Portland cement versus MTA as a root-end filling material. A pilot study

PURPOSE To assess periradicular lesions clinically and by computed tomography (CT) after endodontic surgery using either Portland cement or mineral trioxide aggregate (MTA) as a root-end filling material.METHODS: Three patients diagnosed with periradicular lesions by cone-beam CT underwent endodontic surgery with root-end filling. Patient A was treated with MTA as the root-end filling material, patient B was treated with Portland cement and patient C had two teeth treated, one with MTA and the other with Portland cement. Six months after surgery, the patients were assessed clinically and by CT scan and the obtained results were compared.RESULTS: Periradicular tissue regeneration was observed in all cases, with no significant differences in bone formation when comparing the use of MTA and Portland cement as root-end filling materials.CONCLUSION: Both mineral trioxide aggregate and Portland cement were successful in the treatment of periradicular lesions.Univ Vale Sapucai UNIVAS, Sci Appl Hlth, Pouso Alegre, MG, BrazilUniv Vale Sapucai, Sci Appl Hlth, Pouso Alegre, MG, BrazilFed Univ São Paulo UNIFESP, Translat Surg Grad Program, Sci Appl Hlth, UNIVAS, Pouso Alegre, MG, BrazilUniversidade Federal de São Paulo, Div Plast Surg, Dept Surg & Translat Surg Grad Program, São Paulo, BrazilIA CNPq, Med CAPES 3, São Paulo, BrazilFed Univ São Paulo UNIFESP, Translat Surg Grad Program, Sci Appl Hlth, UNIVAS, Pouso Alegre, MG, BrazilUniversidade Federal de São Paulo, Div Plast Surg, Dept Surg & Translat Surg Grad Program, São Paulo, BrazilWeb of Scienc

New U-Pb zircon dating of Late Neoproterozoic magmatism in Western Meseta (Morocco)

We present new U-Pb zircon ages from magmatic rocks of the Western Meseta, part of the Moroccan Variscan belt. The Neoproterozoic–Cambrian stratigraphy in the region of Goäida (Aguelmous massif, SE of Moroccan Central Massif) consists of limestones with conglomeratic and felsic volcaniclastic levels, pelites and mafic volcanic rocks assigned to the Cambrian which unconformably overlie rhyolites, andesites and rhyodacites and felsic tuffs associated with the Aguelmous granite of probable Neoproterozoic age. The Neoproterozoic–Cambrian stratigraphy of the region of Sidi Ali is roughly similar and also includes a volcanic-sedimentary complex with limestones, arkoses rhyolites and conglomerates. These conglomerates contain pebbles of granite and rhyolite, whose source may be the Neoproterozoic basement. In order to constrain the age of the Precambrian felsic magmatism we sampled and dated zircons (LA-ICPMS) from the Goäida granite and a pebble of granite included in the conglomeratic levels of the volcanicsedimentary complex at Sidi Ali dome (central Rehamna massif). In the Goäida granite, zircon ages are Ediacaran ranging between ~ 610 Ma and ~ 540 Ma, with a discordia upper intercept age of 598±32 Ma (MSWD=0.04) that could be interpreted as the age of intrusion. However, if we consider only the two youngest ages we obtain a Concordia age of 590±3 Ma (MSWD= 0.34). In the Sidi Ali pebble sample the majority of zircon ages are Cryogenian–Ediacaran in the range ~ 640–600 Ma, with the youngest yielding a Concordia age of 609±2 Ma (MSWD=0.04), indicating the intrusion age of the granite from which the pebble derived. These results support the existence of Cadomian/Pan-African magmatism in the Western Meseta of Morocco, characterized by the intrusion of granites at ~ 609 Ma and ~ 590 Ma. This result is important for studies of sedimentary provenance and to improve paleogeographic reconstructions of the northern margin of Gondwana during the Neoproterozoic

Intra-crustal recycling and crustal-mantle interactions in

In situ O-isotope compositions of detrital, inherited and melt-precipitated zircons with Neoproterozoic to Ordovician ages are presented to assess the crustal evolution of the North Gondwana margin. Different groups of pre-Mesozoic rocks from SW Iberia were targeted: i) Ediacaran paragneisses and meta-greywakes of the Ossa-Morena Zone – the Serie Negra Group deposited at ~ 560 Ma in a Cadomian magmatic arc setting (Pereira et al., 2008); ii) Early to Middle Cambrian orthogneisses and volcaniclastic rocks of the Ossa-Morena Zone – Evora Massif igneous complexes related to ensialic rifting at ~ 530–500 Ma (Pereira et al., 2008, Chichorro et al., 2008); iii) Late Cambrian to Early Ordovician volcaniclastic rocks and granites of the Ossa-Morena–Central Iberian transition zone – the Urra Formation and Portalegre granite formed at ~ 495– 488 Ma in a extensional setting (Solá et al., 2008); iv) Carboniferous granitoids (Nisa and Arraiolos granites) containing inherited zircons with Cambrian to Ordovician ages (Solá, this volume). A compilation the results for the period ~ 3.4 Ga to ~ 450 Ma reveals that: a) Archean zircons show little variation in d18O, with most values lying between 4.7 and 7.5‰, (average 6.2‰) comparable with usual d18O of zircons from Archean elsewhere (e.g., Valley et al., 2005); b) the range of d18O in Paleoproterozoic grains increases between 2.1 and 1.8 Ga with d18O >7.5‰, indicating increasing supracrustal recycling, but at ~ 1.8 Ga the d18O has mantle-like values (<5.1‰), documenting a crustal growth episode at this time; c) rare Mesoproterozoic grains have mildly evolved d18O values in the range 5.6–7.1‰); d) Tonian grains have low d18O values (4.2–5.6‰) typical of mantle-derived juvenile magmas but also higher values of 9.9‰ suggesting intra-crustal recycling; e) Cryogenian–Ordovician zircons show more variable and higher d18O values (~4 to >10‰), indicating great diversity and mixing of sources through intra-crustal recycling and crust–mantle interactions; f) some d18O values near to or below mantle composition (5.3 ± 0.3‰) were recorded at ~ 590 Ma (Ediacaran) suggesting input of mantle material into the crust; g) a decrease in variance of d18O occurs from 575 Ma to the Ediacaran/Cambrian boundary, suggesting a relative decrease in the magmatic contribution of surface-derived material; h) in Cambrian times, the average d18O is higher in the 536–520Ma interval (7.0‰) than in the 520–488 interval (6.2‰), which can be taken as a signal of gradual opening of the system to mantle-derived, mafic, rift-related igneous complexes; i) higher values of d18O (>7.5 ‰) recorded at ~ 623–574 Ma and 490–470Ma mark periods of pronounced increase in crustal recycling

