur as dimers.From our present results in conjunction with other previously established interactions we construct a 3D model in which VP24 acts as a core protein that directly associates with VP26, VP28, VP38A, VP51A and WSV010 to form a membrane-associated protein complex. VP19 and VP37 are attached to this complex via association with VP51A and VP28, respectively. Through the VP26-VP51C interaction this envelope complex is anchored to the nucleocapsid, which is made of layers of rings formed by VP664. A 3D model of the nucleocapsid and the surrounding outer membrane is presented

Measurement of ZZ production in leptonic final states at {\surd}s of 1.96 TeV at CDF

In this paper we present a precise measurement of the total ZZ production cross section in pp collisions at {\surd}s= 1.96 TeV, using data collected with the CDF II detector corresponding to an integrated luminosity of approximately 6 fb-1. The result is obtained by combining separate measurements in the four-charged (lll'l'), and two-charged-lepton and two-neutral-lepton (llvv) decay modes of the Z. The combined measured cross section for pp {\to} ZZ is 1.64^(+0.44)_(-0.38) pb. This is the most precise measurement of the ZZ production cross section in 1.96 TeV pp collisions to date.Comment: submitted to Phys. Rev. Let

Measurement of b hadron lifetimes in exclusive decays containing a J/psi in p-pbar collisions at sqrt(s)=1.96TeV

We report on a measurement of $b$-hadron lifetimes in the fully reconstructed decay modes B^+ -->J/Psi K+, B^0 --> J/Psi K*, B^0 --> J/Psi Ks, and Lambda_b --> J/Psi Lambda using data corresponding to an integrated luminosity of 4.3 ${\rm fb}^{-1}$, collected by the CDF II detector at the Fermilab Tevatron. The measured lifetimes are $\tau$B^+ = $1.639 \pm 0.009 ({\rm stat}) \pm 0.009 {\rm (syst) ~ ps}$, $\tau$B^0 = $1.507 \pm 0.010 ({\rm stat}) \pm 0.008 {\rm (syst) ~ ps}$ and $\tau$Lambda_b = $1.537 \pm 0.045 ({\rm stat}) \pm 0.014 {\rm (syst) ~ ps}$. The lifetime ratios are $\tau$B^+/$\tau$B^0 = $1.088 \pm 0.009 ({\rm stat})\pm 0.004 ({\rm syst})$ and $\tau$Lambda_b/$\tau$B^0 = $1.020 \pm 0.030 ({\rm stat})\pm 0.008 ({\rm syst})$. These are the most precise determinations of these quantities from a single experiment.Comment: revised version. accepted for PRL publicatio

Search for High Mass Resonances Decaying to Muon Pairs in root s=1.96 TeV p(p)over-bar Collisions

We present a search for a new narrow, spin-1, high mass resonance decaying to mu(+)mu(-) + X, using a matrix-element-based likelihood and a simultaneous measurement of the resonance mass and production rate. In data with 4.6 fb(-1) of integrated luminosity collected by the CDF detector in p (p) over bar collisions at root s = 1960 GeV, the most likely signal cross section is consistent with zero at 16% confidence level. We therefore do not observe evidence for a high mass resonance and place limits on models predicting spin-1 resonances, including M > 1071 GeV/c(2) at 95% confidence level for a Z' boson with the same couplings to fermions as the Z boson

Measurement of b Hadron Lifetimes in Exclusive Decays Containing a J/Psi in p(p)over-bar Collisions at root s=1.96 TeV

We report on a measurement of b-hadron lifetimes in the fully reconstructed decay modes B+-> J/psi K+, B-0 -> J/psi K*(892)(0), B-0 -> J/psi K-s(0), and Lambda(0)(b)-> J/psi Lambda(0) using data corresponding to an integrated luminosity of 4.3 fb(-1), collected by the CDF II detector at the Fermilab Tevatron. The measured lifetimes are tau(B+)=[1.639 +/- 0.009(stat)+/- 0.009(syst)]ps, tau(B-0)=[1.507 +/- 0.010(stat)+/- 0.008(syst)]ps, and tau(Lambda(0)(b))=[1.537 +/- 0.045(stat)+/- 0.014(syst)]ps. The lifetime ratios are tau(B+)/tau(B-0)=[1.088 +/- 0.009(stat)+/- 0.004(syst)] and tau(Lambda(0)(b))/tau(B-0)=[1.020 +/- 0.030(stat)+/- 0.008(syst)]. These are the most precise determinations of these quantities from a single experiment

Using the aminomethyl-chemmatrix beads to achieve the purpose of protein equalization

