Clinical Profile of Patients with Osteoarthritis of the Knee A Study of 162 Cases

One hundred sixty two patients of osteoarthritis (OA)knee were studied to describe their clinical profile. Thepatients were included according to the criteria developedby the American College of Rheumatology. Detailedhistory, clinical examination and X-rays were carried out.The data were analysed statistically and the results wereexpressed in percentage and frequency. In this study, 96(59.3%) were male and 66 (40.7%) were female. Themean age of the subject was 53.73 ± 11.35 years. Mostof the patients of were in the age group of 50 to 59 years.Maximum number of females in the age group of 35 to45 years was affected. Most of the males were affectedin the later ages, between 55 to 65 years. Most of thepatients were middle class (68.5%) and housewives(35.8%). Mean height was 159.99 ± 8.12 cm and meanweight was 63.34 ± 11.60 kg. Mean duration of symptomswas 25.25 ± 38.85 months. Most patients gave the historyof gradual onset of the pain (87.7%). Most of the patientshad no morning stiffness in the knee (90.1%). Morningstiffness was present in 9.3% but it was for less than onehour. Maximum patients had intermittent pain (53.7%)but 46.3% patients had constant pain. By this study, itcan be concluded that OA knee is commoner in malesbut females develop it earlier in the life than the males

Structure and Function of Ethics Committee in Bangladesh

A cross-sectional study was done on 50 ethics committee members from 15 different Ethics Committee (EC) over a period of 6 months from February 2018 to June 2018 to understand the structure and function of ECs in Bangladesh. Most of the ECs were male predominant (66.3%) and maximum ECs had technical members (93.33%). Only 8.3% ECs had lay person. Forty percent of the ECs did not update SOP routinely. Most of the ECs had no provision of training for its members (79.2%) and had no budget (71.8%) for the purpose of running EC efficiently. Different ECs had different quorum to start the meeting. Maximum ECs service were voluntary (82.22%). A little less than half of the respondents (45.76%) felt that their decision had not been noted down if disagreed against majority of vote in the ECs and did not placed in the minute. Maximum respondents (88.18%) did not know whether there was any law in Bangladesh to create a EC. A big percentage (89%) of ECs did not monitored by authorized body to guide and oversee the functioning of EC. This article concluded that some ECs followed the international rules and regulation to formation and function the ECs but still a handsome number of ECs were lag behind in Bangladesh. The capacity of ECs can only be strengthened by training and various recognition/accreditation programs.

Simplified and complete phase-field fracture formulations for heterogeneous materials and their solution using a Fast Fourier Transform based numerical method

This paper focuses on the numerical implementation of phase-field models of fracture using the Fast Fourier Transform based numerical method. Recent developments in that field rely on the separate solution of a coupled problem where the mechanical equilibrium problem is solved first, and then the phase-field evolution equation. The latter involves a diffusion term which has been simplified in previous works relying on the Fast Fourier Transform based numerical method. This simplification has theoretically no effect for homogeneous materials, but might influence predictions significantly for heterogeneous materials where fracture properties vary between the different components. In this paper, the influence of this simplification is assessed and a complete formulation is proposed as well as a novel implementation of this formulation using the Fast Fourier Transform based numerical method. The assessment relies on simulations with a material containing two components, one of them being defined as unbreakable by using higher fracture properties. Using the simplified formulation, the presence of an artificial diffusion of damage between the two components is evidenced, and non-zero damage values are observed in the unbreakable component. Although the complete formulation leads to an increase of the number of iterations to solve the phase-field evolution equation, it suppresses completely the diffusion of damage towards the unbreakable component. The two formulations, in fact, lead to identical results when the fracture properties are homogeneous, but the results diverge both in terms of local fracture patterns and global stress–strain relations when the fracture properties contrast increases. This difference is also more pronounced when the regularization length introduced by the phase-field model increases.</p

Simplified and complete phase-field fracture formulations for heterogeneous materials and their solution using a Fast Fourier Transform based numerical method

