4 research outputs found

    Cosmological Simulations of Galaxy Groups and Clusters-III: Constraining Quasar Feedback Models with the Atacama Large Millimeter Array

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    The thermal Sunyaev-Zeldovich (SZ) effect serves as a direct potential probe of the energetic outflows from quasars that are responsible for heating the intergalactic medium. In this work, we use the GIZMO meshless finite mass hydrodynamic cosmological simulation SIMBA (Dave et al. 2019), which includes different prescriptions for quasar feedback, to compute the SZ effect arising from different feedback modes. From these theoretical simulations, we perform mock observations of the Atacama Large Millimeter Array (ALMA) in four bands (320 GHz, 135 GHZ, 100 GHz and 42 GHz) to characterize the feasibility of direct detection of the quasar SZ signal. Our results show that for all the systems we get an enhancement of the SZ signal, when there is radiative feedback, while the signal gets suppressed when the jet mode of feedback is introduced in the simulations. Our mock ALMA maps reveal that, with the current prescription of jet feedback, the signal goes below the detection threshold of ALMA. We also find that the signal is higher for high redshift systems, making it possible for ALMA and cross SZ-X-ray studies to disentangle the varying modes of quasar feedback and their relative importance in the cosmological context.Comment: Accepted for publication in Ap

    Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

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    Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
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