Synthesis, antimicrobial and anticancer activities of some 2-thiohydantoin derivatives

641-648The vital organic compound 3-[(2-hydroxy-3-methoxybenzylidene)- amino]-2-thiohydantoin 3 has been prepared via the reaction of 2-hydroxy-3-methoxybenzaldehyde 1 with thiosemicarbazide to give N-[(2-hydroxy-3-methoxybenzylidene) amino]thiourea 2, followed by cyclization of 2 with ethyl chloroacetate in the presence of fused sodium acetate. The treatment of compound 3 with aromatic aldehydes, 3-substituted phenacylbromide and aryl diazonium salts affords the corresponding 5-arylidene-3-substituted-2-thiohydantoins 4, l-aroylmethyl-3-substituted-2-thiohydantoins 6 and 5-arylazo-3-substituted-2-thiohydantoins 7, respectively. The synthesized compound have been characterized on the basis of IR, 1H NMR, mass spectral data and elemental analysis. Some of the synthesized 2-thiohydantoin derivatives also exhibited antibacterial and antitumor activities

Full Paper An Efficient Synthesis and Reactions of Novel Indolylpyridazinone Derivatives with Expected Biological Activity

Abstract: Reaction of 4-anthracen-9-yl-4-oxo-but-2-enoic acid (1) with indole gave the corresponding butanoic acid 2. Cyclocondensation of 2 with hydrazine hydrate, phenyl hydrazine, semicarbazide and thiosemicarbazide gave the pyridazinone derivatives 3ad. Reaction of 3a with POCl3 for 30 min gave the chloropyridazine derivative 4a, which was used to prepare the corresponding carbohydrate hydrazone derivatives 5a-d. Reaction of chloropyridazine 4a with some aliphatic or aromatic amines and anthranilic acid gave 6a-f and 7, respectively. When the reaction of the pyridazinone derivative 3a with POCl3 was carried out for 3 hr an unexpected product 4b was obtained. The structure of 4b was confirmed by its reaction with hydrazine hydrate to give hydrazopyridazine derivative 9, which reacted in turn with acetyl acetone to afford 10. Reaction of 4b with methylamine gave 11, which reacted with methyl iodide to give the trimethylammonium iodide derivative 12. The pyridazinone 3a also reacted with benzene- or 4-toluenesulphonyl chloride to give 13a-b and with aliphatic or aromatic aldehydes to give 14a-g. All proposed structures were supported by IR, 1 H-NMR, 13 C-NMR, and MS spectroscopic data. Some of the new products showed antibacterial activity

Co-doped zinc oxide nanoparticles embedded in Polyvinylalcohol Hydrogel as solar light derived photocatalyst disinfection and removal of coloured pollutants

In this study Co doped ZnO NPs (CoZnO) were synthesized by using polyvinyl alcohol hydrogel (PVA HG) as platform for methyl orange dye (MO) degradation. CoZnO/PVA photocatalysts are not only effective to degrade organic pollutants but also used for disinfection the water. Co-doped zinc oxide nanoparticles (CoZnO NPs) as an excellent photocatalyst were synthesized by the coprecipitation method. ZnO NPs due to its large band gap is only UV light mediated photocatalyst which is only 4% of solar spectrum. In order to fully utilize of solar spectrum, low cast Co transition metal was doped to ZnO NPs to make is visible light derived photocatalyst by lowering its band gap. A high adsorption power of PVA HG enhance photocatalyst activity. For this purpose, Polyvinyl alcohol hydrogel was used along with Co doped ZnO NPs to enhance the photocatalytic activity. Polyvinyl alcohol hydrogel (PVA HG) was prepared by basic hydrolysis of polyvinyl acetate gel which was prepared by free radical emulsion method using diacrylate crosslinker. Co-doped ZnO NPs were formed in the PVA HG matrix by coprecipitation method. The doping concentration of Co was changed from 0-16%(w/w). and optimized for best photocatalytic ability. The 12% Co-doped ZnO NPs showed best photocatalytic ability. So, 12CoZnO NPs were incorporated in the PVAHG for dye degradation and disinfection study. The 12CoZnO/PVA yielded composite showed an extreme rise in photocatalytic efficiency and completely mineralized MO in 48 min. The prepared composite showed better degradation of methylene blue than 12CoZnO NPs under UV-vis light radiation. The stability of PVA/CoZnO NC for photodegradation of dye was verified by a recycling experiment of the composite