This paper focuses on the numerical implementation of phase-field models of fracture using the Fast Fourier Transform based numerical method. Recent developments in that field rely on the separate solution of a coupled problem where the mechanical equilibrium problem is solved first, and then the phase-field evolution equation. The latter involves a diffusion term which has been simplified in previous works relying on the Fast Fourier Transform based numerical method. This simplification has theoretically no effect for homogeneous materials, but might influence predictions significantly for heterogeneous materials where fracture properties vary between the different components. In this paper, the influence of this simplification is assessed and a complete formulation is proposed as well as a novel implementation of this formulation using the Fast Fourier Transform based numerical method. The assessment relies on simulations with a material containing two components, one of them being defined as unbreakable by using higher fracture properties. Using the simplified formulation, the presence of an artificial diffusion of damage between the two components is evidenced, and non-zero damage values are observed in the unbreakable component. Although the complete formulation leads to an increase of the number of iterations to solve the phase-field evolution equation, it suppresses completely the diffusion of damage towards the unbreakable component. The two formulations, in fact, lead to identical results when the fracture properties are homogeneous, but the results diverge both in terms of local fracture patterns and global stress–strain relations when the fracture properties contrast increases. This difference is also more pronounced when the regularization length introduced by the phase-field model increases.</p

Screening of systemic fungicides and biochemicals against seed borne mycoflora associated with Momordica charantia

Study of seed borne fungi associated with bitter gourd seeds were conducted under in vitro condition in Department of Plant Pathology, Bahauddin Zakariya University, Multan, Pakistan. Two hundred (200) seed samples of Momordica charantia (bitter gourd) were collected from southern regions of Punjab province (Multan, Khanewal and Bahawalpur). Six fungal species were isolated out of which Aspergillus flavus showed highest percentage that is, 27.3% followed by Rhizopus stolonifer 17.98%, Alternaria alternata 13.34%, Aspergillus niger 5.23%, Myrothecium roridum 7.37% and Fusarium solani 6.69%. More number of fungi was observed by using blotter paper technique when compared with agar plate method. Of the three systemic fungicides used include ridomil gold MZ, bavistin, and score; and two low cost chemicals such as salicylic acid and boric acid. Ridomil gold MZ gave good results at all concentrations (20, 30 and 40 mg/10 ml) against all the isolated fungi compared with other fungicides. Salicyclic acid gave the best results against isolated fungi compared to boric acid.Key words: Myrothecium roridum, bitter gourd, salicyclic acid, southern Punjab, bavistin, Pakistan

Effects of fertilizer application schemes and soil environmental factors on nitrous oxide emission fluxes in a rice-wheat cropping system, east China

Nitrous oxide (N2O) is a potent greenhouse gas (GHG) with agricultural soils representing its largest anthropogenic source. However, the mechanisms involved in the N2O emission and factors affecting N2O emission fluxes in response to various nitrogenous fertilizer applications remain uncertain. We conducted a four-year (2012–2015) field experiment to assess how fertilization scheme impacts N2O emissions from a rice-wheat cropping system in eastern China. The fertilizer treatments included Control (CK), Conventional fertilizer (CF), CF with shallow-irrigation (CF+SI), CF with deep-irrigation system (CF+DI), Optimized fertilizer (OF), OF with Urease inhibitor (OF+UI), OF with conservation tillage (OF+CT) and Slow-release fertilizer (SRF). N2O emissions were measured by a closed static chamber method. N2O emission fluxes ranged from 0.61 μg m-2 h-1 to 1707 μg m-2 h-1, indicating a significant impact of nitrogen fertilizer and cropping type on N2O emissions. The highest crop yields for wheat (3515–3667 kg ha-1) and rice (8633–8990 kg ha-1) were observed under the SRF and OF+UI treatments with significant reduction in N2O emissions by 16.94–21.20% and 5.55–7.93%, respectively. Our findings suggest that the SRF and OF+UI treatments can be effective in achieving maximum crop yield and lowering N2O emissions for the rice-wheat cropping system in eastern China

Parenting behavior and the risk of becoming a victim and a bully/victim : a meta-analysis study

Objective: Being bullied has adverse effects on children's health. Children's family experiences and parenting behavior before entering school help shape their capacity to adapt and cope at school and have an impact on children's peer relationship, hence it is important to identify how parenting styles and parent–child relationship are related to victimization in order to develop intervention programs to prevent or mitigate victimization in childhood and adolescence. Methods: We conducted a systematic review of the published literature on parenting behavior and peer victimization using MEDLINE, PsychINFO, Eric and EMBASE from 1970 through the end of December 2012. We included prospective cohort studies and cross-sectional studies that investigated the association between parenting behavior and peer victimization. Results: Both victims and those who both bully and are victims (bully/victims) were more likely to be exposed to negative parenting behavior including abuse and neglect and maladaptive parenting. The effects were generally small to moderate for victims (Hedge's g range: 0.10–0.31) but moderate for bully/victims (0.13–0.68). Positive parenting behavior including good communication of parents with the child, warm and affectionate relationship, parental involvement and support, and parental supervision were protective against peer victimization. The protective effects were generally small to moderate for both victims (Hedge's g: range: −0.12 to −0.22) and bully/victims (−0.17 to −0.42). Conclusions: Negative parenting behavior is related to a moderate increase of risk for becoming a bully/victim and small to moderate effects on victim status at school. Intervention programs against bullying should extend their focus beyond schools to include families and start before children enter school

