113 research outputs found
Angelman syndrome: advancing the research frontier of neurodevelopmental disorders
- Author
- Publication venue
- Springer US
- Publication date
- 01/01/2010
- Field of study
This report is a meeting summary of the 2010 Angelman Syndrome Foundation's scientific symposium on the neuroscience of UBE3A. Angelman syndrome is characterized by loss of speech, severe developmental delay, seizures, and ataxia. These core symptoms are caused by maternal allele disruptions of a single geneâUBE3A. UBE3A encodes an E3 ubiquitin ligase that targets certain proteins for proteasomal degradation. This biology has led to the expectation that the identification of Ube3a protein targets will lead to therapies for Angelman syndrome. The recent discovery of Ube3a substrates such as Arc (activity-regulated cytoskeletal protein) provides new insight into the mechanisms underlying the synaptic function and plasticity deficits caused by the loss of Ube3a. In addition to identifying Ube3a substrates, there have also been recent advances in understanding UBE3A's integrated role in the neuronal repertoire of genes and protein interactions. A developmental picture is now emerging whereby UBE3A gene dosage on chromosome 15 alters synaptic function, with deficiencies leading to Angelman syndrome and overexpression associated with classic autism symptomatology
Aberrant Regulation of HDAC2 Mediates Proliferation of Hepatocellular Carcinoma Cells by Deregulating Expression of G1/S Cell Cycle Proteins
- Author
- A Brehm
- A Hrzenjak
- A Pathil
- BH Huang
- CD Laherty
- CY Gui
- Hong Jian Xie
- Hyun Jin Bae
- J Luo
- J Song
- Jeong Kyu Kim
- JH Noh
- Ji Heon Noh
- Jung Woo Eun
- Jung Young Lee
- K Nakano
- Kwang Hwa Jung
- M Niyazi
- MA Glozak
- Maurizio Pesce
- Min Gyu Kim
- N Batty
- NA Franken
- O Witt
- P Gallinari
- P Kaler
- P Laurent-Puig
- P Marks
- P Zhu
- RI Yarden
- S Armeanu
- Suk Woo Nam
- SW Nam
- W Huang
- W Weichert
- W Weichert
- Won Sang Park
- X Grana
- XJ Yang
- Y Sowa
- Young Gyoon Chang
- YS Lu
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for immune responses and is often significantly overexpressed in solid tumors; but little is known about its role in human hepatocellular carcinoma (HCC). In this study, we showed that targeted-disruption of HDAC2 resulted in reduction of both tumor cell growth and de novo DNA synthesis in Hep3B cells. We then demonstrated that HDAC2 regulated cell cycle and that disruption of HDAC2 caused G1/S arrest in cell cycle. In G1/S transition, targeted-disruption of HDAC2 selectively induced the expression of p16INK4A and p21WAF1/Cip1, and simultaneously suppressed the expression of cyclin D1, CDK4 and CDK2. Consequently, HDAC2 inhibition led to the down-regulation of E2F/DP1 target genes through a reduction in phosphorylation status of pRb protein. In addition, sustained suppression of HDAC2 attenuated in vitro colony formation and in vivo tumor growth in a mouse xenograft model. Further, we found that HDAC2 suppresses p21WAF1/Cip1 transcriptional activity via Sp1-binding site enriched proximal region of p21WAF1/Cip1 promoter. In conclusion, we suggest that the aberrant regulation of HDAC2 may play a pivotal role in the development of HCC through its regulation of cell cycle components at the transcription level providing HDAC2 as a relevant target in liver cancer therapy
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
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- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
- Antillon E
- Antipov P
- Antonelli L
- Anttila E
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
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- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
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- Avetisyan A
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- Wilson M. G.
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- Wingerter-Seez I.
- Wingham M
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- Womersley WJ
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- Wosiek B. K.
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- Wraight K.
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- Wu S
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- Wulf E.
- Wulz CE
- Wurthwein F
- Wynne B. M.
- Wyslouch B
- Xaplanteris L.
- Xella S.
- Xie S
- Xie S.
- Xie Z
- Xu D.
- Xu N.
