278 research outputs found
On the Evolution Equation for Magnetic Geodesics
In this paper we prove the existence of long time solutions for the parabolic
equation for closed magnetic geodesics.Comment: In this paper we prove the existence of long time solutions for the
parabolic equation for closed magnetic geodesic
Delayed diagnosis of cystic fibrosis associated with R117H on a background of 7T polythymidine tract at intron 8
AbstractWe report late diagnoses of cystic fibrosis (CF) in two men aged 61 and 65 years. At the time of presentation, both patients had significant pulmonary disease. In each case two CFTR gene mutations were identified, including R117H on a background of a poly T genotype of 7T/9T. Patients with two identified CFTR mutations which include the R117H/7T anomaly should be followed up routinely as they remain susceptible to severe lung disease
Spinodal decomposition, nuclear fog and two characteristic volumes in thermal multifragmentation
Thermal multifragmentation of hot nuclei is interpreted as the nuclear
liquid-fog phase transition inside the spinodal region. The experimental data
for p(8.1GeV) + Au collisions are analyzed within the framework of the
statistical multifragmentation model (SMM) for the events with emission of at
least two IMFs. It is found that the partition of hot nuclei is specified after
expansion to a volume equal to Vt = (2.6+-0.3) Vo, with Vo as the volume at
normal density. However, the freeze-out volume is found to be twice as large:
Vf = (5+-1) Vo.Comment: 8 pages, 6 figures, to be published in Nucl.Phys.
Oscillation of the tunnel splitting in nanospin systems within the particle mapping formalism
The oscillation of tunnel splitting in the biaxial spin system within
magnetic field along the anisotropy axis is analyzed within the particle
mapping approach, rather than in the (\theta-\phi) spin coherent-state
representation. In our mapping procedure, the spin system is transformed into a
particle moving in the restricted geometry whose wave function subjects
to the boundary condition involving additional phase shift. We obtain the new
topological phase that plays the same role as the Wess-Zumino action in spin
coherent-state representation. Considering the interference of two possible
trajectories, instanton and anti-instanton, we get the identical condition for
the field at which tunneling is quenched, with the previous result within spin
coherent-state representation.Comment: 11 pages, 1 figure; Some typographical errors have been correcte
Comparative Study of Multifragmentation of Gold Nuclei Induced by Relativistic Protons, He, and C
Multiple emission of intermediate-mass fragments has been studied for the
collisions of p, He and C on Au with the setup FASA. The mean
IMF multiplicities (for the events with at least one IMF) are saturating at the
value of for the incident energies above 6 GeV. The observed IMF
multiplicities cannot be described in a two-stage scenario, a fast cascade
followed by a statistical multifragmentation. Agreement with the measured IMF
multiplicities is obtained by introducing an intermediate phase and modifying
empirically the excitation energies and masses of the remnants.
The angular distributions and energy spectra from the p-induced collisions
are in agreement with the scenario of ``thermal'' multifragmentation of a hot
and diluted target spectator. In the case of C+Au(22.4 GeV) and
He(14.6 GeV)+Au collisions, deviations from a pure thermal break-up are
seen in the energy spectra of the emitted fragments, which are harder than
those both from model calculations and from the measured ones for p-induced
collisions. This difference is attributed to a collective flow.Comment: 33 pages 15 figures, accepted in Nucl. Phys.
A transcribed enhancer dictates mesendoderm specification in pluripotency.
Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage specification during development. Here, we evaluate remodeling of the enhancer landscape and modulation of the lncRNA transcriptome during mesendoderm specification. We sort mesendodermal progenitors from differentiating embryonic stem cells (ESCs) according to Eomes expression, and find that enhancer usage is coordinated with mesendoderm-specific expression of key lineage-determining transcription factors. Many of these enhancers are associated with the expression of lncRNAs. Examination of ESC-specific enhancers interacting in three-dimensional space with mesendoderm-specifying transcription factor loci identifies MesEndoderm Transcriptional Enhancer Organizing Region (Meteor). Genetic and epigenetic manipulation of the Meteor enhancer reveal its indispensable role during mesendoderm specification and subsequent cardiogenic differentiation via transcription-independent and -dependent mechanisms. Interestingly, Meteor-deleted ESCs are epigenetically redirected towards neuroectodermal lineages. Loci, topologically associating a transcribed enhancer and its cognate protein coding gene, appear to represent therefore a class of genomic elements controlling developmental competence in pluripotency
Cognitive mechanisms associated with auditory sensory gating
Sensory gating is a neurophysiological measure of inhibition that is characterised by a reduction in the P50 event-related potential to a repeated identical stimulus. The objective of this work was to determine the cognitive mechanisms that relate to the neurological phenomenon of auditory sensory gating. Sixty participants underwent a battery of 10 cognitive tasks, including qualitatively different measures of attentional inhibition, working memory, and fluid intelligence. Participants additionally completed a paired-stimulus paradigm as a measure of auditory sensory gating. A correlational analysis revealed that several tasks correlated significantly with sensory gating. However once fluid intelligence and working memory were accounted for, only a measure of latent inhibition and accuracy scores on the continuous performance task showed significant sensitivity to sensory gating. We conclude that sensory gating reflects the identification of goal-irrelevant information at the encoding (input) stage and the subsequent ability to selectively attend to goal-relevant information based on that previous identification
Solving math problems: Where and why does the solution process go astray?
Wetensch. publicatieFaculteit der Sociale Wetenschappe
A2ML1 and otitis media: novel variants, differential expression, and relevant pathways
A genetic basis for otitis media is established, however, the role of rare variants in disease etiology is largely unknown. Previously a duplication variant within A2ML1 was identified as a significant risk factor for otitis media in an indigenous Filipino population and in US children. In this report exome and Sanger sequencing was performed using DNA samples from the indigenous Filipino population, Filipino cochlear implantees, US probands, Finnish, and Pakistani families with otitis media. Sixteen novel, damaging A2ML1 variants identified in otitis media patients were rare or low-frequency in population-matched controls. In the indigenous population, both gingivitis and A2ML1 variants including the known duplication variant and the novel splice variant c.4061 + 1 G>C were independently associated with otitis media. Sequencing of salivary RNA samples from indigenous Filipinos demonstrated lower A2ML1 expression according to the carriage of A2ML1 variants. Sequencing of additional salivary RNA samples from US patients with otitis media revealed differentially expressed genes that are highly correlated with A2ML1 expression levels. In particular, RND3 is upregulated in both A2ML1 variant carriers and high-A2ML1 expressors. These findings support a role for A2ML1 in keratinocyte differentiation within the middle ear as part of otitis media pathology and the potential application of ROCK inhibition in otitis media
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