38 research outputs found
The fast declining Type Ia supernova 2003gs, and evidence for a significant dispersion in near-infrared absolute magnitudes of fast decliners at maximum light
We obtained optical photometry of SN 2003gs on 49 nights, from 2 to 494 days
after T(B_max). We also obtained near-IR photometry on 21 nights. SN 2003gs was
the first fast declining Type Ia SN that has been well observed since SN
1999by. While it was subluminous in optical bands compared to more slowly
declining Type Ia SNe, it was not subluminous at maximum light in the near-IR
bands. There appears to be a bimodal distribution in the near-IR absolute
magnitudes of Type Ia SNe at maximum light. Those that peak in the near-IR
after T(B_max) are subluminous in the all bands. Those that peak in the near-IR
prior to T(B_max), such as SN 2003gs, have effectively the same near-IR
absolute magnitudes at maximum light regardless of the decline rate Delta
m_15(B).
Near-IR spectral evidence suggests that opacities in the outer layers of SN
2003gs are reduced much earlier than for normal Type Ia SNe. That may allow
gamma rays that power the luminosity to escape more rapidly and accelerate the
decline rate. This conclusion is consistent with the photometric behavior of SN
2003gs in the IR, which indicates a faster than normal decline from
approximately normal peak brightness.Comment: 41 pages, 13 figures, to be published in the December, 2009, issue of
the Astronomical Journa
The Most Slowly Declining Type Ia Supernova 2001ay
We present optical and near-infrared photometry, as well as ground-based
optical spectra and Hubble Space Telescope ultraviolet spectra, of the Type Ia
supernova (SN) 2001ay. At maximum light the Si II and Mg II lines indicated
expansion velocities of 14,000 km/sec, while Si III and S II showed velocities
of 9,000 km/sec There is also evidence for some unburned carbon at 12,000
km/sec. SN 2001ay exhibited a decline-rate parameter Delta m_15(B) = 0.68 \pm
0.05 mag; this and the B-band photometry at t > +25 d past maximum make it the
most slowly declining Type Ia SN yet discovered. Three of four
super-Chandrasekhar-mass candidates have decline rates almost as slow as this.
After correction for Galactic and host-galaxy extinction, SN 2001ay had M_B =
-19.19 and M_V = -19.17 mag at maximum light; thus, it was not overluminous in
optical bands. In near-infrared bands it was overluminous only at the 2-sigma
level at most. For a rise time of 18 d (explosion to bolometric maximum) the
implied Ni-56 yield was (0.58 \pm 0.15)/alpha M_Sun, with alpha = L_max/E_Ni
probably in the range 1.0 to 1.2. The Ni-56 yield is comparable to that of many
Type Ia supernovae. The "normal" Ni-56 yield and the typical peak optical
brightness suggest that the very broad optical light curve is explained by the
trapping of the gamma rays in the inner regions.Comment: 57 pages, 22 figures. To be published in the Astronomical Journal
(September 2011
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Exploration of variables in the fabrication of pyrolysed photoresist
The increased use of pyrolysed photoresist films (PPF) as electrode material intensifies the need to know what fabrication variables are important in the pyrolysis process. The main factor effects of seven variables (three time/temperature heating levels plus the position in the furnace tube) in the fabrication of PPF were investigated by a Plackett and Burman, eight-run, experimental design. In the three-step pyrolysis programme, gas flow had a large effect on the surface cleanliness and roughness. It was also observed that the position in the furnace affected the resistivity of the PPF. Fabrication parameters that give rapid electron transfer to redox species in solution, that provide low surface oxide and that lead to low surface roughness were identified. The guidelines on what fabrication conditions to employ to give a variety of different electrode characteristics are presented.9 page(s
Nanoconfinement Allows a Less Active Cascade Catalyst to Produce More C<sub>2+</sub> Products in Electrochemical CO<sub>2</sub> Reduction
Enzymes with multiple distinct active sites linked by
substrate
channels combined with control over the solution environment near
the active sites enable the formation of complex products from simple
reactants via the confinement of intermediates. We mimic this concept
to facilitate the electrochemical carbon dioxide reduction reaction
using nanoparticles with a core that produces intermediate CO at different
rates and a porous copper shell. CO2 reacts at the core
to produce CO which then diffuses through the Cu to give higher order
hydrocarbon molecules. By altering the rate of CO2 delivery,
the activity of the CO producing site, and the applied potential,
we show that the nanoparticle with lower activity for CO formation
produces greater amounts of hydrocarbon products. This is attributed
to a combination of higher local pH and the lower amount of CO, resulting
in more stable nanoparticles. However, when lower amounts of CO2 were delivered to the core, the particles that are more active
for CO formation produce more C3 products. The importance
of these results is twofold. They show that in cascade reactions,
more active intermediate producing catalysts do not necessarily give
greater amounts of high-value products. The effect an intermediate
producing active site has on the local solution environment around
the secondary active site plays an important role. As the less active
catalyst for producing CO also possesses greater stability, we show
that nanoconfinement can be used to get the best of both worlds with
regard to having a stable catalyst with high activity
Controlling Platinum Active Sites on Silver Nanoparticles for Hydrogen Evolution Reaction
Growing Pt on Ag nanoparticles is a promising approach
to forming
catalysts that present active sites with both Pt and Ag available
to improve the activity for the hydrogen evolution reaction (HER).
By carefully controlling the concentration of a Pt precursor, the
amount of Pt-decorated particles onto the Ag nanoparticles could be
controlled to grow Pt islands between 0.6 and 1.5 nm. As a result,
the relative amounts of the Ag–Pt active sites could be tuned.
The smallest, 0.6 nm Pt islands on the Ag nanoparticle, with the highest
ratio of Ag–Pt to Pt–Pt sites was found to have the
highest activity and an accelerated Volmer step. DFT modeling showed
that the improved performance was due to increased electron density
on Pt from electron donation from neighboring Ag that leads to weaker
Pt–H binding and the presence of more oxophilic Ag that can
bind −OH on the active site that accelerates the water splitting