49 research outputs found
Local iron homeostasis in the breast ductal carcinoma microenvironment
- Author
- A Mantovani
- AA Alkhateeb
- AC Vargas
- Alexandra Rêma
- Arnaud Cruz Paula
- B Manger
- B Ruffell
- BA Diwan
- Berta Martins da Silva
- C Delaby
- Carlos Lopes
- D Hrabinski
- DG DeNardo
- DM Paulnock
- DR Richardson
- DY Shin
- Fátima Faria
- G Corna
- G Dranoff
- Graça Porto
- HJ Thompson
- HY Dong
- J Arezes
- J Folkman
- JP Pinto
- JW Pollard
- JW Pollard
- K Pietras
- KJ Britten
- L Tesfay
- LD Miller
- M Sharma
- M Singh
- M Sousa de
- M Sousa de
- M Taylor
- Maria Gomez-Lazaro
- MD Knutson
- MF Macedo
- MH Dorner
- MJ Bissell
- ML Wallander
- MS Pollack
- NC Andrews
- Oriana Marques
- P Jezequel
- Paula Silva
- RL Elliott
- S Recalcati
- S Zhang
- SB Coffelt
- SI Shpyleva
- SMA Mahmoud
- SZ Liu
- TF Gajewski
- W Wang
- X Huang
- XJ Ma
- Y Chen
- Y Cui
- Y Zhang
- ZK Pinnix
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Abstract
BACKGROUND:
While the deregulation of iron homeostasis in breast epithelial cells is acknowledged, iron-related alterations in stromal inflammatory cells from the tumor microenvironment have not been explored.
METHODS:
Immunohistochemistry for hepcidin, ferroportin 1 (FPN1), transferrin receptor 1 (TFR1) and ferritin (FT) was performed in primary breast tissues and axillary lymph nodes in order to dissect the iron-profiles of epithelial cells, lymphocytes and macrophages. Furthermore, breast carcinoma core biopsies frozen in optimum cutting temperature (OCT) compound were subjected to imaging flow cytometry to confirm FPN1 expression in the cell types previously evaluated and determine its cellular localization.
RESULTS:
We confirm previous results by showing that breast cancer epithelial cells present an 'iron-utilization phenotype' with an increased expression of hepcidin and TFR1, and decreased expression of FT. On the other hand, lymphocytes and macrophages infiltrating primary tumors and from metastized lymph nodes display an 'iron-donor' phenotype, with increased expression of FPN1 and FT, concomitant with an activation profile reflected by a higher expression of TFR1 and hepcidin. A higher percentage of breast carcinomas, compared to control mastectomy samples, present iron accumulation in stromal inflammatory cells, suggesting that these cells may constitute an effective tissue iron reservoir. Additionally, not only the deregulated expression of iron-related proteins in epithelial cells, but also on lymphocytes and macrophages, are associated with clinicopathological markers of breast cancer poor prognosis, such as negative hormone receptor status and tumor size.
CONCLUSIONS:
The present results reinforce the importance of analyzing the tumor microenvironment in breast cancer, extending the contribution of immune cells to local iron homeostasis in the tumor microenvironment context.info:eu-repo/semantics/publishedVersio
Pembauran Budaya di Desa Rantau Sakti Kecamatan Tambusai Utara Kabupaten Rokan Hulu
- Author
- A Mantovani
- A Ström
- Andrew Collins
- AP Bradley
- BJ Deroo
- C Cortes
- C Péqueux
- CC Burges
- CK Osborne
- D DeNardo
- D Eccles
- DF Easton
- Diana Eccles
- DW Huang
- DW Huang
- G Harburg
- G Mor
- G Solinas
- H Iwase
- HJ Ban
- I Guyon
- I Guyon
- J Listgarten
- JA Cruz
- Joerg Fliege
- K Wang
- K-D Yu
- L Björnström
- L Dunnwald
- M Clemons
- M Hall
- M Klagsbrun
- MJ Reed
- N Roodi
- P Maguire
- PB Gupta
- R Chen
- R Hähnel
- RD Leek
- RL Seal
- Rosanna Upstill-Goddard
- S Ménard
- S Paruthiyil
- S Purcell
- S-H Chen
- Sajjad Rafiq
- Sarah Ennis
- SI Grivennikov
- SMA Mahmoud
- Syed A. Aziz
- T Fawcett
- TI Andersen
- V Vapnik
- WD Foulkes
- WF Anderson
- William Tapper
- WJ Lee
- Y Li
- Y Li
- Publication venue
- Riau University
