Status report of the NA48 experiment at the CERN SPS

The aim of the NA48 experiment at the CERN SPS is to measure direct CP violation in neutral kaon decays thus determining the parameter $\epsilon'/\epsilon$ with an accuracy of $2\times 10^{-4}$. The advantages of NA48 with respect to previous experiments are high statistics and reduced systematic effects. The principle of the experiment and the performance of the detector components are presented.Comment: To appear in the procs of the 6th Conf. on the Intersection of Particle and Nuclear Physics, Big Sky, Montana (CIPANP97); 7 pages including 3 figure

Niñez en situación de calle : Reflexiones a partir de dos experiencias de intervención

Fil: Talamonti, Paula. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina

Psoriasis Area and Severity Index response in moderate-severe psoriatic patients switched to adalimumab: results from the OPPSA study

Background: Few studies have compared the efficacy of switching to adalimumab in the real-life setting in plaque psoriasis patients. Objective: To evaluate the effect of adalimumab in psoriasis patients previously treated with other biologics. Methods: In this multicentre study, psoriasis patients (N = 262) treated with an anti-TNF-alpha agent, ustekinumab or naïve to biologics then switched to adalimumab were included. Disease severity was assessed by the Psoriasis Area and Severity Index (PASI) at baseline and after 3, 6, 12, 24 and 36 months. The association between clinical risk factors and achievement of PASI response was evaluated by logistic regression. Results: Adalimumab treatment resulted in a decrease in PASI (15.1 ± 6.2 at baseline vs. 2.7 ± 4.8 at 6 months, P < 0.0001), regardless of previous biologic treatment. Furthermore, adalimumab allowed 92.5%, 79% and 56% of patients to achieve PASI response (PASI 50, 75 and 90, respectively) and complete remission (PASI 100 response) in 48.4% of patients, by 6 months and maintained over 3 years, independent of prior biologic treatment. The absence of metabolic syndrome, dyslipidemia, hypertension and lower PASI and lower age at baseline was associated with achievement of PASI response at 3, 6 and 12 months, whereas at later time points (24 and 36 months), PASI 90 and PASI 100 response was associated with diagnosis of psoriasis/psoriatic arthritis. Conclusion: Adalimumab was effective at reducing PASI score over 3 years, irrespective of whether patients were biologic naïve or previously treated with a TNF-alpha or IL-12/23 inhibitor

Human-Machine Interface Development For Modifying Driver Lane Change Behavior In Manual, Automated, And Shared Control Automated Driving

Rear-end crashes are common on U.S. roads. Driver assistance and automated driving technologies can reduce rear-end crashes (among other crash types as well). Braking is assumed for forward collision warning (FCW) and automatic emergency braking (AEB) systems. Braking is also used for adaptive cruise control (ACC) and in automated driving systems more generally. However, steering may be advised in an emergency if the adjacent lane is clear and braking is unlikely to avoid a collision. Steering around an obstacle when feasible also eliminates the risk of becoming the new forward collision hazard. Driver assist technology like emergency steer assist (ESA) and Level 2 or Level 3 automated driving systems might facilitate manual emergency lane changes but may require the driver to manually initiate the maneuver, something which drivers are often reluctant to do. An Human-Machine Interface (HMI) might advise the driver of a steerable path when feasible in forward collision hazard situations. Such an HMI might also advise a driver of normal lane change opportunities that can reduce travel time, increase fuel efficiency, or simply enhance the driving experience by promoting `flow.\u27 This dissertation investigated the propensity of drivers to brake only versus steer in both manual and automated driving situations that end in a high-intensity forward collision hazard. A audio-visual Field of Safe Travel (FOST) cluster display and haptic steering wheel HMI were developed to advise drivers in both discretionary and emergency situations of a lane change opportunity. The HMI was tested in a moving base simulator in manual driving, in fully autonomous driving, and in shared-control autonomous driving during a simulated highway commute that ended in an high-intensity forward collision hazard situation. Results indicated that a) driver response was affected by the nature of the automated driving (faster response in hands-on shared control versus hands-off fully autonomous driving); b) exposure to the HMI in normal lane changes both familiarized the driver with the HMI and introduced a mental set that steering was also a possibility rather than braking only; c) but that drivers used their direct vision to determine their response in the emergency event. A methodological issue related to mental set was also uncovered and resolved through screening studies. The final study brought the dissertation full-circle, comparing hands-off fully automated driving to hands-on shared control automated driving in the context of either providing some or no exposure to the developed LCA system concept. Results of the final study indicated that shared control lies somewhere between that of manual driving and hands-off fully automate driving. Benefits were also shown to exist for the LCA system concept irrespective of whether the discrete haptic profiles are included or not. The discrete haptic profiles did not statistically reliably increase response times to the FC hazard event, although they do show a trend toward decreasing response variability. This finding solidified the fact that by implementing a system for benign driving that aids in establishing a mental set to steer around an obstacle may actually be beneficial for rear-end crash scenarios. This dissertation’s contributions include a) audio-visual FOST display concepts; b) discrete haptic steering display concepts; c) a paired-comparisons scaling for urgency for haptic displays applied while driving; d) a new ``mirage scenario\u27\u27 methodology for eliciting subjective assessments in the context of a forward collision hazard, briefly presented then removed, without risk of simulator sickness, and e) a methodological lesson for others who wish to investigate semi-automated and automated driving interventions and must manage driver mental set carefully