Quality of anti-malarial drugs provided by public and private healthcare providers in south-east Nigeria

BACKGROUND: There is little existing knowledge about actual quality of drugs provided by different providers in Nigeria and in many sub-Saharan African countries. Such information is important for improving malaria treatment that will help in the development and implementation of actions designed to improve the quality of treatment. The objective of the study was to determine the quality of drugs used for the treatment of malaria in a broad spectrum of public and private healthcare providers. METHODS: The study was undertaken in six towns (three urban and three rural) in Anambra state, south-east Nigeria. Anti-malarials (225 samples), which included artesunate, dihydroartemisinin, sulphadoxine-pyrimethamine (SP), quinine, and chloroquine, were either purchased or collected from randomly selected providers. The quality of these drugs was assessed by laboratory analysis of the dissolution profile using published pharmacopoeial monograms and measuring the amount of active ingredient using high performance liquid chromatography (HPLC). FINDINGS: It was found that 60 (37%) of the anti-malarials tested did not meet the United States Pharmacopoeia (USP) specifications for the amount of active ingredients, with the suspect drugs either lacking the active ingredients or containing suboptimal quantities of the active ingredients. Quinine (46%) and SP formulations (39%) were among drugs that did not satisfy the tolerance limits published in USP monograms. A total of 78% of the suspect drugs were from private facilities, mostly low-level providers, such as patent medicine dealers (vendors). CONCLUSION: This study found that there was a high prevalence of poor quality drugs. The findings provide areas for public intervention to improve the quality of malaria treatment services. There should be enforced checks and regulation of drug supply management as well as stiffer penalties for people stocking substandard and counterfeit drugs

Modelling and optimization of factors influencing adsorptive performance of agrowaste-derived Nanocellulose Iron Oxide Nanobiocomposites during remediation of Arsenic contaminated groundwater

Nanocellulose Iron Oxide Nanobiocomposites (NIONs) were synthesized from rice husk and sugarcane bagasse derived nanocelluloses for adsorptive removal of arsenic and associated contaminants present in groundwater samples. These NIONSs were superparamagnetic, hence magnetically recoverable and demonstrated promising recyclability. Synthesis of NIONs was confirmed by Transmission electron microscopy (TEM), X-Ray Diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopic (XPS). FTIR and XPS data together with adsorption kinetics provide insights into probable adsorption mechanism of Arsenic by NIONs. The experimental conditions for 10 different variants were modelled using response surface methodology (RSM) based on central composite design (CCD), considering the parameters; adsorbate dosage, adsorbent dosage, pH and contact time. The results identified the best performing variants and the optimal conditions for maximal absorption (~99%). These results were validated using a three-layer feed-forward Multilayer Perceptron (MLP) based Artificial Neural Network (ANN) model. Both RSM and ANN chemometric models were in close conformity for optimized conditions of highest adsorption by specific variants. The standardized conditions were used to expand the study to field-based arsenic contaminated groundwater samples and their performance to commercial adsorbents. NIONs show promising commercial potential for water remediation applications due to their high adsorptive performance, magnetic recoverability and recyclability

The half-degree matters for heat-related health impacts under the 1.5 °C and 2 °C warming scenarios: Evidence from ambulance data in Shenzhen, China

The Paris Agreement has prompted much interest in the societal and health impacts of limiting global warming to 1.5 °C and 2 °C. Previous assessments of differential impacts of two targets indicate that 1.5 °C warming target would substantially reduce the impact on human health compared to 2 °C, but they mainly focused on the magnitude of temperature changes under future climate change scenarios without any consideration of greater frequency of cumulative heat exposures within a day. Here we quantified the health risks of compound daytime and nighttime hot extremes using morbidity data in a megacity of China, and also identified the time-period of heat exposure with higher risks. Then we projected future morbidity burden attributable to compound hot extremes due to the half-degree warming. We estimated that the 2 °C warming scenario by 2100 as opposed to 1.5 °C would increase annual heat-related ambulance dispatches by 31% in Shenzhen city. Substantial additional impacts were associated with occurrence of consecutive hot days and nights, with ambulance dispatches increased by 82%. Our results suggested that compound hot extremes should be considered in assessment of heat-related health impacts, particularly in the context of climate change. Minimizing the warming of climate in a more ambitious target can significantly reduce the health damage