- Publication date
- 01/01/2013
- Field of study
This study is to research how the intercourse of culture that existed in the Rantau Sakti village Tambusai Utara District and Rokan Hulu Regent intertribal nasions of Java, Medan Java, Batak, Minang, and Melayu. Theres a launching factors and hindrance factors too in culture intercourse. The data tekhnic collection with the koesioner, interview, and documentation. And the analisys of data is descriptive where the data presented in the form of a diagrams, percentages, pictures, and explanations. The research results show that The lives of the multicultural that could lead to the occurrence of intercourse of culture through assimilation, acculturation, and amalgamation. The intercourse of culture through three aspects of it can run well theres happened in Rantau Sakti village on seven principles like language, system of knowledge , a social organization , celebration life and technologi, means of subsistence, religion, and art . There is also intercourse of culture with amalgamation culture that leads to assimilation and acculturation. Its launching factor are the attitude of tolerance and open, in common religion, and the same occasion in the economic field. While the hindrance factor are differences of religion and stereotype (ethnic prejudice). Those two factors each happened to the process of changing culture with assimilation, acculturation, and amalgamation That leads to a positive thing.Keyword: The Culture Intercourse, Inter-ethnic
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
- Author
- A Hollestelle
- AE Teschendorff
- Ali Bashashati
- Andrew Green
- Andy G. Lynch
- Anita Langerød
- Anne-Lise Børresen-Dale
- Arnie Purushotham
- AV Kapp
- BE Stranger
- Carlos Caldas
- Christina Curtis
- CM Perou
- D Holland
- DH Teng
- Doug Speed
- Elena Provenzano
- Florian Markowetz
- FM Blows
- Gavin Ha
- Gholamreza Haffari
- Gordon Wishart
- GR Bignell
- Gulisa Turashvili
- HG Russnes
- Ian Ellis
- J Daniel
- J Li
- J Tan
- James D. Brenton
- JS Parker
- K Chin
- L Hughes-Davies
- LA Brown
- Leigh Murphy
- Mark J. Dunning
- MK McConechy
- Oscar M. Rueda
- Peter Watson
- R Shen
- R Tibshirani
- RJ Leary
- Roslin Russell
- S Jones
- SA Christopher
- Samuel Aparicio
- Sarah Pinder
- SF Chin
- Shamith Samarajiwa
- Simon Tavaré
- SMA Mahmoud
- Sohrab P. Shah
- Stefan Gräf
- Steven McKinney
- Suet-Feung Chin
- T Santarius
- T Sørlie
- Y Chen
- Y Gilad
- Yinyin Yuan
- Publication venue
- Nature
- Publication date
- 18/04/2012
- Field of study
The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set of 997 and 995 primary breast tumours, respectively, with long-term clinical follow-up. Inherited variants (copy number variants and single nucleotide polymorphisms) and acquired somatic copy number aberrations (CNAs) were associated with expression in ~40% of genes, with the landscape dominated by cis- and trans-acting CNAs. By delineating expression outlier genes driven in cis by CNAs, we identified putative cancer genes, including deletions in PPP2R2A, MTAP and MAP2K4. Unsupervised analysis of paired DNA–RNA profiles revealed novel subgroups with distinct clinical outcomes, which reproduced in the validation cohort. These include a high-risk, oestrogen-receptor-positive 11q13/14 cis-acting subgroup and a favourable prognosis subgroup devoid of CNAs. Trans-acting aberration hotspots were found to modulate subgroup-specific gene networks, including a TCR deletion-mediated adaptive immune response in the ‘CNA-devoid’ subgroup and a basal-specific chromosome 5 deletion-associated mitotic network. Our results provide a novel molecular stratification of the breast cancer population, derived from the impact of somatic CNAs on the transcriptome
