Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)

We find that CD11c(+) cells with many markers of dendritic cells (DCs) are a major cell type in the skin lesions of psoriasis. These CD11c(+) cells, which are evident in both epidermis and dermis, are the sites for the expression of two mediators of inflammation, inducible nitric oxide synthase (iNOS) and TNF-α in diseased skin. These cells express HLA-DR, CD40, and CD86, lack the Langerin and CD14 markers of Langerhans cells and monocytes, respectively, and to a significant extent express the DC maturation markers DC-LAMP and CD83. Treatment of psoriasis with efalizumab (anti-CD11a, Raptiva) strongly reduces infiltration by these DCs in patients responding to this agent. Disease activity after therapy was more related to DC infiltrates and iNOS mRNA levels than T cell infiltrates, and CD11c(+) cells responded more quickly to therapy than epidermal keratinocytes. Our results suggest that a type of DC, which resembles murine “Tip-DCs” that can accumulate during infection, has proinflammatory effects in psoriasis through nitric oxide and TNF-α production, and can be an important target for suppressive therapies

The protective and detrimental effects of self-construal on perceived rejection from heritage culture members

This article has been made available through the Brunel Open Access Publishing Fund.Individuals may perceive themselves as interdependent and similar with close others, or as independent and distinct. Do these differences in self-construal influence perceptions of rejection from those closest to us? Few studies have investigated the antecedents of intragroup marginalisation – the perception of rejection from family and friends due to not conforming to the prescribed values and expectations of one’s heritage culture. Furthermore, the implications of perceived intragroup marginalisation for psychological adjustment and an integrated bicultural identity are unclear. To gauge the effects of self-construals on perceived intragroup marginalisation and psychological adjustment (i.e., subjective well-being and flourishing) and an integrated bicultural identity, we increased the cognitive accessibility of independent and interdependent self-construals through a priming manipulation. Participants were recruited via Amazon MTurk and completed the measures online. Our results showed that priming an interdependent self-construal decreased perceived intragroup marginalisation from family and, in turn, poor psychological adjustment and bicultural identity conflict. Conversely, participants primed with an independent self-construal reported increased perceptions of intragroup marginalisation from their family and, in turn, decreased psychological adjustment and increased identity conflict. These findings support the benefits of an interdependent self and the disadvantages of an independent self for minimizing perceived exclusion from heritage culture members

Conjugated Polymers: Relationship Between Morphology and Optical Properties

In this Chapter we will start by briefly summarising the basic concepts of the electronic structure of conjugated polymers. This will enable the discussion of the relevant descriptions of the dielectric function. We will relate these descriptions to the model parameterisations which are used in advanced ellipsometric analysis of thin films such as those used in devices for organic photovoltaics (OPVs) and light emitting diodes (OLEDs). Amongst other things, such parametric descriptions are useful to deal with structural changes in conjugated polymer thin films. Once the models are presented, we will provide representative examples of the nexus between morphology and optical constants, and how the latter can be employed to infer aspects of the former. First, we will discuss how chain conformation affects the optical properties. Then, we will explain the anisotropic behaviour of conjugated polymer films due to their intrinsic molecular anisotropy and review different cases (f. i., oriented films or semicrystalline polymers). We will also describe structural changes that occur upon blending polymers with fullerenes and concomitant variations of the optical properties. Here we will focus on state of the art low band gap polymers mixed with fullerenes. Finally, real-time ellipsometric experiments in which these structure-property relationships can be exploited will be presented.The authors acknowledge financial support from the Spanish Ministry of Economy and Competitiveness through grant MAT2015-70850-P and the Severo Ochoa Programme for Centres of Excellence in R&D (SEV-2015-0496).Peer reviewe

Advances in Genetic Engineering of Microalgae

Hallmann A. Advances in Genetic Engineering of Microalgae. In: Grand Challenges in Algae Biotechnology. Grand Challenges in Biology and Biotechnology. Cham: Springer International Publishing; 2020: 159-221