Econometric analysis of the industrial growth determinants in Colombia

An econometric study is carried out using a panel data model with fixed effects to identify the industrial development determinants in Colombia during the term 2005–2015. The database used in the study corresponds to World Bank and the Colombian state. The determinants of industrial growth identified at the theoretical level that allow the enhancement of productive capacities to face foreign competition in Colombia are: innovation; networks of innovations and knowledge among companies and organizations; the interest rate; the capital-product ratio, the unit labor cost; and the exchange rate. The amount invested in scientific, technological and innovation activities by industrial group is the only variable that is not significant in the model

Virus mayaro: un arbovirus que amenaza a Colombia

Los arbovirus (Arthropod Borne Viruses), descubiertos en 1942, son un conjunto de familias y géneros de virus que tienen en común la característica de ser transmitidos por medio de artrópodos, incluye aproximadamente 500 virus de los cuales 150 pueden causar enfermedad en el ser humano y son considerados uno de los más importantes problemas de salud pública en el siglo XXI, debido a que su vigilancia y prevención depende del control y estudio de sus vectores. El virus mayaro es una zoonosis producida por un arbovirus de la familia Togaviridae, género Alphavirus, el cual es endémico y reemergente en los bosques tropicales de América del Sur y es transmitido al humano por tres mosquitos del género Haemagogus, y especies de Aedes como A. aegypti, A. albopictus e inclusive A. scapularis. Su descubrimiento fue en 1954 en Trinidad y Tobago, y desde entonces ha sido aislado en humanos, vertebrados silvestres y mosquitos en Bolivia, Brasil, Colombia, Guyana, Guyana Francesa, Perú y Surinam. Tiene una incidencia muy baja de circulación en América, especialmente en la región amazónica de Brasil, Bolivia y Perú. La presencia del virus mayaro en Colombia es una enorme amenaza a futuro, debido a que el vector Aedes principalmente A. aegypti es endémico en el país, además de que limita con países que han sufrido de brotes epidémicos del virus como Venezuela, Brasil, Perú y Ecuador. Su presentación clínica es similar a la del dengue y el chikungunya, incluye fiebre de presentación aguda que dura de 3 a 5 días, cefaleas intensas, dolor retro orbital, artralgias que pueden durar semanas o incluso meses, mialgias, vómitos, diarreas y erupciones. El diagnóstico puede realizarse por medio de hemaglutinación, PCR RT, entre otras. Es necesario implementar políticas claras en salud pública para determinar el riesgo inminente que tienen nuestras fronteras para el ingreso de este virus a nuestro país, socializar los conocimientos que se tienen de los arbovirus en especial del virus del mayaro y sus implicaciones en la salud humana. Abstract The arbovirus discovered in 1942, Arboviruses (Arthropod Borne Viruses) discovered in 1942 are a set of families and genera of viruses that have the common characteristic of being transmitted by means of arthropods... They are a set of families and genus of viruses that have in common the characteristic of being transmitted by arthropods, including about 500 viruses of which about 150 can cause human disease and are considered one of the problems public health most important in the XXI century because its surveillance and prevention depends on the control and study of their vector. Virus mayaro is a zoonosis caused by an arbovirus of the Togaviridae family, Alphavirus genus, which is endemic and re-emerging in the tropical forests of South America and is transmit to humans three by genus Haemagogus mosquitoes and species of aedes as A. aegypti, A. albopictus and even A. scapularis. His discovery was in 1954 in Trinidad and Tobago, and has since been isolated in humans, wild vertebrates and mosquitoes in Bolivia, Brazil, Colombia, Guyana, French Guyana, Peru and Suriname. Circulates with low incidence in America, especially in the Amazon region of Brazil, Bolivia and Peru. The presence of mayaro virus in Colombia is a major threat in the future, because the vector Aedes mainly A. aegypti it is endemic in the country, considering that the countries bordering Colombia have suffered outbreaks as Venezuela, Brazil, Peru and Ecuador. Its clinical presentation is very similar to that of dengue and chikungunya, including fever of acute presentation lasting from 3 to 5 days, severe headache, retro-orbital pain, joint pain that can last weeks or even months, myalgia, vomiting, diarrhea and rashes. Diagnosis it can made by hemagglutination, RT PCR, among other