Hypericum sp.: essential oil composition and biological activities
- Author
- A Baruah
- A Bertoli
- A Bertoli
- A Bertoli
- A Cakir
- A Cakir
- A Cakir
- A Ferraz
- A Ferreira
- A Guardo Di
- A Kakhky
- A Kirakosyan
- A Kirakosyan
- A Kornfeld
- A Mourey
- A Nahrstedt
- A Pieroni
- A Piovan
- A Poutaraud
- A Rančcić
- A Sokmen
- A Trovato
- A Wójcik
- A Đorđević
- ABF Ferraz
- AC Schmitt
- ACP Dias
- ACP Dias
- ACP Dias
- Ana P. Guedes
- AP Guedes
- AP Guedes
- APM Bernardi
- B Demirci
- B Gudžic
- B Gudžić
- B Lange
- B Prado
- B Vinterhalter
- B Öztürk
- BA Silva
- C Giuliani
- C Mathis
- C Mathis
- C Mathis
- CC Sánchez-Mateo
- CC Sánchez-Mateo
- D Fritz
- D Ivanova
- D Mockutė
- D Schwarz
- E Banchio
- E Bombardelli
- E Galati
- E Tozlu
- E Yildirim
- EV Costa
- F Bakkali
- F Bougard
- F Chen
- F Conforti
- F Demirci
- F Maggi
- F Souret
- FR Pretto
- FX Maquart
- G Ferretti
- G Franklin
- G Franklin
- G Franklin
- G Kızıl
- G Pintore
- G-Q Zheng
- G. Franklin
- GM Kitanov
- H Jayasuriyab
- H Karim
- HP Bais
- I Abreu
- I Kubo
- I Schwob
- I Schwob
- I Schwob
- J Camejo-Rodrigues
- J Heilmann
- J Koperdáková
- J Radusiene
- J Soelberg
- JL Hartwell
- K Adam
- K Danova
- K Helmja
- K Hosni
- K Ishiguro
- K Morteza-Semnani
- K Nakano
- K Saeb
- K Tawaha
- KHC Baser
- L Decosterd
- L Maffi
- L Panizi
- L Pistelli
- L Rocha
- M Cardona
- M Cardoso
- M Couladis
- M Couladis
- M Cowan
- M Moura
- M Pavlović
- M Spiteller
- Manuel Fernandes-Ferreira
- N Aligiannis
- N Radulovic
- N Robson
- O Touafek
- P Avato
- P Avato
- P Mercke
- P Mukherjee
- P Mártonfi
- P Veronese
- P Weyerstahl
- PAG Santos
- PK Mukherjee
- PML Lourenço
- PV Petrakis
- R Alwis De
- R Andrews
- R Daudt
- R Rabanal
- R Thimmaraju
- RM Rabanal
- RS Chauhan
- S Apaydin
- S Burt
- S Crockett
- S Gadzovska
- S Griffin
- S Jaric
- S Kültür
- S Mahmoud
- S Martin
- S Uribe
- SJ Murch
- SL Crockett
- SL Crockett
- SMA Zobayed
- SMA Zobayed
- SR Rao
- SR Rao
- T Nogueira
- V Saroglou
- W Feng
- X-H Cui
- X-H Cui
- Y Tambe
- Z Toker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2012
- Field of study
Phytochemical composition of Hypericum
genus has been investigated for many years. In the recent past, studies on the essential oils (EO) of this genus have been progressing and many of them have reported interesting biological activities. Variations in the EO composition of Hypericum species influenced
by seasonal variation, geographic distribution, phenological cycle and type of the organ in which EO are produced and/or accumulated have also been reported. Although many reviews attributed to the characterization
as well as biological activities of H. perforatum
crude extracts have been published, no review has been published on the EO composition and biological activities of Hypericum species until recently (Crockett
in Nat Prod Commun 5(9):1493–1506, 2010;
Bertoli et al. in Global Sci Books 5:29–47, 2011). In this article, we summarize and update information regarding the composition and biological activities of Hypericum species EO. Based on experimental work carried out in our laboratory we also mention possible biotechnology approaches envisaging EO improvement of some species of the genus.Fundação para a Ciência e a Tecnologia (FCT) - project PTDC/AGR AAM/70418/2006, SFRH/BD/
13283/2003
Evidence for Top Quark Production in Nucleus-Nucleus Collisions
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Adloff C
- Adzic P
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmed A
- Ahuja S
- Akbiyik M
- Akchurin N
- Akgun B
- Akpinar A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Aldá Júnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allen B
- Almond J
- Alvarez Gonzalez B
- Alverson G
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Ambrogi F