Diversidade fenotípica e qualidade das carcaças de caprinos crioulos com potencial genético quanto à resistência à verminose

The objective of this work was to phenotypically characterize creole goats of the Moxotó, Azul, Canindé, Repartida, Marota, and Graúna breeds, comparing them with the Boer, Anglo Nubian, and Alpine exotic breeds, to identify the genetic groups of greater potential for carcass quality and resistance to infection caused by worm. Data on morphometric measurements were obtained for the count of worm eggs in grams of feces (WEGF), Famacha score, carcass measurements, and body weight from 308 animals, in a farm in the state of Piauí, Brazil. Repartida goats showed the highest average for wither height (61.55 cm) and rump height (62.16 cm), and Moxotó goats had the greatest ear length (13.45 cm). The Moxotó breed showed the highest means for carcass and body weight. The lowest average for body weight was observed in Azul goats (24.35 kg), and the lowest WEGF was detected in Repartida goats (200 eggs per gram of feces). The average Famacha score was 2.77. Average linkage was the method that best summarized the information on the morphometric and carcass data. The use of morphometric and carcass measurements provides satisfactory results in the phenotypic characterization of the animals. The Brazilian creole goats, which are considered resistant to worm infection and show high-quality carcass traits, may be indicated for conservation and genetic breeding programs.O objetivo deste trabalho foi caracterizar fenotipicamente caprinos crioulos das raças Moxotó, Azul, Canindé, Repartida, Marota e Graúna, em comparação às raças exóticas Boer, Anglo Nubiana e Alpina, para identificar grupos genéticos de maior potencial para qualidade de carcaça e resistência à verminose. Dados de medidas morfométricas foram obtidos quanto à contagem de ovos de vermes por grama de fezes (OVGF), ao escore Famacha, às medidas de carcaça e ao peso corporal de 308 animais de uma fazenda no Estado do Piauí. Os caprinos Repartida apresentaram a maior média de altura de cernelha (61,55 cm) e altura de garupa (62,16 cm), e os caprinos Moxotó, o maior comprimento de orelha (13,45 cm). A raça Moxotó apresentou as maiores médias de carcaça e peso corporal. O menor peso corporal médio foi dos caprinos Azul (24,35 kg), e o menor valor de OVGF foi o dos caprinos Repartida (200 ovos por grama de fezes). Para o escore Famacha, a média foi 2,77. O método da ligação média foi o que melhor resumiu a informação dos dados morfométricos e de carcaça. O uso de medidas morfométricas e de carcaça apresentou resultados satisfatórios na caracterização fenotípica dos animais. Os caprinos crioulos, considerados resistentes à verminose e com características de carcaça de boa qualidade, poderão ser indicados para programas de conservação e melhoramento genético

Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence.

Schistosomiasis is a parasitic disease caused by trematode worms of the genus Schistosoma and affects over 200 million people worldwide. The control and treatment of this neglected tropical disease is based on a single drug, praziquantel, which raises concerns about the development of drug resistance. This, and the lack of efficacy of praziquantel against juvenile worms, highlights the urgency for new antischistosomal therapies. In this review we focus on innovative approaches to the identification of antischistosomal drug candidates, including the use of automated assays, fragment-based screening, computer-aided and artificial intelligence-based computational methods. We highlight the current developments that may contribute to optimizing research outputs and lead to more effective drugs for this highly prevalent disease, in a more cost-effective drug discovery endeavor

The need for communication between clinicians and pathologists in the context of oral and maxillofacial diseases

Good communication between clinicians and pathologists is a vital element in the diagnostic process, and poor communication can adversely affect patient care. There is a lack of research about communication in diagnostic oral and maxillofacial pathology. This narrative review explores different aspects of the quality of communication between clinicians and oral pathologists, with a focus on the diagnosis of oral and maxillofacial diseases. An electronic search was carried out in MEDLINE through the PubMed, Scopus, and Embase databases up to April 2021. No studies reporting communication, its adequacy or the required skills between clinicians and pathologists in oral diagnosis were found. According to studies published in medicine, strategies for improving communication skills include clinicianpathologist collaboration; a well-formatted, clear and thorough report; training in communication skills; and patient-centered care. Further studies evaluating the current practices and quality in oral and maxillofacial pathology are required to identify barriers and encourage optimal communication to facilitate diagnosis, as well as patient safety.The Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES), the Brazilian National Council for Scientific and Technological Development, CNPq and a PhD scholarship from the São Paulo State Research Foundation.https://www.scielo.br/j/bordm2022Oral Pathology and Oral Biolog

Updated cardiovascular prevention guideline of the Brazilian Society of Cardiology: 2019

Sem informação113478788

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

Peer reviewe