49 research outputs found
LâexpĂ©rience amĂ©ricaine et la rĂ©forme de la tarification hospitaliĂšre en France â commentaire de lâarticle de J. Newhouse
LâexpĂ©rience amĂ©ricaine et la rĂ©forme de la tarification hospitaliĂšre en France â commentaire de lâarticle de J. Newhouse
Development of a new pan-European testate amoeba transfer function for reconstructing peatland palaeohydrology
In the decade since the first pan-European testate amoeba-based transfer function for peatland palaeohydrological reconstruction was published, a vast amount of additional data collection has been undertaken by the research community. Here, we expand the pan-European dataset from 128 to 1799 samples, spanning 35° of latitude and 55° of longitude. After the development of a new taxonomic scheme to permit compilation of data from a wide range of contributors and the removal of samples with high pH values, we developed ecological transfer functions using a range of model types and a dataset of âŒ1300 samples. We rigorously tested the efficacy of these models using both statistical validation and independent test sets with associated instrumental data. Model performance measured by statistical indicators was comparable to other published models. Comparison to test sets showed that taxonomic resolution did not impair model performance and that the new pan-European model can therefore be used as an effective tool for palaeohydrological reconstruction. Our results question the efficacy of relying on statistical validation of transfer functions alone and support a multi-faceted approach to the assessment of new models. We substantiated recent advice that model outputs should be standardised and presented as residual values in order to focus interpretation on secure directional shifts, avoiding potentially inaccurate conclusions relating to specific water-table depths. The extent and diversity of the dataset highlighted that, at the taxonomic resolution applied, a majority of taxa had broad geographic distributions, though some morphotypes appeared to have restricted ranges
Chicken lung lectin is a functional C-type lectin and inhibits haemagglutination by influenza A virus
Many proteins of the calcium-dependent (C-type) lectin family have been shown to play an important role in innate immunity. They can bind to a broad range of carbohydrates, which enables them to interact with ligands present on the surface of micro-organisms.We previously reported the finding of a new putative chicken lectin, which was predominantly localized to the respiratory tract, and thus termed chicken lung lectin (cLL). In order to investigate the biochemical and biophysical properties of cLL, the recombinant protein was expressed, affinity purified and characterized. Recombinant cLL was expressed as four differently sized peptides, which is most likely due to post-translational modification. Crosslinking of the protein led to the formation of two high-molecular weight products, indicating that cLL forms trimeric and possibly even multimeric subunits. cLL was shown to have lectin activity, preferentially binding to a-mannose in a calcium-dependent manner. Furthermore, cLL was shown to inhibit the haemagglutination-activity of human isolates of influenza A virus, subtype H3N2 and H1N1. These result show that cLL is a true C-type lectin with a very distinct sugar specificity, and that this chicken lectin could play an important role in innate immunity
Evaluating the use of testate amoeba for palaeohydrological reconstruction in permafrost peatlands
The melting of high-latitude permafrost peatlands is a major concern due to a potential positive feedback on global climate change. We examine the ecology of testate amoebae in permafrost peatlands, based on sites in Sweden (~ 200 km north of the Arctic Circle). Multivariate statistical analysis confirms that water-table depth and moisture content are the dominant controls on the distribution of testate amoebae, corroborating the results from studies in mid-latitude peatlands. We present a new testate amoeba-based water table transfer function and thoroughly test it for the effects of spatial autocorrelation, clustered sampling design and uneven sampling gradients. We find that the transfer function has good predictive power; the best-performing model is based on tolerance-downweighted weighted averaging with inverse deshrinking (performance statistics with leave-one-out cross validation: R2 = 0.87, RMSEP = 5.25 cm). The new transfer function was applied to a short core from Stordalen mire, and reveals a major shift in peatland ecohydrology coincident with the onset of the Little Ice Age (c. AD 1400). We also applied the model to an independent contemporary dataset from Stordalen and find that it outperforms predictions based on other published transfer functions. The new transfer function will enable palaeohydrological reconstruction from permafrost peatlands in Northern Europe, thereby permitting greatly improved understanding of the long-term ecohydrological dynamics of these important carbon stores as well as their responses to recent climate change
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The high energy Universe at ultra-high resolution: the power and promise of X-ray interferometry
We propose the development of X-ray interferometry (XRI), to reveal the Universe at high energies with ultra-high spatial resolution. With baselines which can be accommodated on a single spacecraft, XRI can reach 100 ÎŒ as resolution at 10 Ă
(1.2 keV) and 20 ÎŒ as at 2 Ă