- Amendola C
- Amin N
- Amram O
- Amsler C
- Anagnostou G
- Anderson D
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Ang L
- Antchev G
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Atakisi IO
- Atanasov I
- Ather MW
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awan MIM
- Ayala E
- Aydogmus Sen F
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babounikau I
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Baldenegro Barrera C
- Ball AH
- Ban Y
- Band R
- Banerjee S
- Banerjee S
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes VE
- Barney D
- Baron O
- Barrio Luna M
- Bartek R
- Bartosik N
- Bartók M
- Baselga M
- Baskakov A
- Bastos D
- Battilana C
- Baty A
- Bauerdick LAT
- Baur S
- Baxter S
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Becerril Gonzalez H
- Bechtel J
- Beghin D
- Behera PK
- Behera SC
- Behnke O
- Bein S
- Belchior Batista Das Chagas E
- Belforte S
- Bell KW
- Bellan R
- Belloni A
- Bellora A
- Belyaev A
- Belyaev A
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benecke A
- Benelli G
- Beni N
- Benitez JF
- Benussi L
- Beretvas A
- Bergauer T
- Berger P
- Berger T
- Beri SB
- Bermúdez Martínez A
- Bernardes CA
- Bernet C
- Berry D
- Berryhill J
- Bertacchi V
- Besancon M
- Beschi A
- Bhal E
- Bhandari R
- Bhardwaj A
- Bharti M
- Bhat MA
- Bhat PC
- Bhatnagar V
- Bhattacharya R
- Bhattacharya S
- Bhattacharya S
- Bhattacharya S
- Bheesette S
- Bhowmik D
- Bhowmik S
- Bhyun JH
- Bi R
- Bialkowska H
- Bianchini L
- Bianco M
- Bianco S
- Biasini M
- Biino C
- Bilei GM
- Bilin B
- Bilki B
- Bin Anuar AA
- Bisello D
- Black K
- Blekman F
- Blinov V
- Bloch D
- Bloch P
- Bloom K
- Bluj M
- Blumenfeld B
- Boccali T
- Bocci A
- Bodek A
- Boimska B
- Boletti A
- Bologna S
- Bols ES
- Bonacorsi D
- Bonanomi M
- Bonchev M
- Bonomally S
- Boos E
- Boran F
- Borchsh V
- Borg J
- Borgonovi L
- Bornheim A
- Borras K
- Bortignon P
- Bose T
- Bossini E
- Botta C
- Botta V
- Boudoul G
- Bouhali O
- Bourgatte G
- Bourilkov D
- Bozzo M
- Bragagnolo A
- Braghieri A
- Braibant-Giacomelli S
- Brainerd C
- Brandt S
- Branson JG
- Bravo C
- Breedon R
- Breeze S
- Brew C
- Brigljevic V
- Brinkerhoff A
- Brivio F
- Brochero Cifuentes JA
- Brom J-M
- Brondolin E
- Brooke JJ
- Brown RM
- Brunner D
- Bruno G
- Brzhechko D
- Brücken E
- Bucci R
- Buccilli A
- Buchanan J
- Buchmuller O
- Bueghly J
- Bundock A
- Bunkowski K
- Buontempo S
- Burkett K
- Burkle B
- Burns D
- Burt K
- Bury F
- Busson P
- Busza W
- Butalla S
- Butler JN
- Butler PH
- Butz E
- Bylinkin A
- Bylsma B
- Byszuk A
- Cabrera A
- Cabrillo IJ
- Cadamuro L
- Caillol C
- Cakir A
- Calabria C
- Calandri A
- Calderon De La Barca Sanchez M
- Calderon A
- Cali IA
- Call K
- Calligaris L
- Calzaferri S
- Camen C
- Caminada L
- Campagnari C
- Campanini R
- Campbell A
- Camporesi T
- Candelise V
- Canelli MF
- Canepa A
- Cankocak K
- Capiluppi P
- Cappati A
- Caputo C
- Caraway B
- Cardini A
- Cardwell B
- Carle A
- Carlin R
- Carrera Jarrin E
- Carrillo Montoya CA
- Carrillo Moreno S
- Cartiglia N
- Carvalho Antunes De Oliveira A
- Carvalho W
- Casarsa M
- Caspart R
- Cassese A
- Castaldi R
- Castaneda Hernandez A
- Castilla-Valdez H
- Castro A
- Cavallari F
- Cavallo FR
- Cavallo N
- Cavanaugh R
- Ceard L
- Ceccarelli R
- Cepaitis V
- Cepeda M
- Cerati GB
- Cerci S
- Cerminara G
- Cerrada M
- Cerri O
- Cetorelli F
- Chabert EC
- Chahal GS
- Chang P
- Chang P
- Chanon N
- Chao Y
- Chapon E
- Charaf O
- Charlot C
- Chatterjee RM
- Chatterjee S
- Chauhan S
- Chauhan S
- Chawla R
- Chazin Quero B
- Checchia P
- Chekhovsky V
- Chen C
- Chen G
- Chen GM
- Chen HS
- Chen KF
- Chen M
- Chen PH
- Chen X
- Chen Y
- Chen Y
- Chen Z
- Chenarani S
- Cheng T
- Cheng Y
- Cherepanov V