Virus mayaro: un arbovirus que amenaza a Colombia

Los arbovirus (Arthropod Borne Viruses), descubiertos en 1942, son un conjunto de familias y géneros de virus que tienen en común la característica de ser transmitidos por medio de artrópodos, incluye aproximadamente 500 virus de los cuales 150 pueden causar enfermedad en el ser humano y son considerados uno de los más importantes problemas de salud pública en el siglo XXI, debido a que su vigilancia y prevención depende del control y estudio de sus vectores. El virus mayaro es una zoonosis producida por un arbovirus de la familia Togaviridae, género Alphavirus, el cual es endémico y reemergente en los bosques tropicales de América del Sur y es transmitido al humano por tres mosquitos del género Haemagogus, y especies de Aedes como A. aegypti, A. albopictus e inclusive A. scapularis. Su descubrimiento fue en 1954 en Trinidad y Tobago, y desde entonces ha sido aislado en humanos, vertebrados silvestres y mosquitos en Bolivia, Brasil, Colombia, Guyana, Guyana Francesa, Perú y Surinam. Tiene una incidencia muy baja de circulación en América, especialmente en la región amazónica de Brasil, Bolivia y Perú. La presencia del virus mayaro en Colombia es una enorme amenaza a futuro, debido a que el vector Aedes principalmente A. aegypti es endémico en el país, además de que limita con países que han sufrido de brotes epidémicos del virus como Venezuela, Brasil, Perú y Ecuador. Su presentación clínica es similar a la del dengue y el chikungunya, incluye fiebre de presentación aguda que dura de 3 a 5 días, cefaleas intensas, dolor retro orbital, artralgias que pueden durar semanas o incluso meses, mialgias, vómitos, diarreas y erupciones. El diagnóstico puede realizarse por medio de hemaglutinación, PCR RT, entre otras. Es necesario implementar políticas claras en salud pública para determinar el riesgo inminente que tienen nuestras fronteras para el ingreso de este virus a nuestro país, socializar los conocimientos que se tienen de los arbovirus en especial del virus del mayaro y sus implicaciones en la salud humana. Abstract The arbovirus discovered in 1942, Arboviruses (Arthropod Borne Viruses) discovered in 1942 are a set of families and genera of viruses that have the common characteristic of being transmitted by means of arthropods... They are a set of families and genus of viruses that have in common the characteristic of being transmitted by arthropods, including about 500 viruses of which about 150 can cause human disease and are considered one of the problems public health most important in the XXI century because its surveillance and prevention depends on the control and study of their vector. Virus mayaro is a zoonosis caused by an arbovirus of the Togaviridae family, Alphavirus genus, which is endemic and re-emerging in the tropical forests of South America and is transmit to humans three by genus Haemagogus mosquitoes and species of aedes as A. aegypti, A. albopictus and even A. scapularis. His discovery was in 1954 in Trinidad and Tobago, and has since been isolated in humans, wild vertebrates and mosquitoes in Bolivia, Brazil, Colombia, Guyana, French Guyana, Peru and Suriname. Circulates with low incidence in America, especially in the Amazon region of Brazil, Bolivia and Peru. The presence of mayaro virus in Colombia is a major threat in the future, because the vector Aedes mainly A. aegypti it is endemic in the country, considering that the countries bordering Colombia have suffered outbreaks as Venezuela, Brazil, Peru and Ecuador. Its clinical presentation is very similar to that of dengue and chikungunya, including fever of acute presentation lasting from 3 to 5 days, severe headache, retro-orbital pain, joint pain that can last weeks or even months, myalgia, vomiting, diarrhea and rashes. Diagnosis it can made by hemagglutination, RT PCR, among other

Chronic lymphocytic leukemia patients with IGH translocations are characterized by a distinct genetic landscape with prognostic implications

Chromosome 14q32 rearrangements/translocations involving the immunoglobulin heavy chain (IGH) are rarely detected in chronic lymphocytic leukemia (CLL). The prognostic significance of the IGH translocation is controversial and its mutational profile remains unknown. Here, we present for the first time a comprehensive next-generation sequencing (NGS) analysis of 46 CLL patients with IGH rearrangement (IGHR-CLLs) and we demonstrate that IGHR-CLLs have a distinct mutational profile with recurrent mutations in NOTCH1, IGLL5, POT1, BCL2, FBXW7, ZMYM3, MGA, BRAF and HIST1H1E genes. Interestingly, BCL2 and FBXW7 mutations were significantly associated with this subgroup and almost half of BCL2, IGLL5 and HISTH1E mutations reported were previously identified in non-Hodgkin lymphomas. Notably, IGH/BCL2 rearrangements were associated with a lower mutation frequency and carried BCL2 and IGLL5 mutations, while the other IGHR-CLLs had mutations in genes related to poor prognosis (NOTCH1, SF3B1 and TP53) and shorter time to first treatment (TFT). Moreover, IGHR-CLLs patients showed a shorter TFT than CLL patients carrying 13q-, normal fluorescence in situ hybridization (FISH) and +12 CLL, being this prognosis particularly poor when NOTCH1, SF3B1, TP53, BIRC3 and BRAF were also mutated. The presence of these mutations not only was an independent risk factor within IGHR-CLLs, but also refined the prognosis of low-risk cytogenetic patients (13q-/normal FISH). Hence, our study demonstrates that IGHR-CLLs have a distinct mutational profile from the majority of CLLs and highlights the relevance of incorporating NGS and the status of IGH by FISH analysis to refine the risk-stratification CLL model

