Superforms in six-dimensional superspace

Indexación: Web of ScienceWe investigate the complex of differential forms in curved, six-dimensional, N = (1, 0) superspace. The superconformal group acts on this complex by super-Weyl transformations. An ambi-twistor-like representation of a second conformal group arises on a pure spinor subspace of the cotangent space. The p-forms are defined by super-Weylcovariant tensor fields on this pure spinor subspace. The on-shell dynamics of such fields is superconformal. We construct the superspace de Rham complex by successively obstructing the closure of forms. We then extend the analysis to composite forms obtained by wedging together forms of lower degree. Finally, we comment on applications to integration in curved superspace and propose a superspace formulation of the abelian limit of the non-abelian tensor hierarchy of N = (1, 0) superconformal models.http://link.springer.com/article/10.1007%2FJHEP05%282016%29016#aboutarticl

Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells

The granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R binds to the GM-CSF receptor complex with low affinity and acts as a competitive antagonist. In addition, it has been reported to be a potent direct activator of apoptosis in primary human acute myeloid leukemia (AML) cells. We have confirmed the ability of E21R to neutralize the biologic effects of GM-CSF and investigated its activity on primary AML blasts. We find that it failed to induce cell death in blast cells from 23 separate AML cases treated in vitro at concentrations of E21R up to 30 µg/mL. Significant cell death resulted in all cases after incubation with cytosine arabinoside. The lack of effect of E21R on AML blasts was unlikely to be due to an absence of functional GM-CSF receptors because 13 cases demonstrated an increase in cell number with the addition of exogenous GM-CSF. These results do not support the use of E21R for the treatment of AML