- Xue Z
- Yagil A
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- Yoo HD
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- Yun JC
- Yuste C
- Zabi A
- Zabolotny W
- Zachariadou A
- Zalewski P
- Zampieri A
- Zanetti M
- Zang SL
- Zarubin A
- Zatzerklyany A
- Zeidler C
- Zeinali M
- Zeise M
- Zelepoukine S
- Zeuner WD
- Zeyrek M
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- Zhang L
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- Zheng Y
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- Zhu K
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Zielinski M
- Zilizi G
- Zinonos Z
- Zito G
- Zoeller MH
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- Zuranski A
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- Zych P
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
HDAC1 Inactivation Induces Mitotic Defect and Caspase-Independent Autophagic Cell Death in Liver Cancer
- Author
- A Brehm
- Andrei L. Gartel
- C Nishioka
- CY Gui
- EJ Noonan
- F Scarlatti
- G Lagger
- GL Wang
- Hanna Park
- Hong Jian Xie
- Hyun Jin Bae
- J Luo
- JD Yang
- Jeong Kyu Kim
- JH Noh
- Ji Heon Noh
- JR Whetstine
- Jung Woo Eun
- Jung Young Lee
- K Miyake
- K Nakano
- KB Glaser
- Kwang Hwa Jung
- L Huang
- M Niyazi
- M Oh
- MA Glozak
- Min Gyu Kim
- N Keshelava
- NH Kim
- O Witt
- P Iakova
- P Marks
- RH Wilting
- RI Yarden
- S Ropero
- S Senese
- S Yamamoto
- SE Rundlett
- Suk Woo Nam
- SW Nam
- T Rikimaru
- W Weichert
- W Weichert
- W Weichert
- Y Shao
- Y Sowa
- YL Liu
- Young Gyoon Chang
- Publication venue
- Public Library of Science
- Publication date
- 04/04/2012
- Field of study
Histone deacetylases (HDACs) are known to play a central role in the regulation of several cellular properties interlinked with the development and progression of cancer. Recently, HDAC1 has been reported to be overexpressed in hepatocellular carcinoma (HCC), but its biological roles in hepatocarcinogenesis remain to be elucidated. In this study, we demonstrated overexpression of HDAC1 in a subset of human HCCs and liver cancer cell lines. HDAC1 inactivation resulted in regression of tumor cell growth and activation of caspase-independent autophagic cell death, via LC3B-II activation pathway in Hep3B cells. In cell cycle regulation, HDAC1 inactivation selectively induced both p21WAF1/Cip1 and p27Kip1 expressions, and simultaneously suppressed the expression of cyclin D1 and CDK2. Consequently, HDAC1 inactivation led to the hypophosphorylation of pRb in G1/S transition, and thereby inactivated E2F/DP1 transcription activity. In addition, we demonstrated that HDAC1 suppresses p21WAF1/Cip1 transcriptional activity through Sp1-binding sites in the p21WAF1/Cip1 promoter. Furthermore, sustained suppression of HDAC1 attenuated in vitro colony formation and in vivo tumor growth in a mouse xenograft model. Taken together, we suggest the aberrant regulation of HDAC1 in HCC and its epigenetic regulation of gene transcription of autophagy and cell cycle components. Overexpression of HDAC1 may play a pivotal role through the systemic regulation of mitotic effectors in the development of HCC, providing a particularly relevant potential target in cancer therapy
Cortical Synaptic Transmission and Plasticity in Acute Liver Failure Are Decreased by Presynaptic Events
- Author
- A Ossato
- A Rey del
- AG Carter
- AR Jayakumar
- B Gorg
- Barbara ZabĹocka
- Bartosz Bobula
- C Hermenegildo
- C Imig
- D Haussinger
- DC Crawford
- EB Cook
- FF Poordad
- Grzegorz Hess
- J Albrecht
- J Albrecht
- Jan Albrecht
- JN Crawley
- Joanna Sowa
- K Michel
- K Milewski
- K Milewski
- KA Matkowskyj
- M Belanger
- M McMillin
- M Zielinska
- M Zielinska
- Magdalena ZieliĹska
- Mariusz Popek
- MaĹgorzata Frontczak-Baniewicz
- MC Papadopoulos
- MD Munoz
- P Fan
- P Fan
- P Jaholkowski
- P Monfort
- P Monfort
- P Monfort
- R Prakash
- RafaĹ Polowy
- RC Malenka
- Robert Kuba Filipkowski
- S Wen
- SJ Corne
- SW Provencher
- V Felipo
- V Rangroo Thrane
- W Hilgier
- W Hilgier
- W Raabe
- W Raabe
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Monitoring the Size and Lateral Dynamics of ErbB1 Enriched Membrane Domains through Live Cell Plasmon Coupling Microscopy
- Author
- A Abulrob
- A Kusumi
- A Kusumi
- A Szabo
- A Tsuji
- AD Douglass
- AHA Clayton
- AHA Clayton
- AHA Clayton
- AK Jain
- AN Bader
- B Yan
- B Yan