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE

Combined search for the quarks of a sequential fourth generation

Results are presented from a search for a fourth generation of quarks produced singly or in pairs in a data set corresponding to an integrated luminosity of 5 inverse femtobarns recorded by the CMS experiment at the LHC in 2011. A novel strategy has been developed for a combined search for quarks of the up and down type in decay channels with at least one isolated muon or electron. Limits on the mass of the fourth-generation quarks and the relevant Cabibbo-Kobayashi-Maskawa matrix elements are derived in the context of a simple extension of the standard model with a sequential fourth generation of fermions. The existence of mass-degenerate fourth-generation quarks with masses below 685 GeV is excluded at 95% confidence level for minimal off-diagonal mixing between the third- and the fourth-generation quarks. With a mass difference of 25 GeV between the quark masses, the obtained limit on the masses of the fourth-generation quarks shifts by about +/- 20 GeV. These results significantly reduce the allowed parameter space for a fourth generation of fermions.Comment: Replaced with published version. Added journal reference and DO

Measurement of the t t-bar production cross section in the dilepton channel in pp collisions at sqrt(s) = 7 TeV

The t t-bar production cross section (sigma[t t-bar]) is measured in proton-proton collisions at sqrt(s) = 7 TeV in data collected by the CMS experiment, corresponding to an integrated luminosity of 2.3 inverse femtobarns. The measurement is performed in events with two leptons (electrons or muons) in the final state, at least two jets identified as jets originating from b quarks, and the presence of an imbalance in transverse momentum. The measured value of sigma[t t-bar] for a top-quark mass of 172.5 GeV is 161.9 +/- 2.5 (stat.) +5.1/-5.0 (syst.) +/- 3.6(lumi.) pb, consistent with the prediction of the standard model.Comment: Replaced with published version. Included journal reference and DO

Search for anomalous t t-bar production in the highly-boosted all-hadronic final state

A search is presented for a massive particle, generically referred to as a Z', decaying into a t t-bar pair. The search focuses on Z' resonances that are sufficiently massive to produce highly Lorentz-boosted top quarks, which yield collimated decay products that are partially or fully merged into single jets. The analysis uses new methods to analyze jet substructure, providing suppression of the non-top multijet backgrounds. The analysis is based on a data sample of proton-proton collisions at a center-of-mass energy of 7 TeV, corresponding to an integrated luminosity of 5 inverse femtobarns. Upper limits in the range of 1 pb are set on the product of the production cross section and branching fraction for a topcolor Z' modeled for several widths, as well as for a Randall--Sundrum Kaluza--Klein gluon. In addition, the results constrain any enhancement in t t-bar production beyond expectations of the standard model for t t-bar invariant masses larger than 1 TeV.Comment: Submitted to the Journal of High Energy Physics; this version includes a minor typo correction that will be submitted as an erratu

Search for New Physics with Jets and Missing Transverse Momentum in pp collisions at sqrt(s) = 7 TeV

A search for new physics is presented based on an event signature of at least three jets accompanied by large missing transverse momentum, using a data sample corresponding to an integrated luminosity of 36 inverse picobarns collected in proton--proton collisions at sqrt(s)=7 TeV with the CMS detector at the LHC. No excess of events is observed above the expected standard model backgrounds, which are all estimated from the data. Exclusion limits are presented for the constrained minimal supersymmetric extension of the standard model. Cross section limits are also presented using simplified models with new particles decaying to an undetected particle and one or two jets

Measurement of the Z/gamma* + b-jet cross section in pp collisions at 7 TeV

The production of b jets in association with a Z/gamma* boson is studied using proton-proton collisions delivered by the LHC at a centre-of-mass energy of 7 TeV and recorded by the CMS detector. The inclusive cross section for Z/gamma* + b-jet production is measured in a sample corresponding to an integrated luminosity of 2.2 inverse femtobarns. The Z/gamma* + b-jet cross section with Z/gamma* to ll (where ll = ee or mu mu) for events with the invariant mass 60 < M(ll) < 120 GeV, at least one b jet at the hadron level with pT > 25 GeV and abs(eta) < 2.1, and a separation between the leptons and the jets of Delta R > 0.5 is found to be 5.84 +/- 0.08 (stat.) +/- 0.72 (syst.) +(0.25)/-(0.55) (theory) pb. The kinematic properties of the events are also studied and found to be in agreement with the predictions made by the MadGraph event generator with the parton shower and the hadronisation performed by PYTHIA.Comment: Submitted to the Journal of High Energy Physic