Exploding Head Syndrome: Clinical Features, Theories about Etiology, and Prevention Strategies in a Large International Sample

OBJECTIVE: Exploding head syndrome (EHS) is a benign sensory parasomnia characterized by the perception of loud noises or a sense of explosion in the head. Few studies have assessed clinical features and little is known about demographic differences or prevention strategies. PATIENTS/METHODS: A cross-sectional study of 3286 individuals with and 2954 without lifetime EHS episodes was conducted via online questionnaires. RESULTS: Those with EHS had shorter sleep durations, longer sleep onset latencies, poorer sleep quality, and less sleep efficiency, but effect sizes for these differences were small. Females were slightly more likely than males to endorse EHS. 44.4% of individuals with EHS experienced significant fear during episodes, but fewer reported clinically significant distress (25.0%) or interference (10.1%) as a result of EHS. Most sufferers believed it to be a brain-based phenomenon, but a small minority endorsed anomalous causes. Five prevention strategies with >50% reported effectiveness were identified. CONCLUSIONS: EHS was assessed in the largest sample to date. Though associated with clinical impacts, no empirically supported interventions yet exist. The five prevention strategies may prove useful for treatment development

Cost model relationships between textile manufacturing processes and design details for transport fuselage elements

Textile manufacturing processes offer potential cost and weight advantages over traditional composite materials and processes for transport fuselage elements. In the current study, design cost modeling relationships between textile processes and element design details were developed. Such relationships are expected to help future aircraft designers to make timely decisions on the effect of design details and overall configurations on textile fabrication costs. The fundamental advantage of a design cost model is to insure that the element design is cost effective for the intended process. Trade studies on the effects of processing parameters also help to optimize the manufacturing steps for a particular structural element. Two methods of analyzing design detail/process cost relationships developed for the design cost model were pursued in the current study. The first makes use of existing databases and alternative cost modeling methods (e.g. detailed estimating). The second compares design cost model predictions with data collected during the fabrication of seven foot circumferential frames for ATCAS crown test panels. The process used in this case involves 2D dry braiding and resin transfer molding of curved 'J' cross section frame members having design details characteristic of the baseline ATCAS crown design

New infrared star clusters in the Northern and Equatorial Milky Way with 2MASS

We carried out a survey of infrared star clusters and stellar groups on the 2MASS J, H and K_s all-sky release Atlas in the Northern and Equatorial Milky Way (350 < l < 360, 0 < l < 230). The search in this zone complements that in the Southern Milky Way (Dutra et al. 2003a). The method concentrates efforts on the directions of known optical and radio nebulae. The present study provides 167 new infrared clusters, stellar groups and candidates. Combining the two studies for the whole Milky Way, 346 infrared clusters, stellar groups and candidates were discovered, whereas 315 objects were previously known. They constitute an important new sample for future detailed studies.Comment: Accepted to Astronomy and Astrophysic

Study of Photon Dominated Regions in Cepheus B

Aim: The aim of the paper is to understand the emission from the photon dominated regions in Cepheus B, estimate the column densities of neutral carbon in bulk of the gas in Cepheus B and to derive constraints on the factors which determine the abundance of neutral carbon relative to CO. Methods: This paper presents 15'x15' fully sampled maps of CI at 492 GHz and 12CO 4-3 observed with KOSMA at 1' resolution. The new observations have been combined with the FCRAO 12CO 1-0, IRAM-30m 13CO 2-1 and C18O 1-0 data, and far-infrared continuum data from HIRES/IRAS. The KOSMA-tau spherical PDR model has been used to understand the CI and CO emission from the PDRs in Cepheus B and to explain the observed variation of the relative abundances of both C^0 and CO. Results: The emission from the PDR associated with Cepheus B is primarily at V_LSR between -14 and -11 km s^-1. We estimate about 23% of the observed CII emission from the molecular hotspot is due to the ionized gas in the HII region. Over bulk of the material the C^0 column density does not change significantly, (2.0+-1.4)x10^17 cm^-2, although the CO column density changes by an order of magnitude. The observed \cbyco abundance ratio varies between 0.06 and 4 in Cepheus B. We find an anti-correlation of the observed C/CO abundance ratio with the observed hydrogen column density, which holds even when all previous observations providing C/CO ratios are included. Here we show that this observed variation of C/CO abundance with total column density can be explained only by clumpy PDRs consisting of an ensemble of clumps. At high H2 column densities high mass clumps, which exhibit low C/CO abundance, dominate, while at low column densities, low mass clumps with high C/CO abundance dominate.Comment: 12 pages, 10 figures, Accepted for publication in A&