(6 keV), enabling imaging and imaging-spectroscopy of (for example) X-ray coronae of nearby accreting supermassive black holes (SMBH) and the SMBH âshadowâ; SMBH accretion flows and outflows; X-ray binary winds and orbits; stellar coronae within âŒ100 pc and many exoplanets which transit across them. For sufficiently luminous sources XRI will resolve sub-pc scales across the entire observable Universe, revealing accreting binary SMBHs and enabling trigonometric measurements of the Hubble constant with X-ray light echoes from quasars or explosive transients. A multi-spacecraft âconstellationâ interferometer would resolve well below 1 ÎŒ as, enabling SMBH event horizons to be resolved in many active galaxies and the detailed study of the effects of strong field gravity on the dynamics and emission from accreting gas close to the black hole
Controls on midâocean ridge normal fault seismicity across spreading rates from rateâandâstate friction models
Author Posting. © American Geophysical Union., 2018. This article is posted here by permission of American Geophysical Union.for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Solid Earth 123 (2018): 6719-6733, doi:10.1029/2018JB015545.Recent seismic and geodetic observations have led to a growing realization that a significant amount of fault slip at plate boundaries occurs aseismically and that the amount of aseismic slip varies across tectonic settings. Seismic moment release rates measured along the fastâspreading East Pacific Rise suggest that the majority of fault slip occurs aseismically. By contrast, at the slowâspreading MidâAtlantic Ridge seismic slip may represent up to 60% of total fault displacement. In this study, we use rateâandâstate friction models to quantify the seismic coupling coefficient, defined as the fraction of total fault slip that occurs seismically, on midâocean ridge normal faults and investigate controls on fault behavior that might produce variations in coupling observed at oceanic spreading centers. We find that the seismic coupling coefficient scales with the ratio of the downdip width of the seismogenic area (W) to the critical earthquake nucleation size (h*). At midâocean ridges, W is expected to increase with decreasing spreading rate. Thus, the relationship between seismic coupling and W/h* predicted from our models explains the firstâorder variations in seismic coupling coefficient as a function of spreading rate.National Science Foundation (NSF) Grant Numbers: EARâ10â10432, OCEâ10â61203;
NSF | GEO | Division of Earth Sciences (EAR);
NSF | GEO | Division of Ocean Sciences (OCE)2019-02-1
Feedback by massive stars and the emergence of superbubbles. II. X-ray properties
This article has an erratum M. Krause, et al., âFeedback by massive stars and the emergence of superbubbles. II. X-ray propertiesâ, Astronomy & Astrophysics, Vol. 566, June 2014. This version of record is available online at: https://www.aanda.org/articles/aa/abs/2014/06/aa23871-14/aa23871-14.html Reproduced with Permission from Astronomy and Astrophysics, © ESO 2014.Context. In a previous paper we investigated the energy transfer of massive stars to the interstellar medium (ISM) as a function of time and the geometrical configuration of three massive stars via 3D-mesh-refining hydrodynamics simulations, following the complete evolution of the massive stars and their supernovaewith the exception of non-thermal processes. Aims. To compare our results against observations we derivethermalX-ray properties of the ISM from our simulations and compare them to observations of superbubbles in general, to the well-studied nearby Orion-Eridanus superbubble and to the diffuse soft X-ray emission of nearby galaxies. Methods. We analysed our ISM simulation results with the help of spectra for plasma temperatures between 0.1 and 10 keV and computed the spectral evolution and the spatio-temporal distribution of the hot gas. Results. Despite significant input of high-temperature gas from supernovae and fast stellar winds, the resultingthermalX-ray spectra are generally very soft, with most of the emission well below 1 keV. We show that this is due to mixing triggered by resolved hydrodynamic instabilities. Supernovae enhance the X-ray luminosity of a superbubble by 1â2 orders of magnitude for a time span of about 0.1 Myr; which is longer if a supernova occurs in a larger superbubble and shorter in higher energy bands. Peak superbubble luminosities of the order of 1036 erg s-1 are reproduced well. The strong decay of the X-ray luminosity is due to bubble expansion, hydrodynamic instabilities related to the acceleration of the superbubbleâs shell thanks to the sudden energy input, and subsequent mixing. We also find global oscillations of our simulated superbubbles, which produce spatial variations of the X-ray spectrum, similar to what we see in the Orion-Eridanus cavity. We calculated the fraction of energy emitted in X-rays and find that with a value of a few times 10-4, it is about a factor of ten below the measurements for nearby galaxies. Conclusions. Our models explain the observed soft spectra and peak X-ray luminosities of individual superbubbles. Each supernova event inside a superbubble produces a fairly similar heating-entrainment-cooling sequence, and the energy content of superbubbles is always determined by a specific fraction of the energy released by one supernova. For a given superbubble, soft X-rays trace the internal energy content well with moderate scatter. Some mechanism seems to delay the energy loss in real superbubbles compared to our simulations. Alternatively, some mechanism other thanthermal emission ofsuperbubbles may contribute to the soft X-ray luminosity of star-forming galaxies.Peer reviewe