- BF Lillemeier
- BjĂśrn M. Reinhard
- BM Reinhard
- C Mineo
- C Sonnichsen
- CM Warren
- CYJ Wei
- ED Sheets
- F de Lange
- F Ozcan
- FV Subach
- G Carpenter
- G Orr
- Guoxin Rong
- GX Rong
- GX Rong
- H Ueno
- HC Kolb
- HS Wiley
- HY Wang
- HY Wang
- I Chung
- J Aaron
- J Schlessinger
- J Wang
- J Yguerabide
- J Yguerabide
- JA Prescher
- JR Lakowicz
- JW VanTeeffelen
- K Mayawala
- K Murase
- K Roepstorff
- K Suzuki
- KH Su
- LL Yang
- M Takeuchi
- MD Marmor
- MJ Crow
- MJ Crow
- MJ Saxton
- MP Sheetz
- MY Hsieh
- N Ariotti
- Nikos K. Karamanos
- NL Andrews
- P Nagy
- P Nagy
- P Nagy
- PK Jain
- Q Tang
- S Brinkers
- S Saffarian
- S Schultz
- S Yang
- ST Low-Nam
- SW Hell
- T Ha
- V Balzani
- X Michalet
- Y Chen
- Y Sowa
- Y Yarden
- Y-H Yang
- ZY Xiao
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
To illuminate the role of the spatial organization of the epidermal growth factor receptor (ErbB1) in signal transduction quantitative information about the receptor topography on the cell surface, ideally on living cells and in real time, are required. We demonstrate that plasmon coupling microscopy (PCM) enables to detect, size, and track individual membrane domains enriched in ErbB1 with high temporal resolution. We used a dendrimer enhanced labeling strategy to label ErbB1 receptors on epidermoid carcinoma cells (A431) with 60 nm Au nanoparticle (NP) immunolabels under physiological conditions at 37°C. The statistical analysis of the spatial NP distribution on the cell surface in the scanning electron microscope (SEM) confirmed a clustering of the NP labels consistent with a heterogeneous distribution of ErbB1 in the plasma membrane. Spectral shifts in the scattering response of clustered NPs facilitated the detection and sizing of individual NP clusters on living cells in solution in an optical microscope. We tracked the lateral diffusion of individual clusters at a frame rate of 200 frames/s while simultaneously monitoring the configurational dynamics of the clusters. Structural information about the NP clusters in their membrane confinements were obtained through analysis of the electromagnetic coupling of the co-confined NP labels through polarization resolved PCM. Our studies show that the ErbB1 receptor is enriched in membrane domains with typical diameters in the range between 60â250 nm. These membrane domains exhibit a slow lateral diffusion with a diffusion coefficient of â=â|0.0054Âą0.0064| Âľm2/s, which is almost an order of magnitude slower than the mean diffusion coefficient of individual NP tagged ErbB1 receptors under identical conditions
Validity assessment of the PROMIS fatigue domain among people living with HIV
- Author
- AC Justice
- AW Wu
- BB Reeve
- BJ Feldman
- BW Pence
- D Cella
- D Mungas
- D. L. Patrick
- D. S. Batey
- DA DeWalt
- DA Newcombe
- DU Junghaenel
- E Jong
- E. Paez
- F. M. Yang
- H. M. Crane
- HM Crane
- I Al-Dakkak
- J Barroso
- J Barroso
- J Barroso
- JA Johnson
- JA Johnson
- JC Walsh
- JS Lai
- K Kroenke
- K. H. Mayer
- KF Cook
- KK OâBrien
- KK OâBrien
- L. Dant
- L. E. Gibbons
- L. S. Morales
- M daCosta DiBonaventura
- M Lu
- M. J. Mugavero
- M. M. Kitahata
- MA Chesney
- MJ Simmonds
- MM Kitahata
- NA Sowa
- P. K. Crane
- PK Crane
- R Harding
- R. Fredericksen
- RJ Fredericksen
- RJ Fredericksen
- RL Spitzer
- RP McDonald
- SC Kalichman
- SF Garcia
- ST Lawrence
- SW Choi
- T. C. Edwards
- TC Edwards
- TP Giordano
- VC Marconi
- W. C. Mathews
- WHO Assist Working Group
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
CMS Data Processing Workflows during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anisimov A
- Antillon E
- Antipov P
- Antonelli L
- Anttila E
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arnold B
- Arora S
- Artamonov A
- Asaadi J
- Asghar MI
- Ashby S
- Askew A
- Atac M
- Atramentov O
- Auffray E
- Aurisano A
- Autermann C
- Avery P
- Avetisyan A
- Avila C
- Awan MIM
- Ayan AS
- Ayhan A
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babb J
- Babucci E
- Baccaro S
- Bacchetta N
- Bacchi W
- Bachtis M
- Baden D
- Badgett W
- Baechler J
- Baer H
- Baesso P
- Baffioni S
- Bagby L
- Bagliesi G
- Bahk SY
- Bailleux D
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Baldin B
- Ball AH
- Ball G
- Ballin J
- Bally SL
- Ban Y
- Bandurin D
- Banerjee S
- Banerjee S
- Banicz K