Production of two highly abundant 2-methyl-branched fatty acids by blooms of the globally significant marine cyanobacteria Trichodesmium erythraeum

© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Gosselin, K. M., Nelson, R. K., Spivak, A. C., Sylva, S. P., Van Mooy, B. A. S., Aeppli, C., Sharpless, C. M., O’Neil, G. W., Arrington, E. C., Reddy, C. M., & Valentine, D. L. Production of two highly abundant 2-methyl-branched fatty acids by blooms of the globally significant marine cyanobacteria Trichodesmium erythraeum. ACS Omega, 6(35), (2021): 22803–22810, https://doi.org/10.1021/acsomega.1c03196.The bloom-forming cyanobacteria Trichodesmium contribute up to 30% to the total fixed nitrogen in the global oceans and thereby drive substantial productivity. On an expedition in the Gulf of Mexico, we observed and sampled surface slicks, some of which included dense blooms of Trichodesmium erythraeum. These bloom samples contained abundant and atypical free fatty acids, identified here as 2-methyldecanoic acid and 2-methyldodecanoic acid. The high abundance and unusual branching pattern of these compounds suggest that they may play a specific role in this globally important organism.This work was funded with grants from the National Science Foundation grants OCE-1333148, OCE-1333162, and OCE-1756254 and the Woods Hole Oceanographic Institution (IR&D). GCxGC analysis made possible by WHOI’s Investment in Science Fund

A cluster of outflows in the Vulpecula Rift

We present $^{12}$CO, $^{13}$CO and C$^{18}$O (J=3$-$2) observations of a new cluster of outflows in the Vulpecula Rift with HARP-B on the JCMT. The mass associated with the outflows, measured using the $^{12}$CO HARP-B observations and assuming a distance to the region of 2.3 kpc, is 129 \msol{}, while the mass associated with the dense gas from C$^{18}$O observations is 458 \msol{} and the associated sub-millimeter core has a mass of 327 $\pm$ 112 \msol{} independently determined from Bolocam 1.1mm data. The outflow-to-core mass ratio is therefore $\sim$0.4, making this region one of the most efficient observed thus far with more than an order of magnitude more mass in the outflow than would be expected based on previous results. The kinetic energy associated with the flows, 94$\times10^{45}$ ergs, is enough to drive the turbulence in the local clump, and potentially unbind the local region altogether. The detection of SiO (J=8$-$7) emission toward the outflows indicates that the flow is still active, and not simply a fossil flow. We also model the SEDs of the four YSOs associated with the molecular material, finding them all to be of mid to early B spectral type. The energetic nature of the outflows and significant reservoir of cold dust detected in the sub-mm suggest that these intermediate mass YSOs will continue to accrete and become massive, rather than reach the main sequence at their current mass.Comment: 11 pages, 8 figures and 3 tables. Accepted to MNRAS. A higher-resolution version of figure 1 will be included in the published version and is available from the authors upon request. Updated with red and blue wings swapped to match doppler shif

High-resolution FUSE and HST ultraviolet spectroscopy of the white dwarf central star of Sh 2-216

LS V +4621 is the DAO-type central star of the planetary nebula Sh 2-216. We perform a comprehensive spectral analysis of high-resolution, high-S/N ultraviolet observations obtained with FUSE and STIS aboard the HST as well as the optical spectrum of LS V +4621 by means of state-of-the-art NLTE model-atmosphere techniques in order to compare its photospheric properties to theoretical predictions from stellar evolution theory as well as from diffusion calculations. From the N IV - NV, O IV - O VI, Si IV - Si V, and Fe V - Fe VII ionization equilibria, we determined an effective temperature of 95 +/- 2 kK with high precision. The surface gravity is log g = 6.9 +/- 0.2. An unexplained discrepancy appears between the spectroscopic distance d = 224 +46/-58 pc and the parallax distance d = 129 +6/-5 pc of LS V +4621. For the first time, we have identified Mg IV and Ar VI absorption lines in the spectrum of a hydrogen-rich central star and determined the Mg and Ar abundances as well as the individual abundances of iron-group elements (Cr, Mn, Fe, Co, and Ni). With the realistic treatment of metal opacities up to the iron group in the model-atmosphere calculations, the so-called Balmer-line problem (found in models that neglect metal-line blanketing) vanishes. Spectral analysis by means of NLTE model atmospheres has presently arrived at a high level of sophistication, which is now hampered largely by the lack of reliable atomic data and accurate line-broadening tables. Strong efforts should be made to improve upon this situation.Comment: 13 pages, 20 figure