- Chernyavskaya N
- Chertok M
- Cheung HWK
- Chhibra SS
- Chiarito B
- Chierici R
- Chinellato J
- Chistov R
- Chlebana F
- Cho S
- Choi J
- Choi S
- Choi Y
- Chou JP
- Choudhary BC
- Choudhury S
- Chu J
- Chudasama R
- Chwalek T
- Ciangottini D
- Ciocca C
- Ciocci MA
- Cipriani M
- Ciriolo V
- Cirkovic P
- Citron M
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clement E
- Clerbaux B
- CMS Collaboration
- Cockerill DJA
- Coelho E
- Colaleo A
- Cole JE
- Colino N
- Collard C
- Colling D
- Cometti S
- Connor P
- Consuegra Rodríguez S
- Contardo D
- Conway J
- Conway R
- Cooper SI
- Cooperstein S
- Corcodilos L
- Cornelis T
- Correia Silva G
- Cosby C
- Cossutti F
- Costa M
- Costa S
- Coubez X
- Couderc F
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Cranshaw DJ
- Creanza D
- Cremonesi M
- Cristella L
- Csanad M
- Csorgo T
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cummings G
- Cussans D
- Cutts D
- Czellar S
- D'Alessandro R
- D'Alfonso M
- D'Enterria D
- D'Hondt J
- Da Costa EM
- Da Rold A
- Da Silveira GG
- Dabrowski A
- Daci N
- Dalchenko M
- Dallavalle GM
- Damarseckin S
- Damgov J
- Danilov M
- Danilov V
- Daponte V
- Darwish MR
- Das P
- Das S
- Dasgupta A
- Dash D
- Daskalakis G
- Dasu S
- Datta A
- Dauncey P
- David A
- David P
- Davies G
- Davignon O
- De Barbaro P
- De Boer W
- De Bruyn I
- De Castro Manzano P
- De Clercq J
- De Cosa A
- De Filippis N
- De Guio F
- De Iorio A
- De Jesus Damiao D
- De La Cruz B
- De La Cruz-Burelo E
- De Lentdecker G
- De Leo K
- De Palma M
- De Roeck A
- De Trocóniz JF
- De Wit A
- De Wolf EA
- Deelen N
- Defranchis MM
- Deile M
- Dejardin M
- Del Burgo R
- Del Re D
- Delaere C
- Delannoy AG
- Delannoy H
- Delcourt M
- Delgado Peris A
- Delgado A
- Dell'Orso R
- Della Negra M
- Della Ricca G
- Demaria N
- Demina R
- Demiragli Z
- Demiroglu ZS
- Denegri D
- Depasse P
- Derdzinski M
- Dermenev A
- Dev N
- Dewanjee RK
- Dezoort G
- Dharmaratna WGD
- Dhingra N
- Di Croce D
- Di Domenico MR
- Di Florio A
- Di Francesco A
- Di Marco E
- Di Maria R
- Di Mattia A
- Di Pilato A
- Diab B
- Diamantopoulou M
- Diaz D
- Didukh L
- Diemoz M
- Dierlamm A
- Dildick S
- Dilsiz K
- Dimitrov A
- Dimova T
- Dinardo ME
- Dini P
- Diotalevi T
- Dissertori G
- Dittmann J
- Dittmar M
- Dittmer S
- Dobson M
- Dobur D
- Dodd L
- Dogra S
- Dolek F
- Dolen J
- Dominguez A
- Domínguez Damiani D
- Donato S
- Donegà M
- Donertas IS
- Dordevic M
- Dorfer C
- Dorigo T
- Dorney B
- Doroba K
- Dorsett A
- Dosselli U
- Dozen C
- Dragicevic M
- Dremin I
- Dreyer T
- Duarte Campderros J
- Duarte J
- Dube S
- Dudko L
- Dugad S
- Duh YT
- Dulemba JL
- Dumanoglu I
- Dupont N
- Durgut S
- Duric S
- Durkin LS
- Dutta D
- Dutta I
- Dutta S
- Dutta V
- Dziwok C
- Dünser M
- Ebrahimi A
- Eckerlin G
- Ecklund KM
- Eckstein D
- Eerola P
- Ehataht K
- Eichhorn T
- El Mamouni H
- El Morabit K
- Eliseev D
- Elkafrawy T
- Elliott-Peisert A
- Ellis KV
- Elmer P
- Elmetenawee W
- Elvira VD
- Elwood A
- Eminizer M
- Emriskova N
- Eno SC
- Epshteyn V
- Erbacher R
- Erdmann M
- Erdmann W
- Erice C
- Erodotou E
- Errico F
- Ershov A
- Erö J
- Escalante Del Valle A
- Eskut E
- Estevez Banos LI
- Etesami SM
- Eusebi R
- Evangelou I
- Evans A
- Evdokimov O
- Everaerts P
- Eysermans J
- Fabbri F
- Fabozzi F
- Faccioli P
- Fackeldey P
- Fallavollita F
- Fallon C
- Falmagne G
- Faltermann N
- Fanfani A
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- Publication venue
- Publication date
- 01/01/2019
- Field of study
Peer reviewe
Measurement of inclusive very forward jet cross sections in proton-lead collisions at \sqrt{sNN} = 5:02 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
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- Acosta JG
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- Yetkin EA