- Bansal S
- Banzuzi K
- Barashko V
- Barbagli G
- Barberis E
- Barbone L
- Barcala JM
- Barcellan L
- Bard R
- Bargassa P
- Baringer P
- Barnes VE
- Barnett BA
- Barney D
- Barone L
- Bartalini P
- Bartoloni A
- Bartz E
- Basegmez S
- Battilana C
- Baty C
- Baud A
- Bauer G
- Bauer J
- Bauerdick LAT
- Baur U
- Bawa HS
- Bazterra VE
- Bean A
- Beauceron S
- Beaudette F
- Beaumont W
- Bechtel F
- Bedjidian M
- Bedoya CF
- Beetz CP
- Behrens U
- Bejar JC
- Belforte S
- Beliy N
- Bell KW
- Bellan P
- Bellan R
- Bellato M
- Bellinger JN
- Belotelov I
- Benaglia A
- Bencze G
- Bendavid J
- Bender W
- Benedetti D
- Benelli G
- Benettoni M
- Beni N
- Benucci L
- Benussi L
- Benvenuti AC
- Berengueres JOL
- Beretvas A
- Bergauer H
- Bergauer T
- Beri SB
- Bernardini J
- Bernet C
- Berntzon L
- Berretta L
- Berry D
- Berry E
- Berryhill J
- Bertani M
- Bertl W
- Bertoldi M
- Berzano U
- Besancon M
- Besson A
- Betchart B
- Betev B
- Betts RR
- Beuselinck R
- Bhat PC
- Bhatnagar V
- Bhattacharya S
- Bhattacharya S
- Bhatti A
- Biallass P
- Bianchini L
- Bianco S
- Biasini M
- Biasotto M
- Biery K
- Biino C
- Bilei GM
- Bilki B
- Bilmis S
- Binkley M
- Bisello D
- Bitioukov S
- Blaha J
- Blekman F
- Bloch D
- Bloch I
- Bloch P
- Bloom K
- Bluj M
- Blum P
- Blumenfeld B
- Blyweert S
- Boccali T
- Bocci A
- Bockelman B
- Bodek A
- Bodin D
- Boeriu O
- Boldini M
- Boldizsar L
- Bolla G
- Bolognesi S
- Bolton T
- Bona M
- Bonacorsi D
- Bonato A
- Bondar N
- Bontenackels M
- Boos E
- Borcherding F
- Borgia MA
- Bornheim A
- Borras K
- Borrello L
- Borsato E
- Bortoletto D
- Bos J
- Bose M
- Bose S
- Bose T
- Bosi F
- Bostock F
- Botta C
- Boudoul G
- Bouhali O
- Bourgeois N
- Bourilkov D
- Bourrel T
- Boutemeur M
- Boutle S
- Braibant-Giacomelli S
- Branca A
- Branson JG
- Brauer R
- Braunschweig W
- Breedon R
- Brett AM
- Breuker H
- Brew C
- Bricola S
- Briggs R
- Brigljevic V
- Broccolo G
- Brom JM
- Brooke JJ
- Brown RM
- Brun H
- Bruno G
- Buchmuller O
- Budd H
- Buege V
- Buehler M
- Bunin P
- Bunkowski K
- Bunn J
- Buontempo S
- Burkett K
- Burtovoy V
- Busson P
- Busza W
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
- Antillon E
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- Anttila E
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- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
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- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arnold B
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- Artamonov A
- Asaadi J
- Asghar MI
- Ashby S
- Askew A
- Atac M
- Atramentov O
- Auffray E
- Aurisano A
- Autermann C
- Avery P
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- Ayan AS
- Ayhan A
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- Zilizi G
- Zinonos Z
- Zito G
- Zoeller MH
- Zotto P
- Zub S
- Zumerle G
- Zuranski A
- Zuyeuski R
- Zych P
- Publication venue
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at âs=7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
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- Agostino L
- Agram JL
- Aguilar-Benitez M
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- Yun JC
- Zabi A
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- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang SL
- Zarubin A
- Zatzerklyaniy A
- Zeidler C
- Zeinali M
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- Zennamo J
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
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- Zhu B
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- Zhukov V
- Zhukova V
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- Zinonos Z
- Zito G
- Zoeller MH
- Zorbilmez C
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2010
- Field of study
This is the pre-print version of the Published Article which can be accessed from the link below.Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at âs=7ââTeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity dNch/dΡ||Ρ|<0.5=5.78Âą0.01(stat)Âą0.23(syst) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from âs=0.9 to 7 TeV is [66.1Âą1.0(stat)Âą4.2(syst)]%. The mean transverse momentum is measured to be 0.545Âą0.005(stat)Âą0.015(syst)ââGeV/c. The results are compared with similar measurements at lower energies
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