Input and output order of recall as early markers of cognitive decline

This thesis explored the effects of age on free recall patterns in episodic memory. Neuropsychological and neuroimaging instruments were used to investigate the input (i.e., serial position effects) and output (i.e., temporal vs. spatial contiguity) of free recall in younger vs. healthy older individuals and in older adults with cognitive decline. In study 1 (Chapter 4), primacy (intended as the tendency to better remember items presented at the beginning of a list compared to the middle) at delayed recall was the most accurate serial position effect in predicting conversion to early stage Mild Cognitive Impairment (MCI), from a baseline of cognitively functioning older adults. In study 2 (Chapter 5), age differences in the use of spatial vs. temporal contiguity (intended as the tendency to retrieve items following the temporal, or spatial, context in which they have been learned) were explored in younger vs. healthy older adults. It was found that temporal contiguity was the most utilised associative process in both groups, although older adults showed lower temporal contiguity compared to younger adults. In study 3 (Chapter 6), the universality of temporal contiguity and the relationship between attentional processes and the output order of free recall were examined. Temporal vs. spatial contiguity were investigated during tasks meant to interfere with encoding processes, that is Divided Attention (DA) tasks and tasks involving presentation of verbal vs. pictorial material. Results showed consistent use of temporal contiguity in all experimental conditions, therefore suggesting the ubiquity of temporal contiguity and its involvement in retrieval processes. In study 4 (Chapter 7), the output order in free recall was investigated in younger and older adults in relation to prefrontal blood oxygenation, by means of functional Near-Infrared Spectroscopy (fNIRS). It was found that areas involved during temporal contiguity change with age, as younger adults showed greater activity of the right prefrontal cortex, whilst older adults engaged alternative or opposite regions. In study 5 (Chapter 8) the use of unrelated memory lists was investigated as a sensitive measure to detect age-related differences on the use of temporal vs. spatial contiguity. Moreover, age-associated differences in the use of temporal contiguity were explored at immediate vs. delayed recall. It was found that unrelated lists are able to detect age-related changes in the use of contiguity effects, and that temporal contiguity is negatively affected in both younger and older adults at delayed recall. In study 6 (Chapter 9) temporal clustering was investigated as potential predictor of conversion to Cognitive Unimpaired Declining (CUD) status, from a baseline of cognitively functioning older individuals. Results supported the hypothesis that temporal contiguity is a marker of cognitive decline, also when controlling for genetic information and for variables typically used in clinical practice. In summary, the findings of this thesis show that the input and output order of free recall, although quite stable, decline with age and that they may be added as a potential tool for early detection in clinical settings, and in the research field

Patient satisfaction after auditory implant surgery. ten-year experience from a single implanting unit center