大部分生物抽取液(譬如：血清、胸腔液)的組成蛋白質濃度差距非常大，差距可以超過1010，也因為這非常巨大的濃度差距，那些已經被發現而且研究的非常透徹的幾個主要組成蛋白質，會遮蔽在生物抽取液中其他濃度非常低的蛋白質，使得低濃度蛋白質不容易被偵測到，因此這些低濃度蛋白質的偵測和分離是現階段蛋白質體學中一個有待克服的障礙。近年來，一些用來減少生物抽取液中各蛋白質濃度差距的方法被發展出來，在此，我們利用aminomethyl-chemmatrix微珠，因為此微珠具有兩性端(疏水端及親水端)可以去抓取蛋白質，期望可以達到平衡胸腔液樣品中各蛋白質濃度差距。我們分析處理過後的胸腔液樣品，發現那些低濃度蛋白質比較容易被二維電泳偵測到，我們接著用此方式去處理正常人的胸腔液和癌症病人的胸腔液，那些在病人和正常人中表現有差異的低濃度蛋白質較容易用二維電泳區分，而在這些有表現差異的低濃度蛋白質中，我們希望能找到屬於癌症病人的生物標記。Most of biological extracts (e.g., serum, pleural effusion) have an extremely wide dynamic concentration range of over ten orders of magnitude, so a few well-characterized, high-abundant proteins mask the signal of other low abundance proteins. The separation and detection of low abundant proteins in the proteome is still an obstacle to be solved. Many methods which can make the “hidden proteome” become easier to research are developed in recently. We report here the use of amiomethyl-chemmatrix beads to reduce the dynamic concentration range in pleural effusion (PE). The amiomethyl-chemmatrix beads have the amphiphilic nature to equalize the concentration of different protein species. After treatment with the bead, the low abundance proteins in PE are easier to detect by 2-DE PAGE. The differences in the treated PE from normal person and lung cancer person are easier determined by 2-DE PAGE and we expect that the cancer biomarkers will be discovered among the different proteomes between these two treated PE.1. Introduction…………………………………………………………………………8. Materials and methods……………………………………………………...……15 2.1. Materials……………………………………………………………….…….15.2. Methods…………………………….………………………….……………..16 2.2.1. Protein equalization by using Aminomethyl-ChemMatrix bead…....…16 2.2.2. Desalting of the eluant………………………..………………………16 2.2.3. Two-dimensional electrophoresis……………………………..……….17.2.4. In-gel digestion………………………………………………………...18.2.5. In-solution digestion…………………………………………………...19.2.6. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) ………………………………………...………………...20. Results……………………………………………………………………………..21 3.1. The dynamic range of protein concentration in PE were decreasing after equalization technology……………………………………………………....21 3.2. The optimal loading capacity of this bead ……………………………..…......22 3.3. Application of this method to PE from normal person and lung cancer patient and compared the differences between PE…………………………………...22.4. Protein identification by LC MS/MS…………………………..……………..23. Discussion…………………………………………………………………………25. Conclusion…………………………………………………………………………27. References…………………….…….……………………………………………..28. Figures…………………………………………………………………………..…35. Tables………………………………………………………………………………4

Development of a SoLoMo Game-Based Application for Supporting Local Cultural Learning in Taiwan

Recently, the development of local cultural features and tourism has become important in Taiwan. To support local cultural education, relevant studies have developed outdoor learning approaches and integrated mobile technology to connect real-world and digital-world learning resources. Nevertheless, the above-mentioned developments are usually suitable for a specific learning process and activity. In other words, students may lack the motivation to engage in the same learning process repeatedly after participating in the learning activity. Therefore, to promote students’ local cultural learning, this study developed a game-based local cultural learning application based on the social, local, and mobile (SoLoMo) principle. To investigate the effect of the proposed approach on students’ learning performance with regard to local culture, a quasi-experiment was conducted on a society course at a Taiwanese elementary school. The experimental-group students learned with the proposed approach, while the control-group students learned with the conventional mobile learning approach. The experimental results showed that, compared with the conventional mobile learning approach, the proposed approach significantly improved the students’ learning achievement, learning retention, and learning motivation. Moreover, it was also found that most students showed positive perceptions toward the usage of the proposed application

Secondary structure of the CP variants (A) CP36 and (B) CP102, evaluated according to the parameter Δδ_Cα−Δδ_Cβ.

<p>The chemical shift values for ¹³C_α and ¹³C_β of CP36 and CP102 were obtained, and Δδ_Cα and Δδ_Cβ were calculated from the differences between the experimental values and random coil values. The value of Δδ_Cα−Δδ_Cβ for each residue represents the average of three consecutive residues, centered at the particular residue. The Δδ_Cα−Δδ_Cβ value derived from native NpuInt C1G (indicated by closed circles) is overlaid onto the CP results for comparison. The corresponding secondary structure of C1G is depicted at the top. The difference (ΔΔδ) in (Δδ_Cα−Δδ_Cβ) between each CP variant and C1G was calculated and is indicated at the bottom of the figure.</p