807 research outputs found
Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons
The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABAA-mediated responses rendering GABA hyperpolarizing in adult neurons. We have previously shown that BDNF upregulates KCC2 in immature neurons through the transcription factor Egr4. The effect of BDNF on Egr4 and KCC2 was shown to be dependent on the activation of ERK1/2. Here we demonstrate that the trophic factor neurturin can also trigger Egr4 expression and upregulate KCC2 in an ERK1/2-dependent manner. These results show that Egr4 is an important component in the mechanism for trophic factor-mediated upregulation of KCC2 in immature neurons involving the activation of specific intracellular pathways common to BDNF and Neurturin
Azimuthal dependence of pion source radii in Pb+Au collisions at 158 A GeV
We present results of a two-pion correlation analysis performed with the
Au+Pb collision data collected by the upgraded CERES experiment in the fall of
2000. The analysis was done in bins of the reaction centrality and the pion
azimuthal emission angle with respect to the reaction plane. The pion source,
deduced from the data, is slightly elongated in the direction perpendicular to
the reaction plane, similarly as was observed at the AGS and at RHIC.Comment: 5 pages, 2 figure
Elliptic flow of charged pions, protons and strange particles emitted in Pb+Au collisions at top SPS energy
Differential elliptic flow spectra v2(pT) of \pi-, K0short, p, \Lambda have
been measured at \sqrt(s NN)= 17.3 GeV around midrapidity by the
CERN-CERES/NA45 experiment in mid-central Pb+Au collisions (10% of
\sigma(geo)). The pT range extends from about 0.1 GeV/c (0.55 GeV/c for
\Lambda) to more than 2 GeV/c. Protons below 0.4 GeV/c are directly identified
by dE/dx. At higher pT, proton elliptic flow v2(pT) is derived as a
constituent, besides \pi+ and K+, of the elliptic flow of positive pion
candidates. The retrieval requires additional inputs: (i) of the particle
composition, and (ii) of v2(pT) of positive pions. For (i), particle ratios
obtained by NA49 were adapted to CERES conditions; for (ii), the measured
v2(pT) of negative pions is substituted, assuming \pi+ and \pi- elliptic flow
magnitudes to be sufficiently close. The v2(pT) spectra are compared to
ideal-hydrodynamics calculations. In synopsis of the series \pi- - K0short - p
- \Lambda, flow magnitudes are seen to fall with decreasing pT progressively
even below hydro calculations with early kinetic freeze-out (Tf= 160 MeV)
leaving not much time for hadronic evolution. The proton v2(pT) data show a
downward swing towards low pT with excursions into negative v2 values. The
pion-flow isospin asymmetry observed recently by STAR at RHIC, invalidating in
principle our working assumption, is found in its impact on proton flow
bracketed from above by the direct proton flow data, and not to alter any of
our conclusions. Results are discussed in perspective of recent viscous
dynamics studies which focus on late hadronic stages.Comment: 38 pages, 27 figures, 2 tables. Abstract and parts of introduction
made more comprehensible; corrected typos; acknowledgement added. To appear
in Nucl.Phys.
Particle Production at Large Transverse Momentum with ALICE
We present transverse momentum distributions of inclusive charged particles
and identified hadrons in and Pb--Pb collisions at \rs= 2.76 TeV,
measured by ALICE at the LHC. The Pb--Pb data are presented in intervals of
collision centrality and cover transverse momenta up to 50 GeV/. Nuclear
medium effects are studied in terms of the nuclear modification factor \raa.
The results indicate a strong suppression of high- particles in Pb--Pb
collisions, consistent with a large energy loss of hard-scattered partons in
the hot, dense and long-lived medium created at the LHC. We compare the
preliminary results for inclusive charged particles to previous results from
RHIC and calculations from energy loss models. Furthermore, we compare the
nuclear modification factors of inclusive charged particles to those of
identified , , K, and .Comment: Talk given at Quark Matter 2011 conferenc
Bioelectrochemical conversion of CO2 to value added product formate using engineered Methylobacterium extorquens
The conversion of carbon dioxide to formate is a fundamental step for building C1 chemical platforms. Methylobacterium extorquens AM1 was reported to show remarkable activity converting carbon dioxide into formate. Formate dehydrogenase 1 from M. extorquens AM1 (MeFDH1) was verified as the key responsible enzyme for the conversion of carbon dioxide to formate in this study. Using a 2% methanol concentration for induction, microbial harboring the recombinant MeFDH1 expressing plasmid produced the highest concentration of formate (26.6 mM within 21 hours) in electrochemical reactor. 60 ??M of sodium tungstate in the culture medium was optimal for the expression of recombinant MeFDH1 and production of formate (25.7 mM within 21 hours). The recombinant MeFDH1 expressing cells showed maximum formate productivity of 2.53 mM/g-wet cell/hr, which was 2.5 times greater than that of wild type. Thus, M. extorquens AM1 was successfully engineered by expressing MeFDH1 as recombinant enzyme to elevate the production of formate from CO2 after elucidating key responsible enzyme for the conversion of CO2 to formate
Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at = 5.02 TeV
Two-particle angular correlations between unidentified charged trigger and
associated particles are measured by the ALICE detector in p-Pb collisions at a
nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum
range 0.7 5.0 GeV/ is examined,
to include correlations induced by jets originating from low
momen\-tum-transfer scatterings (minijets). The correlations expressed as
associated yield per trigger particle are obtained in the pseudorapidity range
. The near-side long-range pseudorapidity correlations observed in
high-multiplicity p-Pb collisions are subtracted from both near-side
short-range and away-side correlations in order to remove the non-jet-like
components. The yields in the jet-like peaks are found to be invariant with
event multiplicity with the exception of events with low multiplicity. This
invariance is consistent with the particles being produced via the incoherent
fragmentation of multiple parton--parton scatterings, while the yield related
to the previously observed ridge structures is not jet-related. The number of
uncorrelated sources of particle production is found to increase linearly with
multiplicity, suggesting no saturation of the number of multi-parton
interactions even in the highest multiplicity p-Pb collisions. Further, the
number scales in the intermediate multiplicity region with the number of binary
nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/161
Charge separation relative to the reaction plane in Pb-Pb collisions at TeV
Measurements of charge dependent azimuthal correlations with the ALICE
detector at the LHC are reported for Pb-Pb collisions at TeV. Two- and three-particle charge-dependent azimuthal correlations in
the pseudo-rapidity range are presented as a function of the
collision centrality, particle separation in pseudo-rapidity, and transverse
momentum. A clear signal compatible with a charge-dependent separation relative
to the reaction plane is observed, which shows little or no collision energy
dependence when compared to measurements at RHIC energies. This provides a new
insight for understanding the nature of the charge dependent azimuthal
correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286
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