185 research outputs found
Classical Limit of Demagnetization in a Field Gradient
We calculate the rate of decrease of the expectation value of the transverse
component of spin for spin-1/2 particles in a magnetic field with a spatial
gradient, to determine the conditions under which a previous classical
description is valid. A density matrix treatment is required for two reasons.
The first arises because the particles initially are not in a pure state due to
thermal motion. The second reason is that each particle interacts with the
magnetic field and the other particles, with the latter taken to be via a
2-body central force. The equations for the 1-body Wigner distribution
functions are written in a general manner, and the places where quantum
mechanical effects can play a role are identified. One that may not have been
considered previously concerns the momentum associated with the magnetic field
gradient, which is proportional to the time integral of the gradient. Its
relative magnitude compared with the important momenta in the problem is a
significant parameter, and if their ratio is not small some non-classical
effects contribute to the solution.
Assuming the field gradient is sufficiently small, and a number of other
inequalities are satisfied involving the mean wavelength, range of the force,
and the mean separation between particles, we solve the integro- partial
differential equations for the Wigner functions to second order in the strength
of the gradient. When the same reasoning is applied to a different problem with
no field gradient, but having instead a gradient to the z-component of
polarization, the connection with the diffusion coefficient is established, and
we find agreement with the classical result for the rate of decrease of the
transverse component of magnetization.Comment: 22 pages, no figure
Immunization with Toxoplasma gondii GRA17 deletion mutant induces partial protection and survival in challenged mice
Toxoplasmosis remains a world-threatening disease largely because of the lack of a fully effective vaccine. Here, we created a ΔGRA17 mutant by disrupting the virulence factor GRA17 using CRISPR-Cas9 method. Then, we tested whether ΔGRA17 tachyzoites can be used as a live-attenuated vaccine against acute, chronic, and congenital Toxoplasma gondii infection in mice. Immune response evoked by ΔGRA17 immunization suggested a sequential Th1 and Th2 T cell response, indicated by high levels of Th1 and a mixed Th1/Th2 cytokines at 28 and 70 days after immunization, respectively. ΔGRA17-mediated immunity fully protected mice against lethal infection with wild-type (wt) RH strain, heterologous challenge with PYS, and TgC7 strains of the Chinese ToxoDB#9 genotype, and T. gondii Pru strain. Although parasite cysts were detected in 8 out of 10 immunized mice, cyst burden in the brain was significantly reduced (P < 0.05) in immunized mice (53 ± 15 cysts/brain) compared to non-immunized mice (4,296 ± 687 cysts/brain). In respect to congenital infection, the litter size, survival rate, and body weight (BW) of pups born to ΔGRA17-immunized dams were not different compared to pups born to naïve control dams (P = 0.24). However, a marked reduction in the litter size (P < 0.001), survival rate, and BW (P < 0.01) of pups born to non-immunized and infected dams was detected. Also, immunized dams infected with type II Pru strain had significantly (P < 0.001) less cyst burden in the brain compared with non-immunized and infected dams. These findings show that immunization with ΔGRA17 strain evokes cell-mediated and neutralizing antibody responses and confers some degree of protection against challenge with homologous and heterologous virulent T. gondii strains
Gas Accretion and Galactic Chemical Evolution: Theory and Observations
This chapter reviews how galactic inflows influence galaxy metallicity. The
goal is to discuss predictions from theoretical models, but particular emphasis
is placed on the insights that result from using models to interpret
observations. Even as the classical G-dwarf problem endures in the latest round
of observational confirmation, a rich and tantalizing new phenomenology of
relationships between , , SFR, and gas fraction is emerging both in
observations and in theoretical models. A consensus interpretation is emerging
in which star-forming galaxies do most of their growing in a quiescent way that
balances gas inflows and gas processing, and metal dilution with enrichment.
Models that explicitly invoke this idea via equilibrium conditions can be used
to infer inflow rates from observations, while models that do not assume
equilibrium growth tend to recover it self-consistently. Mergers are an overall
subdominant mechanism for delivering fresh gas to galaxies, but they trigger
radial flows of previously-accreted gas that flatten radial gas-phase
metallicity gradients and temporarily suppress central metallicities. Radial
gradients are generically expected to be steep at early times and then
flattened by mergers and enriched inflows of recycled gas at late times.
However, further theoretical work is required in order to understand how to
interpret observations. Likewise, more observational work is needed in order to
understand how metallicity gradients evolve to high redshifts.Comment: Invited review to appear in Gas Accretion onto Galaxies, Astrophysics
and Space Science Library, eds. A. J. Fox & R. Dav\'e, to be published by
Springer. 29 pages, 2 figure
Psychological models of mental disorder, human rights, and compulsory mental health care in the community
Spintronics: Fundamentals and applications
Spintronics, or spin electronics, involves the study of active control and
manipulation of spin degrees of freedom in solid-state systems. This article
reviews the current status of this subject, including both recent advances and
well-established results. The primary focus is on the basic physical principles
underlying the generation of carrier spin polarization, spin dynamics, and
spin-polarized transport in semiconductors and metals. Spin transport differs
from charge transport in that spin is a nonconserved quantity in solids due to
spin-orbit and hyperfine coupling. The authors discuss in detail spin
decoherence mechanisms in metals and semiconductors. Various theories of spin
injection and spin-polarized transport are applied to hybrid structures
relevant to spin-based devices and fundamental studies of materials properties.
