Morphological alterations and stress protein variations in lung biopsies obtained from autopsies of covid-19 subjects

Molecular chaperones, many of which are heat shock proteins, play a role in cell stress response and regulate the immune system in various ways, such as in inflammatory/autoimmune reactions. It would be interesting to study the involvement of these molecules in the damage done to COVID-19-infected lungs. In our study, we performed a histological analysis and an immunomorphological evaluation on lung samples from subjects who succumbed to COVID-19 and subjects who died from other causes. We also assessed Hsp60 and Hsp90 distribution in lung samples to determine their location and post-translational modifications. We found histological alterations that could be considered pathognomonic for COVID-19-related lung disease. Hsp60 and Hsp90 immunopositivity was significantly higher in the COVID-19 group compared to the controls, and immunolocalization was in the plasma membrane of the endothelial cells in COVID-19 subjects. The colocalization ratios for Hsp60/3-nitrotyrosine and Hsp60/acetylate-lisine were significantly increased in the COVID-19 group compared to the control group, similar to the colocalization ratio for Hsp90/acetylate-lisine. The histological and immunohistochemical findings led us to hypothesize that Hsp60 and Hsp90 might have a role in the onset of the thromboembolic phenomena that lead to death in a limited number of subjects affected by COVID-19. Further studies on a larger number of samples obtained from autopsies would allow to confirm these data as well as discover new biomarkers useful in the battle against this disease

The environment of radio galaxies: a signature of AGN feedback at high redshifts

We use the semi-analytical model of galaxy formation GALFORM to characterize an indirect signature of active galactic nucleus (AGN) feedback in the environment of radio galaxies at high redshifts. The predicted environment of radio galaxies is denser than that of radio-quiet galaxies with the same stellar mass. This is consistent with observational results from the CARLA survey. Our model shows that the differences in environment are due to radio galaxies being hosted by dark matter haloes that are ∼1.5 dex more massive than those hosting radio-quiet galaxies with the same stellar mass. By running a control simulation in which AGN feedback is switched off, we identify AGN feedback as the primary mechanism affecting the build up of the stellar component of radio galaxies, thus explaining the different environment in radio galaxies and their radio-quiet counterparts. The difference in host halo mass between radio-loud and radio-quiet galaxies translates into different galaxies populating each environment. We predict a higher fraction of passive galaxies around radio-loud galaxies compared to their radio-quiet counterparts. Furthermore, such a high fraction of passive galaxies shapes the predicted infrared luminosity function in the environment of radio galaxies in a way that is consistent with observational findings. Our results suggest that the impact of AGN feedback at high redshifts and environmental mechanisms affecting galaxies in high halo masses can be revealed by studying the environment of radio galaxies, thus providing new constraints on galaxy formation physics at high redshifts

J-PLUS: The javalambre photometric local universe survey

ABSTRACT: TheJavalambrePhotometric Local UniverseSurvey (J-PLUS )isanongoing 12-band photometricopticalsurvey, observingthousands of squaredegrees of theNorthernHemispherefromthededicated JAST/T80 telescope at the Observatorio Astrofísico de Javalambre (OAJ). The T80Cam is a camera with a field of view of 2 deg2 mountedon a telescopewith a diameter of 83 cm, and isequippedwith a uniquesystem of filtersspanningtheentireopticalrange (3500–10 000 Å). Thisfiltersystemis a combination of broad-, medium-, and narrow-band filters, optimallydesigned to extracttherest-framespectralfeatures (the 3700–4000 Å Balmer break region, Hδ, Ca H+K, the G band, and the Mg b and Ca triplets) that are key to characterizingstellartypes and delivering a low-resolutionphotospectrumforeach pixel of theobservedsky. With a typicaldepth of AB ∼21.25 mag per band, thisfilter set thusallowsforanunbiased and accuratecharacterization of thestellarpopulation in our Galaxy, itprovidesanunprecedented 2D photospectralinformationforall resolved galaxies in the local Universe, as well as accuratephoto-z estimates (at the δ z/(1 + z)∼0.005–0.03 precisionlevel) formoderatelybright (up to r ∼ 20 mag) extragalacticsources. Whilesomenarrow-band filters are designedforthestudy of particular emissionfeatures ([O II]/λ3727, Hα/λ6563) up to z < 0.017, theyalsoprovidewell-definedwindowsfortheanalysis of otheremissionlines at higherredshifts. As a result, J-PLUS has thepotential to contribute to a widerange of fields in Astrophysics, both in thenearbyUniverse (MilkyWaystructure, globular clusters, 2D IFU-likestudies, stellarpopulations of nearby and moderate-redshiftgalaxies, clusters of galaxies) and at highredshifts (emission-line galaxies at z ≈ 0.77, 2.2, and 4.4, quasi-stellarobjects, etc.). Withthispaper, wereleasethefirst∼1000 deg2 of J-PLUS data, containingabout 4.3 millionstars and 3.0 milliongalaxies at r <  21mag. With a goal of 8500 deg2 forthe total J-PLUS footprint, thesenumbers are expected to rise to about 35 millionstars and 24 milliongalaxiesbytheend of thesurvey.Funding for the J-PLUS Project has been provided by the Governments of Spain and Aragón through the Fondo de Inversiones de Teruel, the Spanish Ministry of Economy and Competitiveness (MINECO; under grants AYA2017-86274-P, AYA2016-77846-P, AYA2016-77237-C3-1-P, AYA2015-66211-C2-1-P, AYA2015-66211-C2-2, AYA2012-30789, AGAUR grant SGR-661/2017, and ICTS-2009-14), and European FEDER funding (FCDD10-4E-867, FCDD13-4E-2685

