122 research outputs found
Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women
A consensus view of soyabean phyto-oestrogens in clinical interventions in post-menopausal women is presented that is based on data from the EU-funded project Phytohealth. The phyto-oestrogens, primarily genistein and daidzein, were given as soyabean-protein isolates, whole-soyabean foods or extracts, supplements or pure compounds. A comprehensive literature search was conducted with well-defined inclusion or exclusion criteria. For areas for which substantial research exists only placebo-controlled double-blind randomised controlled trials (RCT) conducted on healthy post-menopausal women were included. For emerging areas all available human studies in post-menopausal women were reviewed. In order to make cross comparisons between studies the doses of isoflavones were calculated as aglycone equivalents. There is a suggestion, but no conclusive evidence, that isoflavones from the sources studied so far have a beneficial effect on bone health. The consumption of whole-soyabean foods and soyabean-protein isolates has some beneficial effects on lipid markers of cardiovascular risk. The consumption of isolated isoflavones does not affect blood lipid levels or blood pressure, although it may improve endothelial function. For menopausal symptoms there is currently limited evidence that soyabean-protein isolates, soyabean foods or red-clover (Trifolium pratense L.) extract are effective but soyabean isoflavone extracts may be effective in reducing hot flushes. There are too few RCT studies to reach conclusions on the effects of isoflavones on breast cancer, colon cancer, diabetes or cognitive function. The health benefits of soyabean phyto-oestrogens in healthy post-menopausal women are subtle and even some well-designed studies do not show protective effects. Future studies should focus on high-risk post-menopausal women, especially in the areas of diabetes, CVD, breast cancer and bone healt
Integrated land and water-borne geophysical surveys shed light on the sudden drying of large karst lakes in southern Mexico
Karst water resources play an important role in drinking water supply but are highly vulnerable to even slight changes in climate. Thus, solid and spatially dense geological information is needed to model the response of karst hydrological systems to such changes. Additionally, environmental information archived in lake sediments can be used to understand past climate effects on karst water systems. In the present study, we carry out a multi-methodological geophysical survey to investigate the geological situation and sedimentary infill of two karst lakes (Metzabok and Tzibaná) of the Lacandon Forest in Chiapas, southern Mexico. Both lakes present large seasonal lake-level fluctuations and experienced an unusually sudden and strong lake-level decline in the first half of 2019, leaving Lake Metzabok (maximum depth ∼25 m) completely dry and Lake Tzibaná (depth ∼70 m) with a water level decreased by approx. 15 m. Before this event, during a lake-level high stand in March 2018, we collected water-borne seismic data with a sub-bottom profiler (SBP) and transient electromagnetic (TEM) data with a newly developed floating single-loop configuration. In October 2019, after the sudden drainage event, we took advantage of this unique situation and carried out complementary measurements directly on the exposed lake floor of Lakes Metzabok and Tzibaná. During this second campaign, we collected time-domain induced polarization (TDIP) and seismic refraction tomography (SRT) data. By integrating the multi-methodological data set, we (1) identify 5–6 m thick, likely undisturbed sediment sequences on the bottom of both lakes, which are suitable for future paleoenvironmental drilling campaigns, (2) develop a comprehensive geological model implying a strong interconnectivity between surface water and karst aquifer, and (3) evaluate the potential of the applied geophysical approach for the reconnaissance of the geological situation of karst lakes. This methodological evaluation reveals that under the given circumstances, (i) SBP and TDIP phase images consistently resolve the thickness of the fine-grained lacustrine sediments covering the lake floor, (ii) TEM and TDIP resistivity images consistently detect the upper limit of the limestone bedrock and the geometry of fluvial deposits of a river delta, and (iii) TDIP and SRT images suggest the existence of a layer that separates the lacustrine sediments from the limestone bedrock and consists of collapse debris mixed with lacustrine sediments. Our results show that the combination of seismic methods, which are most widely used for lake-bottom reconnaissance, with resistivity-based methods such as TEM and TDIP can significantly improve the interpretation by resolving geological units or bedrock heterogeneities, which are not visible from seismic data. Only the use of complementary methods provides sufficient information to develop comprehensive geological models of such complex karst environment
Investigating variation in replicability
Although replication is a central tenet of science, direct replications are rare in psychology. This research tested variation in the replicability of 13 classic and contemporary effects across 36 independent samples totaling 6,344 participants. In the aggregate, 10 effects replicated consistently. One effect – imagined contact reducing prejudice – showed weak support for replicability. And two effects – flag priming influencing conservatism and currency priming influencing system justification – did not replicate. We compared whether the conditions such as lab versus online or US versus international sample predicted effect magnitudes. By and large they did not. The results of this small sample of effects suggest that replicability is more dependent on the effect itself than on the sample and setting used to investigate the effect
Introduction to EJES special journal issue on ‘Feminist Interventions in Intermedial Studies'
Abstract
The feminist project has radicalised text/image relationships in myriad ways, disrupting the contours of discipline and medium. The multifaceted recyclings of a transdisciplinary methodology remind us that although in the past decades text/image studies has become an established academic research field in the first decades of the twenty-first century, its subversive potential to challenge cultural hegemonies has not diminished. On the contrary, intermedial fusions remain loaded with political and ethical issues that are in search of sites of resistance for marginalised, othered social subjects and meanings. The introduction explains how this special journal issue emerges from and is addressed to the politically significant network of feminist researchers -- artists, theoreticians, activists -- we believe we share ties with on account of putting the study of intermediality in the service of 'constructing a radically new understanding of our world in all its horror and hope' (Pollock, 1988: 22)
Many Labs 2: Investigating Variation in Replicability Across Samples and Settings
We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p < .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p < .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely highpowered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP
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