- Yilmaz Y
- Yohay R
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- Yu I
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- Yumiceva F
- Yusli MN
- Zabel J
- Zabi A
- Zaganidis N
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zarucki M
- Zeinali M
- Zenaiev O
- Zenz SC
- Zeuner WD
- Zevi Della Porta G
- Zeyrek M
- Zghiche A
- Zhang A
- Zhang F
- Zhang H
- Zhang J
- Zhang S
- Zhang Z
- Zhao J
- Zhaozhong S
- Zhiltsov V
- Zhokin A
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- Zhu RY
- Zhukov V
- Zientek M
- Zito G
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- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2019
- Field of study
Measurements of differential cross sections for inclusive very forward jet production in proton-lead collisions as a function of jet energy are presented. The data were collected with the CMS experiment at the LHC in the laboratory pseudorapidity range −6.6 < η < −5.2. Asymmetric beam energies of 4 TeV for protons and 1.58 TeV per nucleon for Pb nuclei were used, corresponding to a center-of-mass energy per nucleon pair of \sqrt{sNN} = 5:02 TeV. Collisions with either the proton (p+Pb) or the ion (Pb+p) traveling towards the negative η hemisphere are studied. The jet cross sections are unfolded to stable-particle level cross sections with p_{T} ≳ 3 GeV, and compared to predictions from various Monte Carlo event generators. In addition, the cross section ratio of p+Pb and Pb+p data is presented. The results are discussed in terms of the saturation of gluon densities at low fractional parton momenta. None of the models under consideration describes all the data over the full jet-energy range and for all beam configurations. Discrepancies between the differential cross sections in data and model predictions of more than two orders of magnitude are observed
Observation of the B-s(0) -> X(3872)phi Decay
- Author
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- Takahashi Y
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- Zuolo D
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- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Using a data sample of proton-proton collisions at root s = 13 TeV, corresponding to an integrated luminosity of 140 fb(-1) collected by the CMS experiment in 2016-2018, the B-s(0) -> X(3872)phi decay is observed. Decays into J/psi pi(+)pi(-) and K+K- are used to reconstruct, respectively, the X(3872) and phi. The ratio of the product of branching fractions B[B-s(0) -> X(3872)phi]B[X(3872) -> J/psi pi(+)pi(-)] to the product B[B-s(0) ->psi(2S)phi]B[psi(2S) -> J/psi pi(+)pi(-)] is measured to be [2.21 +/- 0.29(stat) +/- 0.17(syst)]%. The ratio B[B-s(0) -> X(3872)phi]/B[B-0 -> X(3872)K-0] is found to be consistent with one, while the ratio B[B-s(0) -> X(3872)phi]/B[B+-> X(3872)K+] is two times smaller. This suggests a difference in the production dynamics of the X(3872) in B-0 and B(0)s meson decays compared to B+. The reported observation may shed new light on the nature of the X(3872) particle.Peer reviewe
Local iron homeostasis in the breast ductal carcinoma microenvironment
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- AA Alkhateeb
- AC Vargas
- Alexandra Rêma
- Arnaud Cruz Paula
- B Manger
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- DG DeNardo
- DM Paulnock
- DR Richardson
- DY Shin
- Fátima Faria
- G Corna
- G Dranoff
- Graça Porto
- HJ Thompson
- HY Dong
- J Arezes
- J Folkman
- JP Pinto
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- KJ Britten
- L Tesfay
- LD Miller
- M Sharma
- M Singh
- M Sousa de
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- Maria Gomez-Lazaro
- MD Knutson
- MF Macedo
- MH Dorner
- MJ Bissell
- ML Wallander