J-PLUS: The Javalambre Photometric Local Universe Survey

The Javalambre Photometric Local Universe Survey (J-PLUS) is an ongoing 12-band photometric optical survey, observing thousands of square degrees of the Northern Hemisphere from the dedicated JAST/T80 telescope at the Observatorio Astrofisico de Javalambre (OAJ). The T80Cam is a camera with a field of view of 2 deg(2) mounted on a telescope with a diameter of 83 cm, and is equipped with a unique system of filters spanning the entire optical range (3500-10 000 angstrom). This filter system is a combination of broad-, medium-, and narrow-band filters, optimally designed to extract the rest-frame spectral features (the 3700-4000 angstrom Balmer break region, H delta, Ca H+K, the G band, and the Mg b and Ca triplets) that are key to characterizing stellar types and delivering a low-resolution photospectrum for each pixel of the observed sky. With a typical depth of AB similar to 21.25 mag per band, this filter set thus allows for an unbiased and accurate characterization of the stellar population in our Galaxy, it provides an unprecedented 2D photospectral information for all resolved galaxies in the local Universe, as well as accurate photo-z estimates (at the delta z/(1 + z) similar to 0.005-0.03 precision level) for moderately bright (up to r similar to 20 mag) extragalactic sources. While some narrow-band filters are designed for the study of particular emission features ([O II]/lambda 3727, H alpha/lambda 6563) up to z < 0.017, they also provide well-defined windows for the analysis of other emission lines at higher redshifts. As a result, J-PLUS has the potential to contribute to a wide range of fields in Astrophysics, both in the nearby Universe (Milky Way structure, globular clusters, 2D IFU-like studies, stellar populations of nearby and moderate-redshift galaxies, clusters of galaxies) and at high redshifts (emission-line galaxies at z approximate to 0.77, 2.2, and 4.4, quasi-stellar objects, etc.). With this paper, we release the first similar to 1000 deg(2) of J-PLUS data, containing about 4.3 million stars and 3.0 million galaxies at r < 21 mag. With a goal of 8500 deg(2) for the total J-PLUS footprint, these numbers are expected to rise to about 35 million stars and 24 million galaxies by the end of the survey

Interactive access and optimization of a CMS computing farm

CMS data taking at LHC is going on and its computing activity is increasing day after day. The need of efficient and reliable computing centers to run analysis and MC production is getting more and more pressing. The requirements, in terms of func tionalities and performance, coming from the physics local community on a typical Tier2 for the everyday work will be described. A report will be given on the tests performed and the results achieved while attempting to improve a typical Tier2. Important improvements on the storage performance have been achieved through a patient optimization of several layers starting from the hardware to the storage manager software. In particular the performance and the functionalities obtained using two different stor age manager solutions, dCache and StoRM/Lustre, will be presented. Particular attention has been taken regarding the batch system configuration and its scheduling policy to better fulfill the requirements of the different use cases. Several optimization t ests have been performed to provide dynamic resources to the interactive work in order to accommodate both the batch typical Tier2 activity and the interactive activity as it is required in a Tier3 site. This result was obtained by means of an advanced co nfiguration of the farm and in particular of the batch system used on the Tier2 batch farm. As a consequence of the optimization a great improvement in the efficiency of resource usage has been observed and a substantial reduction of the manpower required to provide an efficient and reliable interactive service has been achieved

Anatomy of the Cervical Spine

The vertebral column is divided into regions and consists of 32-35 vertebrae, separated from each other by intervertebral discs. Functionally, the vertebrae form a single structure designed to maintain an upright posture and balance countering gravity, enabling locomotion and every other kinetic movement against applied force and resistance. Therefore, the two basic requirements of the spine are rigidity, for static efficiency and protection of the spinal cord and spinal nerves, and flexibility, for the kinematics of the spine. Vertebrae forming the different parts of the spine have joints that allow diverse spine movements, such as rotation, inclination, flexion and extension of the head. The cervical spine is mainly innervated by the cervical plexus. The cervical plexus is composed of the anastomosis of ventral branches of the first four cervical nerves and by an anastomotic branch of fifth one, forming the ansa cervicalis