Numerical solution of the eXtended Pom-Pom model for viscoelastic free surface flows

In this paper we present a finite difference method for solving two-dimensional viscoelastic unsteady free surface flows governed by the single equation version of the eXtended Pom-Pom (XPP) model. The momentum equations are solved by a projection method which uncouples the velocity and pressure fields. We are interested in low Reynolds number flows and, to enhance the stability of the numerical method, an implicit technique for computing the pressure condition on the free surface is employed. This strategy is invoked to solve the governing equations within a Marker-and-Cell type approach while simultaneously calculating the correct normal stress condition on the free surface. The numerical code is validated by performing mesh refinement on a two-dimensional channel flow. Numerical results include an investigation of the influence of the parameters of the XPP equation on the extrudate swelling ratio and the simulation of the Barus effect for XPP fluids

The fluctuation-dissipation theorem and the linear Glauber model

We obtain exact expressions for the two-time autocorrelation and response functions of the $d$-dimensional linear Glauber model. Although this linear model does not obey detailed balance in dimensions $d\geq 2$, we show that the usual form of the fluctuation-dissipation ratio still holds in the stationary regime. In the transient regime, we show the occurence of aging, with a special limit of the fluctuation-dissipation ratio, $X_{\infty}=1/2$, for a quench at the critical point.Comment: Accepted for publication (Physical Review E

Kinetic Ising System in an Oscillating External Field: Stochastic Resonance and Residence-Time Distributions

Experimental, analytical, and numerical results suggest that the mechanism by which a uniaxial single-domain ferromagnet switches after sudden field reversal depends on the field magnitude and the system size. Here we report new results on how these distinct decay mechanisms influence hysteresis in a two-dimensional nearest-neighbor kinetic Ising model. We present theoretical predictions supported by numerical simulations for the frequency dependence of the probability distributions for the hysteresis-loop area and the period-averaged magnetization, and for the residence-time distributions. The latter suggest evidence of stochastic resonance for small systems in moderately weak oscillating fields.Comment: Includes updated results for Fig.2 and minor text revisions to the abstract and text for clarit

Linear Invariant Systems Theory for Signal Enhancement

This paper discusses a linear time invariant (LTI) systems approach to signal enhancement via projective subspace techniques. It provides closed form expressions for the frequency response of data adaptive finite impulse response eigenfilters. An illustrative example using speech enhancement is also presented.Este artigo apresenta a aplicação da teoria de sistemas lineares invariantes no tempo (LTI) na análise de técnicas de sub-espaço. A resposta em frequência dos filtros resultantes da decomposição em valores singulares é obtida aplicando as propriedades dos sistemas LTI

Changes in the diet and body size of a small herbivorous mammal (hispid cotton rat, \u3ci\u3eSigmodon hispidus\u3c/i\u3e) following the late Pleistocene megafauna extinction

The catastrophic loss of large-bodied mammals during the terminal Pleistocene likely led to cascading effects within communities. While the extinction of the top consumers probably expanded the resources available to survivors of all body sizes, little work has focused on the responses of the smallest mammals. Here, we use a detailed fossil record from the southwestern United States to examine the response of the hispid cotton rat Sigmodon hispidus to biodiversity loss and climatic change over the late Quaternary. In particular, we focus on changes in diet and body size. We characterize diet through carbon (δ13C) and nitrogen (δ15N) isotope analysis of bone collagen in fossil jaws and body size through measurement of fossil teeth; the abundance of material allows us to examine population level responses at millennial scale for the past 16 ka. Sigmodon was not present at the cave during the full glacial, first appearing at ~16 ka after ice sheets were in retreat. It remained relatively rare until ~12 ka when warming tempera­tures allowed it to expand its species range northward. We find variation in both diet and body size of Sigmodon hispidus over time: the average body size of the population varied by ~20% (90–110 g) and mean δ13C and δ15N values ranged between −13.5 to −16.5‰ and 5.5 to 7.4‰ respectively. A state–space model suggested changes in mass were influenced by diet, maximum temperature and community structure, while the modest changes in diet were most influenced by community structure. Sigmodon maintained a fairly similar dietary niche over time despite contemporaneous changes in climate and herbivore community composition that followed the megafauna extinc­tion. Broadly, our results suggest that small mammals may be as sensitive to shifts in local biotic interactions within their ecosystem as they are to changes in climate and large-scale biodiversity loss

Resource communication. sIMfLOR - platform for portuguese forest simulators

Abstract In the last decades there has been an increasing number of forest models developed for the main species of the Portuguese forest. Forest models support management decisions by predicting long term stand development under alternative scenarios and taking into account all the components of the ecosystem. However, in most cases, there is a gap between the models developed and their application by decision-makers. The platform for Portuguese Forest Simulators (sIMfLOR) tries to overcome this gap integrating a wide variety of forest models into simulators and providing a baseline tool for forest managers in Portugal. As an integrated modular platform, sIMfLOR makes available forest simulators for the Portuguese forest with user-friendly interfaces to facilitate the introduction of the information for the simulators. The platform displays stand and regional simulators, interfaces to generate required inputs and also auxiliary tools. As the platform focus on end-users, it allows visualization of the simulators outputs in default graphics which can easily be edited by users. The sIMfLOR platform can be permanently accessed at http://www.isa.utl.pt/cef/forchange/fctools