Water and ammonia abundances in S140 with the Odin satellite

We have used the Odin satellite to obtain strip maps of the ground-state rotational transitions of ortho-water and ortho-ammonia, as well as CO(5-4) and 13CO(5-4) across the PDR, and H218O in the central position. A physi-chemical inhomogeneous PDR model was used to compute the temperature and abundance distributions for water, ammonia and CO. A multi-zone escape probability method then calculated the level populations and intensity distributions. These results are compared to a homogeneous model computed with an enhanced version of the RADEX code. H2O, NH3 and 13CO show emission from an extended PDR with a narrow line width of ~3 kms. Like CO, the water line profile is dominated by outflow emission, however, mainly in the red wing. The PDR model suggests that the water emission mainly arises from the surfaces of optically thick, high density clumps with n(H2)>10^6 cm^-3 and a clump water abundance, with respect to H2, of 5x10^-8. The mean water abundance in the PDR is 5x10^-9, and between ~2x10^-8 -- 2x10^-7 in the outflow derived from a simple two-level approximation. Ammonia is also observed in the extended clumpy PDR, likely from the same high density and warm clumps as water. The average ammonia abundance is about the same as for water: 4x10^-9 and 8x10^-9 given by the PDR model and RADEX, respectively. The similarity of water and ammonia PDR emission is also seen in the almost identical line profiles observed close to the bright rim. Around the central position, ammonia also shows some outflow emission although weaker than water in the red wing. Predictions of the H2O(110-101) and (111-000) antenna temperatures across the PDR are estimated with our PDR model for the forthcoming observations with the Herschel Space Observatory.Comment: 13 pages, 14 figures, 10 tables. Accepted for publication in Astronomy & Astrophysics 14 November 200

Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer

Novel treatment strategies, including nanomedicine, are needed for improving management of triple-negative breast cancer. Patients with triple-negative breast cancer, when considered as a group, have a worse outcome after chemotherapy than patients with breast cancers of other subtypes, a finding that reflects the intrinsically adverse prognosis associated with the disease. The aim of this study was to improve the efficacy of docetaxel by incorporation into a novel nanoparticle platform for the treatment of taxane-resistant triple-negative breast cancer. Rod-shaped nanoparticles encapsulating docetaxel were fabricated using an imprint lithography based technique referred to as Particle Replication in Nonwetting Templates (PRINT). These rod-shaped PLGA-docetaxel nanoparticles were tested in the C3(1)-T-antigen (C3Tag) genetically engineered mouse model (GEMM) of breast cancer that represents the basal-like subtype of triple-negative breast cancer and is resistant to therapeutics from the taxane family. Thi..

Far infrared mapping of three Galactic star forming regions : W3(OH), S 209 & S 187

Three Galactic star forming regions associated with W3(OH), S209 and S187 have been simultaneously mapped in two trans-IRAS far infrared (FIR) bands centered at ~ 140 and 200 micron using the TIFR 100 cm balloon borne FIR telescope. These maps show extended FIR emission with structures. The HIRES processed IRAS maps of these regions at 12, 25, 60 & 100 micron have also been presented for comparison. Point-like sources have been extracted from the longest waveband TIFR maps and searched for associations in the other five bands. The diffuse emission from these regions have been quantified, which turns out to be a significant fraction of the total emission. The spatial distribution of cold dust (T < 30 K) for two of these sources (W3(OH) & S209), has been determined reliably from the maps in TIFR bands. The dust temperature and optical depth maps show complex morphology. In general the dust around S209 has been found to be warmer than that in W3(OH) region.Comment: Accepted for publication in Journal of Astrophysics and Astronomy (20 pages including 8 figures & 3 tables