Experimental work is reviewed with the emphasis on projected applications, in
which external electric and magnetic fields and illumination by light will be
used to control spin and charge dynamics to create new functionalities not
feasible or ineffective with conventional electronics.Comment: invited review, 36 figures, 900+ references; minor stylistic changes
from the published versio
Simulations of the Milky Way's central molecular zone -- II. Star formation
The Milky Way's central molecular zone (CMZ) has emerged in recent years as a
unique laboratory for the study of star formation. Here we use the simulations
presented in Tress et al. 2020 to investigate star formation in the CMZ. These
simulations resolve the structure of the interstellar medium at sub-parsec
resolution while also including the large-scale flow in which the CMZ is
embedded. Our main findings are as follows. (1) While most of the star
formation happens in the CMZ ring at , a significant
amount also occurs closer to SgrA* at . (2) Most of
the star formation in the CMZ happens downstream of the apocentres, consistent
with the "pearls-on-a-string" scenario, and in contrast to the notion that an
absolute evolutionary timeline of star formation is triggered by pericentre
passage. (3) Within the timescale of our simulations ( Myr), the
depletion time of the CMZ is constant within a factor of . This suggests
that variations in the star formation rate are primarily driven by variations
in the mass of the CMZ, caused for example by AGN feedback or
externally-induced changes in the bar-driven inflow rate, and not by variations
in the depletion time. (4) We study the trajectories of newly born stars in our
simulations. We find several examples that have age and 3D velocity compatible
with those of the Arches and Quintuplet clusters. Our simulations suggest that
these prominent clusters originated near the collision sites where the
bar-driven inflow accretes onto the CMZ, at symmetrical locations with respect
to the Galactic centre, and that they have already decoupled from the gas in
which they were born.Comment: Accepted for publication in MNRAS. Movies of the simulations can be
found at: https://www.youtube.com/channel/UCwnzfO-xLxzRDz9XsexfPo
Toxoplasma gondii: CD8 T Cells Cry for CD4 Help
Toxoplasma gondii, an apicomplexan parasite, is a pathogenic protozoan that can infect the central nervous system. In pregnant women, infection can result in congenital problems of the fetus, while in immunocompromised individual it can lead to severe neurological consequences. Although CD8 T cells play an important effector role in controlling the chronic infection, their maintenance is dependent on the critical help provided by CD4 T cells. In a recent study, we demonstrated that reactivation of the infection in chronically infected host is a consequence of CD8 T dysfunction caused by CD4 T cell exhaustion. Furthermore, treatment of chronically infected host with antigen-specific non-exhausted CD4 T cells can restore CD8 T cell functionality and prevent reactivation of the latent infection. The exhaustion status of CD4 T cells is mediated by the increased expression of the transcription factor BLIMP-1, and deletion of this molecule led to the restoration of CD4 T cell function, reversal of CD8 exhaustion and prevention of reactivation of the latent infection. In a recent study from our laboratory, we also observed an increased expression of miR146a levels by CD4 T cells from the chronically infected animals. Recent reports have demonstrated that microRNAs (especially miR146a) has a strong impact on the immune system of T. gondii infected host. Whether these molecules have any role in the BLIMP-1 up-regulation and dysfunctionality of these cells needs to be investigated
Planetary Rings
Planetary rings are the only nearby astrophysical disks, and the only disks
that have been investigated by spacecraft. Although there are significant
differences between rings and other disks, chiefly the large planet/ring mass
ratio that greatly enhances the flatness of rings (aspect ratios as small as
1e-7), understanding of disks in general can be enhanced by understanding the
dynamical processes observed at close-range and in real-time in planetary
rings. We review the known ring systems of the four giant planets, as well as
the prospects for ring systems yet to be discovered. We then review planetary
rings by type. The main rings of Saturn comprise our system's only dense broad
disk and host many phenomena of general application to disks including spiral
waves, gap formation, self-gravity wakes, viscous overstability and normal
modes, impact clouds, and orbital evolution of embedded moons. Dense narrow
rings are the primary natural laboratory for understanding shepherding and
self-stability. Narrow dusty rings, likely generated by embedded source bodies,
are surprisingly found to sport azimuthally-confined arcs. Finally, every known
ring system includes a substantial component of diffuse dusty rings. Planetary
rings have shown themselves to be useful as detectors of planetary processes
around them, including the planetary magnetic field and interplanetary
impactors as well as the gravity of nearby perturbing moons. Experimental rings
science has made great progress in recent decades, especially numerical
simulations of self-gravity wakes and other processes but also laboratory
investigations of coefficient of restitution and spectroscopic ground truth.
The age of self-sustained ring systems is a matter of debate; formation
scenarios are most plausible in the context of the early solar system, while
signs of youthfulness indicate at least that rings have never been static
phenomena.Comment: 82 pages, 34 figures. Final revision of general review to be
published in "Planets, Stars and Stellar Systems", P. Kalas and L. French
(eds.), Springer (http://refworks.springer.com/sss
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
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