N-acetylcysteine serves as substrate of 3-mercaptopyruvate sulfurtransferase and stimulates sulfide metabolism in colon cancer cells

Hydrogen sulfide (H2S) is an endogenously produced signaling molecule. The enzymes 3-mercaptopyruvate sulfurtransferase (MST), partly localized in mitochondria, and the inner mitochondrial membrane-associated sulfide:quinone oxidoreductase (SQR), besides being respectively involved in the synthesis and catabolism of H2S, generate sulfane sulfur species such as persulfides and polysulfides, currently recognized as mediating some of the H2S biological effects. Reprogramming of H2S metabolism was reported to support cellular proliferation and energy metabolism in cancer cells. As oxidative stress is a cancer hallmark and N-acetylcysteine (NAC) was recently suggested to act as an antioxidant by increasing intracellular levels of sulfane sulfur species, here we evaluated the effect of prolonged exposure to NAC on the H2S metabolism of SW480 colon cancer cells. Cells exposed to NAC for 24 h displayed increased expression and activity of MST and SQR. Furthermore, NAC was shown to: (i) persist at detectable levels inside the cells exposed to the drug for up to 24 h and (ii) sustain H2S synthesis by human MST more effectively than cysteine, as shown working on the isolated recombinant enzyme. We conclude that prolonged exposure of colon cancer cells to NAC stimulates H2S metabolism and that NAC can serve as a substrate for human MST

Application of the Matlab® Linprog function to plan the short term operation of hydro stations considered as price makers

The restructuring of power systems induced newchallenges to generation companies in terms of adequatelyplanning the operation of power stations in order to maximizetheir profits. In this scope, hydro resources are becomingextremely valuable given the revenues that their operation cangenerate. In this paper we describe the application of theMatlab® Linprog optimization function to solve the Short TermHydro Scheduling Problem, HSP, admitting that some stationsare installed in the same cascade and that some of them havepumping capabilities. The optimization module to solve the HSPproblem is then integrated in an iterative process to take intoaccount the impact that the operation decisions regarding thehydro stations under analysis have on the market prices. Theupdated market prices are then used to run again the HSPproblem thus enabling considering the hydro stations as pricemakers. The developed approach is illustrated using a systembased on the Portuguese Douro River cascade that includes 9hydro stations (4 of them are pumping stations) and a totalinstalled capacity of 1485 MW

Simultaneous targeting of Eph receptors in glioblastoma

Eph tyrosine kinase receptors are frequently overexpressed and functional in many cancers, and they are attractive candidates for targeted therapy. Here, we analyzed the expression of Eph receptor A3, one of the most up-regulated factors in glioblastoma cells cultured under tumorsphere-forming conditions, together with EphA2 and EphB2 receptors. EphA3 was overexpressed in up to 60% of glioblastoma tumors tested, but not in normal brain. EphA3 was localized in scattered areas of the tumor, the invasive ring, and niches near tumor vessels. EphA3 co-localized with macrophage/leukocyte markers, suggesting EphA3 expression on tumor-infiltrating cells of bone marrow origin. We took advantage of the fact that ephrinA5 (eA5) is a ligand that binds EphA3, EphA2 and EphB2 receptors, and used it to construct a novel targeted anti-glioblastoma cytotoxin. The eA5-based cytotoxin potently and specifically killed glioblastoma cells with an IC(50) of at least 10(−11) M. This and similar cytotoxins will simultaneously target different compartments of glioblastoma tumors while mitigating tumor heterogeneity

COPD and cardiovascular disease

COPD is one of the major public health problems in people aged 40 years or above. It is currently the 4th leading cause of death in the world and projected to be the 3rd leading cause of death by 2020. COPD and cardiac comorbidities are frequently associated. They share common risk factors, pathophysiological processes, signs and symptoms, and act synergistically as negative prognostic factors. Cardiac disease includes a broad spectrum of entities with distinct pathophysiology, treatment and prognosis. From an epidemiological point of view, patients with COPD are particularly vulnerable to cardiac disease. Indeed, mortality due to cardiac disease in patients with moderate COPD is higher than mortality related to respiratory failure. Guidelines reinforce that the control of comorbidities in COPD has a clear benefit over the potential risk associated with the majority of the drugs utilized. On the other hand, the true survival benefits of aggressive treatment of cardiac disease and COPD in patients with both conditions have still not been clarified. Given their relevance in terms of prevalence and prognosis, we will focus in this paper on the management of COPD patients with ischemic coronary disease, heart failure and dysrhythmia.Novartis Portugal Novartisinfo:eu-repo/semantics/publishedVersio