Conclusions: The satisfaction rate of the subjects with an auditory implant appears strictly related to the resulting auditory improvement, and the surgical variables would play a prevailing role in respect to the esthetic factors. Objectives: To assess the rate of satisfaction in subjects who underwent the surgical application of an auditory device at a single Implanting Center Unit. Method: A series of validated questionnaires has been administered to subjects who underwent the surgical application of different auditory devices. The Glasgow Benefit Inventory (GBI), the Visual Analog Scale (VAS), and the Abbreviated Profile of Hearing Aid Benefit (APHAB) have been used to compare the implanted situation with the hearing-aided one; a percutaneous bone conductive implant (pBCI) with an active middle ear implant (AMEI) on the round window in mixed hearing loss; and an invisible, fully-implantable device with a frankly and bulky semi-implantable device. Results: The mean GBI scores were higher in Vibrant Soundbridge (VSB)VR and BonebridgeVR subjects, without significant differences among the various devices. The mean VAS score increased for all the devices in comparison with the conventional hearing aid. The mean APHAB score was similarly better in the implanted condition as total and partial scores

Safety of COVID-19 vaccines in patients with psoriasis undergoing therapy with anti-interleukin agents

Introduction: There is very limited kn3e safety of COVID-19 vaccines in patients with psoriasis who are being treated with biological agents. We present our experience in 369 patients with moderate-to-severe psoriasis undergoing therapy with anti-IL agents who were vaccinated against SARS-CoV-2. Areas covered: None of the 369 patients referred to any serious adverse event related to vaccination against COVID-19, while about one-third reported mild adverse events similar to those seen in the general population that were resolved within 48 hours. No patient discontinued biological therapy to receive a COVID-19 vaccine. Expert opinion: Our observations provide evidence that COVID-19 vaccines can be considered safe in patients with moderate-to-severe psoriasis who are receiving anti-IL therapy

Early assessment of vestibular function after unilateral cochlear implant surgery

Introduction&nbsp;: Cochlear implantation (CI) has been reported to negatively effect on the vestibular function. The study of the vestibular function has variably been conducted by different types of diagnostic tools. The combined use of modern, rapidly performable diagnostic tools could reveal useful for standardizing the evaluation protocol. Methods: In a group of 28 subjects undergoing CI, the video Head Impulse Test (vHIT), the cervical Vestibular Evoked Myogenic Potentials (cVEMPS) and the short-form of Dizziness Handicap Inventory (DHI) questionnaire were investigated pre-operatively and post-operatively (implant on and off) in both the implanted and the contralateral, non-implanted ear. All surgeries were performed with a round window approach (RWA), except for three otosclerosis cases were the extended RWA (eRWA) was used. Results: The vHIT of the lateral semicircular canal showed a pre-operative vestibular involvement in nearly 50% of the cases, whilst the three canals were contemporarily affected in only 14% of them. In all the hypo-functional subjects, cVEMPs were absent. A low VOR gain in all the investigated SSCC was found in 4 subjects (14%). In those subjects, (21.7%) in whom cVEMPs were pre-operatively present and normal in the operated side, absence of response was post-operatives recorded. Discussion/Conclusion: The vestibular protocol applied for the study showed to be appropriate for distinguishing between the CI operated and the non-operated ear. In this regard, cVEMPs showed to be more sensitive than vHIT for revealing a vestibular sufferance after CI, although without statistical significance. Finally, the use of the RWA surgery was apparently not avoiding signs of vestibular impairment to occur

The impact of national and international financial crises on mental health and well-being: a systematic review

Background: Evidence suggests that financial crises and poor mental health are reciprocally related, butno systematic review has been conducted to synthesise the existing literature on the impact of nationaland international financial crises on population-level mental health and well-being.Aims: The aim of this study was to systematically review the available literature on the global impactof financial crises on mental health and well-being outcomes.Methods: After registration on PROSPERO, a systematic search was conducted in PsycINFO, MEDLINE,Wiley, and Web of Science for papers published until 21 November 2022. Following the PreferredReporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement, 98 papers were identifiedas meeting eligibility criteria. Included studies were assessed using the Mixed Methods Appraisal Tool(MMAT) and results were presented in a formal narrative synthesis.Results: Our findings show that financial crises are significantly associated with well-being andoccurrence of psychological conditions. Several socio-demographic, cultural, and country-specificcharacteristics played a crucial role in the prevention of population mental health decline in periods offinancial crises.Conclusions: Based on the findings of this review, evidence-based recommendations were developedto guide the design of policy actions that protect population mental health during and after financialcrises