Effects of Pasteurization on Antihyperglycemic and Chemical Parameter of Xoconostle (Stenocereus stellatus) Juice

Background and Objective: The antihyperglycemic effect is associated with the pre-hispanic fruit xoconostle or tunillo (Stenocereus stellatus, Pfeiffer and Riccobono). This fruit includes in various varieties, distinguished by color. Xoconostle fruits are highly perishable. Therefore, the aim of this study was to assess antihyperglycemic effects of xoconostle juice before (fresh) and after pasteurization. The study focused on the white and red varieties of xoconostle. Material and Methods: In this study, the method involved collecting juice from xoconostle fruits, followed by pasteurization. Chemical, physical and microbial parameters were assessed for the juice and the ability to decrease capillary glucose levels (antihyperglycemic effect) was assessed in male Wistar rats. Results and Conclusion: Pasteurization process led to decreases in total phenolic content of the red variety of xoconostle fruit, while the white variety showed increases in malic acid content. Despite these changes, fresh and pasteurized juices of the two varieties showed lower blood glucose levels, compared to the control group. Red variety demonstrated a stronger antihyperglycemic effect. In conclusion, pasteurization did not affect pharmacological effects of xoconostle juice, making it a viable preservation method without compromising the antihyperglycemic charac-teristics. Results of this research suggest a conservation method which preserve the antihyperglycemic effects while extending its shelf life. Conflict of interest: The authors declare no conflict of interest

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Psicoach Digital Platform

El presente trabajo de investigación está enfocado en la necesidad de disminuir los altos índices de problemas de salud mental que sufre nuestro país, más del 80% de peruanos con problemas psicológicos no reciben un adecuado tratamiento, el presente documento elabora la puesta en marcha de la empresa Psicoach que tiene como principal objetivo facilitar el acceso a los pacientes, a un servicio psicológico con los más altos estándares de calidad a través de nuestra plataforma digital. La empresa estará ubicada en Av. Encalada 1090 Of. 201 – Santiago de Surco. La ejecución del presente proyecto requiere de una inversión total de S/. 100 534 soles, dicha cantidad será financiada con el 70% de recursos propios y el 30% por aporte de terceros. Se espera que: - El flujo de Caja Financiero da como resultado un VAN de S/. 223,998.00 y una TIR de 71%, con un periodo de recupero 1 año 10 meses. - El estado de Resultados proyecta una utilidad neta acumulada al quinto año de S/. 105,315.00. Los principales resultado que la empresa proyecta para el primer año son ingresos de ventas por S /. 631 457. 00.The present research work is focused on the need to reduce the high rates of mental health problems that our country suffers, more than 80% of Peruvians with psychological problems do not receive adequate treatment, this document elaborates the implementation of the Psicoach company whose main objective is to facilitate access to patients, to a psychological service with the highest quality standards through our digital platform. The company will be located at Av. Encalada 1090 Of. 201 - Santiago de Surco. The execution of this project requires a total investment of S /. 100 534 soles, this amount will be financed with 70% of own funds and 30% by third-party contributions. The free availability cash flow results in a NPV of S /. 223,998.00 and an IRR of 71%, with a recovery period of 1 year and 10 months. The income statement projects a cumulative net profit for the fifth year of S /. 105,315.00. The main results that the company projects for the first year are sales revenues of S /. 631 457. 00.Trabajo de investigació