Innovation Development for Highly Energy-Efficient Housing: Opportunities and Challenges Related to the Adoption of Passive Houses

In previous years we have seen a recognition of the significant potential that exists for reducing energy use through innovation in residential buildings. This study investigates innovation challenges and identifies opportunities that could lead to a rapid increase in the adoption of highly energy-efficient housing concepts, particularly that of the passive house. To this end, it exemplifies, interprets and develops the innovation adoption theory through an investigation of views and experiences on the supply side, the demand side and the policy side. It highlights successful innovation trajectories and barriers experienced by businesses. It addresses both problems and positive experiences from the perspective of the end user and investigates different policy approaches. As such, the research reveals important features of innovation-adoption strategies in the building sector. It shows how multi-player enterprise collaboration plays a key role, and the study also recommends the development of quality assurance schemes. It makes a valuable contribution to discussions about how active the role of government policymakers and enterprise networks should be

Net zero energy building: a review of current definitions and definition development in Belgium

peer reviewedThe recast of the European Performance of Buildings Directive (EPBD) requires the uptake of a definition of so called ‘nearly zero energy’ buildings (nZEB). Belgium was first to set a definition for a ‘net zero energy house’ (NZEB) in 2009. Every year the definition is revised for consistency with shortcomings and emerging issues. The Belgian definition raised many questions regarding (1) the net balance, (2) the application and calculation method (3) the indoor air quality and comfort, (4) energy use included in the balance, (5) the type of buildings, (6) the accepted renewable energy supply options, (7) the quality assurance and monitoring and (8) energy storage and the connection to the energy infrastructure. Therefore, the paper presents a review on the current Belgian definition and its market status in comparison with the international context. The aim of the paper is to review current definition discussions and pave the way to a more consistent definition

PathwayExplorer: web service for visualizing high-throughput expression data on biological pathways

While generation of high-throughput expression data is becoming routine, the fast, easy, and systematic presentation and analysis of these data in a biological context is still an obstacle. To address this need, we have developed PathwayExplorer, which maps expression profiles of genes or proteins simultaneously onto major, currently available regulatory, metabolic and cellular pathways from KEGG, BioCarta and GenMAPP. PathwayExplorer is a platform-independent web server application with an optional standalone Java application using a SOAP (simple object access protocol) interface. Mapped pathways are ranked for the easy selection of the pathway of interest, displaying all available genes of this pathway with their expression profiles in a selectable and intuitive color code. Pathway maps produced can be downloaded as PNG, JPG or as high-resolution vector graphics SVG. The web service is freely available at ; the standalone client can be downloaded at

GOLD.db: genomics of lipid-associated disorders database

BACKGROUND: The GOLD.db (Genomics of Lipid-Associated Disorders Database) was developed to address the need for integrating disparate information on the function and properties of genes and their products that are particularly relevant to the biology, diagnosis management, treatment, and prevention of lipid-associated disorders. DESCRIPTION: The GOLD.db provides a reference for pathways and information about the relevant genes and proteins in an efficiently organized way. The main focus was to provide biological pathways with image maps and visual pathway information for lipid metabolism and obesity-related research. This database provides also the possibility to map gene expression data individually to each pathway. Gene expression at different experimental conditions can be viewed sequentially in context of the pathway. Related large scale gene expression data sets were provided and can be searched for specific genes to integrate information regarding their expression levels in different studies and conditions. Analytic and data mining tools, reagents, protocols, references, and links to relevant genomic resources were included in the database. Finally, the usability of the database was demonstrated using an example about the regulation of Pten mRNA during adipocyte differentiation in the context of relevant pathways. CONCLUSIONS: The GOLD.db will be a valuable tool that allow researchers to efficiently analyze patterns of gene expression and to display them in a variety of useful and informative ways, allowing outside researchers to perform queries pertaining to gene expression results in the context of biological processes and pathways

TiSGeD: a database for tissue-specific genes

Summary: The tissue-specific genes are a group of genes whose function and expression are preferred in one or several tissues/cell types. Identification of these genes helps better understanding of tissue–gene relationship, etiology and discovery of novel tissue-specific drug targets. In this study, a statistical method is introduced to detect tissue-specific genes from more than 123 125 gene expression profiles over 107 human tissues, 67 mouse tissues and 30 rat tissues. As a result, a novel subject-specialized repository, namely the tissue-specific genes database (TiSGeD), is developed to represent the analyzed results. Auxiliary information of tissue-specific genes was also collected from biomedical literatures

Web Platforms Integrating Supply and Demand for Energy Renovations

OTB ReseachOTB Research Institute for the Built Environmen

Non-tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia

Composition of tumour immune cell infiltrates correlates with response to treatment and overall survival (OS) in several cancer settings. We retrospectively examined immune cells present in diagnostic bone marrow aspirates from paediatric patients with B-cell acute lymphoblastic leukaemia. Our analysis identified a sub-group (∼30% of patients) with>2.37% CD20 and>6.05% CD7 expression, which had 100% OS, and a sub-group (∼30% of patients) with ≤2.37% CD20 and ≤6.05% CD7 expression at increased risk of treatment failure (66.7% OS, P < 0.05). Immune cell infiltrate at diagnosis may predict treatment response and could provide a means to enhance immediate treatment risk stratification

Policy Challenges for the Development of Energy Flexibility Services

European energy policies call for an increased share of renewable energy sources and a more active role of the energy consumer. This is facilitated by, amongst others, buildings becoming energy flexible hubs, supporting smart energy grids with demand response strategies. While there is abundant technical research in this field, the related business and policy development is less well documented. This research scopes existing policy programmes and identifies opportunities and barriers to business development supporting energy flexible buildings. Using examples from seven European countries, this work reviews influencing niche management factors such as existing policy instruments, business development cases and identified stakeholder concerns, using literature research, narrative analysis and stakeholder research. National policy pathways show many differences but confirm that European buildings might become active players in the energy market, by providing energy storage, demand response and/or shifts in the use of energy sources. Slow sustained business development for energy flexibility services was mainly identified in the retail industry, and for energy service companies and aggregators. The direct involvement of end users in energy flexible buildings is still difficult. Stakeholders call for policy improvement, especially concerning the development of flexible energy tariffs, supporting incentives, awareness raising and more stakeholder-targeted business development

Collaboration opportunities in advanced housing renovation

AbstractIn theory, there is huge potential for reducing the energy consumed by existing single-family houses by thoroughly renovating them. For the successful market development of highly energy-efficient integrated renovations, supply chain collaboration is very important, while at the same time customer demand for integrated renovations has to be stimulated. A research and networking methodology was developed within the framework of the One Stop Shop project to identify and develop collaboration opportunities for advanced housing renovation in Belgium, Denmark, Finland and Norway. The research identified key supply-side needs through interviews and questionnaires, and analysed important elements for the development of a web-based portal that can connect supply and demand. The project further developed ideas and methods for collaboration and business model generation between different players on the renovation market. These different research results contributed to defining new business opportunities related to process innovation to unburden the homeowner and to achieve less fragmented renovation processes

The immune score as a new possible approach for the classification of cancer

The outcome prediction in cancer is usually achieved by evaluating tissue samples obtained during surgical removal of the primary tumor focusing on their histopathological characteristics. Tumor staging (AJCC/UICC-TNM classification) summarizes data on tumor burden (T), presence of cancer cells in draining and regional lymph nodes (N), and evidence for metastases (M). However, this classification provides limited prognostic information in estimating the outcome in cancer and does not predict response to therapy. It is recognized that cancer outcomes can vary significantly among patients within the same stage. Recently, many reports suggest that cancer development is controlled by the host's immune system underlying the importance of including immunological biomarkers for the prediction of prognosis and response to therapy. Data collected from large cohorts of human cancers demonstrated that the immune-classification has a prognostic value that may be superior to the AJCC/UICC TNM-classification. Thus, it is imperative to begin incorporating immune scoring as a prognostic factor and to introduce this parameter as a marker to classify cancers, as part of the routine diagnostic and prognostic assessment of tumors. At the same time, the inherent complexity of quantitative immunohistochemistry, in conjunction with variable assay protocols across laboratories, the different immune cell types analyzed, different region selection criteria, and variable ways to quantify immune infiltration underscore the urgent need to reach assay harmonization. In an effort to promote the immunoscore in routine clinical settings worldwide, the Society for Immunotherapy of Cancer (SITC), the European Academy of Tumor Immunology, the Cancer and Inflammation Program, the National Cancer Institute, National Institutes of Health, USA and "La Fondazione Melanoma" will jointly initiate a task force on Immunoscoring as a New Possible Approach for the Classification of Cancer that will take place in Naples, Italy, February 13th, 2012. The expected outcome will include a concept manuscript that will be distributed to all interested participants for their contribution before publication outlining the goal and strategy to achieve this effort; a preliminary summary to be presented during the "Workshop on Tumor Microenvironment" prior to the SITC annual meeting on October 24th - 25th 2012 in Bethesda, Maryland, USA and finally a "Workshop on Immune Scoring" to be held in Naples in December of 2012 leading to the preparation of a summary document providing recommendations for the harmonization and implementation of the Immune Score as a new component for the classification of cancer