- MS Pollack
- NC Andrews
- Oriana Marques
- P Jezequel
- Paula Silva
- RL Elliott
- S Recalcati
- S Zhang
- SB Coffelt
- SI Shpyleva
- SMA Mahmoud
- SZ Liu
- TF Gajewski
- W Wang
- X Huang
- XJ Ma
- Y Chen
- Y Cui
- Y Zhang
- ZK Pinnix
- Publication venue
- 'Springer Science and Business Media LLC'
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- Field of study
Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU
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- C. Palazzi
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- Ü. Gaygısız
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Contains fulltext :
172380.pdf (publisher's version ) (Open Access
Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients.
- Author
- Publication venue
- Ann Oncol
- Publication date
- 01/08/2014
- Field of study
BACKGROUND: T-cell infiltration in estrogen receptor (ER)-negative breast tumours has been associated with longer survival. To investigate this association and the potential of tumour T-cell infiltration as a prognostic and predictive marker, we have conducted the largest study of T cells in breast cancer to date. PATIENTS AND METHODS: Four studies totalling 12 439 patients were used for this work. Cytotoxic (CD8+) and regulatory (forkhead box protein 3, FOXP3+) T cells were quantified using immunohistochemistry (IHC). IHC for CD8 was conducted using available material from all four studies (8978 samples) and for FOXP3 from three studies (5239 samples)-multiple imputation was used to resolve missing data from the remaining patients. Cox regression was used to test for associations with breast cancer-specific survival. RESULTS: In ER-negative tumours [triple-negative breast cancer and human epidermal growth factor receptor 2 (human epidermal growth factor receptor 2 (HER2) positive)], presence of CD8+ T cells within the tumour was associated with a 28% [95% confidence interval (CI) 16% to 38%] reduction in the hazard of breast cancer-specific mortality, and CD8+ T cells within the stroma with a 21% (95% CI 7% to 33%) reduction in hazard. In ER-positive HER2-positive tumours, CD8+ T cells within the tumour were associated with a 27% (95% CI 4% to 44%) reduction in hazard. In ER-negative disease, there was evidence for greater benefit from anthracyclines in the National Epirubicin Adjuvant Trial in patients with CD8+ tumours [hazard ratio (HR) = 0.54; 95% CI 0.37-0.79] versus CD8-negative tumours (HR = 0.87; 95% CI 0.55-1.38). The difference in effect between these subgroups was significant when limited to cases with complete data (P heterogeneity = 0.04) and approached significance in imputed data (P heterogeneity = 0.1). CONCLUSIONS: The presence of CD8+ T cells in breast cancer is associated with a significant reduction in the relative risk of death from disease in both the ER-negative [supplementary Figure S1, available at Annals of Oncology online] and the ER-positive HER2-positive subtypes. Tumour lymphocytic infiltration may improve risk stratification in breast cancer patients classified into these subtypes. NEAT ClinicalTrials.gov: NCT00003577.This work was supported by Cancer Research UK (C490/A10119 and C490/A10124) and the NIHR
Cambridge Biomedical Research Centre. HRA was supported by a grant from Addenbrooke’s
Charitable Trust. The BCCA study was supported by an unrestricted educational grant from Sanofi-Aventis Canada. SMAM was supported by a PhD studentship funded by the Government of Egypt.
IOE was funded by Breast Cancer Campaign.This is the author accepted manuscript. The final version can be found on the publisher's website at: http://annonc.oxfordjournals.org/content/early/2014/06/09/annonc.mdu191.long © The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved