Harvesting strategies of fuelwood and kraalwood users at Machibi : identifying the driving factors and feedbacks

Forest and woodland ecosystems provide a variety of natural resources such as fuelwood, brushwood and kraal posts to local communities, as well as possess important cultural and spiritual value. However, many forests and woodlands worldwide have been unsustainably used and managed. Thus, under pressure from the international conservation community to recognise the importance of people's relationships with their surrounding natural environment, particularly for the natural resources it can provide, and given a move away from the management of forests and woodlands for sustained yields, and according to simple cause and effect models, in favour of systems approaches, South Africa has developed some of the most progressive natural resource management policies in the world. Nevertheless, for these policies to be sensitive to local contexts, there remains a need for a better understanding of how local people in different contexts, determine forest and woodland ecosystems to be of use to them, and what 'usefulness' means to different groups of resources users. This is a case study, which examines the role of fuelwood, brushwood and kraal posts in the rural livelihoods of the people of Machibi village, located in the Eastern Cape province of South Africa, through people's preferences for particular landscapes and species, accessed for these purposes, and the trade-offs people make between resource availability and resource accessibility. Key objectives of the study are to 1) determine the preferred landscapes and species for fuelwood, brushwood and kraal posts at Machibi, 2) determine the landscapes and species actually used for fuelwood, brushwood and kraal posts, and 3) with the help of a conceptual model, and using iterative modelling as a tool, determine the factors that influence people's harvesting strategies in terms of the costs and benefits associated with the different landscape and species options. On the basis of this knowledge, the study provides some guiding principles for the better use and management of these landscapes and species for fuelwood, brushwood and kraal posts. An innovative research approach and methodology that integrates social and ecological systems, works across disciplines, and draws on different types of knowledge is used to develop and test a conceptual model of the harvesting strategies of fuelwood and kraalwood users at Machibi. Participatory methods such as workshops, participatory resource mapping, ranking exercises and trend-lines were used to tap into local knowledge while plotless vegetation sampling and GIS maps were used to capture the scientific information. Results showed that people did not always use the landscapes and species they preferred. However, the local people did behave in a rational manner by weighing up the returns from harvesting and accessibility costs associated with the respective options available to them, before selecting the option(s) associated with the greatest net benefits. At the landscape level, people made trade-offs between the returns from harvesting and the accessibility costs of using particular landscapes in addition to costs associated with the physical work of harvesting fuelwood, brushwood or kraal posts from these landscapes. At the species level, people made trade-offs between the returns from harvesting and the accessibility costs of harvesting particular species for fuelwood, brushwood and kraal posts, or the costs of commercial alternatives. Costbenefit factors that influenced people's resource use patterns also differed across landscapes and species for fuelwood, brushwood and kraal posts, respectively. Consequently, a range of diverse and flexible management options and strategies is recommended for the wise use and management of these landscapes and species, focused on short, medium and long term goals. These strategies examine the use of cost - benefit incentives to influence people’s landscape and species use patterns

Lysosomal localization of GLUT8 in the testis – the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction

The class III sugar transport facilitator GLUT8 co-localizes with the lysosomal protein LAMP1 in heterologous expression systems. GLUT8 carries a [D/E]XXXL[L/I]-type dileucine sorting signal that has been postulated to retain the protein in an endosomal/lysosomal compartment via interactions with clathrin adaptor protein (AP) complexes. However, contradictory findings have been described regarding the subcellular localization of the endogenous GLUT8 and the adaptor proteins that interact with its dileucine motif. Here we demonstrate that endogenous GLUT8 is localized in a late endosomal/lysosomal compartment of spermatocytes and spermatids, and that the adaptor complexes AP1 and AP2, but not AP3 or AP4, interact with its N-terminal intracellular domain (NICD). In addition, fusion of the GLUT8 NICD to the tailless lumenal domain of the IL-2 receptor alpha chain (TAC) protein (interleukin-2 receptor α chain) targeted the protein to intracellular membranes, indicating that its N-terminal dileucine signal is sufficient for endosomal/lysosomal targeting of the transporter. The localization and targeting of GLUT8 show striking similarities to sorting mechanisms reported for lysosomal proteins. Therefore, we suggest a potential role for GLUT8 in the so far unexplored substrate transport across intracellular membranes

Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood

Publisher Copyright: © The Authors 2022.Peer reviewedPublisher PD

Thyroid-stimulating hormone and free thyroxine fail to predict the severity and clinical course of hyperemesis gravidarum : A prospective cohort study

Funding information: This prospective cohort study was supported by a research grant from North West Hospital Group, Alkmaar, the Netherlands (Grant number: 2013T085) and by a research grant from the Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam UMC, the Netherlands (Project number: 23346). ACKNOWLEDGMENTS We thank Dr. J.P. Bestwick (employed at Queen Mary University of London, London, UK) and Professor Dr. J.H. Lazarus (employed at Cardiff School of Medicine, Cardiff, UK) for providing TSH medians from their study in the UK. Dr. J.P. Bestwick and Professor Dr. Lazarus have nothing to disclose.Peer reviewedPublisher PD

The mortality impact of bicycle paths and lanes related to physical activity, air pollution exposure and road safety

© 2015 Elsevier Ltd. Objective: Guidelines for bicycle infrastructure design tend to consider safety issues but not wider health issues. This paper explores the overall health impact of bicycle infrastructure provision, including not just road safety impacts, but also the population health impacts stemming from physical activity as well as cyclists' exposure to air pollution. Data and methods: We have summarised key publications on how bicycle paths and lanes affect cyclists' exposure to physical activity, air pollution, and road safety. The health impact is modelled using all-cause mortality as a metric for a scenario with new bicycle lanes and paths in a hypothetical city. Results: The outcomes of the study suggest that, based on currently available research, a reduction of all-cause mortality is to be expected from building bicycle lanes and paths along busy roads with mixed traffic. Increased physical activity through more time spent cycling is the major contribution, but is also the most uncertain aspect. Effects related to air pollution and cycling safety are likely to reduce mortality but are small. The overall benefits are large enough to achieve a high benefit-cost ratio for bicycle infrastructure. Conclusions: The introduction of bicycle paths and lanes is likely to be associated with health benefits, primarily due to increased physical activity. More research is needed to estimate the absolute size of the health benefits. In particular, evaluations of the effects of bicycle infrastructure on time spent cycling are limited or of insufficient quality to infer causality. We recommend before-after studies measuring the effects of different interventions and in areas representing a wide range of base levels of cycling participation

Priorities for research in soil ecology

The ecological interactions that occur in and with soil are of consequence in many ecosystems on the planet. These interactions provide numerous essential ecosystem services, and the sustainable management of soils has attracted increasing scientific and public attention. Although soil ecology emerged as an independent field of research many decades ago, and we have gained important insights into the functioning of soils, there still are fundamental aspects that need to be better understood to ensure that the ecosystem services that soils provide are not lost and that soils can be used in a sustainable way. In this perspectives paper, we highlight some of the major knowledge gaps that should be prioritized in soil ecological research. These research priorities were compiled based on an online survey of 32 editors of Pedobiologia – Journal of Soil Ecology. These editors work at universities and research centers in Europe, North America, Asia, and Australia. The questions were categorized into four themes: (1) soil biodiversity and biogeography, (2) interactions and the functioning of ecosystems, (3) global change and soil management, and (4) new directions. The respondents identified priorities that may be achievable in the near future, as well as several that are currently achievable but remain open. While some of the identified barriers to progress were technological in nature, many respondents cited a need for substantial leadership and goodwill among members of the soil ecology research community, including the need for multi-institutional partnerships, and had substantial concerns regarding the loss of taxonomic expertise

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo