Tailoring residual stress profile of Selective Laser Melted parts byLaser Shock Peening

The paper describes a new approach in controlling and tailoring residual stress profile of parts made by Selective Laser Melting (SLM). SLM parts are well known for the high tensile stresses in the as – built state in the surface or subsurface region. These stresses have a detrimental effect on the mechanical properties and especially on the fatigue life. Laser Shock Peening (LSP) as a surface treatment method was applied on SLM parts and residual stress measurements with the hole – drilling method were performed. Two different grades of stainless steel were used: a martensitic 15-5 precipitation hardenable PH1 and an austenitic 316L. Different LSP parameters were used, varying laser energy, shot overlap, laser spot size and treatments with and without an ablative medium. For both materials the as-built (AB) residual stress state was changed to a more beneficial compressive state. The value and the depth of the compressive stress was analyzed and showed a clear dependence on the LSP processing parameters. Application of LSP on SLM parts showed promising results, and a novel method that would combine these two processes is proposed. The use of LSP during the building phase of SLM as a “3D LSP” method would possibly give the advantage of further increasing the depth and volume of compressive residual stresses, and selectively treating key areas of the part, thereby further increasing fatigue life

Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment

The immune system and cancer have a complex relationship with the immune system playing a dual role in tumor development. The effector cells of the immune system can recognize and kill malignant cells while immune system-mediated inflammation can also promote tumor growth and regulatory cells suppress the anti-tumor responses. In the center of all anti-tumor responses is the ability of the immune cells to migrate to the tumor site and to interact with each other and with the malignant cells. Cell adhesion molecules including receptors of the immunoglobulin superfamily and integrins are of crucial importance in mediating these processes. Particularly integrins play a vital role in regulating all aspects of immune cell function including immune cell trafficking into tissues, effector cell activation and proliferation and the formation of the immunological synapse between immune cells or between immune cell and the target cell both during homeostasis and during inflammation and cancer. In this review we discuss the molecular mechanisms regulating integrin function and the role of integrins and other cell adhesion molecules in immune responses and in the tumor microenvironment. We also describe how malignant cells can utilize cell adhesion molecules to promote tumor growth and metastases and how these molecules could be targeted in cancer immunotherapy.Peer reviewe